Works by Balzarini, Jan

Results: 220

Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy.

Published in:

Nature Reviews Microbiology, 2007, v. 5, n. 8, p. 583, doi. 10.1038/nrmicro1707

By:

Balzarini, Jan

Publication type:

Article

Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues.

Published in:

Angewandte Chemie, 2016, v. 128, n. 17, p. 5341, doi. 10.1002/ange.201511808

By:

Gollnest, Tristan;
Dinis de Oliveira, Thiago;
Rath, Anna;
Hauber, Ilona;
Schols, Dominique;
Balzarini, Jan;
Meier, Chris

Publication type:

Article

Assessment of the in vitro broad-spectrum antiviral activity of some selected antitumor metallocene and metallocenium complexes.

Published in:

Applied Organometallic Chemistry, 1989, v. 3, n. 6, p. 491, doi. 10.1002/aoc.590030605

By:

Ward, Sarah G;
Taylor, R Craig;
Köpf-Maier, Petra;
Köpf, Hartmut;
Balzarini, Jan;
De Clercq, Erik

Publication type:

Article

Assessment of the in vitro broad-spectrum antiviral activity of some selected antitumor organotin complexes.

Published in:

Applied Organometallic Chemistry, 1989, v. 3, n. 5, p. 431, doi. 10.1002/aoc.590030509

By:

Ward, Sarah G;
Taylor, R Craig;
Crowe, Alan J;
Balzarini, Jan;
De Clercq, Erik

Publication type:

Article

The dual role of thymidine phosphorylase in cancer development and chemotherapy.

Published in:

Medicinal Research Reviews, 2009, v. 29, n. 6, p. 903, doi. 10.1002/med.20159

By:

Bronckaers, Annelies;
Gago, Federico;
Balzarini, Jan;
Liekens, Sandra

Publication type:

Article

Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): Present and future.

Published in:

Medicinal Research Reviews, 2008, v. 28, n. 5, p. 797, doi. 10.1002/med.20124

By:

Pérez-Pérez, María-Jesús;
Priego, Eva-María;
Hernández, Ana-Isabel;
Familiar, Olga;
Camarasa, María-José;
Negri, Ana;
Gago, Federico;
Balzarini, Jan

Publication type:

Article

The regulation of HIV-1 transcription: Molecular targets for chemotherapeutic intervention.

Published in:

Medicinal Research Reviews, 2006, v. 26, n. 5, p. 595, doi. 10.1002/med.20081

By:

Stevens, Miguel;
De Clercq, Erik;
Balzarini, Jan

Publication type:

Article

Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (pmea) in vivo increases when it is less frequently administered.

Published in:

International Journal of Cancer, 1990, v. 46, n. 2, p. 337, doi. 10.1002/ijc.2910460233

By:

Balzarini, Jan;
Naesens, Lieve;
Clercq, Erik De

Publication type:

Article

Inhibitory effects of 9-(2-Phosphonylmethoxyethyl)adenine and 3′-azido-2′,3′-dideoxythymidine on tumor development in mice inoculated intracerebrally with moloney murine sarcoma virus.

Published in:

International Journal of Cancer, 1990, v. 45, n. 3, p. 486, doi. 10.1002/ijc.2910450319

By:

Balzarini, Jan;
Sobis, Halina;
Naesens, Lieve;
Vandeputte, Michel;
De Clercq, Erik

Publication type:

Article

Comparative inhibitory effects of suramin and other selected compounds on the infectivity and replication of human T-cell lymphotropic virus (HTLV-III)/lymphadenopathy-associated virus (LAV).

Published in:

International Journal of Cancer, 1986, v. 37, n. 3, p. 451, doi. 10.1002/ijc.2910370318

By:

Balzarini, Jan;
Mitsuya, Hiroaki;
De Clercq, Erik;
Broder, Samuel

Publication type:

Article

Antinociceptive and antitumor activity of novel synthetic mononuclear Ruthenium (II) compounds.

Published in:

Journal of Research in Medical Sciences, 2013, v. 18, n. 3, p. 215

By:

Shyam Sunder, A.;
Dhulipala, Satyavati;
Thota, Sreekanth;
Yerra, Rajeshwar;
Balzarini, Jan;
De Clercq, Erik

Publication type:

Article

Synthesis, Antiviral Evaluation, and Computational Studies of Cyclobutane and Cyclobutene L-Nucleoside Analogues.

Published in:

European Journal of Organic Chemistry, 2013, v. 2013, n. 34, p. 7761, doi. 10.1002/ejoc.201301097

By:

Miralles‐Llumà, Rosa;
Figueras, Antoni;
Busqué, Félix;
Alvarez‐Larena, Angel;
Balzarini, Jan;
Figueredo, Marta;
Font, Josep;
Alibés, Ramon;
Maréchal, Jean‐Didier

Publication type:

Article

Diastereoselective Synthesis of (Aryloxy)phosphoramidate Prodrugs.

Published in:

European Journal of Organic Chemistry, 2011, v. 2011, n. 25, p. 4899, doi. 10.1002/ejoc.201100614

By:

Arbelo Román, Cristina;
Wasserthal, Philip;
Balzarini, Jan;
Meier, Chris

Publication type:

Article

Bioreversible Protection of Nucleoside Diphosphates.

Published in:

Angewandte Chemie International Edition, 2008, v. 47, n. 45, p. 8719, doi. 10.1002/anie.200803100

By:

Jessen, Henning Jacob;
Schulz, Tilmann;
Balzarini, Jan;
Meier, Chris

Publication type:

Article

A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity.

Published in:

PLoS Pathogens, 2013, v. 9, n. 7, p. 1, doi. 10.1371/journal.ppat.1003456

By:

Balzarini, Jan;
Andrei, Graciela;
Balestra, Emanuela;
Huskens, Dana;
Vanpouille, Christophe;
Introini, Andrea;
Zicari, Sonia;
Liekens, Sandra;
Snoeck, Robert;
Holý, Antonín;
Perno, Carlo-Federico;
Margolis, Leonid;
Schols, Dominique

Publication type:

Article

Synthesis of 2-carbamoylmethyl-6-β-D-ribofuranosylpyridine with the aid of a Pd(0)-catalyzed reaction.

Published in:

Journal of Heterocyclic Chemistry, 1993, v. 30, n. 5, p. 1245, doi. 10.1002/jhet.5570300513

By:

De Vos, Eric;
Esmans, Eddy L.;
Alderweireldt, Frank C.;
Balzarini, Jan;
De Clercq, Erik

Publication type:

Article

Cyclopentene carbocyclic nucleosides related to the antitumor nucleoside clitocine and their conversion to 8-Aza-neplanocin analogues. Synthesis and antiviral activity.

Published in:

Journal of Heterocyclic Chemistry, 1993, v. 30, n. 5, p. 1393, doi. 10.1002/jhet.5570300536

By:

Marquez, Victor E.;
Lim, Benjamin B.;
Driscoll, John S.;
Snoek, Robert;
Balzarini, Jan;
Ikeda, Satoru;
Andrei, Graciela;
De Clercq, Erick

Publication type:

Article

3′-(1,2,3-Triazol-1-yl)-2′,3′-dideoxythymidine and 3′-(1,2,3-triazol-1-yl)-2′,3′-dideoxyuridine.

Published in:

Journal of Heterocyclic Chemistry, 1989, v. 26, n. 6, p. 1635, doi. 10.1002/jhet.5570260624

By:

Wigerinck, Piet;
Van Aerschot, Arthur;
Claes, Paul;
Balzarini, Jan;
De Clercq, Erik;
Herdewijn, Piet

Publication type:

Article

Antiviral Activity of Synthetic Aminopyrrolic Carbohydrate Binding Agents: Targeting the Glycans of Viral gp120 to Inhibit HIV Entry.

Published in:

Chemistry - A European Journal, 2015, v. 21, n. 28, p. 10089, doi. 10.1002/chem.201501030

By:

Francesconi, Oscar;
Nativi, Cristina;
Gabrielli, Gabriele;
De Simone, Irene;
Noppen, Sam;
Balzarini, Jan;
Liekens, Sandra;
Roelens, Stefano

Publication type:

Article

Synthesis of 3-Nitrosoimidazo[1,2- a]pyridine Derivatives as Potential Antiretroviral Agents.

Published in:

Archiv der Pharmazie, 2001, v. 334, n. 7, p. 224, doi. 10.1002/1521-4184(200107)334:7<224::AID-ARDP224>3.0.CO;2-7

By:

Chaouni-Benabdallah, Aziz;
Galtier, Christophe;
Allouchi, Hassan;
Kherbeche, Abdelhak;
Debouzy, Jean-Claude;
Teulade, Jean-Claude;
Chavignon, Olivier;
Witvrouw, Myriam;
Pannecouque, Christophe;
Balzarini, Jan;
de Clercq, Erik;
Enguehard, Cécile;
Gueiffier, Alain

Publication type:

Article

Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclobutane Ring.

Published in:

Archiv der Pharmazie, 1999, v. 332, n. 10, p. 348, doi. 10.1002/(SICI)1521-4184(199910)332:10<348::AID-ARDP348>3.0.CO;2-H

By:

Figueira, M. José;
Blanco, J. Manuel;
Caamaño, Olga;
Fernández, Franco;
García-Mera, Xerardo;
López, Carmen;
Andrei, Graciela;
Snoeck, Robert;
Padalko, Elisabeth;
Neyts, Johan;
Balzarini, Jan;
Clercq, Erik De

Publication type:

Article

Novel Carbocyclic Nucleosides Containing a Cyclopentyl Ring. Adenosine and Uridine Analogues.

Published in:

Archiv der Pharmazie, 1997, v. 330, n. 8, p. 265, doi. 10.1002/ardp.19973300807

By:

Balo, Carmen;
Fernández, Franco;
Lens, Evangelina;
López, Carmen;
Andrei, Graciela;
Snoeck, Robert;
Balzarini, Jan;
De Clercq, Erik

Publication type:

Article

Synthesis of 5′- N-(α-Amino-β-mercaptoacyl)amino-5′-deoxynucleosides as potential antiviral compounds.

Published in:

Archiv der Pharmazie, 1991, v. 324, n. 8, p. 497, doi. 10.1002/ardp.2503240807

By:

Herranz, Rosario;
Castro-Pichel, Julia;
García-López, M. Teresa;
Pérez, Concepción;
Balzarini, Jan;
De Clercq, Erik

Publication type:

Article

Synthesis and biological evaluation of carbon-11-labeled acyclic and furo[2,3-d]pyrimidine derivatives of bicyclic nucleoside analogues (BCNAs) for structure-brain uptake relationship study of BCNA tracers.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2008, v. 51, n. 3, p. 159, doi. 10.1002/jlcr.1494

By:

Chitneni, Satish K.;
Balzarini, Jan;
Celen, Sofie;
Dyubankova, Natalia;
Verbruggen, Alfons M.;
Bormans, Guy M.

Publication type:

Article

Synthesis and biological evaluation of a lipophilic, fluorine-18-labeled 5-ethynyl-2′-deoxyuridine derivative.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2007, v. 50, n. 7, p. 649, doi. 10.1002/jlcr.1312

By:

Chitneni, Satish K.;
De Ruymaeker, Tom;
Balzarini, Jan;
Verbruggen, Alfons M.;
Bormans, Guy M.

Publication type:

Article

NICTABA and UDA, two GlcNAc-binding lectins with unique antiviral activity profiles.

Published in:

2015

By:

Gordts, Stephanie C;
Renders, Marleen;
Férir, Geoffrey;
Huskens, Dana;
Van Damme, Els J M;
Peumans, Willy;
Balzarini, Jan;
Schols, Dominique

Publication type:

journal article

NICTABA and UDA, two GlcNAc-binding lectins with unique antiviral activity profiles.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2015, v. 70, n. 6, p. 1674, doi. 10.1093/jac/dkv034

By:

Gordts, Stephanie C.;
Renders, Marleen;
Férir, Geoffrey;
Huskens, Dana;
Van Damme, Els J. M.;
Peumans, Willy;
Balzarini, Jan;
Schols, Dominique

Publication type:

Article

An emerging understanding of the Janus face of the human microbiome: enhancement versus impairment of cancer therapy.

Published in:

2014

By:

Vande Voorde, Johan;
Balzarini, Jan;
Liekens, Sandra

Publication type:

Journal Article

An emerging understanding of the Janus face of the human microbiome: enhancement versus impairment of cancer therapy.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2014, v. 69, n. 10, p. 2878, doi. 10.1093/jac/dku201

By:

Vande Voorde, Johan;
Balzarini, Jan;
Liekens, Sandra

Publication type:

Article

Exposure of HIV-1 to a combination of two carbohydrate-binding agents markedly delays drug resistance development and selects for virus strains with compromised fitness.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2014, v. 69, n. 3, p. 582, doi. 10.1093/jac/dkt414

By:

Mathys, Leen;
Balzarini, Jan

Publication type:

Article

Inhibition of infection and transmission of HIV-1 and lack of significant impact on the vaginal commensal lactobacilli by carbohydrate-binding agents.

Published in:

2013

By:

Petrova, Mariya I;
Mathys, Leen;
Lebeer, Sarah;
Noppen, Sam;
Van Damme, Els J M;
Tanaka, Haruo;
Igarashi, Yasuhiro;
Vaneechoutte, Mario;
Vanderleyden, Jos;
Balzarini, Jan

Publication type:

Journal Article

Inhibition of infection and transmission of HIV-1 and lack of significant impact on the vaginal commensal lactobacilli by carbohydrate-binding agents.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 9, p. 2026, doi. 10.1093/jac/dkt152

By:

Petrova, Mariya I.;
Mathys, Leen;
Lebeer, Sarah;
Noppen, Sam;
Van Damme, Els J. M.;
Tanaka, Haruo;
Igarashi, Yasuhiro;
Vaneechoutte, Mario;
Vanderleyden, Jos;
Balzarini, Jan

Publication type:

Article

In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20).

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2009, v. 64, n. 6, p. 1192, doi. 10.1093/jac/dkp380

By:

Jenabian, Mohammad-Ali;
Saïdi, Héla;
Charpentier, Charlotte;
Van Herrewege, Yven;
Son, Jong Chan;
Schols, Dominique;
Balzarini, Jan;
Vanham, Guido;
Bélec, Laurent

Publication type:

Article

FV100 as a new approach for the possible treatment of varicella-zoster virus infection.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2009, v. 64, n. 4, p. 671, doi. 10.1093/jac/dkp294

By:

McGuigan, Christopher;
Balzarini, Jan

Publication type:

Article

Preclinical development of bicyclic nucleoside analogues as potent and selective inhibitors of varicella zoster virus.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2007, v. 60, n. 6, p. 1316, doi. 10.1093/jac/dkm376

By:

Christopher McGuigan;
Ranjith N. Pathirana;
Marco Migliore;
Rina Adak;
Giovanna Luoni;
Arwyn T. Jones;
Alberto DÃez-Torrubia;
Maria-Jose Camarasa;
Sonsoles VelÃ¡zquez;
Geoffrey Henson;
Erik Verbeken;
Rebecca Sienaert;
Lieve Naesens;
Robert Snoeck;
Graciela Andrei;
Jan Balzarini

Publication type:

Article

Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2007, v. 59, n. 1, p. 80

By:

Jan Balzarini;
Dominique Schols;
Kristel Van Laethem;
Erik De Clercq;
Dana Hocková;
Milina Masojidkova;
Antonin Holý

Publication type:

Article

Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2006, v. 57, n. 3, p. 472, doi. 10.1093/jac/dki481

By:

Jan Balzarini;
Els Keyaerts;
Leen Vijgen;
Frank Vandermeer;
Miguel Stevens;
Erik De Clercq;
Herman Egberink;
Marc Van Ranst

Publication type:

Article

Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2005, v. 56, n. 5, p. 847, doi. 10.1093/jac/dki328

By:

Miguel Stevens;
Jan Balzarini;
Oriana Tabarrini;
Graciela Andrei;
Robert Snoeck;
Violetta Cecchetti;
Arnaldo Fravolini;
Erik De Clercq;
Christophe Pannecouque

Publication type:

Article

Limited development and progression of resistance of HIV-1 to the nucleoside analogue reverse transcriptase inhibitor lamivudine in human primary macrophages.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2005, v. 55, n. 6, p. 872, doi. 10.1093/jac/dki104

By:

Stefano Aquaro;
Valentina Svicher;
Francesca Ceccherini-Silberstein;
Alessandra Cenci;
Fabbio Marcuccilli;
Sara Giannella;
Luisa Marcon;
Raffaele Caliò;
Jan Balzarini;
Carlo-Federico Perno

Publication type:

Article

Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication.

Published in:

2002

By:

Balzarini, Jan;
McGuigan, Christopher

Publication type:

journal article

Novel 5-Arylcarbamoyl-2-methylisoxazolidin-3-yl-3-phosphonates as Nucleotide Analogues.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2014, v. 33, n. 8, p. 552, doi. 10.1080/15257770.2014.909046

By:

Kokosza, Kamil;
Balzarini, Jan;
Piotrowska, Dorota G.

Publication type:

Article

Design, Synthesis, Antiviral, and Cytostatic Evaluation of Novel Isoxazolidine Analogues of C -Nucleotides.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2013, v. 32, n. 12, p. 682, doi. 10.1080/15257770.2013.851794

By:

Grabkowska-Drużyc, Magdalena;
Balzarini, Jan;
Piotrowska, DorotaG.

Publication type:

Article

Stereocontrolled Facile Synthesis and Biological Evaluation of (3′ S ) and (3′ R )-3′-Amino (and Azido)-3′-Deoxy Pyranonucleosides.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2012, v. 31, n. 7, p. 522, doi. 10.1080/15257770.2012.696759

By:

Manta, Stella;
Parmenopoulou, Vanessa;
Kiritsis, Christos;
Dimopoulou, Athina;
Kollatos, Nikolaos;
Papasotiriou, Ioannis;
Balzarini, Jan;
Komiotis, Dimitri

Publication type:

Article

Design, Synthesis, Antiviral, and Cytotoxic Evaluation of Novel Phosphonylated 1,2,3-Triazoles as Acyclic Nucleotide Analogues.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2012, v. 31, n. 4, p. 293, doi. 10.1080/15257770.2012.662611

By:

Głowacka, IwonaE.;
Balzarini, Jan;
Wróblewski, AndrzejE.

Publication type:

Article

Synthesis of 5-Substituted 2′-Deoxyuridine-5′- Phosphonate Analogues and Evaluation of their Antiviral Activity.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2012, v. 31, n. 3, p. 256, doi. 10.1080/15257770.2012.654876

By:

Poecke, SaraVan;
Sinnaeve, Davy;
Martins, JoséC.;
Balzarini, Jan;
Calenbergh, SergeVan

Publication type:

Article

Synthesis of Novel 6-Azapyrimidine Acyclic Nucleoside Analogues and Antiviral Evaluation.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2010, v. 29, n. 7, p. 535, doi. 10.1080/15257771003781634

By:

Jasamai, Malina;
Simons, Claire;
Balzarini, Jan

Publication type:

Article

Retained Sensitivity to Cytotoxic Pyrimidine Nucleoside Analogs in Thymidine Kinase 2 Deficient Human Fibroblasts.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2010, v. 29, n. 1, p. 1, doi. 10.1080/15257770903454490

By:

Bjerke, Mia;
Solaroli, Nicola;
Lesko, Nicole;
Balzarini, Jan;
Johansson, Magnus;
Karlsson, Anna

Publication type:

Article

Novel N-3 Substituted TSAO-T Derivatives: Synthesis and Anti-HIV-Evaluation.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2008, v. 27, n. 4, p. 351, doi. 10.1080/15257770801943990

By:

Bonache, María-Cruz;
Quesada, Ernesto;
Sheen, Chih-Wei;
Balzarini, Jan;
Sluis-Cremer, Nicolas;
Pérez-Pérez, MaríaJesús;
Camarasa, María-José;
San-Félix, Ana

Publication type:

Article

Antiviral Activity of 3-(3,5-Dimethylbenzyl)Uracil Derivatives Against Hiv-1 and HCMV.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2007, v. 26, n. 10-12, p. 1553, doi. 10.1080/15257770701545424

By:

Maruyama, Tokumi;
Demizu, Yosuke;
Kozai, Shigetada;
Witvrouw, Myriam;
Pannecouque, Christophe;
Balzarini, Jan;
Snoecks, Robert;
Andrei, Graciella;
De Clercq, Erik

Publication type:

Article

New Developments of the "Lock-in" Modified cycloSal-d4TMPs.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2007, v. 26, n. 10-12, p. 1325, doi. 10.1080/15257770701530707

By:

Vukadinović-Tenter, Dalibor;
Balzarini, Jan;
Meier, Chris

Publication type:

Article