Works matching AU Audia, James

Results: 20

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 3, p. 1199, doi. 10.1523/JNEUROSCI.4129-14.2015

By:

May, Patrick C.;
Willis, Brian A.;
Lowe, Stephen L.;
Dean, Robert A.;
Monk, Scott A.;
Cocke, Patrick J.;
Audia, James E.;
Boggs, Leonard N.;
Borders, Anthony R.;
Brier, Richard A.;
Calligaro, David O.;
Day, Theresa A.;
Ereshefsky, Larry;
Erickson, Jon A.;
Gevorkyan, Hykop;
Gonzales, Celedón R.;
James, Douglas E.;
Jhee, Stanford S.;
Komjathy, Steven F.;
Li, Linglin

Publication type:

Article

In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life.

Published in:

Journal of Neuroscience, 2003, v. 23, n. 26, p. 8844, doi. 10.1523/JNEUROSCI.23-26-08844.2003

By:

Cirrito, John R.;
May, Patrick C.;
O'Dell, Mark A.;
Taylor, Jennie W.;
Parsadanian, Maia;
Cramer, Jeffrey W.;
Audia, James E.;
Nissen, Jeffrey S.;
Bales, Kelly R.;
Paul, Steven M.;
DeMattos, Ronald B.;
Holtzman, David M.

Publication type:

Article

Responses of LNCaP prostatic adenocarcinoma cell cultures to LY300502, a benzoquinolinone human type I 5α-reductase inhibitor.

Published in:

Prostate, 1996, v. 29, n. S6, p. 62, doi. 10.1002/(SICI)1097-0045(1996)6+<62::AID-PROS12>3.0.CO;2-P

By:

Sutkowski, Debra M.;
Audia, James E.;
Goode, Robin L.;
Hsiao, Kenneth C.;
Leibovitch, Ilan Y.;
McNulty, Ann M.;
Neubauer, Blake Lee

Publication type:

Article

[3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2005, v. 371, n. 3, p. 169, doi. 10.1007/s00210-005-1035-9

By:

Wainscott, David B.;
Krushinski, Joseph H.;
Audia, James E.;
Schaus, John M.;
Zgombick, John M.;
Lucaites, Virginia L.;
Nelson, David L.

Publication type:

Article

[3H]LY334370, a novel radioligand for the 5-HT1F receptor. II. Autoradiographic localization in rat, guinea pig, monkey and human brain.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2005, v. 371, n. 3, p. 178, doi. 10.1007/s00210-005-1036-8

By:

Lucaites, Virginia L.;
Krushinski, Joseph H.;
Schaus, John M.;
Audia, James E.;
Nelson, David L.

Publication type:

Article

Corrigendum: The promise and peril of chemical probes.

Published in:

Nature Chemical Biology, 2015, v. 11, n. 11, p. 887, doi. 10.1038/nchembio1115-887c

By:

Arrowsmith, Cheryl H;
Audia, James E;
Austin, Christopher;
Baell, Jonathan;
Bennett, Jonathan;
Blagg, Julian;
Bountra, Chas;
Brennan, Paul E;
Brown, Peter J;
Bunnage, Mark E;
Buser-Doepner, Carolyn;
Campbell, Robert M;
Carter, Adrian J;
Cohen, Philip;
Copeland, Robert A;
Cravatt, Ben;
Dahlin, Jayme L;
Dhanak, Dashyant;
Edwards, Aled M;
Frederiksen, Mathias

Publication type:

Article

The promise and peril of chemical probes.

Published in:

Nature Chemical Biology, 2015, v. 11, n. 8, p. 536, doi. 10.1038/nchembio.1867

By:

Arrowsmith, Cheryl H;
Audia, James E;
Austin, Christopher;
Baell, Jonathan;
Bennett, Jonathan;
Blagg, Julian;
Bountra, Chas;
Brennan, Paul E;
Brown, Peter J;
Bunnage, Mark E;
Buser-Doepner, Carolyn;
Campbell, Robert M;
Carter, Adrian J;
Cohen, Philip;
Copeland, Robert A;
Cravatt, Ben;
Dahlin, Jayme L;
Dhanak, Dashyant;
Edwards, Aled M;
Frye, Stephen V

Publication type:

Article

Early Drug‐Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.

Published in:

ChemMedChem, 2020, v. 15, n. 11, p. 955, doi. 10.1002/cmdc.202000007

By:

Huhn, Annissa J.;
Gardberg, Anna S.;
Poy, Florence;
Brucelle, Francois;
Vivat, Valerie;
Cantone, Nico;
Patel, Gaurav;
Patel, Chirag;
Cummings, Richard;
Sims, Robert;
Levell, Julian;
Audia, James E.;
Bommi‐Reddy, Archana;
Wilson, Jonathan E.

Publication type:

Article

Amyloid β-Mediated Oxidative and Metabolic Stress in Rat Cortical Neurons: No Direct Evidence for a Role for H2O2 Generation.

Published in:

Journal of Neurochemistry, 1996, v. 67, n. 4, p. 1595, doi. 10.1046/j.1471-4159.1996.67041595.x

By:

Zhang, Zhiyuan;
Rydel, Russell E.;
Drzewiecki, Gary J.;
Fuson, Kimberly;
Wright, Sarah;
Wogulis, Mark;
Audia, James E.;
May, Patrick C.;
Hyslop, Paul A.

Publication type:

Article

Improved Preparation of (E)-3-Trimethylsilyl-2-Buten-1-OL.

Published in:

Synthetic Communications, 1983, v. 13, n. 6, p. 531, doi. 10.1080/00397918308081833

By:

Audia, James E.;
Marshall, James A.

Publication type:

Article

Preclinical characterization of LY2886721: A BACE1 inhibitor in clinical development for early Alzheimer's disease

Published in:

2012

By:

May, Patrick;
Boggs, Leonard;
Brier, Richard;
Calligaro, David;
Citron, Martin;
Day, Theresa;
Lin, Suizhen;
Lindstrom, Terry;
Mergott, Dustin;
Monk, Scott;
Sanchez-Felix, Manuel Vicente;
Sheehan, Scott;
Vaught, Grant;
Yang, Zhixiang;
Audia, James

Publication type:

Abstract

BACE inhibitor LY2886721 safety and central and peripheral PK and PD in healthy subjects (HSs)

Published in:

2012

By:

Martenyi, Ferenc;
Dean, Robert A.;
Lowe, Stephen;
Nakano, Masako;
Monk, Scott;
Willis, Brian A.;
Gonzales, Celedon;
Mergott, Dustin;
Leslie, Daugherty;
May, Patrick;
James, Audia;
Gevorkyan, Hakop;
Jhee, Stanford;
Ereshefsky, Larry;
Citron, Martin

Publication type:

Abstract

Preclinical characterization of LY2886721: A BACE1 inhibitor in clinical development for early Alzheimer's disease

Published in:

2012

By:

May, Patrick;
Boggs, Leonard;
Brier, Richard;
Calligaro, David;
Citron, Martin;
Day, Theresa;
Lin, Suizhen;
Lindstrom, Terry;
Mergott, Dustin;
Monk, Scott;
Sanchez-Felix, Manuel Vicente;
Sheehan, Scott;
Vaught, Grant;
Yang, Zhixiang;
Audia, James

Publication type:

Abstract

Central and peripheral pharmacodynamic effects of BACE1 inhibition following oral administration of LY2811376 to PDAPP mice and beagle dog

Published in:

2010

By:

May, Patrick C.;
Boggs, Leonard N.;
Yang, Zhixiang;
Lindstrom, Terry;
Calligaro, David;
Citron, Martin;
Sheehan, Scott;
Audia, James E.

Publication type:

Abstract

Proof-of-concept pharmacodynamic assessment of a prototypic BACE1 inhibitor at steady-state using IV infusion dosing in the PDAPP transgenic mouse model of Alzheimer's disease

Published in:

2010

By:

Boggs, Leonard N.;
Lindstrom, Terry;
Watson, Brian;
Sheehan, Scott;
Audia, James E.;
May, Patrick C.

Publication type:

Abstract

Author Correction: Supporting US public health experts.

Published in:

2021

By:

Cohen, Ron;
Francois, Cedric;
Crowley, John;
Hastings, Paul;
King, Rachel;
Love, Ted W.;
Maraganore, John;
McMurry-Heath, Michelle;
Levin, Jeremy;
Cosignatories;
Adams, Chris;
Al-Shamma, Sunny;
Anderson, Bonnie;
Anzalone, Christopher R.;
Aspinall, Mara G.;
Audia, James E.;
Babler, Martin;
Bacha, Jeffrey;
Bailey, Michael P.;
Bardon, Christiana

Publication type:

Correction Notice

Supporting US public health experts.

Published in:

2020

By:

Cohen, Ron;
Francois, Cedric;
Crowley, John;
Hastings, Paul;
King, Rachel;
Love, Ted W.;
Maraganore, John;
McMurry-Heath, Michelle;
Levin, Jeremy;
Cosignatories;
Adams, Chris;
Al-Shamma, Sunny;
Anderson, Bonnie;
Anzalone, Christopher R.;
Aspinall, Mara G.;
Audia, James E.;
Babler, Martin;
Bacha, Jeffrey;
Bailey, Michael P.;
Bardon, Christiana

Publication type:

Letter

Chinese scientists and US leadership in the life sciences.

Published in:

2019

By:

Holtzman, Steven H.;
Cohen, Ron;
Levin, Jeremy M.;
Maraganore, John;
Signatories to the Statement;
Albers, Jeff;
Aoun, Joseph E.;
Audia, James E.;
Bailey, Michael P.;
Barrett, Peter;
Bartel, David;
Bienamie, Jean-Jacques;
Blum, Robert I.;
Boger, Joshua;
Bollenbacher, Jim;
Bonney, Michael W.;
Booth, Bruce;
Bradbury, Daniel M.;
Brandicourt, Olivier;
Braunwald, Eugene

Publication type:

Letter

Biotech leaders call for free press.

Published in:

Nature Biotechnology, 2018, v. 36, n. 10, p. 920, doi. 10.1038/nbt.4271

By:

Cohen, Ron;
Holtzman, Steven;
Levin, Jeremy M;
Maraganore, John M;
Aberman, Michael;
Adams, Chris;
Adams, Julian;
Albers, Jeffrey;
Anderson, Bonnie;
Aspinall, Mara G;
Audia, James E;
Babler, Martin;
Baltimore, David;
Bancel, Stephane;
Barrett, Peter;
Barry, Zoe;
Bartel, David;
Bienaime, Jean-Jacques;
Blank, Burkhard;
Blum, Robert I

Publication type:

Article

US immigration order strikes against biotech.

Published in:

Nature Biotechnology, 2017, v. 35, n. 3, p. 204, doi. 10.1038/nbt.3824

By:

Levin, Jeremy M;
Holtzman, Steven H;
Maraganore, John;
Hastings, Paul J;
Cohen, Ron;
Dahiyat, Bassil;
Adams, Julian;
Adams, Chris;
Ahrens, Brett;
Albers, Jeff;
Aspinall, Mara G;
Audia, James E;
Babler, Martin;
Barrett, Peter;
Barry, Zoe;
Bermingham, Nessan;
Bloch, Stephen;
Blum, Robert I;
Bolno, Paul B;
Bonney, Michael W

Publication type:

Article

Works matching AU Audia, James

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central Aβ Pharmacodynamic Responses in Mice, Dogs, and Humans.

In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life.

Responses of LNCaP prostatic adenocarcinoma cell cultures to LY300502, a benzoquinolinone human type I 5α-reductase inhibitor.

[<sup>3</sup>H]LY334370, a novel radioligand for the 5-HT<sub>1F</sub> receptor. I. In vitro characterization of binding properties.

[<sup>3</sup>H]LY334370, a novel radioligand for the 5-HT<sub>1F</sub> receptor. II. Autoradiographic localization in rat, guinea pig, monkey and human brain.

Corrigendum: The promise and peril of chemical probes.

The promise and peril of chemical probes.

Early Drug‐Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors.

Amyloid β-Mediated Oxidative and Metabolic Stress in Rat Cortical Neurons: No Direct Evidence for a Role for H<sub>2</sub>O<sub>2</sub> Generation.

Improved Preparation of (E)-3-Trimethylsilyl-2-Buten-1-OL.

Preclinical characterization of LY2886721: A BACE1 inhibitor in clinical development for early Alzheimer's disease

BACE inhibitor LY2886721 safety and central and peripheral PK and PD in healthy subjects (HSs)

Preclinical characterization of LY2886721: A BACE1 inhibitor in clinical development for early Alzheimer's disease

Central and peripheral pharmacodynamic effects of BACE1 inhibition following oral administration of LY2811376 to PDAPP mice and beagle dog

Proof-of-concept pharmacodynamic assessment of a prototypic BACE1 inhibitor at steady-state using IV infusion dosing in the PDAPP transgenic mouse model of Alzheimer's disease

Author Correction: Supporting US public health experts.

Supporting US public health experts.

Chinese scientists and US leadership in the life sciences.

Biotech leaders call for free press.

US immigration order strikes against biotech.