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Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28240-9
By:
- Lebeau, Paul F.;
- Byun, Jae Hyun;
- Platko, Khrystyna;
- Saliba, Paul;
- Sguazzin, Matthew;
- MacDonald, Melissa E.;
- Paré, Guillaume;
- Steinberg, Gregory R.;
- Janssen, Luke J.;
- Igdoura, Suleiman A.;
- Tarnopolsky, Mark A.;
- Wayne Chen, S. R.;
- Seidah, Nabil G.;
- Magolan, Jakob;
- Austin, Richard C.
Publication type:
Article
GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis.
Published in:
Journal of Pathology, 2016, v. 239, n. 4, p. 411, doi. 10.1002/path.4738
By:
- Ayaub, Ehab A;
- Kolb, Philipp S;
- Mohammed‐Ali, Zahraa;
- Tat, Victor;
- Murphy, James;
- Bellaye, Pierre‐Simon;
- Shimbori, Chiko;
- Boivin, Felix J;
- Lai, Rocky;
- Lynn, Edward G;
- Lhoták, Šárka;
- Bridgewater, Darren;
- Kolb, Martin RJ;
- Inman, Mark D;
- Dickhout, Jeffrey G;
- Austin, Richard C;
- Ask, Kjetil
Publication type:
Article
The Emerging Roles of Intracellular PCSK9 and Their Implications in Endoplasmic Reticulum Stress and Metabolic Diseases.
Published in:
Metabolites (2218-1989), 2022, v. 12, n. 3, p. 215, doi. 10.3390/metabo12030215
By:
- Lebeau, Paul F.;
- Platko, Khrystyna;
- Byun, Jae Hyun;
- Makda, Yumna;
- Austin, Richard C.
Publication type:
Article
Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28240-9
By:
- Lebeau, Paul F.;
- Byun, Jae Hyun;
- Platko, Khrystyna;
- Saliba, Paul;
- Sguazzin, Matthew;
- MacDonald, Melissa E.;
- Paré, Guillaume;
- Steinberg, Gregory R.;
- Janssen, Luke J.;
- Igdoura, Suleiman A.;
- Tarnopolsky, Mark A.;
- Wayne Chen, S. R.;
- Seidah, Nabil G.;
- Magolan, Jakob;
- Austin, Richard C.
Publication type:
Article
Endoplasmic Reticulum Protein ERp46 in Renal Cell Carcinoma.
Published in:
PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090389
By:
- Duivenvoorden, Wilhelmina C. M.;
- Paschos, Athanasios;
- Hopmans, Sarah N.;
- Austin, Richard C.;
- Pinthus, Jehonathan H.
Publication type:
Article
Dystrophin isoforms DP71 and DP427 have distinct roles in myogenic cells.
Published in:
1999
By:
- Howard, Perry L.;
- Dally, Ghassan Y.;
- Ditta, Stephanie D.;
- Austin, Richard C.;
- Worton, Ronald G.;
- Klamut, Henry J.;
- Ray, Peter N.;
- Howard, P L;
- Dally, G Y;
- Ditta, S D;
- Austin, R C;
- Worton, R G;
- Klamut, H J;
- Ray, P N
Publication type:
journal article
Fatal attractions that trigger inflammation and drive atherosclerotic disease.
Published in:
European Journal of Clinical Investigation, 2024, v. 54, n. 5, p. 1, doi. 10.1111/eci.14169
By:
- Sharma, Hitesh;
- Mossman, Karen;
- Austin, Richard C.
Publication type:
Article
4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe<sup>-/-</sup> mice.
Published in:
FASEB Journal, 2019, v. 33, n. 7, p. 8406, doi. 10.1096/fj.201802293RR
By:
- Lynn, Edward G.;
- Lhoták, Šárka;
- Lebeau, Paul;
- Byun, Jae Hyun;
- Chen, Jack;
- Platko, Khrystyna;
- Chunhua Shi;
- O'Brien, Edward R.;
- Austin, Richard C.
Publication type:
Article
Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions.
Published in:
FASEB Journal, 2011, v. 25, n. 2, p. 576, doi. 10.1096/fj.10-159319
By:
- Dickhout, Jeffrey G.;
- Lhoták, Šárka;
- Hilditch, Brooke A.;
- Basseri, Sana;
- Colgan, Stephen M.;
- Lynn, Edward G.;
- Carlisle, Rachel E.;
- Ji Zhou;
- Sood, Sudesh K.;
- Ingram, Alistair J.;
- Austin, Richard C.
Publication type:
Article
Mouse models of cystathionine β-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia.
Published in:
FASEB Journal, 2009, v. 23, n. 3, p. 883, doi. 10.1096/fj.08-120584
By:
- Gupta, Sapna;
- Kühnisch, Jirko;
- Mustafa, Aladdin;
- Lhotak, Sarka;
- Schlachterman, Alexander;
- Slifker, Michael J.;
- Klein-Szanto, Andres;
- High, Katherine A.;
- Austin, Richard C.;
- Kruger, Warren D.
Publication type:
Article
The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury.
Published in:
2021
By:
- Lebeau, Paul F.;
- Wassef, Hanny;
- Jae Hyun Byun;
- Platko, Khrystyna;
- Ason, Brandon;
- Jackson, Simon;
- Dobroff, Joshua;
- Shetterly, Susan;
- Richards, William G.;
- Al-Hashimi, Ali A.;
- Doyoon Won, Kevin;
- Mbikay, Majambu;
- Prat, Annik;
- An Tang;
- Paré, Guillaume;
- Pasqualini, Renata;
- Seidah, Nabil G.;
- Arap, Wadih;
- Chrétien, Michel;
- Austin, Richard C.
Publication type:
journal article
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification.
Published in:
International Journal of Cancer, 2009, v. 124, n. 9, p. 1999, doi. 10.1002/ijc.24003
By:
- Sohn, Kyoung-Jin;
- Jang, Hyeran;
- Campan, Mihaela;
- Weisenberger, Daniel J.;
- Dickhout, Jeffrey;
- Wang, Yi-Cheng;
- Cho, Robert C.;
- Yates, Zoe;
- Lucock, Mark;
- Chiang, En-Pei;
- Austin, Richard C.;
- Choi, Sang-Woon;
- Laird, Peter W.;
- Kim, Young-In
Publication type:
Article
Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.
Published in:
Nature Communications, 2016, v. 7, n. 11, p. 13457, doi. 10.1038/ncomms13457
By:
- Pinkosky, Stephen L.;
- Newton, Roger S.;
- Day, Emily A.;
- Ford, Rebecca J.;
- Lhotak, Sarka;
- Austin, Richard C.;
- Birch, Carolyn M.;
- Smith, Brennan K.;
- Filippov, Sergey;
- Groot, Pieter H.E.;
- Steinberg, Gregory R.;
- Lalwani, Narendra D.
Publication type:
Article
Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice.
Published in:
FASEB Journal, 2008, v. 22, n. 7, p. 2569, doi. 10.1096/fj.07-105353
By:
- Ji Zhou;
- Werstuck, Geoff H.;
- Lhoták, Šárka;
- Shi, Yuan Y.;
- Tedesco, Vivienne;
- Trigatti, Bernardo;
- Dickhout, Jeffrey;
- Majors, Alana K.;
- DiBello, Patricia M.;
- Jacobsen, Donald W.;
- Austin, Richard C.
Publication type:
Article
Thrombotic characteristics of extracellular vesicles derived from prostate cancer cells.
Published in:
Prostate, 2018, v. 78, n. 13, p. 953, doi. 10.1002/pros.23653
By:
- Al Saleh, Hassan A.;
- Haas‐Neill, Sandor;
- Al‐Hashimi, Ali;
- Kapoor, Anil;
- Shayegan, Bobby;
- Austin, Richard C.;
- Al‐Nedawi, Khalid
Publication type:
Article
Characterization of Proliferating Lesion-Resident Cells During All Stages of Atherosclerotic Growth.
Published in:
2016
By:
- Lhoták, Šárka;
- Gyulay, Gabriel;
- Cutz, Jean ‐ Claude;
- Al ‐ Hashimi, Ali;
- Trigatti, Bernardo L.;
- Richards, Carl D.;
- Igdoura, Suleiman A.;
- Steinberg, Gregory R.;
- Bramson, Jonathan;
- Ask, Kjetil;
- Austin, Richard C.
Publication type:
journal article
TDAG51 induces renal interstitial fibrosis through modulation of TGF-β receptor 1 in chronic kidney disease.
Published in:
Cell Death & Disease, 2021, v. 12, n. 10, p. 1, doi. 10.1038/s41419-021-04197-3
By:
- Carlisle, Rachel E.;
- Mohammed-Ali, Zahraa;
- Lu, Chao;
- Yousof, Tamana;
- Tat, Victor;
- Nademi, Samera;
- MacDonald, Melissa E.;
- Austin, Richard C.;
- Dickhout, Jeffrey G.
Publication type:
Article
Scratching the Surface—An Overview of the Roles of Cell Surface GRP78 in Cancer.
Published in:
Biomedicines, 2022, v. 10, n. 5, p. 1098, doi. 10.3390/biomedicines10051098
By:
- Chen, Jack;
- Lynn, Edward G.;
- Yousof, Tamana R.;
- Sharma, Hitesh;
- MacDonald, Melissa E.;
- Byun, Jae Hyun;
- Shayegan, Bobby;
- Austin, Richard C.
Publication type:
Article
Endoplasmic reticulum protein ERp46 in prostate adenocarcinoma.
Published in:
Oncology Letters, 2017, v. 13, n. 5, p. 3624, doi. 10.3892/ol.2017.5908
By:
- DUIVENVOORDEN, WILHELMINA C. M.;
- HOPMANS, SARAH N.;
- AUSTIN, RICHARD C.;
- PINTHUS, JEHONATHAN H.
Publication type:
Article
Separate roles of IL‐6 and oncostatin M in mouse macrophage polarization <italic>in vitro</italic> and <italic>in vivo</italic>.
Published in:
Immunology & Cell Biology, 2018, v. 96, n. 3, p. 257, doi. 10.1111/imcb.1035
By:
- Dubey, Anisha;
- Izakelian, Laura;
- Ayaub, Ehab A.;
- Ho, Lilian;
- Stephenson, Kyle;
- Wong, Steven;
- Kwofie, Karen;
- Austin, Richard C.;
- Botelho, Fernando;
- Ask, Kjetil;
- Richards, Carl D.
Publication type:
Article
Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders.
Published in:
IUBMB Life, 2021, v. 73, n. 6, p. 843, doi. 10.1002/iub.2502
By:
- Gonzalez-Gronow, Mario;
- Gopal, Udhayakumar;
- Austin, Richard C.;
- Pizzo, Salvatore V.
Publication type:
Article
Endoplasmic Reticulum Stress and Lipid Metabolism: Mechanisms and Therapeutic Potential.
Published in:
Biotechnology Research International, 2012, p. 1, doi. 10.1155/2012/841362
By:
- Basseri, Sana;
- Austin, Richard C.
Publication type:
Article
Reduced plasma GDF10 levels are positively associated with cholesterol impairment and childhood obesity.
Published in:
Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-51635-1
By:
- Yousof, Tamana R.;
- Mejia-Benitez, Aurora;
- Morrison, Katherine M.;
- Austin, Richard C.
Publication type:
Article
Cloning and characterization of alternatively spliced isoforms of Dp71.
Published in:
Human Molecular Genetics, 1995, v. 4, n. 9, p. 1475
By:
- Richard C., Austin;
- Howard, Perry L.;
- D'Souza, Vinita N;
- Klamut, Henry J.;
- Ray, Peter N.
Publication type:
Article
Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms.
Published in:
Biofactors, 2009, v. 35, n. 2, p. 120, doi. 10.1002/biof.17
By:
- Ji Zhou;
- Austin, Richard C.
Publication type:
Article
A Metabolic Enhancer Protects against Diet-Induced Obesity and Liver Steatosis and Corrects a Pro-Atherogenic Serum Profile in Mice.
Published in:
Nutrients, 2023, v. 15, n. 10, p. 2410, doi. 10.3390/nu15102410
By:
- Platko, Khrystyna;
- Lebeau, Paul F.;
- Nederveen, Joshua P.;
- Byun, Jae Hyun;
- MacDonald, Melissa E.;
- Bourgeois, Jacqueline M.;
- Tarnopolsky, Mark A.;
- Austin, Richard C.
Publication type:
Article
Activation of mesangial cell MAPK in responseto homocysteine.
Published in:
Kidney International, 2004, v. 66, n. 2, p. 733, doi. 10.1111/j.1523-1755.2004.00795.x
By:
- Ingram, Alistair J.;
- Krepinsky, Joan C.;
- James, Leighton;
- Austin, Richard C.;
- Damu Tang;
- Salapatek, Anne Marie;
- Thai, Kerri;
- Scholey, James W.
Publication type:
Article
Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis.
Published in:
Diabetes, 2013, v. 62, n. 1, p. 158, doi. 10.2337/db12-0256
By:
- Basseri, Sana;
- Lhoták, Šárka;
- Fullerton, Morgan D.;
- Palanivel, Rengasamy;
- Hua Jiang;
- Lynn, Edward G.;
- Ford, Rebecca J.;
- Maclean, Kenneth N.;
- Steinberg, Gregory R.;
- Austin, Richard C.
Publication type:
Article

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