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Glial cell line-derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse.
Published in:
Addiction Biology, 2015, v. 20, n. 4, p. 629, doi. 10.1111/adb.12152
By:
- Barak, Segev;
- Wang, Jun;
- Ahmadiantehrani, Somayeh;
- Ben Hamida, Sami;
- Kells, Adrian P.;
- Forsayeth, John;
- Bankiewicz, Krystof S.;
- Ron, Dorit
Publication type:
Article
P2‐027: TARGET ENGAGEMENT IN A PHASE II CLINICAL TRIAL OF AAV2‐NGF GENE THERAPY FOR ALZHEIMER'S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P677, doi. 10.1016/j.jalz.2018.06.711
By:
- Castle, Michael J.;
- Baltanas, Fernando Calvo;
- Kovacs, Imre;
- Nagahara, Alan H.;
- Bankiewicz, Krystof S.;
- Barba, David;
- Tuszynski, Mark H.
Publication type:
Article
Automated Segmentation Tool for Brain Infusions.
Published in:
PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0064452
By:
- Rosenbluth, Kathryn Hammond;
- Gimenez, Francisco;
- Kells, Adrian P.;
- Salegio, Ernesto A.;
- Mittermeyer, Gabriele M.;
- Modera, Kevin;
- Kohal, Anmol;
- Bankiewicz, Krystof S.
Publication type:
Article
Rapid Inverse Planning for Pressure-Driven Drug Infusions in the Brain.
Published in:
PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0056397
By:
- Rosenbluth, Kathryn H.;
- Martin, Alastair J.;
- Mittermeyer, Stephan;
- Eschermann, Jan;
- Dickinson, Peter J.;
- Bankiewicz, Krystof S.
Publication type:
Article
Evaluation of an AAV2-Based Rapamycin-Regulated Glial Cell Line-Derived Neurotrophic Factor (GDNF) Expression Vector System.
Published in:
PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0027728
By:
- Hadaczek, Piotr;
- Beyer, Janine;
- Kells, Adrian;
- Narrow, Wade;
- Bowers, William;
- Federoff, Howard J.;
- Forsayeth, John;
- Bankiewicz, Krystof S.
Publication type:
Article
Differences between lentiviral vector--mediated ex vivo hematopoietic stem cell and adeno-associated virus gene therapies for neurological disorders.
Published in:
Journal of Neurosurgery, 2022, v. 136, n. 5, p. 1501, doi. 10.3171/2021.10.JNS212466.
By:
- Lonser, Russell R.;
- Bankiewicz, Krystof S.
Publication type:
Article
Use of a novel ball-joint guide array for magnetic resonance imaging--guided cannula placement and convective delivery: technical note.
Published in:
Journal of Neurosurgery, 2021, v. 135, n. 2, p. 651, doi. 10.3171/2020.6.JNS201564
By:
- Bankiewicz, Krystof S.;
- Pasterski, Tomasz;
- Kreatsoulas, Daniel;
- Onikijuk, Jakub;
- Mozgiel, Krzysztof;
- Munjal, Vikas;
- Elder, J. Bradley;
- Lonser, Russell R.;
- Zabek, Mirosław
Publication type:
Article
Direct convective delivery of adeno-associated virus gene therapy for treatment of neurological disorders.
Published in:
Journal of Neurosurgery, 2021, v. 134, n. 6, p. 1751, doi. 10.3171/2020.4.JNS20701
By:
- Lonser, Russell R.;
- Akhter, Asad S.;
- Zabek, Mirosław;
- Elder, J. Bradley;
- Bankiewicz, Krystof S.
Publication type:
Article
Evaluation of pressure-driven brain infusions in nonhuman primates by intra-operative 7 tesla MRI.
Published in:
Journal of Magnetic Resonance Imaging, 2012, v. 36, n. 6, p. 1339, doi. 10.1002/jmri.23771
By:
- Rosenbluth, Kathryn H.;
- Martin, Alastair J.;
- Bringas, John;
- Bankiewicz, Krystof S.
Publication type:
Article
Transplantation of Neural Progenitor Cells Expressing Glial Cell Line‐Derived Neurotrophic Factor into the Motor Cortex as a Strategy to Treat Amyotrophic Lateral Sclerosis.
Published in:
Stem Cells, 2018, v. 36, n. 7, p. 1122, doi. 10.1002/stem.2825
By:
- Thomsen, Gretchen M.;
- Avalos, Pablo;
- Ma, Annie A.;
- Alkaslasi, Mor;
- Cho, Noell;
- Wyss, Livia;
- Vit, Jean‐Philippe;
- Godoy, Marlesa;
- Suezaki, Patrick;
- Shelest, Oksana;
- Bankiewicz, Krystof S.;
- Svendsen, Clive N.
Publication type:
Article
Regeneration of the MPTP-Lesioned Dopaminergic System after Convection-Enhanced Delivery of AAV2-GDNF.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 28, p. 9567, doi. 10.1523/JNEUROSCI.0942-10.2010
By:
- Kells, Adrian P.;
- Eberling, Jamie;
- Xiaomin Su;
- Pivirotto, Philip;
- Bringas, John;
- Hadaczek, Piotr;
- Narrow, Wade C.;
- Bowers, William J.;
- Federoff, Howard J.;
- Forsayeth, John;
- Bankiewicz, Krystof S.
Publication type:
Article
Transduction of antigen-presenting cells in the brain by AAV9 warrants caution in preclinical studies.
Published in:
Molecular Therapy, 2015, v. 23, n. 4, p. 612, doi. 10.1038/mt.2015.35
By:
- Forsayeth, John;
- Bankiewicz, Krystof S
Publication type:
Article
AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction.
Published in:
Molecular Therapy, 2014, v. 22, n. 2, p. 329, doi. 10.1038/mt.2013.266
By:
- Samaranch, Lluis;
- Sebastian, Waldy San;
- Kells, Adrian P;
- Salegio, Ernesto A;
- Heller, Gregory;
- Bringas, John R;
- Pivirotto, Philip;
- DeArmond, Stephen;
- Forsayeth, John;
- Bankiewicz, Krystof S
Publication type:
Article
Cerebral Infusion of AAV9 Vector-encoding Non-self Proteins Can Elicit Cell-mediated Immune Responses.
Published in:
Molecular Therapy, 2013, v. 21, n. 1, p. 158, doi. 10.1038/mt.2012.167
By:
- Ciesielska, Agnieszka;
- Hadaczek, Piotr;
- Mittermeyer, Gabriele;
- Zhou, Shangzhen;
- Wright, J Fraser;
- Bankiewicz, Krystof S;
- Forsayeth, John
Publication type:
Article
Merits of Combination Cortical, Subcortical, and Cerebellar Injections for the Treatment of Niemann-Pick Disease Type A.
Published in:
Molecular Therapy, 2012, v. 20, n. 10, p. 1893, doi. 10.1038/mt.2012.118
By:
- Bu, Jie;
- Ashe, Karen M;
- Bringas, John;
- Marshall, John;
- Dodge, James C;
- Cabrera-Salazar, Mario A;
- Forsayeth, John;
- Schuchman, Edward H;
- Bankiewicz, Krystof S;
- Cheng, Seng H;
- Shihabuddin, Lamya S.;
- Passini, Marco A
Publication type:
Article
Canine spontaneous glioma: A translational model system for convection-enhanced delivery.
Published in:
Neuro-Oncology, 2010, v. 12, n. 9, p. 928, doi. 10.1093/neuonc/noq046
By:
- Dickinson, Peter J.;
- LeCouteur, Richard A.;
- Higgins, Robert J.;
- Bringas, John R.;
- Larson, Richard F.;
- Yamashita, Yoji;
- Krauze, Michal T.;
- Forsayeth, John;
- Noble, Charles O.;
- Drummond, Daryl C.;
- Kirpotin, Dmitri B.;
- Park, John W.;
- Berger, Mitchel S.;
- Bankiewicz, Krystof S.
Publication type:
Article
Convection-enhanced delivery of Ls-TPT enables an effective, continuous, low-dose chemotherapy against malignant glioma xenograft model.
Published in:
Neuro-Oncology, 2006, v. 8, n. 3, p. 205, doi. 10.1215/15228517-2006-001
By:
- Saito, Ryuta;
- Krauze, Michal T.;
- Noble, Charles O.;
- Drummond, Daryl C.;
- Kirpotin, Dmitri B.;
- Berger, Mitchel S.;
- Park, John W.;
- Bankiewicz, Krystof S.
Publication type:
Article
Adeno-associated viral vector serotype 9–based gene therapy for Niemann-Pick disease type A.
Published in:
Science Translational Medicine, 2019, v. 11, n. 506, p. 1, doi. 10.1126/scitranslmed.aat3738
By:
- Samaranch, Lluis;
- Pérez-Cañamás, Azucena;
- Soto-Huelin, Beatriz;
- Sudhakar, Vivek;
- Jurado-Arjona, Jerónimo;
- Hadaczek, Piotr;
- Ávila, Jesús;
- Bringas, John R.;
- Casas, Josefina;
- Chen, Haifeng;
- He, Xingxuan;
- Schuchman, Edward H.;
- Cheng, Seng H.;
- Forsayeth, John;
- Bankiewicz, Krystof S.;
- Ledesma, María Dolores
Publication type:
Article
Magnetic resonance imaging-guided phase 1 trial of putaminal AADC gene therapy for Parkinson's disease.
Published in:
2019
By:
- Christine, Chadwick W.;
- Bankiewicz, Krystof S.;
- Van Laar, Amber D.;
- Richardson, R. Mark;
- Ravina, Bernard;
- Kells, Adrian P.;
- Boot, Brendon;
- Martin, Alastair J.;
- Nutt, John;
- Thompson, Marin E.;
- Larson, Paul S.
Publication type:
journal article
The Use of Convection-Enhanced Delivery with Liposomal Toxins in Neurooncology.
Published in:
Toxins, 2011, v. 3, n. 4, p. 369, doi. 10.3390/toxins3040369
By:
- Fiandaca, Massimo S.;
- Berger, Mitchel S.;
- Bankiewicz, Krystof S.
Publication type:
Article
Depletion of AADC activity in caudate nucleus and putamen of Parkinson’s disease patients; implications for ongoing AAV2-AADC gene therapy trial.
Published in:
PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0169965
By:
- Ciesielska, Agnieszka;
- Samaranch, Lluis;
- San Sebastian, Waldy;
- Dickson, Dennis W.;
- Goldman, Samuel;
- Forsayeth, John;
- Bankiewicz, Krystof S.
Publication type:
Article
Persistent GDNF Expression 45 Months after Putaminal Infusion of AAV2‐GDNF in a Patient with Parkinson's Disease.
Published in:
Movement Disorders, 2024, v. 39, n. 8, p. 1412, doi. 10.1002/mds.29820
By:
- Heiss, John D.;
- Ray‐Chaudhury, Abhik;
- Kleiner, David E.;
- Ehrlich, Debra J.;
- Scott, Gretchen;
- Edwards, Nancy A.;
- Goldstein, David S.;
- Hammoud, Dima A.;
- Hadaczek, Piotr;
- Van Laar, Victor S.;
- Graff, Shantelle A.;
- Herscovitch, Peter;
- Lungu, Codrin;
- Hallett, Mark;
- Lonser, Russell R.;
- Zaghloul, Kareem A.;
- Bankiewicz, Krystof S.
Publication type:
Article
Aromatic L-Amino Acid Decarboxylase Gene Therapy Enhances Levodopa Response in Parkinson's Disease.
Published in:
2020
By:
- Nutt, John G.;
- Curtze, Carolin;
- Hiller, Amie;
- Anderson, Shannon;
- Larson, Paul S.;
- Van Laar, Amber D.;
- Richardson, R. Mark;
- Thompson, Marin E.;
- Sedkov, Alexander;
- Leinonen, Mika;
- Ravina, Bernard;
- Bankiewicz, Krystof S.;
- Christine, Chadwick W.
Publication type:
journal article
Trial of magnetic resonance-guided putaminal gene therapy for advanced Parkinson's disease.
Published in:
2019
By:
- Heiss, John D.;
- Lungu, Codrin;
- Hammoud, Dima A.;
- Herscovitch, Peter;
- Ehrlich, Debra J.;
- Argersinger, Davis P.;
- Sinharay, Sanhita;
- Scott, Gretchen;
- Wu, Tianxia;
- Federoff, Howard J.;
- Zaghloul, Kareem A.;
- Hallett, Mark;
- Lonser, Russell R.;
- Bankiewicz, Krystof S.
Publication type:
journal article
Interventional MRI-guided Putaminal Delivery of AAV2-GDNF for a Planned Clinical Trial in Parkinson's Disease.
Published in:
Molecular Therapy, 2011, v. 19, n. 6, p. 1048, doi. 10.1038/mt.2011.11
By:
- Richardson, R Mark;
- Kells, Adrian P;
- Rosenbluth, Kathryn H;
- Salegio, Ernesto Aguilar;
- Fiandaca, Massimo S;
- Larson, Paul S;
- Starr, Philip A;
- Martin, Alastair J;
- Lonser, Russell R;
- Federoff, Howard J;
- Forsayeth, John R;
- Bankiewicz, Krystof S
Publication type:
Article
AAV9: Over the Fence and Into the Woods . . .
Published in:
Molecular Therapy, 2011, v. 19, n. 6, p. 1006, doi. 10.1038/mt.2011.95
By:
- Forsayeth, John R;
- Bankiewicz, Krystof S
Publication type:
Article
Anterograde Axonal Transport of AAV2-GDNF in Rat Basal Ganglia.
Published in:
Molecular Therapy, 2011, v. 19, n. 5, p. 922, doi. 10.1038/mt.2010.248
By:
- Ciesielska, Agnieszka;
- Mittermeyer, Gabriele;
- Hadaczek, Piotr;
- Kells, Adrian P;
- Forsayeth, John;
- Bankiewicz, Krystof S
Publication type:
Article
Eight Years of Clinical Improvement in MPTP-Lesioned Primates After Gene Therapy With AAV2-hAADC.
Published in:
Molecular Therapy, 2010, v. 18, n. 8, p. 1458, doi. 10.1038/mt.2010.106
By:
- Hadaczek, Piotr;
- Eberling, Jamie L.;
- Pivirotto, Philip;
- Bringas, John;
- Forsayeth, John;
- Bankiewicz, Krystof S.
Publication type:
Article
Real-time MR Imaging With Gadoteridol Predicts Distribution of Transgenes After Convection-enhanced Delivery of AAV2 Vectors.
Published in:
Molecular Therapy, 2010, v. 18, n. 8, p. 1490, doi. 10.1038/mt.2010.114
By:
- Xiaomin Su;
- Kells, Adrian P.;
- Aguilar Salegio, Ernesto A.;
- Richardson, R. Mark;
- Hadaczek, Piotr;
- Beyer, Janine;
- Bringas, John;
- Pivirotto, Philip;
- Forsayeth, John;
- Bankiewicz, Krystof S.
Publication type:
Article
Biodistribution of Adeno-associated Virus Type-2 in Nonhuman Primates after Convection-enhanced Delivery to Brain.
Published in:
Molecular Therapy, 2008, v. 16, n. 7, p. 1267, doi. 10.1038/mt.2008.111
By:
- Cunningham, Janet;
- Pivirotto, Philip;
- Bringas, John;
- Suzuki, Brian;
- Vijay, Sharmila;
- Sanftner, Laura;
- Kitamura, Marina;
- Chan, Curtis;
- Bankiewicz, Krystof S.
Publication type:
Article
Long-Term Clinical Improvement in MPTP-Lesioned Primates after Gene Therapy with AAV-hAADC.
Published in:
Molecular Therapy, 2006, v. 14, n. 4, p. 564, doi. 10.1016/j.ymthe.2006.05.005
By:
- Bankiewicz, Krystof S.;
- Forsayeth, John;
- Eberling, Jamie L.;
- Sanchez-Pernaute, Rosario;
- Pivirotto, Philip;
- Bringas, John;
- Herscovitch, Peter;
- Carson, Richard E.;
- Eckelman, William;
- Reutter, Bryan;
- Cunningham, Janet
Publication type:
Article
A Dose-Ranging Study of AAV-hAADC Therapy in Parkinsonian Monkeys.
Published in:
Molecular Therapy, 2006, v. 14, n. 4, p. 571, doi. 10.1016/j.ymthe.2006.04.008
By:
- Forsayeth, John R.;
- Eberling, Jamie L.;
- Sanftner, Laura M.;
- Zhen, Zhu;
- Pivirotto, Philip;
- Bringas, John;
- Cunningham, Janet;
- Bankiewicz, Krystof S.
Publication type:
Article
241. A Dose-Ranging Study of AAV-hAADC Therapy in Parkinsonian Monkeys.
Published in:
Molecular Therapy, 2006, v. 13, p. S93, doi. 10.1016/j.ymthe.2006.08.268
By:
- Forsayeth, John R.;
- Eberling, Jamie L.;
- Sanftner, Laura M.;
- Zhen, Zhu;
- Pivirotto, Philip;
- Bringas, John;
- Cunningham, Janet;
- Bankiewicz, Krystof S.
Publication type:
Article
942. Evaluation of Short (8 Weeks) and Long-Term (3 and 5 Years) Gene Transfer Following Brain Delivery of AAV-AADC Vector in Parkinsonian Monkeys
Published in:
2005
By:
- Daadi, Marcel M.;
- Pivirotto, Philip;
- Bringas, John;
- Cunningham, Janet;
- Forsayeth, John;
- Eberling, Jamie L.;
- Bankiewicz, Krystof S.
Publication type:
Abstract
Real-time MRI-guided intraputaminal AADC gene therapy for advanced Parkinson's disease.
Published in:
Stereotactic & Functional Neurosurgery, 2017, v. 95, p. 170
By:
- Richarson, Mark;
- Christine, Chadwick W.;
- Bankiewicz, Krystof S.;
- Van Laar, Amber;
- Ravina, Bernard;
- Kells, Adrian;
- Boot, Brendon;
- Larson, Paul S.
Publication type:
Article
Novel Platform for MRI-Guided Convection-Enhanced Delivery of Therapeutics: Preclinical Validation in Nonhuman Primate Brain.
Published in:
Stereotactic & Functional Neurosurgery, 2011, v. 89, n. 3, p. 141, doi. 10.1159/000323544
By:
- Richardson, R. Mark;
- Kells, Adrian P.;
- Martin, Alastair J.;
- Larson, Paul S.;
- Starr, Philip A.;
- Piferi, Peter G.;
- Bates, Geoffrey;
- Tansey, Lisa;
- Rosenbluth, Kathryn H.;
- Bringas, John R.;
- Berger, Mitchel S.;
- Bankiewicz, Krystof S.
Publication type:
Article
Chronic convection-enhanced delivery: the next frontier in regional drug infusion for glioblastoma.
Published in:
Journal of Neurosurgery, 2020, v. 133, n. 3, p. 611, doi. 10.3171/2019.4.jns19614
By:
- Butowski, Nicholas A.;
- Bringas, John R.;
- Bankiewicz, Krystof S.;
- Aghi, Manish K.
Publication type:
Article
Infuse-as-you-go convective delivery to enhance coverage of elongated brain targets: technical note.
Published in:
Journal of Neurosurgery, 2020, v. 133, n. 2, p. 530, doi. 10.3171/2019.4.JNS19826
By:
- Sudhakar, Vivek;
- Naidoo, Jerusha;
- Samaranch, Lluis;
- Bringas, John R.;
- Lonser, Russell R.;
- Fiandaca, Massimo S.;
- Bankiewicz, Krystof S.
Publication type:
Article
Development of a novel frameless skull-mounted ball-joint guide array for use in image-guided neurosurgery.
Published in:
Journal of Neurosurgery, 2020, v. 132, n. 2, p. 595, doi. 10.3171/2018.10.JNS182169
By:
- Sudhakar, Vivek;
- Mahmoodi, Amin;
- Bringas, John R.;
- Naidoo, Jerusha;
- Kells, Adrian;
- Samaranch, Lluis;
- Fiandaca, Massimo S.;
- Bankiewicz, Krystof S.
Publication type:
Article
An Engineered Zinc Finger Protein Activator of the Endogenous Glial Cell Line-Derived Neurotrophic Factor Gene Provides Functional Neuroprotection in a Rat Model of Parkinson's Disease.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 49, p. 16469, doi. 10.1523/JNEUROSCI.2440-10.2010
By:
- Laganiere, Josee;
- Keils, Adrian P.;
- Lai, Jeffrey T.;
- Guschin, Dmitry;
- Paschon, David E.;
- Xiangdong Meng;
- Fong, Lauren K.;
- Qi Yu;
- Rebar, Edward J.;
- Gregory, Philip D.;
- Bankiewicz, Krystof S.;
- Forsayeth, John;
- Zhang, H. Steve
Publication type:
Article
An Engineered Zinc Finger Protein Activator of the Endogenous Glial Cell Line-Derived Neurotrophic Factor Gene Provides Functional Neuroprotection in a Rat Model of Parkinson's Disease.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 48, p. 16469, doi. 10.1523/JNEUROSCI.2440-10.2010
By:
- Laganiere, Josee;
- Kells, Adrian P.;
- Lai, Jeffrey T.;
- Guschin, Dmitry;
- Paschon, David E.;
- Xiangdong Meng;
- Fong, Lauren K.;
- Qi Yu;
- Rebar, Edward J.;
- Gregory, Philip D.;
- Bankiewicz, Krystof S.;
- Forsayeth, John;
- Zhang, H. Steve
Publication type:
Article

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