Works matching AU Bédard, Dominique

Results: 19

5-HT2A blockade for dyskinesia and psychosis in Parkinson's disease: is there a limit to the efficacy of this approach? A study in the MPTP-lesioned marmoset and a literature mini-review.

Published in:

Experimental Brain Research, 2019, v. 237, n. 2, p. 435, doi. 10.1007/s00221-018-5434-9

By:

Kwan, Cynthia;
Frouni, Imane;
Bédard, Dominique;
Nuara, Stephen G.;
Gourdon, Jim C.;
Hamadjida, Adjia;
Huot, Philippe

Publication type:

Article

Effect of the selective 5-HT2A receptor antagonist EMD-281,014 on L-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat.

Published in:

Experimental Brain Research, 2019, v. 237, n. 1, p. 29, doi. 10.1007/s00221-018-5390-4

By:

Frouni, Imane;
Kwan, Cynthia;
Bédard, Dominique;
Belliveau, Sébastien;
Bourgeois-Cayer, Élodie;
Gaudette, Fleur;
Beaudry, Francis;
Hamadjida, Adjia;
Huot, Philippe

Publication type:

Article

Effect of the mGlu2 positive allosteric modulator CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset.

Published in:

Journal of Neural Transmission, 2021, v. 128, n. 1, p. 73, doi. 10.1007/s00702-020-02287-8

By:

Frouni, Imane;
Kwan, Cynthia;
Nuara, Stephen G.;
Belliveau, Sébastien;
Kang, Woojin;
Hamadjida, Adjia;
Bédard, Dominique;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

Combined mGlu2 orthosteric stimulation and positive allosteric modulation alleviates l-DOPA-induced psychosis-like behaviours and dyskinesia in the parkinsonian marmoset.

Published in:

Journal of Neural Transmission, 2020, v. 127, n. 7, p. 1023, doi. 10.1007/s00702-020-02185-z

By:

Nuara, Stephen G.;
Hamadjida, Adjia;
Kwan, Cynthia;
Bédard, Dominique;
Frouni, Imane;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

[3H]-NFPS binding to the glycine transporter 1 in the hemi-parkinsonian rat brain.

Published in:

Experimental Brain Research, 2024, v. 242, n. 5, p. 1203, doi. 10.1007/s00221-024-06815-w

By:

Frouni, Imane;
Kim, Esther;
Shaqfah, Judy;
Bédard, Dominique;
Kwan, Cynthia;
Belliveau, Sébastien;
Huot, Philippe

Publication type:

Article

Effect of the mGlu4 positive allosteric modulator ADX-88178 on parkinsonism, psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset.

Published in:

Psychopharmacology, 2023, v. 240, n. 10, p. 2093, doi. 10.1007/s00213-023-06428-1

By:

Frouni, Imane;
Kwan, Cynthia;
Bédard, Dominique;
Kang, Woojin;
Hamadjida, Adjia;
Nuara, Stephen G.;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors.

Published in:

Molecular & Cellular Biology, 2009, v. 29, n. 21, p. 5872, doi. 10.1128/MCB.00112-09

By:

Watson, Mark;
Roulston, Anne;
Bélec, Laurent;
Billot, Xavier;
Marcellus, Richard;
Bédard, Dominique;
Bernier, Cynthia;
Branchaud, Stéphane;
Chan, Helen;
Dairi, Kenza;
Gilbert, Karine;
Goulet, Daniel;
Gratton, Michel-Olivier;
Isakau, Henady;
Jang, Anne;
Khadir, Abdelkrim;
Koch, Elizabeth;
Lavoie, Manon;
Lawless, Michael;
Mai Nguyen

Publication type:

Article

Effect of mGluR2 and mGluR2/3 activators on parkinsonism in the MPTP-lesioned non-human primate.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2024, v. 397, n. 11, p. 9135, doi. 10.1007/s00210-024-03216-2

By:

Frouni, Imane;
Kwan, Cynthia;
Bédard, Dominique;
Hamadjida, Adjia;
Kang, Woojin;
Belliveau, Sébastien;
Nuara, Stephen G.;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

Positive allosteric mGluR2 modulation with BINA alleviates dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2024, v. 397, n. 11, p. 8917, doi. 10.1007/s00210-024-03215-3

By:

Kang, Woojin;
Frouni, Imane;
Bédard, Dominique;
Kwan, Cynthia;
Hamadjida, Adjia;
Nuara, Stephen G.;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

The mGluR2/3 orthosteric agonist LY-404,039 reduces dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, v. 396, n. 10, p. 2347, doi. 10.1007/s00210-023-02587-2

By:

Kang, Woojin;
Nuara, Stephen G.;
Bédard, Dominique;
Frouni, Imane;
Kwan, Cynthia;
Hamadjida, Adjia;
Gourdon, Jim C.;
Gaudette, Fleur;
Beaudry, Francis;
Huot, Philippe

Publication type:

Article

Distribution of [11C]-JNJ-42491293 in the marmoset brain: a positron emission tomography study.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, v. 396, n. 9, p. 2095, doi. 10.1007/s00210-023-02458-w

By:

Kang, Min Su;
Hamadjida, Adjia;
Bédard, Dominique;
Nuara, Stephen G.;
Gourdon, Jim C.;
Frey, Stephen;
Aliaga, Arturo;
Ross, Karen;
Hopewell, Robert;
Bdair, Hussein;
Mathieu, Axel;
Tardif, Christine Lucas;
Soucy, Jean-Paul;
Massarweh, Gassan;
Rosa-Neto, Pedro;
Huot, Philippe

Publication type:

Article

Pharmacokinetic profile of bitopertin, a selective GlyT1 inhibitor, in the rat.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, v. 396, n. 5, p. 1053, doi. 10.1007/s00210-022-02378-1

By:

Frouni, Imane;
Bédard, Dominique;
Bourgeois-Cayer, Élodie;
Hamadjida, Adjia;
Gaudette, Fleur;
Beaudry, Francis;
Huot, Philippe

Publication type:

Article

Monoamine oxidase A inhibition as monotherapy reverses parkinsonism in the MPTP-lesioned marmoset.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, v. 393, n. 11, p. 2139, doi. 10.1007/s00210-020-01927-w

By:

Hamadjida, Adjia;
Nuara, Stephen G.;
Frouni, Imane;
Kwan, Cynthia;
Bédard, Dominique;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2020, v. 393, n. 11, p. 2157, doi. 10.1007/s00210-020-01933-y

By:

Hamadjida, Adjia;
Nuara, Stephen G.;
Kwan, Cynthia;
Frouni, Imane;
Bédard, Dominique;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

Nefazodone reduces dyskinesia, but not psychosis-like behaviours, in the parkinsonian marmoset.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2018, v. 391, n. 12, p. 1339, doi. 10.1007/s00210-018-1549-6

By:

Hamadjida, Adjia;
Nuara, Stephen G.;
Bédard, Dominique;
Frouni, Imane;
Kwan, Cynthia;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

Effect of the mGlu2 positive allosteric modulator biphenyl‐indanone A as a monotherapy and as adjunct to a low dose of L‐DOPA in the MPTP‐lesioned marmoset.

Published in:

European Journal of Neuroscience, 2024, v. 60, n. 9, p. 6175, doi. 10.1111/ejn.16454

By:

Kang, Woojin;
Frouni, Imane;
Kwan, Cynthia;
Bédard, Dominique;
Nuara, Stephen G.;
Hamadjida, Adjia;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

The 5‐HT2A/2C inverse agonist nelotanserin alleviates L‐DOPA‐induced dyskinesia in the MPTP‐lesioned marmoset.

Published in:

European Journal of Neuroscience, 2024, v. 59, n. 6, p. 1169, doi. 10.1111/ejn.16104

By:

Kwan, Cynthia;
Frouni, Imane;
Bédard, Dominique;
Hamadjida, Adjia;
Nuara, Stephen G.;
Gourdon, Jim C.;
Huot, Philippe

Publication type:

Article

The highly selective mGlu2 receptor positive allosteric modulator LY‐487,379 alleviates l‐DOPA‐induced dyskinesia in the 6‐OHDA‐lesioned rat model of Parkinson's disease.

Published in:

European Journal of Neuroscience, 2020, v. 51, n. 12, p. 2412, doi. 10.1111/ejn.14679

By:

Hamadjida, Adjia;
Sid‐Otmane, Lamia;
Kwan, Cynthia;
Frouni, Imane;
Nafade, Vaidehi;
Bédard, Dominique;
Gagnon, Dave;
Wallman, Marie‐Josée;
Rouillard, Claude;
Parent, André;
Parent, Martin;
Huot, Philippe

Publication type:

Article

Quantitative determination of LY‐404,039, a metabotropic glutamate 2/3 receptor agonist, in rat plasma using chemical derivatization and HPLC–MRM/MS.

Published in:

Biomedical Chromatography, 2022, v. 36, n. 9, p. 1, doi. 10.1002/bmc.5423

By:

Kang, Woojin;
Gaudette, Fleur;
Bédard, Dominique;
Beaudry, Francis;
Huot, Philippe

Publication type:

Article

Works matching AU Bédard, Dominique

5-HT<sub>2A</sub> blockade for dyskinesia and psychosis in Parkinson's disease: is there a limit to the efficacy of this approach? A study in the MPTP-lesioned marmoset and a literature mini-review.

Effect of the selective 5-HT<sub>2A</sub> receptor antagonist EMD-281,014 on L-DOPA-induced abnormal involuntary movements in the 6-OHDA-lesioned rat.

Effect of the mGlu2 positive allosteric modulator CBiPES on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset.

Combined mGlu2 orthosteric stimulation and positive allosteric modulation alleviates l-DOPA-induced psychosis-like behaviours and dyskinesia in the parkinsonian marmoset.

[<sup>3</sup>H]-NFPS binding to the glycine transporter 1 in the hemi-parkinsonian rat brain.

Effect of the mGlu<sub>4</sub> positive allosteric modulator ADX-88178 on parkinsonism, psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset.

The Small Molecule GMX1778 Is a Potent Inhibitor of NAD<sup>+</sup> Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors.

Effect of mGluR<sub>2</sub> and mGluR<sub>2/3</sub> activators on parkinsonism in the MPTP-lesioned non-human primate.

Positive allosteric mGluR<sub>2</sub> modulation with BINA alleviates dyskinesia and psychosis-like behaviours in the MPTP-lesioned marmoset.

The mGluR<sub>2/3</sub> orthosteric agonist LY-404,039 reduces dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset.

Distribution of [<sup>11</sup>C]-JNJ-42491293 in the marmoset brain: a positron emission tomography study.

Pharmacokinetic profile of bitopertin, a selective GlyT<sub>1</sub> inhibitor, in the rat.

Monoamine oxidase A inhibition as monotherapy reverses parkinsonism in the MPTP-lesioned marmoset.

Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset.

Nefazodone reduces dyskinesia, but not psychosis-like behaviours, in the parkinsonian marmoset.

Effect of the mGlu<sub>2</sub> positive allosteric modulator biphenyl‐indanone A as a monotherapy and as adjunct to a low dose of L‐DOPA in the MPTP‐lesioned marmoset.

The 5‐HT<sub>2A/2C</sub> inverse agonist nelotanserin alleviates L‐DOPA‐induced dyskinesia in the MPTP‐lesioned marmoset.

The highly selective mGlu<sub>2</sub> receptor positive allosteric modulator LY‐487,379 alleviates l‐DOPA‐induced dyskinesia in the 6‐OHDA‐lesioned rat model of Parkinson's disease.

Quantitative determination of LY‐404,039, a metabotropic glutamate 2/3 receptor agonist, in rat plasma using chemical derivatization and HPLC–MRM/MS.