Works by Bargou, Ralf C.

Results: 33

Characterization and root cause analysis of immunogenicity to pasotuxizumab (AMG 212), a prostate-specific membrane antigen-targeting bispecific T-cell engager therapy.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1261070

By:

Penny, Hweixian Leong;
Hainline, Kelly;
Theoharis, Nathaniel;
Bin Wu;
Christian Brandl;
Webhofer, Christian;
McComb, Mason;
Wittemer-Rump, Sabine;
Koca, Gökben;
Stienen, Sabine;
Bargou, Ralf C.;
Hummel, Horst-Dieter;
Loidl, Wolfgang;
Grüllich, Carsten;
Eggert, Tobias;
Tran, Ben;
Mytych, Daniel T.

Publication type:

Article

Characterization and root cause analysis of immunogenicity to pasotuxizumab (AMG 212), a prostate-specific membrane antigen-targeting bispecific T-cell engager therapy.

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1261070

By:

Penny, Hweixian Leong;
Hainline, Kelly;
Theoharis, Nathaniel;
Bin Wu;
Brandl, Christian;
Webhofer, Christian;
McComb, Mason;
Wittemer-Rump, Sabine;
Koca, Gökben;
Stienen, Sabine;
Bargou, Ralf C.;
Hummel, Horst-Dieter;
Loidl, Wolfgang;
Grüllich, Carsten;
Eggert, Tobias;
Tran, Ben;
Mytych, Daniel T.

Publication type:

Article

Tumour stage distribution and survival of malignant melanoma in Germany 2002-2011.

Published in:

BMC Cancer, 2016, v. 16, p. 1, doi. 10.1186/s12885-016-2963-0

By:

Schoffer, Olaf;
Schülein, Stefanie;
Arand, Gerlinde;
Arnholdt, Hans;
Baaske, Dieter;
Bargou, Ralf C.;
Becker, Nikolaus;
Beckmann, Matthias W.;
Bodack, Yves;
Böhme, Beatrix;
Bozkurt, Tayfun;
Breitsprecher, Regine;
Buchali, Andre;
Burger, Elke;
Burger, Ulrike;
Dommisch, Klaus;
Elsner, Gudrun;
Fernschild, Karin;
Flintzer, Ulrike;
Funke, Uwe

Publication type:

Article

Ancistrocladinium A Induces Apoptosis in Proteasome Inhibitor-Resistant Multiple Myeloma Cells: A Promising Therapeutic Agent Candidate.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 8, p. 1181, doi. 10.3390/ph16081181

By:

Brünnert, Daniela;
Seupel, Raina;
Goyal, Pankaj;
Bach, Matthias;
Schraud, Heike;
Kirner, Stefanie;
Köster, Eva;
Feineis, Doris;
Bargou, Ralf C.;
Schlosser, Andreas;
Bringmann, Gerhard;
Chatterjee, Manik

Publication type:

Article

Durability of complete response after blinatumomab therapy for relapsed/refractory diffuse large B-cell lymphoma.

Published in:

2020

By:

Viardot, Andreas;
Hess, Georg;
Bargou, Ralf C.;
Morley, Nicholas J.;
Gritti, Giuseppe;
Goebeler, Maria-Elisabeth;
Iskander, Karim;
Cohan, David;
Zhang, Alicia;
Franklin, Janet;
Coyle, Luke

Publication type:

Letter

Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia.

Published in:

Leukemia & Lymphoma, 2020, v. 61, n. 11, p. 2665, doi. 10.1080/10428194.2020.1780583

By:

Gökbuget, Nicola;
Zugmaier, Gerhard;
Dombret, Hervé;
Stein, Anthony;
Bonifacio, Massimiliano;
Graux, Carlos;
Faul, Christoph;
Brüggemann, Monika;
Taylor, Kate;
Mergen, Noemi;
Reichle, Albrecht;
Horst, Heinz-August;
Havelange, Violaine;
Topp, Max S.;
Bargou, Ralf C.

Publication type:

Article

The heat shock transcription factor 1 as a potential new therapeutic target in multiple myeloma.

Published in:

British Journal of Haematology, 2013, v. 160, n. 4, p. 465, doi. 10.1111/bjh.12164

By:

Heimberger, Tanja;
Andrulis, Mindaugas;
Riedel, Simone;
Stühmer, Thorsten;
Schraud, Heike;
Beilhack, Andreas;
Bumm, Thomas;
Bogen, Bjarne;
Einsele, Hermann;
Bargou, Ralf C.;
Chatterjee, Manik

Publication type:

Article

Combined targeting of MEK/ MAPK and PI3 K/ Akt signalling in multiple myeloma.

Published in:

British Journal of Haematology, 2012, v. 159, n. 4, p. 430, doi. 10.1111/bjh.12039

By:

Steinbrunn, Torsten;
Stühmer, Thorsten;
Sayehli, Cyrus;
Chatterjee, Manik;
Einsele, Hermann;
Bargou, Ralf C.

Publication type:

Article

Preclinical anti-myeloma activity of the novel HDAC-inhibitor JNJ-26481585.

Published in:

British Journal of Haematology, 2010, v. 149, n. 4, p. 529, doi. 10.1111/j.1365-2141.2010.08126.x

By:

Stühmer, Thorsten;
Arts, Janine;
Chatterjee, Manik;
Borawski, Johanna;
Wolff, André;
King, Peter;
Einsele, Hermann;
Leo, Eugen;
Bargou, Ralf C.

Publication type:

Article

Anti-myeloma activity of the novel 2-aminothienopyrimidine Hsp90 inhibitor NVP-BEP800.

Published in:

British Journal of Haematology, 2009, v. 147, n. 3, p. 319, doi. 10.1111/j.1365-2141.2009.07852.x

By:

Stühmer, Thorsten;
Chatterjee, Manik;
Grella, Evelyn;
Seggewiss, Ruth;
Langer, Christian;
Müller, Sabine;
Schoepfer, Joseph;
Garcia-Echeverria, Carlos;
Quadt, Cornelia;
Jensen, Michael R.;
Einsele, Hermann;
Bargou, Ralf C.

Publication type:

Article

Induction of the death-promoting gene bax-α sensitizes cultured breast-cancer cells to drug-induced apoptosis.

Published in:

International Journal of Cancer, 1996, v. 67, n. 1, p. 138, doi. 10.1002/(SICI)1097-0215(19960703)67:1<138::AID-IJC22>3.0.CO;2-9

By:

Wagener, Christian;
Bargou, Ralf C.;
Daniel, Peter T.;
Bommert, Kurt;
Mapara, Markus Y.;
Royer, Hans D.;
Dörken, Bernd

Publication type:

Article

Lymphotoxin-α/β heterodimer is expressed on leukemic hairy cells and activated human B lymphocytes.

Published in:

International Journal of Cancer, 1994, v. 58, n. 2, p. 248, doi. 10.1002/ijc.2910580217

By:

Mapara, Markus Y.;
Bargou, Ralf C.;
Beck, Christian;
Heilig, Benhard;
Dörken, Bernd;
Moldenhauer, Gerhard

Publication type:

Article

Assessment of TP53 lesions for p53 system functionality and drug resistance in multiple myeloma using an isogenic cell line model.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-54407-4

By:

Munawar, Umair;
Roth, Markus;
Barrio, Santiago;
Wajant, Harald;
Siegmund, Daniela;
Bargou, Ralf C.;
Kortüm, K. Martin;
Stühmer, Thorsten

Publication type:

Article

The IL-6 receptor antagonist SANT-7 overcomes bone marrow stromal cell-mediated drug resistance of multiple myeloma cells.

Published in:

International Journal of Cancer, 2001, v. 93, n. 5, p. 674, doi. 10.1002/ijc.1388

By:

Hönemann, Dirk;
Chatterjee, Manik;
Savino, Rocco;
Bommert, Kurt;
Burger, Renate;
Gramatzki, Martin;
Dörken, Bernd;
Bargou, Ralf C.

Publication type:

Article

Selective Pharmacologic Activation of the p53-Dependent Pathway as a Therapeutic Strategy for Hematologic Malignancies.

Published in:

Cell Cycle, 2006, v. 5, n. 1, p. 39

By:

Stühmer, Thorsten;
Bargou, Ralf C.

Publication type:

Article

The heat shock protein 70 inhibitor VER155008 suppresses the expression of HSP27, HOP and HSP90β and the androgen receptor, induces apoptosis, and attenuates prostate cancer cell growth.

Published in:

Journal of Cellular Biochemistry, 2020, v. 121, n. 1, p. 407, doi. 10.1002/jcb.29195

By:

Brünnert, Daniela;
Langer, Clara;
Zimmermann, Luise;
Bargou, Ralf C.;
Burchardt, Martin;
Chatterjee, Manik;
Stope, Matthias B.

Publication type:

Article

T-cell-mediated lysis of B cells induced by a CD19xCD3 bispecific single-chain antibody is perforin dependent and death receptor independent.

Published in:

Cancer Immunology, Immunotherapy, 2004, v. 53, n. 7, p. 625, doi. 10.1007/s00262-003-0496-2

By:

Gruen, Michael;
Bommert, Kurt;
Bargou, Ralf C.

Publication type:

Article

A simple approach for multi-targeted shRNA-mediated inducible knockdowns using Sleeping Beauty vectors.

Published in:

PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0205585

By:

Fink, Severin;
Zugelder, Laurens;
Roth, Bernhard;
Brandt, Evelyn;
Meloche, Sylvain;
Izsvák, Zsuzsanna;
Bargou, Ralf C.;
Stühmer, Thorsten

Publication type:

Article

Long‐term survival of patients with relapsed/refractory acute lymphoblastic leukemia treated with blinatumomab.

Published in:

Cancer (0008543X), 2021, v. 127, n. 4, p. 554, doi. 10.1002/cncr.33298

By:

Topp, Max S.;
Gökbuget, Nicola;
Zugmaier, Gerhard;
Stein, Anthony S.;
Dombret, Hervé;
Chen, Yuqi;
Ribera, Josep‐Maria;
Bargou, Ralf C.;
Horst, Heinz‐August;
Kantarjian, Hagop M.

Publication type:

Article

Blinatumomab treatment of older adults with relapsed/refractory B-precursor acute lymphoblastic leukemia: Results from 2 phase 2 studies.

Published in:

2016

By:

Kantarjian, Hagop M.;
Stein, Anthony S.;
Bargou, Ralf C.;
Grande Garcia, Carlos;
Larson, Richard A.;
Stelljes, Matthias;
Gökbuget, Nicola;
Zugmaier, Gerhard;
Benjamin, Jonathan E.;
Zhang, Alicia;
Jia, Catherine;
Topp, Max S.

Publication type:

journal article

Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma.

Published in:

2015

By:

Seggewiss‐Bernhardt, Ruth;
Bargou, Ralf C.;
Goh, Yeow Tee;
Stewart, A. Keith;
Spencer, Andrew;
Alegre, Adrian;
Bladé, Joan;
Ottmann, Oliver G.;
Fernandez‐Ibarra, Cristina;
Lu, Hong;
Pain, Scott;
Akimov, Mikhail;
Iyer, Swaminathan Padmanabhan

Publication type:

journal article

PI3K-dependent multiple myeloma cell survival is mediated by the PIK3 CA isoform.

Published in:

British Journal of Haematology, 2014, v. 166, n. 4, p. 529, doi. 10.1111/bjh.12920

By:

Hofmann, Claudia;
Stühmer, Thorsten;
Schmiedl, Nadine;
Wetzker, Reinhard;
Mottok, Anja;
Rosenwald, Andreas;
Langer, Christian;
Zovko, Josip;
Chatterjee, Manik;
Einsele, Hermann;
Bargou, Ralf C.;
Steinbrunn, Torsten

Publication type:

Article

Loss of Serum and Glucocorticoid-Regulated Kinase 3 (SGK3) Does Not Affect Proliferation and Survival of Multiple Myeloma Cell Lines.

Published in:

PLoS ONE, 2015, v. 10, n. 4, p. 1, doi. 10.1371/journal.pone.0122689

By:

Hausmann, Stefan;
Brandt, Evelyn;
Köchel, Carolin;
Einsele, Hermann;
Bargou, Ralf C.;
Seggewiss-Bernhardt, Ruth;
Stühmer, Thorsten

Publication type:

Article

Efficient Transient Transfection of Human Multiple Myeloma Cells by Electroporation – An Appraisal.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0097443

By:

Steinbrunn, Torsten;
Chatterjee, Manik;
Bargou, Ralf C.;
Stühmer, Thorsten

Publication type:

Article

The IKK Inhibitor Bay 11-7082 Induces Cell Death Independent from Inhibition of Activation of NFκB Transcription Factors.

Published in:

PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0059292

By:

Rauert-Wunderlich, Hilka;
Siegmund, Daniela;
Maier, Eduard;
Giner, Tina;
Bargou, Ralf C.;
Wajant, Harald;
Stühmer, Thorsten

Publication type:

Article

Survival outcomes in patients with relapsed/refractory or MRD-positive B-cell acute lymphoblastic leukemia treated with blinatumomab.

Published in:

Therapeutic Advances in Hematology, 2023, v. 14, p. 1, doi. 10.1177/20406207231201454

By:

Kantarjian, Hagop M.;
Logan, Aaron C.;
Zaman, Faraz;
Gökbuget, Nicola;
Bargou, Ralf C.;
Zeng, Yi;
Zugmaier, Gerhard;
Locatelli, Franco

Publication type:

Article

OAB-017: Attenuation of T cell cytotoxicity mediated by CD200 expression on multiple myeloma cells.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S11, doi. 10.1016/S2152-2650(21)02091-7

By:

Shah, Pooja;
Stühmer, Thorsten;
Brünnert, Daniela;
Munawar, Umair;
Leich, Ellen;
Kraus, Sabrina;
Chatterjee, Manik;
Schlosser, Andreas;
Bargou, Ralf C.;
Einsele, Hermann;
Berberich-Siebelt, Friederike;
Steinbrunn, Torsten

Publication type:

Article

Functional characterization of the RAL-dependent survival pathway in multiple myeloma.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2019, v. 19, p. e138, doi. 10.1016/j.clml.2019.09.230

By:

Seibold, Marcel;
Stühmer, Thorsten;
Mottok, Anja;
Scholz, Claus;
Chatterjee, Manik;
Leich, Ellen;
Barrio, Santiago;
Kortüm, K.M.;
Schlosser, Andreas;
Rosenwald, Andreas;
Einsele, Hermann;
Bargou, Ralf C.;
Steinbrunn, Torsten

Publication type:

Article

CD200 expressing multiple myeloma cells show increased resistance against T cell-mediated cytotoxicity.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2019, v. 19, p. e138, doi. 10.1016/j.clml.2019.09.229

By:

Shah, Pooja;
Stühmer, Thorsten;
Brünnert, Daniela;
Munawar, Umair;
Chatterjee, Manik;
Hudecek, Michael;
Einsele, Hermann;
Berberich-Siebelt, Friederike;
Bargou, Ralf C.;
Steinbrunn, Torsten

Publication type:

Article

RalA and RalB are Potential Therapeutic Targets in Multiple Myeloma Which Mediate Cell Survival Independently of Oncogenic RAS.

Published in:

Clinical Lymphoma, Myeloma & Leukemia, 2017, v. 17, p. e110, doi. 10.1016/j.clml.2017.03.200

By:

Steinbrunn, Torsten;
Seibold, Marcel;
Stühmer, Thorsten;
Schmiedl, Nadine;
Mottok, Anja;
Leich, Ellen;
Scholz, Claus;
Chatterjee, Manik;
Rosenwald, Andreas;
Einsele, Hermann;
Bargou, Ralf C.

Publication type:

Article

Overexpression of the death-promoting gene bax-α sensitizes human BL-41 Burkitt lymphoma cells for surface IgM-mediated apoptosis.

Published in:

European Journal of Immunology, 1997, v. 27, n. 9, p. 2466, doi. 10.1002/eji.1830270947

By:

Weinmann, Pamela;
Bommert, Kurt;
Mapara, Markus Y.;
Dörken, Bernd;
Bargou, Ralf C.

Publication type:

Article

Induction of Bax-α precedes apoptosis in a human B lymphoma cell line: potential role of the bcl-2 gene family in surface IgM-mediated apoptosi.

Published in:

European Journal of Immunology, 1995, v. 25, n. 3, p. 770, doi. 10.1002/eji.1830250322

By:

Bargou, Ralf C.;
Bommert, Kurt;
Weinmann, Pamela;
Daniel, Peter T.;
Wagener, Christian;
Mapara, Markus Y.;
Dörken, Bernd

Publication type:

Article

On-target restoration of a split T cell-engaging antibody for precision immunotherapy.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-13196-0

By:

Banaszek, Agnes;
Bumm, Thomas G. P.;
Nowotny, Boris;
Geis, Maria;
Jacob, Kim;
Wölfl, Matthias;
Trebing, Johannes;
Kucka, Kirstin;
Kouhestani, Dina;
Gogishvili, Tea;
Krenz, Bastian;
Lutz, Justina;
Rasche, Leo;
Hönemann, Dirk;
Neuweiler, Hannes;
Heiby, Julia C.;
Bargou, Ralf C.;
Wajant, Harald;
Einsele, Hermann;
Riethmüller, Gert

Publication type:

Article