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The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation—First Insights.
- Published in:
- Biomedicines, 2024, v. 12, n. 6, p. 1336, doi. 10.3390/biomedicines12061336
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Transthoracic echocardiography is a simple tool for size matching in cardiac xenotransplantation.
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- Xenotransplantation, 2024, v. 31, n. 3, p. 1, doi. 10.1111/xen.12861
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Consistent survival in consecutive cases of life-supporting porcine kidney xenotransplantation using 10GE source pigs.
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- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-47679-6
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Novel factors potentially initiating acute antibody‐mediated rejection in pig kidney xenografts despite an efficient immunosuppressive regimen.
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- Xenotransplantation, 2024, v. 31, n. 2, p. 1, doi. 10.1111/xen.12859
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Hemodynamics in pig‐to‐baboon heterotopic thoracic cardiac xenotransplantation: Recovery from perioperative cardiac xenograft dysfunction and impairment by cardiac overgrowth.
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- Xenotransplantation, 2024, v. 31, n. 1, p. 1, doi. 10.1111/xen.12841
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Genetic Engineering of Donor Pig for the First Human Cardiac Xenotransplantation: Combatting Rejection, Coagulopathy, Inflammation, and Excessive Growth.
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- Current Cardiology Reports, 2023, v. 25, n. 11, p. 1649, doi. 10.1007/s11886-023-01978-4
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Expression of human thrombomodulin by GalTKO.hCD46 pigs modulates coagulation cascade activation by endothelial cells and during ex vivo lung perfusion with human blood.
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- Xenotransplantation, 2023, v. 30, n. 6, p. 1, doi. 10.1111/xen.12828
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In vitro and in vivo immune assessments of genetically‐engineered pig skin grafts in New World (squirrel) monkeys.
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- Xenotransplantation, 2023, v. 30, n. 6, p. 1, doi. 10.1111/xen.12832
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Glycocalyx dynamics and the inflammatory response of genetically modified porcine endothelial cells.
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- Xenotransplantation, 2023, v. 30, n. 5, p. 1, doi. 10.1111/xen.12820
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Increased human complement pathway regulatory protein gene dose is associated with increased endothelial expression and prolonged survival during ex‐vivo perfusion of GTKO pig lungs with human blood.
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- Xenotransplantation, 2023, v. 30, n. 4, p. 1, doi. 10.1111/xen.12812
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Systemic inflammation in the xenotransplant recipient (SIXR) can occur in the absence of pCMV infection.
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- Xenotransplantation, 2023, v. 30, n. 2, p. 1, doi. 10.1111/xen.12796
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Assessment of glomerular filtration and tubular secretion in baboons with life‐supporting pig kidney grafts.
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- Xenotransplantation, 2023, v. 30, n. 2, p. 1, doi. 10.1111/xen.12795
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Knock‐out of N‐glycolylneuraminic acid attenuates antibody‐mediated rejection in xenogenically perfused porcine lungs.
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- Xenotransplantation, 2022, v. 29, n. 6, p. 1, doi. 10.1111/xen.12784
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Observations on hydronephrosis after pig kidney transplantation in baboons.
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- Xenotransplantation, 2022, v. 29, n. 6, p. 1, doi. 10.1111/xen.12779
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The road to the first FDA‐approved genetically engineered pig heart transplantation into human.
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- Xenotransplantation, 2022, v. 29, n. 5, p. 1, doi. 10.1111/xen.12776
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Cardiac and Pulmonary Histopathology in Baboons Following Genetically-Engineered Pig Orthotopic Heart Transplantation.
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- Annals of Transplantation, 2022, v. 27, p. 1, doi. 10.12659/AOT.935338
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The Renin‐Angiotensin System after Pig Kidney Transplantation in Baboons.
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- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.L7769
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Profound thrombocytopenia associated with administration of multiple anti‐inflammatory agents in baboons.
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- Immunity, Inflammation & Disease, 2022, v. 10, n. 3, p. 1, doi. 10.1002/iid3.588
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Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation.
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- Transplant International, 2022, v. 35, n. 3, p. 49, doi. 10.3389/ti.2022.10171
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hEPCR.hTBM.hCD47.hHO‐1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood.
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- Xenotransplantation, 2022, v. 29, n. 2, p. 1, doi. 10.1111/xen.12731
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Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood.
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- Xenotransplantation, 2022, v. 29, n. 2, p. 1, doi. 10.1111/xen.12725
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An intrinsic link to an extrinsic cause of cardiac xenograft growth after xenotransplantation: Commentary (in response to) : Zaman, R. et al. Selective loss of resident macrophage‐derived insulin‐like growth factor‐1 abolishes adaptive cardiac growth to stress. Immunity 54, 2057–2071.e6 (2021)
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- Xenotransplantation, 2022, v. 29, n. 1, p. 1, doi. 10.1111/xen.12724
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The Role of Interleukin-6 (IL-6) in the Systemic Inflammatory Response in Xenograft Recipients and in Pig Kidney Xenograft Failure.
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- Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.788949
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Initial experimental experience of triple‐knockout pig red blood cells as potential sources for transfusion in alloimmunized patients with sickle cell disease.
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- Transfusion, 2021, v. 61, n. 11, p. 3104, doi. 10.1111/trf.16667
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Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models.
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- Xenotransplantation, 2021, v. 28, n. 6, p. 1, doi. 10.1111/xen.12712
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Initial evidence that blockade of the CD40/CD154 costimulation pathway alone is sufficient as maintenance therapy in xenotransplantation.
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- Xenotransplantation, 2021, v. 28, n. 6, p. 1, doi. 10.1111/xen.12721
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Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons.
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- Xenotransplantation, 2021, v. 28, n. 6, p. 1, doi. 10.1111/xen.12715
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Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation.
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- Xenotransplantation, 2021, v. 28, n. 4, p. 1, doi. 10.1111/xen.12701
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Natural anti‐pig antibodies in infant baboons.
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- Xenotransplantation, 2021, v. 28, n. 4, p. 1, doi. 10.1111/xen.12692
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Evidence suggesting that deletion of expression of N‐glycolylneuraminic acid (Neu5Gc) in the organ‐source pig is associated with increased antibody‐mediated rejection of kidney transplants in baboons.
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- Xenotransplantation, 2021, v. 28, n. 4, p. 1, doi. 10.1111/xen.12700
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Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation.
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- Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.667093
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Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies.
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- Xenotransplantation, 2021, v. 28, n. 2, p. 1, doi. 10.1111/xen.12664
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Impact of donor and prolonged cold ischemia time of neonatal pig pancreas on neonatal pig islet transplant outcome.
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- Xenotransplantation, 2021, v. 28, n. 2, p. 1, doi. 10.1111/xen.12663
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The problem of the "4th xenoantigen" after pig organ transplantation in non‐human primates may be overcome by expression of human "protective" proteins.
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- Xenotransplantation, 2021, v. 28, n. 2, p. 1, doi. 10.1111/xen.12658
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Pig kidney xenotransplantation: Progress toward clinical trials.
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- Clinical Transplantation, 2021, v. 35, n. 1, p. 1, doi. 10.1111/ctr.14139
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Antibody reactivity with new antigens revealed in multi‐transgenic triple knockout pigs may cause early loss of pig kidneys in baboons.
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- Xenotransplantation, 2021, v. 28, n. 1, p. 1, doi. 10.1111/xen.12642
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The human T‐cell proliferative response to triple‐knockout pig cells in mixed lymphocyte reaction.
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- Xenotransplantation, 2020, v. 27, n. 5, p. 1, doi. 10.1111/xen.12619
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The final obstacle to successful pre‐clinical xenotransplantation?
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- Xenotransplantation, 2020, v. 27, n. 5, p. 1, doi. 10.1111/xen.12596
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Effect of intravenous immunoglobulin (IVIg) on primate complement-dependent cytotoxicity of genetically engineered pig cells: relevance to clinical xenotransplantation.
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-68505-1
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Heterotopic Porcine Cardiac Xenotransplantation in the Intra-Abdominal Position in a Non-Human Primate Model.
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-66430-x
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Old World Monkeys are less than ideal transplantation models for testing pig organs lacking three carbohydrate antigens (Triple-Knockout).
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-66311-3
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Expression of human thrombomodulin on porcine endothelial cells can reduce platelet aggregation but did not reduce activation of complement or endothelium – an experimental study.
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- Transplant International, 2020, v. 33, n. 4, p. 437, doi. 10.1111/tri.13573
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Transgenic expression of human CD47 reduces phagocytosis of porcine endothelial cells and podocytes by baboon and human macrophages.
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- Xenotransplantation, 2020, v. 27, n. 1, p. N.PAG, doi. 10.1111/xen.12549
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Intra‐bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to >60 days and promotes increased porcine lung transplant survival.
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- Xenotransplantation, 2020, v. 27, n. 1, p. N.PAG, doi. 10.1111/xen.12552
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Justification of specific genetic modifications in pigs for clinical organ xenotransplantation.
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- Xenotransplantation, 2019, v. 26, n. 4, p. N.PAG, doi. 10.1111/xen.12516
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Carbohydrate antigen expression and anti‐pig antibodies in New World capuchin monkeys: Relevance to studies of xenotransplantation.
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- Xenotransplantation, 2019, v. 26, n. 3, p. N.PAG, doi. 10.1111/xen.12498
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Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood.
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- Xenotransplantation, 2019, v. 26, n. 2, p. N.PAG, doi. 10.1111/xen.12458
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Cardiac xenografts show reduced survival in the absence of transgenic human thrombomodulin expression in donor pigs.
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- Xenotransplantation, 2019, v. 26, n. 2, p. N.PAG, doi. 10.1111/xen.12465
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Multiple genetically modified GTKO/hCD46/HLA‐E/hβ2−mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood.
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- Xenotransplantation, 2018, v. 25, n. 5, p. 1, doi. 10.1111/xen.12390
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GalT‐KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels.
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- Xenotransplantation, 2018, v. 25, n. 5, p. 1, doi. 10.1111/xen.12391
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