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Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15.
Published in:
Cancer & Metabolism, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40170-021-00274-5
By:
- Zunica, Elizabeth R. M.;
- Axelrod, Christopher L.;
- Cho, Eunhan;
- Spielmann, Guillaume;
- Davuluri, Gangarao;
- Alexopoulos, Stephanie J.;
- Beretta, Martina;
- Hoehn, Kyle L.;
- Dantas, Wagner S.;
- Stadler, Krisztian;
- King, William T.;
- Pergola, Kathryn;
- Irving, Brian A.;
- Langohr, Ingeborg M.;
- Yang, Shengping;
- Hoppel, Charles L.;
- Gilmore, L. Anne;
- Kirwan, John P.
Publication type:
Article
Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32135-0
By:
- Queiroz, Andre Lima;
- Dantas, Ezequiel;
- Ramsamooj, Shakti;
- Murthy, Anirudh;
- Ahmed, Mujmmail;
- Zunica, Elizabeth R. M.;
- Liang, Roger J.;
- Murphy, Jessica;
- Holman, Corey D.;
- Bare, Curtis J.;
- Ghahramani, Gregory;
- Wu, Zhidan;
- Cohen, David E.;
- Kirwan, John P.;
- Cantley, Lewis C.;
- Axelrod, Christopher L.;
- Goncalves, Marcus D.
Publication type:
Article
BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control.
Published in:
EMBO Molecular Medicine, 2020, v. 12, n. 7, p. 1, doi. 10.15252/emmm.202012088
By:
- Axelrod, Christopher L;
- King, William T;
- Davuluri, Gangarao;
- Noland, Robert C;
- Hall, Jacob;
- Hull, Michaela;
- Dantas, Wagner S;
- Zunica, Elizabeth RM;
- Alexopoulos, Stephanie J;
- Hoehn, Kyle L;
- Langohr, Ingeborg;
- Stadler, Krisztian;
- Doyle, Haylee;
- Schmidt, Eva;
- Nieuwoudt, Stephan;
- Fitzgerald, Kelly;
- Pergola, Kathryn;
- Fujioka, Hisashi;
- Mey, Jacob T;
- Fealy, Ciaran
Publication type:
Article
Foregut Exclusion Enhances Incretin and Insulin Secretion After Roux-en-Y Gastric Bypass in Adults With Type 2 Diabetes.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2021, v. 106, n. 10, p. e4192, doi. 10.1210/clinem/dgab255
By:
- Kirwan, John P.;
- Axelrod, Christopher L.;
- Kullman, Emily L.;
- Malin, Steven K.;
- Dantas, Wagner S.;
- Pergola, Kathryn;
- del Rincon, Juan Pablo;
- Brethauer, Stacy A.;
- Kashyap, Sangeeta R.;
- Schauer, Philip R.
Publication type:
Article
Phytochemical Targeting of Mitochondria for Breast Cancer Chemoprevention, Therapy, and Sensitization.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 22, p. 14152, doi. 10.3390/ijms232214152
By:
- Zunica, Elizabeth R. M.;
- Axelrod, Christopher L.;
- Kirwan, John P.
Publication type:
Article
Effects of metformin on glucose metabolism and mitochondrial function in patients with obstructive sleep apnea: A pilot randomized trial.
Published in:
Physiological Reports, 2024, v. 12, n. 3, p. 1, doi. 10.14814/phy2.15948
By:
- Zunica, Elizabeth R. M.;
- Heintz, Elizabeth C.;
- Dantas, Wagner S.;
- Hebert, R. Caitlin;
- Tanksley, MaKayla;
- Beyl, Robbie A.;
- Mader, Edward C.;
- Kirwan, John P.;
- Axelrod, Christopher L.;
- Singh, Prachi
Publication type:
Article
UCC118 supplementation reduces exercise-induced gastrointestinal permeability and remodels the gut microbiome in healthy humans.
Published in:
Physiological Reports, 2019, v. 7, n. 22, p. 1, doi. 10.14814/phy2.14276
By:
- Axelrod, Christopher L.;
- Brennan, Connery J.;
- Cresci, Gail;
- Paul, Deborah;
- Hull, Michaela;
- Fealy, Ciarán E.;
- Kirwan, John P.
Publication type:
Article
UCC118 supplementation reduces exercise‐induced gastrointestinal permeability and remodels the gut microbiome in healthy humans.
Published in:
Physiological Reports, 2019, v. 7, n. 21, p. 1, doi. 10.14814/phy2.14276
By:
- Axelrod, Christopher L.;
- Brennan, Connery J.;
- Cresci, Gail;
- Paul, Deborah;
- Hull, Michaela;
- Fealy, Ciarán E.;
- Kirwan, John P.
Publication type:
Article
Obesity Management in the Primary Prevention of Hepatocellular Carcinoma.
Published in:
Cancers, 2022, v. 14, n. 16, p. 4051, doi. 10.3390/cancers14164051
By:
- Zunica, Elizabeth R. M.;
- Heintz, Elizabeth C.;
- Axelrod, Christopher L.;
- Kirwan, John P.
Publication type:
Article
Mitochondrial Uncoupling Decreases Sarcopenic Obesity By Activation of Skeletal Muscle Mitochondrial Quality Control and Attenuated ER Stress.
Published in:
FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.L7532
By:
- Dantas, Wagner S.;
- Zunica, Elizabeth R. M.;
- Heintz, Elizabeth C.;
- Hoppel, Charles L.;
- Axelrod, Christopher L.;
- Kirwan, John P.
Publication type:
Article
Exercise training remodels human skeletal muscle mitochondrial fission and fusion machinery towards a pro‐elongation phenotype.
Published in:
Acta Physiologica, 2019, v. 225, n. 4, p. N.PAG, doi. 10.1111/apha.13216
By:
- Fealy, Ciarán E.;
- Mulya, Anny;
- Axelrod, Christopher L.;
- Kirwan, John P.
Publication type:
Article
Bariatric surgery alters mitochondrial function in gut mucosa.
Published in:
Surgical Endoscopy & Other Interventional Techniques, 2023, v. 37, n. 11, p. 8810, doi. 10.1007/s00464-023-10351-z
By:
- Ross, Robert C.;
- Heintz, Elizabeth C.;
- Zunica, Elizabeth R. M.;
- Townsend, R. Leigh;
- Spence, Amanda E.;
- Schauer, Philip R.;
- Kirwan, John P.;
- Axelrod, Christopher L.;
- Albaugh, Vance L.
Publication type:
Article
Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control.
Published in:
Journal of Cachexia, Sarcopenia & Muscle, 2022, v. 13, n. 3, p. 1821, doi. 10.1002/jcsm.12982
By:
- Dantas, Wagner S.;
- Zunica, Elizabeth R.M.;
- Heintz, Elizabeth C.;
- Vandanmagsar, Bolormaa;
- Floyd, Z. Elizabeth;
- Yu, Yongmei;
- Fujioka, Hisashi;
- Hoppel, Charles L.;
- Belmont, Kathryn P.;
- Axelrod, Christopher L.;
- Kirwan, John P.
Publication type:
Article
Gastric Bypass Surgery Improves the Skeletal Muscle Ceramide/S1P Ratio and Upregulates the AMPK/ SIRT1/ PGC-1α Pathway in Zucker Diabetic Fatty Rats.
Published in:
Obesity Surgery, 2019, v. 29, n. 7, p. 2158, doi. 10.1007/s11695-019-03800-z
By:
- Huang, Hazel;
- Axelrod, Christopher L.;
- Kirwan, John P.;
- Aminian, Ali;
- Hassan, Monique;
- Dan, Olivia;
- Schauer, Philip R.;
- Brethauer, Stacy A.
Publication type:
Article
Metabolomic Fingerprints of Medical Therapy Versus Bariatric Surgery in Patients With Obesity and Type 2 Diabetes: The STAMPEDE Trial.
Published in:
Diabetes Care, 2024, v. 47, n. 11, p. 2024, doi. 10.2337/dc24-0859
By:
- Axelrod, Christopher L.;
- Hari, Adithya;
- Dantas, Wagner S.;
- Kashyap, Sangeeta R.;
- Schauer, Philip R.;
- Kirwan, John P.
Publication type:
Article
Editorial: Nutrition, sarcopenia, and sarcopenic obesity.
Published in:
Frontiers in Nutrition, 2023, p. 1, doi. 10.3389/fnut.2023.1335927
By:
- Berger, Nathan A.;
- Ming Yang;
- Yoke Mun Chan;
- Axelrod, Christopher L.;
- Sikalidis, Angelos K.;
- Wen Hu;
- Lin Kang
Publication type:
Article
Restricting bioenergetic efficiency enhances longevity and mitochondrial redox capacity in Drosophila melanogaster.
Published in:
Aging Cell, 2024, v. 23, n. 5, p. 1, doi. 10.1111/acel.14107
By:
- Taylor, Analisa L.;
- Dubuisson, Olga;
- Pandey, Pritika;
- Zunica, Elizabeth R. M.;
- Vandanmagsar, Bolormaa;
- Dantas, Wagner S.;
- Johnson, Alyssa;
- Axelrod, Christopher L.;
- Kirwan, John P.
Publication type:
Article
Weight‐independent effects of Roux‐en‐Y gastric bypass surgery on remission of nonalcoholic fatty liver disease in mice.
Published in:
Obesity (19307381), 2023, v. 31, n. 12, p. 2960, doi. 10.1002/oby.23876
By:
- Axelrod, Christopher L.;
- Langohr, Ingeborg;
- Dantas, Wagner S.;
- Heintz, Elizabeth C.;
- Vandanmagsar, Bolormaa;
- Yang, Shengping;
- Zunica, Elizabeth R. M.;
- Townsend, R. Leigh;
- Albaugh, Vance L.;
- Berthoud, Hans‐Rudolf;
- Kirwan, John P.
Publication type:
Article
Insulin resistance persists despite a metabolically healthy obesity phenotype.
Published in:
Obesity (19307381), 2022, v. 30, n. 1, p. 39, doi. 10.1002/oby.23312
By:
- Hoddy, Kristin K.;
- Axelrod, Christopher L.;
- Mey, Jacob T.;
- Hari, Adithya;
- Beyl, Robbie A.;
- Blair, Jourdan B.;
- Dantas, Wagner S.;
- Kirwan, John P.
Publication type:
Article
The Role of Nutrition in Mitigating the Effects of COVID-19 from Infection through PASC.
Published in:
Nutrients, 2023, v. 15, n. 4, p. 866, doi. 10.3390/nu15040866
By:
- Mey, Jacob T.;
- Kirwan, John P.;
- Axelrod, Christopher L.
Publication type:
Article
GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion.
Published in:
Diabetes, 2023, v. 72, n. 8, p. 1070, doi. 10.2337/db22-0019
By:
- Zhang, Hui;
- Mulya, Anny;
- Nieuwoudt, Stephan;
- Vandanmagsar, Bolormaa;
- McDowell, Ruth;
- Heintz, Elizabeth C.;
- Zunica, Elizabeth R.M.;
- Collier, J. Jason;
- Bozadjieva-Kramer, Nadejda;
- Seeley, Randy J.;
- Axelrod, Christopher L.;
- Kirwan, John P.
Publication type:
Article
Erratum. Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling. Diabetes 2020;69:1675-1691.
Published in:
2021
By:
- Dantas, Wagner S.;
- Roschel, Hamilton;
- Murai, Igor H.;
- Gil, Saulo;
- Davuluri, Gangarao;
- Axelrod, Christopher L.;
- Ghosh, Sujoy;
- Newman, Susan S.;
- Zhang, Hui;
- Shinjo, Samuel K.;
- das Neves, Willian;
- Merege-Filho, Carlos;
- Teodoro, Walcy R.;
- Capelozzi, Vera L.;
- Pereira, Rosa Maria;
- Benatti, Fabiana B.;
- de Sá-Pinto, Ana L.;
- de Cleva, Roberto;
- Santo, Marco A.;
- Kirwan, John P.
Publication type:
journal article
Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling.
Published in:
2020
By:
- Dantas, Wagner S.;
- Roschel, Hamilton;
- Murai, Igor H.;
- Gil, Saulo;
- Davuluri, Gangarao;
- Axelrod, Christopher L.;
- Ghosh, Sujoy;
- Newman, Susan S.;
- Zhang, Hui;
- Shinjo, Samuel K.;
- das Neves, Willian;
- Merege-Filho, Carlos;
- Teodoro, Walcy R.;
- Capelozzi, Vera L.;
- Pereira, Rosa Maria;
- Benatti, Fabiana B.;
- de Sá-Pinto, Ana L.;
- de Cleva, Roberto;
- Santo, Marco A.;
- Kirwan, John P.
Publication type:
journal article
163-OR: Metabolically Unhealthy Obese Is Transient and Improves with Aerobic Exercise.
Published in:
Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-163-OR
By:
- HODDY, KRISTIN K.;
- AXELROD, CHRISTOPHER L.;
- MEY, JACOB T.;
- HARI, ADITHYA;
- BEYL, ROBBIE A.;
- KIRWAN, JOHN P.
Publication type:
Article
238-LB: Dietary Protein Restriction Induces Myocardial Dysfunction Despite Reducing Body Weight in Aged C57BL/6J Mice.
Published in:
Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-238-LB
By:
- AXELROD, CHRISTOPHER L.;
- DANTAS, WAGNER S.;
- DAVULURI, GANGARAO;
- KING, WILLIAM T.;
- HILL, CRISTAL M.;
- MORRISON, CHRISTOPHER;
- KIRWAN, JOHN P.
Publication type:
Article
1904-P: Metabolomic Fingerprints after Metabolic Surgery: The STAMPEDE Trial.
Published in:
Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-1904-P
By:
- DANTAS, WAGNER S.;
- AXELROD, CHRISTOPHER L.;
- HARI, ADITHYA;
- KASHYAP, SANGEETA;
- SCHAUER, PHILIP;
- KIRWAN, JOHN P.
Publication type:
Article
276-OR: Rethinking Metabolically Healthy Obesity: What Is the Underlying Risk?
Published in:
Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-276-OR
By:
- AXELROD, CHRISTOPHER L.;
- HARI, ADITHYA;
- MEY, JACOB T.;
- BEYL, ROBBIE A.;
- KIRWAN, JOHN P.
Publication type:
Article
1945-P: The Mitochondrial Protein DRP1 Is Required for Endogenous Fatty Acid Oxidation.
Published in:
Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-1945-P
By:
- KING, WILLIAM T.;
- AXELROD, CHRISTOPHER L.;
- DAVULURI, GANGARAO;
- NOLAND, ROBERT C.;
- KIRWAN, JOHN P.
Publication type:
Article
1928-P: GDF15 Protects against Insulin Resistance in Individuals with Type 2 Diabetes.
Published in:
Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-1928-P
By:
- ZHANG, HUI;
- DANTAS, WAGNER;
- KING, WILLIAM T.;
- AXELROD, CHRISTOPHER L.;
- GIL, SAULO;
- MURAI, IGOR;
- ROSCHEL, HAMILTON;
- GUALANO, BRUNO;
- KIRWAN, JOHN P.
Publication type:
Article
190-OR: Weight-Loss after Exercise Increases Non-Insulin-Dependent Glucose Clearance in Adults with Metabolic Syndrome.
Published in:
Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-190-OR
By:
- HARI, ADITHYA;
- AXELROD, CHRISTOPHER L.;
- MEY, JACOB T.;
- KIRWAN, JOHN P.
Publication type:
Article

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