Works by Barinka, Cyril

Results: 42

Retinitis pigmentosa-linked mutations impair the snRNA unwinding activity of SNRNP200 and reduce pre-mRNA binding of PRPF8.

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-025-05621-z

By:

Zimmann, Felix;
McNicoll, Francois;
Thakur, Prasoon Kumar;
Blažíková, Michaela;
Kubovčiak, Jan;
Hernández Cañás, María Clara;
Nováková, Zora;
Bařinka, Cyril;
Kolář, Michal;
Staněk, David;
Müller-McNicoll, Michaela;
Cvačková, Zuzana

Publication type:

Article

Evaluation of <sup>111</sup>In-DOTA-5D3, a Surrogate SPECT Imaging Agent for Radioimmunotherapy of Prostate-Specific Membrane Antigen.

Published in:

Journal of Nuclear Medicine, 2019, v. 60, n. 3, p. 400, doi. 10.2967/jnumed.118.214403

By:

Banerjee, Sangeeta Ray;
Kumar, Vivek;
Lisok, Ala;
Plyku, Donika;
Nováková, Zora;
Brummet, Mary;
Wharram, Bryan;
Barinka, Cyril;
Hobbs, Robert;
Pomper, Martin G.

Publication type:

Article

Glu-Ureido–Based Inhibitors of Prostate-Specific Membrane Antigen: Lessons Learned During the Development of a Novel Class of Low-Molecular-Weight Theranostic Radiotracers.

Published in:

Journal of Nuclear Medicine, 2017, v. 58, p. 17S, doi. 10.2967/jnumed.116.186775

By:

Kopka, Klaus;
Benešová, Martina;
Bařinka, Cyril;
Haberkorn, Uwe;
Babich, John

Publication type:

Article

Characterization of the class IIa histone deacetylases substrate specificity.

Published in:

FASEB Journal, 2022, v. 36, n. 5, p. 1, doi. 10.1096/fj.202101663R

By:

Kutil, Zsofia;
Meleshin, Marat;
Baranova, Petra;
Havlinova, Barbora;
Schutkowski, Mike;
Barinka, Cyril

Publication type:

Article

Tunable Multivalent Platform for Immune Recruitment to Lower Antigen Expressing Cancers.

Published in:

Angewandte Chemie, 2023, v. 135, n. 9, p. 1, doi. 10.1002/ange.202214659

By:

Lake, Benjamin P. M.;
Wylie, Ryan G.;
Bařinka, Cyril;
Rullo, Anthony F.

Publication type:

Article

A prostate-specific membrane antigen activated molecular rotor for real-time fluorescence imaging.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25746-6

By:

Zhang, Jingming;
Rakhimbekova, Anastasia;
Duan, Xiaojiang;
Yin, Qingqing;
Foss, Catherine A.;
Fan, Yan;
Xu, Yangyang;
Li, Xuesong;
Cai, Xuekang;
Kutil, Zsofia;
Wang, Pengyuan;
Yang, Zhi;
Zhang, Ning;
Pomper, Martin G.;
Wang, Yiguang;
Bařinka, Cyril;
Yang, Xing

Publication type:

Article

Uncovering the essential roles of glutamate carboxypeptidase 2 orthologs in Caenorhabditis elegans.

Published in:

Bioscience Reports, 2024, v. 44, n. 1, p. 1, doi. 10.1042/BSR20230502

By:

Panska, Lucie;
Nedvedova, Stepanka;
Vacek, Vojtech;
Krivska, Daniela;
Konecny, Lukas;
Knop, Filip;
Kutil, Zsofia;
Skultetyova, Lubica;
Leontovyc, Adrian;
Ulrychova, Lenka;
Sakanari, Judy;
Asahina, Masako;
Barinka, Cyril;
Macurkova, Marie;
Dvorak, Jan

Publication type:

Article

Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.

Published in:

FEBS Journal, 2009, v. 276, n. 16, p. 4448, doi. 10.1111/j.1742-4658.2009.07152.x

By:

Hlouchova, Klara;
Barinka, Cyril;
Konvalinka, Jan;
Lubkowski, Jacek

Publication type:

Article

Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis.

Published in:

FEBS Journal, 2007, v. 274, n. 18, p. 4731, doi. 10.1111/j.1742-4658.2007.06021.x

By:

Mlčochov, Petra;
Plechanovov, Anna;
Bařinka, Cyril;
Mahadevan, Daruka;
Saldanha, Jose W.;
Rulíšek, Lubomír;
Konvalinka&, Jan

Publication type:

Article

Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors.

Published in:

Biological Chemistry, 2005, v. 386, n. 4, p. 339, doi. 10.1515/BC.2005.041

By:

Caffrey, Conor R.;
Placha, Lenka;
Barinka, Cyril;
Hradilek, Martin;
Dostal, Jiř;í;
Sajid, Mohammed;
McKerrow, James H.;
Majer, Pavel;
Konvalinka, Jan;
Vondrášek, Jiří

Publication type:

Article

Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-21147-x

By:

Novakova, Zora;
Milosevic, Mirko;
Kutil, Zsofia;
Ondrakova, Marketa;
Havlinova, Barbora;
Kasparek, Petr;
Sandoval-Acuña, Cristian;
Korandova, Zuzana;
Truksa, Jaroslav;
Vrbacky, Marek;
Rohlena, Jakub;
Barinka, Cyril

Publication type:

Article

Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 2, p. 1358, doi. 10.3390/ijms25021358

By:

Baselious, Fady;
Hilscher, Sebastian;
Robaa, Dina;
Barinka, Cyril;
Schutkowski, Mike;
Sippl, Wolfgang

Publication type:

Article

Continuous Fluorescent Sirtuin Activity Assay Based on Fatty Acylated Lysines.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 8, p. 7416, doi. 10.3390/ijms24087416

By:

Zessin, Matthes;
Meleshin, Marat;
Hilscher, Sebastian;
Schiene-Fischer, Cordelia;
Barinka, Cyril;
Jung, Manfred;
Schutkowski, Mike

Publication type:

Article

Selectivity of Hydroxamate- and Difluoromethyloxadiazole-Based Inhibitors of Histone Deacetylase 6 In Vitro and in Cells.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 5, p. 4720, doi. 10.3390/ijms24054720

By:

Ptacek, Jakub;
Snajdr, Ivan;
Schimer, Jiri;
Kutil, Zsofia;
Mikesova, Jana;
Baranova, Petra;
Havlinova, Barbora;
Tueckmantel, Werner;
Majer, Pavel;
Kozikowski, Alan;
Barinka, Cyril

Publication type:

Article

Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 1, p. 369, doi. 10.3390/ijms23010369

By:

Ibrahim, Hany S.;
Abdelsalam, Mohamed;
Zeyn, Yanira;
Zessin, Matthes;
Mustafa, Al-Hassan M.;
Fischer, Marten A.;
Zeyen, Patrik;
Sun, Ping;
Bülbül, Emre F.;
Vecchio, Anita;
Erdmann, Frank;
Schmidt, Matthias;
Robaa, Dina;
Barinka, Cyril;
Romier, Christophe;
Schutkowski, Mike;
Krämer, Oliver H.;
Sippl, Wolfgang

Publication type:

Article

Engineered Fragments of the PSMA-Specific 5D3 Antibody and Their Functional Characterization.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 18, p. 6672, doi. 10.3390/ijms21186672

By:

Novakova, Zora;
Belousova, Nikola;
Foss, Catherine A.;
Havlinova, Barbora;
Gresova, Marketa;
Das, Gargi;
Lisok, Ala;
Prada, Adam;
Barinkova, Marketa;
Hubalek, Martin;
Pomper, Martin G.;
Barinka, Cyril

Publication type:

Article

BRAT1 links Integrator and defective RNA processing with neurodegeneration.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32763-6

By:

Cihlarova, Zuzana;
Kubovciak, Jan;
Sobol, Margarita;
Krejcikova, Katerina;
Sachova, Jana;
Kolar, Michal;
Stanek, David;
Barinka, Cyril;
Yoon, Grace;
Caldecott, Keith W.;
Hanzlikova, Hana

Publication type:

Article

Tunable Multivalent Platform for Immune Recruitment to Lower Antigen Expressing Cancers.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 9, p. 1, doi. 10.1002/anie.202214659

By:

Lake, Benjamin P. M.;
Wylie, Ryan G.;
Bařinka, Cyril;
Rullo, Anthony F.

Publication type:

Article

The calcium‐binding site of human glutamate carboxypeptidase II is critical for dimerization, thermal stability, and enzymatic activity.

Published in:

Protein Science: A Publication of the Protein Society, 2018, v. 27, n. 9, p. 1575, doi. 10.1002/pro.3460

By:

Ptacek, Jakub;
Nedvedova, Jana;
Navratil, Michal;
Havlinova, Barbora;
Konvalinka, Jan;
Barinka, Cyril

Publication type:

Article

Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.

Published in:

Protein Science: A Publication of the Protein Society, 2004, v. 13, n. 6, p. 1627, doi. 10.1110/ps.04622104

By:

Barinka, Cyril;
Šácha, Pavel;
Sklenář, Jan;
Man, Petr;
Bezouška, Karel;
Slusher, Barbara S.;
Konvalinka, Jan

Publication type:

Article

Carboxy-terminal polyglutamylation regulates signaling and phase separation of the Dishevelled protein.

Published in:

EMBO Journal, 2024, v. 43, n. 22, p. 5635, doi. 10.1038/s44318-024-00254-7

By:

Kravec, Marek;
Šedo, Ondrej;
Nedvědová, Jana;
Micka, Miroslav;
Šulcová, Marie;
Zezula, Nikodém;
Gömöryová, Kristína;
Potěšil, David;
Sri Ganji, Ranjani;
Bologna, Sara;
Červenka, Igor;
Zdráhal, Zbyněk;
Harnoš, Jakub;
Tripsianes, Konstantinos;
Janke, Carsten;
Bařinka, Cyril;
Bryja, Vítězslav

Publication type:

Article

Novel Monoclonal Antibodies Recognizing Human Prostate-Specific Membrane Antigen (PSMA) as Research and Theranostic Tools.

Published in:

Prostate, 2017, v. 77, n. 7, p. 749, doi. 10.1002/pros.23311

By:

Nováková, Zora;
Foss, Catherine A.;
Copeland, Benjamin T.;
Morath, Volker;
Baranová, Petra;
Havlínová, Barbora;
Skerra, Arne;
Pomper, Martin G.;
Barinka, Cyril

Publication type:

Article

Prostate-specific membrane antigen and its truncated form PSM′.

Published in:

Prostate, 2009, v. 69, n. 5, p. 471, doi. 10.1002/pros.20894

By:

Mlčochová, Petra;
Bařinka, Cyril;
Tykvart, Jan;
Šácha, Pavel;
Konvalinka, Jan

Publication type:

Article

Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs.

Published in:

Prostate, 2008, v. 68, n. 2, p. 171, doi. 10.1002/pros.20676

By:

Rovenská, Miroslava;
Hlouchová, Klára;
Šácha, Pavel;
Mlčochová, Petra;
Horák, Vratislav;
Zámečník, Josef;
Bařinka, Cyril;
Konvalinka, Jan

Publication type:

Article

Author Correction: Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells.

Published in:

2019

By:

Knox, Tessa;
Sahakian, Eva;
Banik, Debarati;
Hadley, Melissa;
Palmer, Erica;
Noonepalle, Satish;
Kim, Jennifer;
Powers, John;
Gracia-Hernandez, Maria;
Oliveira, Vasco;
Cheng, Fengdong;
Chen, Jie;
Barinka, Cyril;
Pinilla-Ibarz, Javier;
Lee, Norman H.;
Kozikowski, Alan;
Villagra, Alejandro

Publication type:

Correction Notice

Targeting prostate cancer by new bispecific monocyte engager directed to prostate-specific membrane antigen.

Published in:

PLoS ONE, 2025, v. 20, n. 3, p. 1, doi. 10.1371/journal.pone.0307353

By:

Das, Gargi;
Ptacek, Jakub;
Campbell, Jana;
Li, Xintang;
Havlinova, Barbora;
Noonepalle, Satish kumar;
Villagra, Alejandro;
Barinka, Cyril;
Novakova, Zora

Publication type:

Article

Characterization of glutamate carboxypeptidase 2 orthologs in trematodes.

Published in:

Parasites & Vectors, 2022, v. 15, n. 1, p. 1, doi. 10.1186/s13071-022-05556-5

By:

Jedlickova, Lucie;
Peterkova, Kristyna;
Boateng, Enoch Mensah;
Ulrychova, Lenka;
Vacek, Vojtech;
Kutil, Zsofia;
Jiang, Zhenze;
Novakova, Zora;
Snajdr, Ivan;
Kim, Juan;
O'Donoghue, Anthony J.;
Barinka, Cyril;
Dvorak, Jan

Publication type:

Article

Characterization of glutamate carboxypeptidase 2 orthologs in trematodes.

Published in:

Parasites & Vectors, 2022, v. 15, n. 1, p. 1, doi. 10.1186/s13071-022-05556-5

By:

Jedlickova, Lucie;
Peterkova, Kristyna;
Boateng, Enoch Mensah;
Ulrychova, Lenka;
Vacek, Vojtech;
Kutil, Zsofia;
Jiang, Zhenze;
Novakova, Zora;
Snajdr, Ivan;
Kim, Juan;
O'Donoghue, Anthony J.;
Barinka, Cyril;
Dvorak, Jan

Publication type:

Article

Structural basis of prostate-specific membrane antigen recognition by the A9g RNA aptamer.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 19, p. 11130, doi. 10.1093/nar/gkaa494

By:

Ptacek, Jakub;
Zhang, Dong;
Qiu, Liming;
Kruspe, Sven;
Motlova, Lucia;
Kolenko, Petr;
Novakova, Zora;
Shubham, Shambhavi;
Havlinova, Barbora;
Baranova, Petra;
Chen, Shi-Jie;
Zou, Xiaoqin;
Giangrande, Paloma;
Barinka, Cyril

Publication type:

Article

Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.

Published in:

EMBO Journal, 2006, v. 25, n. 6, p. 1375, doi. 10.1038/sj.emboj.7600969

By:

Mesters, Jeroen R.;
Barinka, Cyril;
Weixing Li;
Tsukamoto, Takashi;
Majer, Pavel;
Slusher, Barbara S.;
Konvalinka, Jan;
Hilgenfeld, Rolf

Publication type:

Article

The unraveling of substrate specificity of histone deacetylase 6 domains using acetylome peptide microarrays and peptide libraries.

Published in:

FASEB Journal, 2019, v. 33, n. 3, p. 4035, doi. 10.1096/fj.201801680R

By:

Kutil, Zsofia;
Skultetyova, Lubica;
Rauh, David;
Meleshin, Marat;
Snajdr, Ivan;
Novakova, Zora;
Mikesova, Jana;
Pavlicek, Jiri;
Hadzima, Martin;
Baranova, Petra;
Havlinova, Barbora;
Majer, Pavel;
Schutkowski, Mike;
Barinka, Cyril

Publication type:

Article

Biochemical characterization of human glutamate carboxypeptidase III.

Published in:

Journal of Neurochemistry, 2007, v. 101, n. 3, p. 682, doi. 10.1111/j.1471-4159.2006.04341.x

By:

Hlouchová, Klára;
Bařinka, Cyril;
Klusák, Vojtěch;
Šácha, Pavel;
Mlčochová, Petra;
Majer, Pavel;
RulíŠek, Lubomír;
Konvalinka, Jan

Publication type:

Article

Utilization of an optimized AlphaFold protein model for structure‐based design of a selective HDAC11 inhibitor with anti‐neuroblastoma activity.

Published in:

Archiv der Pharmazie, 2024, v. 357, n. 10, p. 1, doi. 10.1002/ardp.202400486

By:

Baselious, Fady;
Hilscher, Sebastian;
Hagemann, Sven;
Tripathee, Sunita;
Robaa, Dina;
Barinka, Cyril;
Hüttelmaier, Stefan;
Schutkowski, Mike;
Sippl, Wolfgang

Publication type:

Article

Development and therapeutic evaluation of 5D3(CC-MLN8237)<sub>3.2</sub> antibody-theranostic conjugates for PSMA-positive prostate cancer therapy.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1385598

By:

Liatsou, Ioanna;
Assefa, Betelhem;
Liyanage, Wathsala;
Surasinghe, Sharmane;
Nováková, Zora;
Bařinka, Cyril;
Gabrielson, Kathleen;
Raman, Venu;
Artemov, Dmitri;
Hapuarachchige, Sudath

Publication type:

Article

Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16972-5

By:

Henrichs, Verena;
Grycova, Lenka;
Barinka, Cyril;
Nahacka, Zuzana;
Neuzil, Jiri;
Diez, Stefan;
Rohlena, Jakub;
Braun, Marcus;
Lansky, Zdenek

Publication type:

Article

Heterologous expression and purification of recombinant human protoporphyrinogen oxidase IX: A comparative study.

Published in:

PLoS ONE, 2021, v. 16, n. 11, p. 1, doi. 10.1371/journal.pone.0259837

By:

Novakova, Zora;
Khuntsaria, Daria;
Gresova, Marketa;
Mikesova, Jana;
Havlinova, Barbora;
Shukla, Shivam;
Kolarova, Lucie;
Vesela, Katerina;
Martasek, Pavel;
Barinka, Cyril

Publication type:

Article

Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate

Published in:

FEBS Letters, 2003, v. 535, n. 1-3, p. 44, doi. 10.1016/S0014-5793(02)03855-3

By:

Střıšovský, Kvido;
Jirásková, Jana;
Bařinka, Cyril;
Majer, Pavel;
Rojas, Camilo;
Slusher, Barbara S.;
Konvalinka, Jan

Publication type:

Article

Selection and characterization of Anticalins targeting human prostate-specific membrane antigen (PSMA).

Published in:

PEDS: Protein Engineering, Design & Selection, 2016, v. 29, n. 3, p. 105, doi. 10.1093/protein/gzv065

By:

Barinka, Cyril;
Ptacek, Jakub;
Richter, Antonia;
Novakova, Zora;
Morath, Volker;
Skerra, Arne

Publication type:

Article

Glycoforms of human prostate‐specific membrane antigen (PSMA) in human cells and prostate tissue.

Published in:

Prostate, 2022, v. 82, n. 1, p. 132, doi. 10.1002/pros.24254

By:

Yuan, Wei;
Liu, Baoqin;
Sanda, Miloslav;
Wei, Renhuizi;
Benicky, Julius;
Novakova, Zora;
Barinka, Cyril;
Goldman, Radoslav

Publication type:

Article

In‐solution structure and oligomerization of human histone deacetylase 6 – an integrative approach.

Published in:

FEBS Journal, 2023, v. 290, n. 3, p. 821, doi. 10.1111/febs.16616

By:

Shukla, Shivam;
Komarek, Jan;
Novakova, Zora;
Nedvedova, Jana;
Ustinova, Kseniya;
Vankova, Pavla;
Kadek, Alan;
Uetrecht, Charlotte;
Mertens, Haydyn;
Barinka, Cyril

Publication type:

Article

Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities.

Published in:

FEBS Journal, 2016, v. 283, n. 1, p. 130, doi. 10.1111/febs.13557

By:

Novakova, Zora;
Cerny, Jiri;
Choy, Cindy J.;
Nedrow, Jessie R.;
Choi, Joeseph K.;
Lubkowski, Jacek;
Berkman, Clifford E.;
Barinka, Cyril

Publication type:

Article

Structural and biochemical characterization of the folyl-poly-γ- l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II.

Published in:

FEBS Journal, 2014, v. 281, n. 14, p. 3228, doi. 10.1111/febs.12857

By:

Navrátil, Michal;
Ptáček, Jakub;
Šácha, Pavel;
Starková, Jana;
Lubkowski, Jacek;
Bařinka, Cyril;
Konvalinka, Jan

Publication type:

Article