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Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium.
- Published in:
- 2018
- By:
- Publication type:
- journal article
Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.
- Published in:
- 2018
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- Publication type:
- journal article
The novel late Na<sup>+</sup> current inhibitor, GS-6615 (eleclazine) and its anti-arrhythmic effects in rabbit isolated heart preparations.
- Published in:
- 2016
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- Publication type:
- journal article
Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations.
- Published in:
- Frontiers in Physiology, 2013, v. 4, p. 1, doi. 10.3389/fphys.2013.00282
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- Publication type:
- Article
The A<sub>2B</sub> adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease.
- Published in:
- FASEB Journal, 2012, v. 26, n. 6, p. 2546, doi. 10.1096/fj.11-200907
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- Publication type:
- Article
Adenosine A2B Receptor and Hyaluronan Modulate Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease.
- Published in:
- American Journal of Respiratory Cell & Molecular Biology, 2013, v. 49, n. 6, p. 1038, doi. 10.1165/rcmb.2013-0089OC
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- Publication type:
- Article
A<sub>2B</sub> Adenosine Receptors Induce IL-19 from Bronchial Epithelial Cells, Resulting in TNF-α Increase.
- Published in:
- American Journal of Respiratory Cell & Molecular Biology, 2006, v. 35, n. 5, p. 587, doi. 10.1165/rcmb.2005-0476OC
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- Publication type:
- Article
Synergy between A<sub>2B</sub> Adenosine Receptors and Hypoxia in Activating Human Lung Fibroblasts.
- Published in:
- American Journal of Respiratory Cell & Molecular Biology, 2005, v. 32, n. 1, p. 2, doi. 10.1165/rcmb.2004-0103OC
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- Publication type:
- Article
A<sub>2B</sub> Adenosine Receptors Increase Cytokine Release by Bronchial Smooth Muscle Cells.
- Published in:
- American Journal of Respiratory Cell & Molecular Biology, 2004, v. 30, n. 1, p. 118, doi. 10.1165/rcmb.2003-0118OC
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- Publication type:
- Article
Atrial-Selective Sodium Channel Block as a Strategy for Suppression of Atrial Fibrillation.
- Published in:
- Annals of the New York Academy of Sciences, 2008, v. 1123, p. 105, doi. 10.1196/annals.1420.012
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- Publication type:
- Article
Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice.
- Published in:
- 2020
- By:
- Publication type:
- journal article
Sodium channel block by ranolazine in an experimental model of stretch-related atrial fibrillation: prolongation of interatrial conduction time and increase in post-repolarization refractoriness.
- Published in:
- EP: Europace, 2013, v. 15, n. 5, p. 761, doi. 10.1093/europace/eus399
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- Publication type:
- Article
The risk of sudden cardiac death in patients with non-ST elevation acute coronary syndrome and prolonged QTc interval: effect of ranolazine.
- Published in:
- EP: Europace, 2013, v. 15, n. 3, p. 429, doi. 10.1093/europace/eus400
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- Publication type:
- Article
Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation.
- Published in:
- EP: Europace, 2013, v. 15, n. 3, p. 317, doi. 10.1093/europace/eus380
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- Publication type:
- Article
Adenosine: Cardiac Electrophysiology.
- Published in:
- Pacing & Clinical Electrophysiology, 1991, v. 14, n. 11, p. 1672, doi. 10.1111/j.1540-8159.1991.tb02742.x
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- Publication type:
- Article
A Microcomputer System for On-Line Study of Atrioventricular Node Accommodation.
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- Pacing & Clinical Electrophysiology, 1987, v. 10, n. 6, p. 1301, doi. 10.1111/j.1540-8159.1987.tb04966.x
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- Publication type:
- Article
Blockade of Na+ Channels in Pancreatic [alpha]-Cells Has Antidiabetic Effects.
- Published in:
- 2014
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- Publication type:
- Journal Article
Blockade of Na<sup>+</sup> Channels in Pancreatic α-Cells Has Antidiabetic Effects.
- Published in:
- Diabetes, 2014, v. 63, n. 10, p. 3545, doi. 10.2337/db13-1562
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- Publication type:
- Article
Anti-Diabetic Effects of CVT-3619, Metformin and Pioglitazone Alone and Combined in ZDF Rats.
- Published in:
- Diabetes, 2007, v. 56, p. A132
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- Publication type:
- Article
Late sodium current contributes to diastolic cell Ca<sup>2+</sup> accumulation in chronic heart failure.
- Published in:
- Journal of Physiological Sciences, 2010, v. 60, n. 4, p. 245, doi. 10.1007/s12576-010-0092-0
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- Publication type:
- Article
Expression and function of A<sub>2B</sub> adenosine receptors in the U87MG tumor cells.
- Published in:
- Drug Development Research, 2003, v. 58, n. 4, p. 405, doi. 10.1002/ddr.10212
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- Publication type:
- Article
Negative chronotropic effect of CVT-510 in anesthetized and awake rats.
- Published in:
- Drug Development Research, 2001, v. 52, n. 1/2, p. 424, doi. 10.1002/ddr.1143
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- Publication type:
- Article
Renal effects of BG9719, a specific A<sub>1</sub> adenosine receptor antagonist, in congestive heart failure.
- Published in:
- Drug Development Research, 1998, v. 45, n. 3/4, p. 166, doi. 10.1002/(SICI)1098-2299(199811/12)45:3/4<166::AID-DDR12>3.0.CO;2-P
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- Publication type:
- Article
Cardiac electrophysiological actions of adenosine.
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- Drug Development Research, 1998, v. 45, n. 3/4, p. 420, doi. 10.1002/(SICI)1098-2299(199811/12)45:3/4<420::AID-DDR43>3.0.CO;2-Y
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- Publication type:
- Article
Adenosine system in the heart.
- Published in:
- Drug Development Research, 1993, v. 28, n. 3, p. 263, doi. 10.1002/ddr.430280313
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- Publication type:
- Article
Effects of Ranolazine in Patients With Chronic Angina in Patients With and Without Percutaneous Coronary Intervention for Acute Coronary Syndrome: Observations From the MERLIN-TIMI 36 Trial.
- Published in:
- Clinical Cardiology, 2015, v. 38, n. 8, p. 469, doi. 10.1002/clc.22425
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- Publication type:
- Article
Ranolazine for the Treatment of Heart Failure With Preserved Ejection Fraction: Background, Aims, and Design of the RALI-DHF Study.
- Published in:
- Clinical Cardiology, 2011, v. 34, n. 7, p. 426, doi. 10.1002/clc.20897
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- Publication type:
- Article
A temporal window of vulnerability for development of atrial fibrillation with advancing heart failure.
- Published in:
- European Journal of Heart Failure, 2014, v. 16, n. 3, p. 271, doi. 10.1002/ejhf.28
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- Publication type:
- Article
CVT-4325 Inhibits Myocardial Fatty Acid Uptake and Improves Left Ventricular Systolic Function without Increasing Myocardial Oxygen Consumption in Dogs with Chronic Heart Failure.
- Published in:
- Cardiovascular Drugs & Therapy, 2007, v. 21, n. 1, p. 9, doi. 10.1007/s10557-006-0496-5
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- Publication type:
- Article
Ranolazine Exerts Potent Effects on Atrial Electrical Properties and Abbreviates Atrial Fibrillation Duration in the Intact Porcine Heart.
- Published in:
- Journal of Cardiovascular Electrophysiology, 2009, v. 20, n. 7, p. 796, doi. 10.1111/j.1540-8167.2009.01437.x
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- Publication type:
- Article
Potent Antiarrhythmic Effects of Chronic Amiodarone in Canine Pulmonary Vein Sleeve Preparations.
- Published in:
- Journal of Cardiovascular Electrophysiology, 2009, v. 20, n. 7, p. 803, doi. 10.1111/j.1540-8167.2009.01449.x
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- Publication type:
- Article
Effect of Ranolazine on Ventricular Vulnerability and Defibrillation Threshold in the Intact Porcine Heart.
- Published in:
- Journal of Cardiovascular Electrophysiology, 2008, v. 19, n. 10, p. 1073, doi. 10.1111/j.1540-8167.2008.01204.x
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- Publication type:
- Article
The Role of Sodium Channel Current in Modulating Transmural Dispersion of Repolarization and Arrhythmogenesis.
- Published in:
- Journal of Cardiovascular Electrophysiology, 2006, v. 17, p. S79, doi. 10.1111/j.1540-8167.2006.00388.x
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- Publication type:
- Article
Ranolazine Improves Abnormal Repolarization and Contraction in Left Ventricular Myocytes of Dogs with Heart Failure by Inhibiting Late Sodium Current.
- Published in:
- Journal of Cardiovascular Electrophysiology, 2006, v. 17, p. S169, doi. 10.1111/j.1540-8167.2006.00401.x
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- Publication type:
- Article
Potentiating Effect of Acetylcholine on Stimulation by Isoproterenol of L-Type Ca<sup>2+</sup> Current and Arrhythmogenic Triggered Activity in Guinea Pig Ventricular Myocytes.
- Published in:
- Journal of Cardiovascular Electrophysiology, 1998, v. 9, n. 7, p. 718, doi. 10.1111/j.1540-8167.1998.tb00959.x
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- Publication type:
- Article
Cardiac Electrophysiology and Pharmacology of Adenosine.
- Published in:
- Journal of Cardiovascular Electrophysiology, 1990, v. 1, n. 4, p. 327
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- Publication type:
- Article
Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure.
- Published in:
- PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0032659
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- Publication type:
- Article
Alterations in Adenosine Metabolism and Signaling in Patients with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis.
- Published in:
- PLoS ONE, 2010, v. 5, n. 2, p. 1, doi. 10.1371/journal.pone.0009224
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- Publication type:
- Article
Contribution of I<sub>K,ADO</sub> to the negative dromotropic effect of adenosine.
- Published in:
- Basic Research in Cardiology, 2002, v. 97, n. 4, p. 286, doi. 10.1007/s00395-002-0349-8
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- Publication type:
- Article
Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism.
- Published in:
- Basic Research in Cardiology, 2002, v. 97, n. 4, p. 295, doi. 10.1007/s00395-002-0354-y
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- Publication type:
- Article
Ranolazine: Ion-channel-blocking actions and in vivo electrophysiological effects.
- Published in:
- British Journal of Pharmacology, 2004, v. 142, n. 8, p. 1300, doi. 10.1038/sj.bjp.0705879
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- Publication type:
- Article
Tonic activity of the rat adipocyte A1-adenosine receptor.
- Published in:
- 2002
- By:
- Publication type:
- journal article
Tonic activity of the rat adipocyte A[sub1]-adenosine receptor.
- Published in:
- British Journal of Pharmacology, 2002, v. 135, n. 6, p. 1457, doi. 10.1038/sj.bjp.0704586
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- Publication type:
- Article
A comparison of an A<sub>1</sub> adenosine receptor agonist (CVT-510) with diltiazem for slowing of AV nodal conduction in guinea-pig.
- Published in:
- British Journal of Pharmacology, 1999, v. 126, n. 1, p. 137, doi. 10.1038/sj.bjp.0702287
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- Publication type:
- Article
Validation of Furchgott's method to determine agonist-dependent A1-adenosine receptor reserve in guinea-pig atrium.
- Published in:
- 1998
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- Publication type:
- journal article
Role of A<sub>2B</sub> adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury.
- Published in:
- Journal of Clinical Investigation, 2006, v. 116, n. 8, p. 2173, doi. 10.1172/JCI27303
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- Publication type:
- Article
Modulation of late sodium current by Ca<sup>2+</sup>-calmodulin-dependent protein kinase II, protein kinase C and Ca<sup>2+</sup> during hypoxia in rabbit ventricular myocytes.
- Published in:
- Experimental Physiology, 2017, v. 102, n. 7, p. 818, doi. 10.1113/EP085990
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- Publication type:
- Article
Protein kinase C and Ca<sup>2+</sup>-calmodulin-dependent protein kinase II mediate the enlarged reverse I<sub>NCX</sub> induced by ouabain-increased late sodium current in rabbit ventricular myocytes.
- Published in:
- Experimental Physiology, 2015, v. 100, n. 4, p. 399, doi. 10.1113/expphysiol.2014.083972
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- Publication type:
- Article
Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A<sub>2A</sub> receptor antagonists.
- Published in:
- Naunyn-Schmiedeberg's Archives of Pharmacology, 2007, v. 375, n. 2, p. 133, doi. 10.1007/s00210-007-0135-0
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- Publication type:
- Article
Multimodal mechanisms and enhanced efficiency of atrial fibrillation cardioversion by pulmonary delivery of a novel flecainide formulation.
- Published in:
- Journal of Cardiovascular Electrophysiology, 2020, v. 31, n. 1, p. 205, doi. 10.1111/jce.14289
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- Publication type:
- Article