Works by Attwa, Mohamed W.

Results: 68

Detection and characterization of olmutinib reactive metabolites by LC–MS/MS: Elucidation of bioactivation pathways.

Published in:

Journal of Separation Science, 2020, v. 43, n. 4, p. 708, doi. 10.1002/jssc.201900818

By:

Attwa, Mohamed W.;
Kadi, Adnan A.;
Abdelhameed, Ali S.

Publication type:

Article

Supramolecular Structure, Hirshfeld Surface Analysis, Morphological Study and DFT Calculations of the Triphenyltetrazolium Cobalt Thiocyanate Complex.

Published in:

Crystals (2073-4352), 2023, v. 13, n. 11, p. 1598, doi. 10.3390/cryst13111598

By:

Ali, Essam A.;
Bechaieb, Rim;
Al-Salahi, Rashad;
Al-Janabi, Ahmed S. M.;
Attwa, Mohamed W.;
Mostafa, Gamal A. E.

Publication type:

Article

Structural Analysis and Reactivity Insights of (E)-Bromo-4-((4-((1-(4-chlorophenyl)ethylidene)amino)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-5-((2-isopropylcyclohexyl)oxy) Furan-2(5H)-one: A Combined Approach Using Single-Crystal X-ray Diffraction, Hirshfeld Surface Analysis, and Conceptual Density Functional Theory

Published in:

Crystals (2073-4352), 2023, v. 13, n. 9, p. 1313, doi. 10.3390/cryst13091313

By:

Bakheit, Ahmed H.;
Attwa, Mohamed W.;
Kadi, Adnan A.;
Alkahtani, Hamad M.

Publication type:

Article

Exploring the Chemical Reactivity, Molecular Docking, Molecular Dynamic Simulation and ADMET Properties of a Tetrahydrothienopyridine Derivative Using Computational Methods.

Published in:

Crystals (2073-4352), 2023, v. 13, n. 7, p. 1020, doi. 10.3390/cryst13071020

By:

Bakheit, Ahmed H.;
Attwa, Mohamed W.;
Kadi, Adnan A.;
Ghabbour, Hazem A.;
Alkahtani, Hamad M.

Publication type:

Article

Evaluation of Alectinib Metabolic Stability in HLMs Using Fast LC-MS/MS Method: In Silico ADME Profile, P450 Metabolic Lability, and Toxic Alerts Screening.

Published in:

Pharmaceutics, 2023, v. 15, n. 10, p. 2449, doi. 10.3390/pharmaceutics15102449

By:

Attwa, Mohamed W.;
AlRabiah, Haitham;
Mostafa, Gamal A. E.;
Kadi, Adnan A.

Publication type:

Article

Identification of Indazole-Based Thiadiazole-Bearing Thiazolidinone Hybrid Derivatives: Theoretical and Computational Approaches to Develop Promising Anti-Alzheimer's Candidates.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 12, p. 1667, doi. 10.3390/ph16121667

By:

Khan, Yousaf;
Khan, Shoaib;
Hussain, Rafaqat;
Rehman, Wajid;
Maalik, Aneela;
Gulshan, Urooba;
Attwa, Mohamed W.;
Darwish, Hany W.;
Ghabbour, Hazem A.;
Ali, Nawab

Publication type:

Article

The Synthesis, In Vitro Bio-Evaluation, and In Silico Molecular Docking Studies of Pyrazoline–Thiazole Hybrid Analogues as Promising Anti-α-Glucosidase and Anti-Urease Agents.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 12, p. 1650, doi. 10.3390/ph16121650

By:

Khan, Yousaf;
Khan, Shoaib;
Hussain, Rafaqat;
Maalik, Aneela;
Rehman, Wajid;
Attwa, Mohamed W.;
Masood, Rafia;
Darwish, Hany W.;
Ghabbour, Hazem A.

Publication type:

Article

An ultra‐fast ultra‐high‐performance liquid chromatography‐tandem mass spectrometry method for estimating the in vitro metabolic stability of palbociclib in human liver microsomes: In silico study for metabolic lability, absorption, distribution, metabolism, and excretion features, and DEREK alerts screening

Published in:

Journal of Separation Science, 2024, v. 47, n. 15, p. 1, doi. 10.1002/jssc.202400346

By:

Attwa, Mohamed W.;
Abdelhameed, Ali S.;
Kadi, Adnan A.

Publication type:

Article

An ultra‐fast green ultra‐high‐performance liquid chromatography‐tandem mass spectrometry method for estimating the in vitro metabolic stability of zotizalkib in human liver microsomes.

Published in:

Journal of Separation Science, 2024, v. 47, n. 15, p. 1, doi. 10.1002/jssc.202400393

By:

Attwa, Mohamed W.;
Abdelhameed, Ali S.;
Kadi, Adnan A.

Publication type:

Article

LC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation.

Published in:

Drug Design, Development & Therapy, 2021, v. 15, p. 3915, doi. 10.2147/DDDT.S321330

By:

Attwa, Mohamed W;
Abdelhameed, Ali S;
Kadi, Adnan A

Publication type:

Article

Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach.

Published in:

Drug Design, Development & Therapy, 2020, v. 14, p. 5259, doi. 10.2147/DDDT.S274018

By:

Abdelhameed, Ali S;
Attwa, Mohamed W;
Kadi, Adnan A

Publication type:

Article

LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay.

Published in:

Drug Design, Development & Therapy, 2020, v. 14, p. 4439, doi. 10.2147/DDDT.S274118

By:

Attwa, Mohamed W;
Abdelhameed, Ali S;
Al-Shakliah, Nasser S;
Kadi, Adnan A

Publication type:

Article

Metabolic Stability Assessment of New PARP Inhibitor Talazoparib Using Validated LC–MS/MS Methodology: In silico Metabolic Vulnerability and Toxicity Studies.

Published in:

Drug Design, Development & Therapy, 2020, v. 14, p. 783, doi. 10.2147/DDDT.S239458

By:

Attwa, Mohamed W;
Kadi, Adnan A;
Abdelhameed, Ali S;
Alhazmi, Hassan A

Publication type:

Article

Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry.

Published in:

Drug Design, Development & Therapy, 2020, v. 14, p. 111, doi. 10.2147/DDDT.S235934

By:

Attwa, Mohamed W;
Kadi, Adnan A;
Darwish, Hany W

Publication type:

Article

A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma.

Published in:

Drug Design, Development & Therapy, 2020, v. 14, p. 407, doi. 10.2147/DDDT.S223573

By:

AlRabiah, Haitham;
Kadi, Adnan A;
Aljohar, Haya I;
Attwa, Mohamed W;
Al-Shakliah, Nasser S;
Attia, Sabry M;
Mostafa, Gamal AE

Publication type:

Article

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling.

Published in:

Drug Design, Development & Therapy, 2017, v. 11, p. 2333, doi. 10.2147/dddt.s140164

By:

Abdel-Aziz, Hatem A.;
Eldehna, Wagdy M.;
Keeton, Adam B.;
Piazza, Gary A.;
Kadi, Adnan A.;
Attwa, Mohamed W.;
Abdelhameed, Ali S.;
Attia, Mohamed I.

Publication type:

Article

Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC-ESI-MS/MS.

Published in:

Chemistry Central Journal, 2018, v. 12, n. 1, p. 1, doi. 10.1186/s13065-018-0467-5

By:

Attwa, Mohamed W.;
Kadi, Adnan A.;
Darwish, Hany W.;
Amer, Sawsan M.;
Al-shakliah, Nasser S.

Publication type:

Article

Validated LC-MS/MS Method for the Quantification of Ponatinib in Plasma: Application to Metabolic Stability.

Published in:

PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0164967

By:

Kadi, Adnan A.;
Darwish, Hany W.;
Attwa, Mohamed W.;
Amer, Sawsan M.

Publication type:

Article

Characterization of in vivo metabolites in rat urine following an oral dose of masitinib by liquid chromatography tandem mass spectrometry.

Published in:

Chemistry Central Journal, 2018, v. 12, n. 1, p. 1, doi. 10.1186/s13065-018-0429-y

By:

Kadi, Adnan A.;
Amer, Sawsan M.;
Darwish, Hany W.;
Attwa, Mohamed W.

Publication type:

Article

Development and validation of an HPLC-MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study.

Published in:

Chemistry Central Journal, 2018, v. 12, n. 1, p. 1, doi. 10.1186/s13065-018-0414-5

By:

Alrabiah, Haitham;
Kadi, Adnan A.;
Attwa, Mohamed W.;
Mostafa, Gamal A. E.

Publication type:

Article

Induced in-source fragmentation pattern of certain novel (1Z,2E)-N-(aryl)propanehydrazonoyl chlorides by electrospray mass spectrometry (ESI-MS/MS).

Published in:

Chemistry Central Journal, 2013, v. 7, n. 1, p. 1, doi. 10.1186/1752-153X-7-16

By:

Abdelhameed, Ali S.;
Attwa, Mohamed W.;
Abdel-Aziz, Hatem A.;
Kadi, Adnan A.

Publication type:

Article

Assessment of the in vitro metabolic stability of CEP-37440, a selective FAK/ALK inhibitor, in HLMs using fast UPLC–MS/MS method: in silico metabolic lability and DEREK alerts screening.

Published in:

Frontiers in Chemistry, 2024, p. 1, doi. 10.3389/fchem.2024.1323738

By:

Attwa, Mohamed W.;
AlRabiah, Haitham;
Abdelhameed, Ali S.;
Kadi, Adnan A.

Publication type:

Article

Liquid chromatographic-tandem mass spectrometric assay for simultaneous quantitation of tofacitinib, cabozantinib and afatinib in human plasma and urine.

Published in:

Tropical Journal of Pharmaceutical Research, 2016, v. 15, n. 12, p. 2683, doi. 10.4314/tjpr.v15i12.21

By:

Kadi, Adnan A.;
Abdelhameed, Ali S.;
Darwish, Hany W.;
Attwa, Mohamed W.;
Bakheit, Ahmed H.

Publication type:

Article

Rapid validated liquid chromatographic method coupled with Tandem mass spectrometry for quantification of nintedanib in human plasma.

Published in:

Tropical Journal of Pharmaceutical Research, 2016, v. 15, n. 11, p. 2467, doi. 10.4314/tjpr.v15i11.23

By:

Darwish, Hany W.;
Attwa, Mohamed W.;
Kadi, Adnan A.

Publication type:

Article

Liquid chromatographic-mass spectrometric method for determination of drug content uniformity of two commonly used dermatology medications in a split-tablet dosage form.

Published in:

Tropical Journal of Pharmaceutical Research, 2016, v. 15, n. 6, p. 1283, doi. 10.4314/tjpr.v15i6.22

By:

Kadi, Adnan A.;
Abdelhameed, Ali S.;
Attwa, Mohamed W.;
Al-Haddab, Mohammad;
Angawi, Rihab F.

Publication type:

Article

An Ultra-Fast Validated Green UPLC-MS/MS Approach for Assessing Revumenib in Human Liver Microsomes: In Vitro Absorption, Distribution, Metabolism, and Excretion and Metabolic Stability Evaluation.

Published in:

Medicina (1010660X), 2024, v. 60, n. 12, p. 1914, doi. 10.3390/medicina60121914

By:

Attwa, Mohamed W.;
Abdelhameed, Ali S.;
Kadi, Adnan A.

Publication type:

Article

An Ultra-Fast Green UHPLC-MS/MS Method for Assessing the In Vitro Metabolic Stability of Dovitinib: In Silico Study for Absorption, Distribution, Metabolism, Excretion, Metabolic Lability, and DEREK Alerts.

Published in:

Medicina (1010660X), 2024, v. 60, n. 10, p. 1626, doi. 10.3390/medicina60101626

By:

Attwa, Mohamed W.;
Abdelhameed, Ali S.;
Kadi, Adnan A.

Publication type:

Article

Multistage fragmentation of ion trap mass spectrometry system and pseudo-MS3 of triple quadrupole mass spectrometry characterize certain (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones: a comparative study.

Published in:

2014

By:

Abdelhameed, Ali S;
Kadi, Adnan A;
Abdel-Aziz, Hatem A;
Angawi, Rihab F;
Attwa, Mohamed W;
Al-Rashood, Khalid A

Publication type:

journal article

Multistage Fragmentation of Ion Trap Mass Spectrometry System and Pseudo-MS³ of Triple Quadrupole Mass Spectrometry Characterize Certain (E)-3-(Dimethylamino)-1-arylprop-2-en-1-ones: A Comparative Study.

Published in:

Scientific World Journal, 2014, p. 1, doi. 10.1155/2014/702819

By:

Abdelhameed, Ali S.;
Kadi, Adnan A.;
Abdel-Aziz, Hatem A.;
Angawi, Rihab F.;
Attwa, Mohamed W.;
Al-Rashood, Khalid A.

Publication type:

Article

Phospholipid-based nano drug delivery system of curcumin using MSP1D1 protein and poloxamer 407: a comparative study for targeted drug delivery to the brain.

Published in:

Journal of Nanoparticle Research, 2024, v. 26, n. 1, p. 1, doi. 10.1007/s11051-023-05921-0

By:

Shariare, Mohammad Hossain;
Mannan, Mahbia;
Khan, Fairouz;
Sharmin, Ayesha;
Attwa, Mohamed W.;
Rahman, A. F. M. Motiur;
Rahman, Mahbubur;
Uddin, Mohammad N.;
Kazi, Mohsin

Publication type:

Article

A Sensitive, Green, and Fast LC–MS/MS Analytical Method for the Quantification of Ribociclib: Evaluation of the Metabolic Stability in HLMs.

Published in:

Separations (2297-8739), 2023, v. 10, n. 9, p. 472, doi. 10.3390/separations10090472

By:

Attwa, Mohamed W.;
Abdelhameed, Ali S.;
Kadi, Adnan A.

Publication type:

Article

A Fast LC-MS/MS Methodology for Estimating Savolitinib in Human Liver Microsomes: Assessment of Metabolic Stability Using In Vitro Metabolic Incubation and In Silico Software Analysis.

Published in:

Separations (2297-8739), 2023, v. 10, n. 8, p. 450, doi. 10.3390/separations10080450

By:

Attwa, Mohamed W.;
AlRabiah, Haitham;
Abdelhameed, Ali S.;
Kadi, Adnan A.

Publication type:

Article

An LC–MS/MS Analytical Method for Quantifying Tepotinib in Human Liver Microsomes: Application to In Vitro and In Silico Metabolic Stability Estimation.

Published in:

Separations (2297-8739), 2023, v. 10, n. 6, p. 330, doi. 10.3390/separations10060330

By:

Attwa, Mohamed W.;
Mostafa, Gamal A. E.;
AlRabiah, Haitham;
Kadi, Adnan A.

Publication type:

Article

Development of a Fast and Sensitive UPLC–MS/MS Analytical Methodology for Fenebrutinib Estimation in Human Liver Microsomes: In Vitro and In Silico Metabolic Stability Evaluation.

Published in:

Separations (2297-8739), 2023, v. 10, n. 5, p. 302, doi. 10.3390/separations10050302

By:

Attwa, Mohamed W.;
Alsibaee, Aishah M.;
Aljohar, Haya I.;
Abdelhameed, Ali S.;
Kadi, Adnan A.

Publication type:

Article

An UPLC–ESI–MS/MS Bioanalytical Methodology for the Quantification of Gilteritinib in Human Liver Microsomes: Application to In Vitro and In Silico Metabolic Stability Estimation.

Published in:

Separations (2297-8739), 2023, v. 10, n. 5, p. 278, doi. 10.3390/separations10050278

By:

Attwa, Mohamed W.;
AlRabiah, Haitham;
Alsibaee, Aishah M.;
Abdelhameed, Ali S.;
Kadi, Adnan A.

Publication type:

Article

A Rapid and Sensitive UPLC-MS/MS Method for Quantifying Capmatinib in Human Liver Microsomes: Evaluation of Metabolic Stability by In Silico and In Vitro Analysis.

Published in:

Separations (2297-8739), 2023, v. 10, n. 4, p. 247, doi. 10.3390/separations10040247

By:

Attwa, Mohamed W.;
Abdelhameed, Ali S.;
Alsibaee, Aishah M.;
Kadi, Adnan A.

Publication type:

Article

Simvastatin: In Vitro Metabolic Profiling of a Potent Competitive HMG-CoA Reductase Inhibitor.

Published in:

Separations (2297-8739), 2022, v. 9, n. 12, p. 400, doi. 10.3390/separations9120400

By:

Yin, Wencui;
Alwabli, Reem I.;
Attwa, Mohamed W.;
Rahman, A. F. M. Motiur;
Kadi, Adnan A.

Publication type:

Article

COMPARATIVE BIOEQUIVALENCE EVALUATION OF TWO BRANDS OF OFLOXACIN 200 MG TABLETS (JEDCOFLACIN® VS. TARIVID®) IN 24 HEALTHY VOLUNTEERS: A RANDOMIZED, SINGLE-DOSE, TWO-PERIOD, TWO-SEQUENCE CROSSOVER STUDY.

Published in:

Digest Journal of Nanomaterials & Biostructures (DJNB), 2013, v. 8, n. 1, p. 239

By:

KADI, ADNAN A.;
AL-HADIYA, BADRADDIN M.;
ATTWA, MOHAMED W.;
ABDELHAMEED, ALI S.;
EL-SAYED, YOUSRY M.;
ATTIA, MOHAMED IBRAHIM

Publication type:

Article

Validated LC-MS/MS assay for quantification of the newly approved tyrosine kinase inhibitor, dacomitinib, and application to investigating its metabolic stability.

Published in:

PLoS ONE, 2019, v. 14, n. 4, p. 1, doi. 10.1371/journal.pone.0214598

By:

Abdelhameed, Ali S.;
Kadi, Adnan A.;
Attwa, Mohamed W.;
AlRabiah, Haitham

Publication type:

Article

Piperazine ring toxicity in three novel anti-breast cancer drugs: an in silico and in vitro metabolic bioactivation approach using olaparib as a case study.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, v. 396, n. 7, p. 1435, doi. 10.1007/s00210-023-02413-9

By:

Alsubi, Thamer A.;
Attwa, Mohamed W.;
Darwish, Hany W.;
Abuelizz, Hatem A.;
Kadi, Adnan A.

Publication type:

Article

Microwave-Assisted Solution-Phase Synthesis and DART-Mass Spectrometric Monitoring of a Combinatorial Library of Indolin-2,3-dione Schiff Bases with Potential Antimycobacterial Activity.

Published in:

Molecules, 2011, v. 16, n. 6, p. 5194, doi. 10.3390/molecules16065194

By:

Aboul-Fadl, Tarek;
Abdel-Aziz, Hatem A.;
Kadi, Adnan;
Ahmad, Pervez;
Elsaman, Tilal;
Attwa, Mohamed W.;
Darwish, Ibrahim A.

Publication type:

Article

Pseudo-MS³ Approach Using Electrospray Mass Spectrometry (ESI-MS/MS) to Characterize Certain (2E)-2-[3-(1H-Imidazol-1-yl)-1-phenylpropylidene] hydrazinecarboxamide Derivatives.

Published in:

Journal of Chemistry, 2014, p. 1, doi. 10.1155/2014/386301

By:

Abdelhameed, Ali S.;
Kadi, Adnan A.;
Attia, Mohamed I.;
Angawi, Rihab F.;
Attwa, Mohamed W.;
Darwish, Hany W.

Publication type:

Article

High Throughput Quantitative Bioanalytical LC/MS/MS Determination of Gemifloxacin in Human Urine.

Published in:

Journal of Chemistry, 2013, p. 1, doi. 10.1155/2013/905704

By:

Kadi, Adnan A.;
Angawi, Rihab F.;
Attwa, Mohamed W.;
Darwish, Hany W.;
Abdelhameed, Ali Saber

Publication type:

Article

Editorial: Drug metabolism-induced organ toxicity.

Published in:

Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1362229

By:

Kadi, Adnan A.;
Yang Li;
Parashar, Abhinav;
Attwa, Mohamed W.

Publication type:

Article

Polycaprolactone—Vitamin E TPGS Micellar Formulation for Oral Delivery of Paclitaxel.

Published in:

Polymers (20734360), 2024, v. 16, n. 15, p. 2232, doi. 10.3390/polym16152232

By:

Binkhathlan, Ziyad;
Ali, Raisuddin;
Yusuf, Osman;
Alomrani, Abdullah H.;
Badran, Mohamed M.;
Alshememry, Abdullah K.;
Alshamsan, Aws;
Alqahtani, Faleh;
Qamar, Wajhul;
Attwa, Mohamed W.

Publication type:

Article

Fabrication and Applications of Potentiometric Membrane Sensors Based on γ-Cyclodextrin and Calixarene as Ionophores for the Determination of a Histamine H1-Receptor Antagonist: Fexofenadine.

Published in:

Polymers (20734360), 2023, v. 15, n. 13, p. 2808, doi. 10.3390/polym15132808

By:

Alrabiah, Haitham;
Ali, Essam A.;
Alsalahi, Rashad A.;
Attwa, Mohamed W.;
Mostafa, Gamal A. E.

Publication type:

Article

Optimization of Environmentally Sustainable UPLC‐PDA Method Using Box–Behnken for Simultaneous Quantifying Curcumin and Candesartan Cilexetil in On‐Demand Formulation for Treatment of Brain Ischemic Injury.

Published in:

Biomedical Chromatography, 2025, v. 39, n. 7, p. 1, doi. 10.1002/bmc.70130

By:

Sherif, Abdelrahman Y.;
Attwa, Mohamed W.;
Elzayat, Ehab M.

Publication type:

Article

Development and validation of HPLC-MS/MS method for the determination of lixivaptan in mouse plasma and its application in a pharmacokinetic study.

Published in:

Biomedical Chromatography, 2017, v. 31, n. 11, p. n/a, doi. 10.1002/bmc.4007

By:

Kadi, Adnan A.;
Alrabiah, Haitham;
Attwa, Mohamed W.;
Attia, Sabry;
Mostafa, Gamal A. E.

Publication type:

Article

An LC-MS/MS method for rapid and sensitive high-throughput simultaneous determination of various protein kinase inhibitors in human plasma.

Published in:

Biomedical Chromatography, 2017, v. 31, n. 2, p. n/a, doi. 10.1002/bmc.3793

By:

Abdelhameed, Ali S.;
Attwa, Mohamed W.;
Kadi, Adnan A.

Publication type:

Article

A highly efficient and sensitive LC-MS/MS method for the determination of afatinib in human plasma: application to a metabolic stability study.

Published in:

Biomedical Chromatography, 2016, v. 30, n. 8, p. 1248, doi. 10.1002/bmc.3674

By:

Kadi, Adnan A.;
Abdelhameed, Ali S.;
Darwish, Hany W.;
Attwa, Mohamed W.;
Al‐Shakliah, Nasser S.

Publication type:

Article