Works by Barda-Saad, Mira

Results: 36

Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 9, p. 798, doi. 10.1038/nsmb1133

By:

Houtman, Jon C. D.;
Yamaguchi, Hiroshi;
Barda-Saad, Mira;
Braiman, Alex;
Bowden, Brent;
Appella, Ettore;
Schuck, Peter;
Samelson, Lawrence E.

Publication type:

Article

Unleashing Natural Killer Cells in the Tumor Microenvironment–The Next Generation of Immunotherapy?

Published in:

Frontiers in Immunology, 2020, p. 1, doi. 10.3389/fimmu.2020.00275

By:

Ben-Shmuel, Aviad;
Biber, Guy;
Barda-Saad, Mira

Publication type:

Article

Commentary: Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse.

Published in:

Frontiers in Immunology, 2018, p. N.PAG, doi. 10.3389/fimmu.2018.02110

By:

Ben-Shmuel, Aviad;
Joseph, Noah;
Barda-Saad, Mira

Publication type:

Article

Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

Published in:

Nature Immunology, 2005, v. 6, n. 1, p. 80, doi. 10.1038/ni1143

By:

Barda-Saad, Mira;
Braiman, Alex;
Titerence, Rachel;
Bunnell, Stephen C.;
Barr, Valarie A.;
Samelson, Lawrence E.

Publication type:

Article

Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.73282

By:

Ben-Shmuel, Aviad;
Sabag, Batel;
Puthenveetil, Abhishek;
Biber, Guy;
Levy, Moria;
Jubany, Tammir;
Awwad, Fatima;
Roy, Roshan Kumar;
Joseph, Noah;
Matalon, Omri;
Kivelevitz, Jessica;
Barda-Saad, Mira

Publication type:

Article

Targeting the actin nucleation promoting factor WASp provides a therapeutic approach for hematopoietic malignancies.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25842-7

By:

Biber, Guy;
Ben-Shmuel, Aviad;
Noy, Elad;
Joseph, Noah;
Puthenveetil, Abhishek;
Reiss, Neria;
Levy, Omer;
Lazar, Itay;
Feiglin, Ariel;
Ofran, Yanay;
Kedmi, Meirav;
Avigdor, Abraham;
Fried, Sophia;
Barda-Saad, Mira

Publication type:

Article

Cbl ubiquitin ligases mediate the inhibition of natural killer cell activity.

Published in:

Communicative & Integrative Biology, 2016, v. 9, n. 6, p. 1, doi. 10.1080/19420889.2016.1216739

By:

Matalon, Omri;
Barda-Saad, Mira

Publication type:

Article

Cbl ubiquitin ligases mediate the inhibition of natural killer cell activity.

Published in:

Communicative & Integrative Biology, 2016, v. 9, n. 5, p. 1, doi. 10.1080/19420889.2016.1216739

By:

Matalon, Omri;
Barda-Saad, Mira

Publication type:

Article

Studies of novel interactions between Nck and VAV SH3 domains.

Published in:

Communicative & Integrative Biology, 2011, v. 4, n. 2, p. 175, doi. 10.4161/cib.4.2.14235

By:

Pauker, Maor H.;
Barda-Saad, Mira

Publication type:

Article

Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity.

Published in:

Science Signaling, 2016, v. 9, n. 429, p. 1, doi. 10.1126/scisignal.aad6182

By:

Matalon, Omri;
Fried, Sophia;
Ben-Shmuel, Aviad;
Pauker, Maor H.;
Joseph, Noah;
Keizer, Danielle;
Piterburg, Marina;
Barda-Saad, Mira

Publication type:

Article

Dysfunctional natural killer cells can be reprogrammed to regain anti-tumor activity.

Published in:

EMBO Journal, 2024, v. 43, n. 13, p. 2552, doi. 10.1038/s44318-024-00094-5

By:

Sabag, Batel;
Puthenveetil, Abhishek;
Levy, Moria;
Joseph, Noah;
Doniger, Tirtza;
Yaron, Orly;
Karako-Lampert, Sarit;
Lazar, Itay;
Awwad, Fatima;
Ashkenazi, Shahar;
Barda-Saad, Mira

Publication type:

Article

Actin retrograde flow controls natural killer cell response by regulating the conformation state of SHP-1.

Published in:

EMBO Journal, 2018, v. 37, n. 5, p. 1, doi. 10.15252/embj.201696264

By:

Matalon, Omri;
Ben‐Shmuel, Aviad;
Kivelevitz, Jessica;
Sabag, Batel;
Fried, Sophia;
Joseph, Noah;
Noy, Elad;
Biber, Guy;
Barda‐Saad, Mira

Publication type:

Article

The Ebola-Glycoprotein Modulates the Function of Natural Killer Cells.

Published in:

Frontiers in Immunology, 2018, p. N.PAG, doi. 10.3389/fimmu.2018.01428

By:

Edri, Avishay;
Shemesh, Avishai;
Iraqi, Muhammed;
Matalon, Omri;
Brusilovsky, Michael;
Hadad, Uzi;
Radinsky, Olga;
Gershoni-Yahalom, Orly;
Dye, John M.;
Mandelboim, Ofer;
Barda-Saad, Mira;
Lobel, Leslie;
Porgador, Angel

Publication type:

Article

Unique ζ-chain motifs mediate a direct TCR-actin linkage critical for immunological synapse formation and T-cell activation.

Published in:

European Journal of Immunology, 2014, v. 44, n. 1, p. 58, doi. 10.1002/eji.201243099

By:

Klieger, Yair;
Almogi‐Hazan, Osnat;
Ish‐Shalom, Eliran;
Pato, Aviad;
Pauker, Maor H.;
Barda‐Saad, Mira;
Wang, Lynn;
Baniyash, Michal

Publication type:

Article

Triple-Color FRET Analysis Reveals Conformational Changes in the WIP-WASp Actin-Regulating Complex.

Published in:

Science Signaling, 2014, v. 7, n. 331, p. 1, doi. 10.1126/scisignal.2005198

By:

Fried, Sophia;
Reicher, Barak;
Pauker, Maor H.;
Eliyahu, Shani;
Matalon, Omri;
Noy, Elad;
Chill, Jordan;
Barda-Saad, Mira

Publication type:

Article

Studying the Dynamics of SLP-76, Nck, and Vav1 Multimolecular Complex Formation in Live Human Cells with Triple-Color FRET.

Published in:

Science Signaling, 2012, v. 5, n. 221, p. 1, doi. 10.1126/scisignal.2002423

By:

Pauker, Maor H.;
Hassan, Nirit;
Noy, Elad;
Reicher, Barak;
Barda-Saad, Mira

Publication type:

Article

A conformational change within the WAVE2 complex regulates its degradation following cellular activation.

Published in:

Scientific Reports, 2017, p. 44863, doi. 10.1038/srep44863

By:

Joseph, Noah;
Biber, Guy;
Fried, Sophia;
Reicher, Barak;
Levy, Omer;
Sabag, Batel;
Noy, Elad;
Barda-Saad, Mira

Publication type:

Article

Ubiquitylation-Dependent Negative Regulation of WASp Is Essential for Actin Cytoskeleton Dynamics.

Published in:

Molecular & Cellular Biology, 2012, v. 32, n. 15, p. 3153, doi. 10.1128/MCB.00161-12

By:

Reicher, Barak;
Joseph, Noah;
David, Ahuvit;
Pauker, Maor H.;
Perl, Orly;
Barda-Saad, Mira

Publication type:

Article

Functional Cooperation between the Proteins Nck and ADAP Is Fundamental for Actin Reorganization.

Published in:

Molecular & Cellular Biology, 2011, v. 31, n. 13, p. 10, doi. 10.1128/MCB.01358-10

By:

Pauker, Maor H.;
Reicher, Barak;
Fried, Sophie;
Perl, Orly;
Barda-Saad, Mira

Publication type:

Article

c-Cbl-Mediated Regulation of LAT-Nucleated Signaling Complexes.

Published in:

Molecular & Cellular Biology, 2007, v. 27, n. 24, p. 18, doi. 10.1128/MCB.00467-07

By:

Balagopalan, Lakshmi;
Barr, Valarie A.;
Sommers, Connie L.;
Barda-Saad, Mira;
Goyal, Amrita;
Isakowitz, Matthew S.;
Samelson, Lawrence E.

Publication type:

Article

The mesenchyme expresses T cell receptor mRNAs: relevance to cell growth control.

Published in:

Oncogene, 2002, v. 21, n. 13, p. 2029, doi. 10.1038/sj.onc.1205269

By:

Barda-Saad, Mira;
Shav-Tal, Yaron;
Rozenszajn, Arie Leon;
Cohen, Michal;
zauberman, Ayelet;
Karmazyn, Asaf;
Parameswaran, Reshmi;
Schori, Hadas;
Ashush, Hagit;
Ben-Nun, Avraham;
Zipori, Dov

Publication type:

Article

Actin Retrograde Flow Regulated by the Wiskott–Aldrich Syndrome Protein Drives the Natural Killer Cell Response.

Published in:

Cancers, 2022, v. 14, n. 15, p. 3756, doi. 10.3390/cancers14153756

By:

Sabag, Batel;
Levy, Moria;
Kivelevitz, Jessica;
Dashevsky, Nataly;
Ben-Shmuel, Aviad;
Puthenveetil, Abhishek;
Awwad, Fatima;
Barda-Saad, Mira

Publication type:

Article

Wiskott- Aldrich syndrome protein - dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes.

Published in:

Immunological Reviews, 2013, v. 256, n. 1, p. 10, doi. 10.1111/imr.12112

By:

Matalon, Omri;
Reicher, Barak;
Barda-Saad, Mira

Publication type:

Article

T-Cell Antigen Receptor-Induced Signaling Complexes: Internalization Via a Cholesterol-Dependent Endocytic Pathway.

Published in:

Traffic, 2006, v. 7, n. 9, p. 1143, doi. 10.1111/j.1600-0854.2006.00464.x

By:

Barr, Valarie A.;
Balagopalan, Lakshmi;
Barda-Saad, Mira;
Polishchuk, Roman;
Boukari, Hacène;
Bunnell, Stephen C.;
Bernot, Kelsie M.;
Toda, Yoko;
Nossal, Ralph;
Samelson, Lawrence E.

Publication type:

Article

Modulation of intrinsic inhibitory checkpoints using nano‐carriers to unleash NK cell activity.

Published in:

EMBO Molecular Medicine, 2022, v. 14, n. 1, p. 1, doi. 10.15252/emmm.202114073

By:

Biber, Guy;
Sabag, Batel;
Raiff, Anat;
Ben‐Shmuel, Aviad;
Puthenveetil, Abhishek;
Benichou, Jennifer I C;
Jubany, Tammir;
Levy, Moria;
Killner, Shiran;
Barda‐Saad, Mira

Publication type:

Article

Ubiquitylation-dependent downregulation of Nck regulates its functional activity.

Published in:

FEBS Letters, 2014, v. 588, n. 21, p. 3808, doi. 10.1016/j.febslet.2014.08.033

By:

Joseph, Noah;
Reicher, Barak;
David, Ahuvit;
Matalon, Omri;
Barda-Saad, Mira

Publication type:

Article

Multiple pathways leading from the T-cell antigen receptor to the actin cytoskeleton network

Published in:

FEBS Letters, 2010, v. 584, n. 24, p. 4858, doi. 10.1016/j.febslet.2010.09.002

By:

Reicher, Barak;
Barda-Saad, Mira

Publication type:

Article

New insights into the role of the disordered WIP N-terminal domain revealed by NMR structural characterization.

Published in:

FEBS Journal, 2015, v. 282, n. 4, p. 700, doi. 10.1111/febs.13174

By:

Elazari‐Shalom, Hila;
Shaked, Hadassa;
Esteban‐Martin, Santiago;
Salvatella, Xavier;
Barda‐Saad, Mira;
Chill, Jordan H.

Publication type:

Article

Examining multiprotein signaling complexes from all angles.

Published in:

FEBS Journal, 2005, v. 272, n. 21, p. 5426, doi. 10.1111/j.1742-4658.2005.04972.x

By:

Houtman, Jon C. D.;
Barda-Saad, Mira;
Samelson, Lawrence E.

Publication type:

Article

Lymphocyte mechanotransduction: The regulatory role of cytoskeletal dynamics in signaling cascades and effector functions.

Published in:

Journal of Leukocyte Biology, 2019, v. 105, n. 6, p. 1261, doi. 10.1002/JLB.MR0718-267R

By:

Ben‐Shmuel, Aviad;
Joseph, Noah;
Sabag, Batel;
Barda‐Saad, Mira

Publication type:

Article

WIP Remodeling Actin behind the Scenes: How WIP Reshapes Immune and Other Functions.

Published in:

International Journal of Molecular Sciences, 2012, v. 13, n. 6, p. 7629, doi. 10.3390/ijms13067629

By:

Noy, Elad;
Fried, Sophia;
Matalon, Omri;
Barda-Saad, Mira

Publication type:

Article

The Mesenchymal Stroma Negatively Regulates B Cell Lymphopoiesis through the Expression of Activin A.

Published in:

Annals of the New York Academy of Sciences, 2003, v. 996, n. 1, p. 245, doi. 10.1111/j.1749-6632.2003.tb03253.x

By:

SHOHAM, TSIPI;
PARAMESWARAN, RESHMI;
SHAV-TAL, YARON;
BARDA-SAAD, MIRA;
ZIPORI, DOV

Publication type:

Article

Bam32: a novel mediator of Erk activation in T cells.

Published in:

International Immunology, 2008, v. 20, n. 7, p. 811, doi. 10.1093/intimm/dxn039

By:

Sommers, Connie L.;
Gurson, Jordan M.;
Surana, Rishi;
Barda-Saad, Mira;
Jan Lee;
Kishor, Aparna;
WenMei Li;
Gasser, Adam J.;
Barr, Valarie A.;
Miyaji, Michihiko;
Love, Paul E.;
Samelson, Lawrence E.

Publication type:

Article

Inhibition of α4β1 Integrin Activity by Small Tellurium Compounds Regulates PD-L1 Expression and Enhances Antitumor Effects.

Published in:

International Journal of Biological Sciences, 2024, v. 21, n. 11, p. 4407, doi. 10.7150/ijbs.95350

By:

Chaouat, Abigael;
Kalechman, Yona;
Hay, Ophir;
Manoim, Julia E.;
Lantner, Tal;
Niderberg, Eitan;
Hauschner, Hagit;
Sredni, Dvora Kenigsbuch;
Cohen, Tal;
Schlesinger, Agata;
Nadler, Ronia;
Barda-Saad, Mira;
Noy, Elad;
Albeck, Michael;
Longo, Dan L.;
Sredni, Benjamin

Publication type:

Article

Cooperative interactions at the SLP-76 complex are critical for actin polymerization.

Published in:

EMBO Journal, 2010, v. 29, n. 14, p. 2315, doi. 10.1038/emboj.2010.133

By:

Barda-Saad, Mira;
Shirasu, Naoto;
Pauker, Maor H.;
Hassan, Nirit;
Perl, Orly;
Balbo, Andrea;
Yamaguchi, Hiroshi;
Houtman, Jon C. D.;
Appella, Ettore;
Schuck, Peter;
Samelson, Lawrence E.

Publication type:

Article

Recruitment and activation of PLCγ1 in T cells: a new insight into old domains.

Published in:

EMBO Journal, 2006, v. 25, n. 4, p. 774, doi. 10.1038/sj.emboj.7600978

By:

Braiman, Alex;
Barda-Saad, Mira;
Sommers, Connie L.;
Samelson, Lawrence E.

Publication type:

Article