Works matching AU Attwa, Mohamed W.
Results: 67
Validated LC-MS/MS assay for quantification of the newly approved tyrosine kinase inhibitor, dacomitinib, and application to investigating its metabolic stability.
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- PLoS ONE, 2019, v. 14, n. 4, p. 1, doi. 10.1371/journal.pone.0214598
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- Article
Piperazine ring toxicity in three novel anti-breast cancer drugs: an in silico and in vitro metabolic bioactivation approach using olaparib as a case study.
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- Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, v. 396, n. 7, p. 1435, doi. 10.1007/s00210-023-02413-9
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- Article
Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC-ESI-MS/MS.
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- Chemistry Central Journal, 2018, v. 12, n. 1, p. 1, doi. 10.1186/s13065-018-0467-5
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- Article
Characterization of in vivo metabolites in rat urine following an oral dose of masitinib by liquid chromatography tandem mass spectrometry.
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- Chemistry Central Journal, 2018, v. 12, n. 1, p. 1, doi. 10.1186/s13065-018-0429-y
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- Article
Development and validation of an HPLC-MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study.
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- Chemistry Central Journal, 2018, v. 12, n. 1, p. 1, doi. 10.1186/s13065-018-0414-5
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- Article
Phospholipid-based nano drug delivery system of curcumin using MSP1D1 protein and poloxamer 407: a comparative study for targeted drug delivery to the brain.
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- Journal of Nanoparticle Research, 2024, v. 26, n. 1, p. 1, doi. 10.1007/s11051-023-05921-0
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- Article
Editorial: Drug metabolism-induced organ toxicity.
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- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1362229
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- Article
An ultra‐fast ultra‐high‐performance liquid chromatography‐tandem mass spectrometry method for estimating the in vitro metabolic stability of palbociclib in human liver microsomes: In silico study for metabolic lability, absorption, distribution, metabolism, and excretion features, and DEREK alerts screening
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- Journal of Separation Science, 2024, v. 47, n. 15, p. 1, doi. 10.1002/jssc.202400346
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- Article
An ultra‐fast green ultra‐high‐performance liquid chromatography‐tandem mass spectrometry method for estimating the in vitro metabolic stability of zotizalkib in human liver microsomes.
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- Journal of Separation Science, 2024, v. 47, n. 15, p. 1, doi. 10.1002/jssc.202400393
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- Article
Detection and characterization of olmutinib reactive metabolites by LC–MS/MS: Elucidation of bioactivation pathways.
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- Journal of Separation Science, 2020, v. 43, n. 4, p. 708, doi. 10.1002/jssc.201900818
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- Article
COMPARATIVE BIOEQUIVALENCE EVALUATION OF TWO BRANDS OF OFLOXACIN 200 MG TABLETS (JEDCOFLACIN® VS. TARIVID®) IN 24 HEALTHY VOLUNTEERS: A RANDOMIZED, SINGLE-DOSE, TWO-PERIOD, TWO-SEQUENCE CROSSOVER STUDY.
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- Digest Journal of Nanomaterials & Biostructures (DJNB), 2013, v. 8, n. 1, p. 239
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- Article
Multistage fragmentation of ion trap mass spectrometry system and pseudo-MS3 of triple quadrupole mass spectrometry characterize certain (E)-3-(dimethylamino)-1-arylprop-2-en-1-ones: a comparative study.
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- 2014
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- Publication type:
- journal article
Multistage Fragmentation of Ion Trap Mass Spectrometry System and Pseudo-MS³ of Triple Quadrupole Mass Spectrometry Characterize Certain (E)-3-(Dimethylamino)-1-arylprop-2-en-1-ones: A Comparative Study.
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- Scientific World Journal, 2014, p. 1, doi. 10.1155/2014/702819
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- Article
Assessment of the in vitro metabolic stability of CEP-37440, a selective FAK/ALK inhibitor, in HLMs using fast UPLC–MS/MS method: in silico metabolic lability and DEREK alerts screening.
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- Frontiers in Chemistry, 2024, p. 1, doi. 10.3389/fchem.2024.1323738
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- Article
Assessment of the in vitro metabolic stability of CEP-37440, a selective FAK/ALK inhibitor, in HLMs using fast UPLC-MS/MS method: in silico metabolic lability and DEREK alerts screening.
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- Frontiers in Chemistry, 2024, p. 1, doi. 10.3389/fchem.2024.1323738
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- Article
Detection and characterization of simvastatin and its metabolites in rat tissues and biological fluids using MALDI high resolution mass spectrometry approach.
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- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-08804-x
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- Article
Enhanced Codelivery of Gefitinib and Azacitidine for Treatment of Metastatic-Resistant Lung Cancer Using Biodegradable Lipid Nanoparticles.
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- Materials (1996-1944), 2023, v. 16, n. 15, p. 5364, doi. 10.3390/ma16155364
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- Article
LC–MS/MS Estimation of Rociletinib Levels in Human Liver Microsomes: Application to Metabolic Stability Estimation.
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- Drug Design, Development & Therapy, 2021, v. 15, p. 3915, doi. 10.2147/DDDT.S321330
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- Article
Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach.
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- Drug Design, Development & Therapy, 2020, v. 14, p. 5259, doi. 10.2147/DDDT.S274018
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- Article
LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay.
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- Drug Design, Development & Therapy, 2020, v. 14, p. 4439, doi. 10.2147/DDDT.S274118
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- Article
Metabolic Stability Assessment of New PARP Inhibitor Talazoparib Using Validated LC–MS/MS Methodology: In silico Metabolic Vulnerability and Toxicity Studies.
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- Drug Design, Development & Therapy, 2020, v. 14, p. 783, doi. 10.2147/DDDT.S239458
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- Article
Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry.
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- Drug Design, Development & Therapy, 2020, v. 14, p. 111, doi. 10.2147/DDDT.S235934
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- Article
A New Validated HPLC-MS/MS Method for Quantification and Pharmacokinetic Evaluation of Dovitinib, a Multi-Kinase Inhibitor, in Mouse Plasma.
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- Drug Design, Development & Therapy, 2020, v. 14, p. 407, doi. 10.2147/DDDT.S223573
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- Article
Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling.
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- Drug Design, Development & Therapy, 2017, v. 11, p. 2333, doi. 10.2147/dddt.s140164
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- Article
Supramolecular Structure, Hirshfeld Surface Analysis, Morphological Study and DFT Calculations of the Triphenyltetrazolium Cobalt Thiocyanate Complex.
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- Crystals (2073-4352), 2023, v. 13, n. 11, p. 1598, doi. 10.3390/cryst13111598
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- Article
Structural Analysis and Reactivity Insights of (E)-Bromo-4-((4-((1-(4-chlorophenyl)ethylidene)amino)-5-phenyl-4H-1,2,4-triazol-3-yl)thio)-5-((2-isopropylcyclohexyl)oxy) Furan-2(5H)-one: A Combined Approach Using Single-Crystal X-ray Diffraction, Hirshfeld Surface Analysis, and Conceptual Density Functional Theory
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- Crystals (2073-4352), 2023, v. 13, n. 9, p. 1313, doi. 10.3390/cryst13091313
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- Article
Exploring the Chemical Reactivity, Molecular Docking, Molecular Dynamic Simulation and ADMET Properties of a Tetrahydrothienopyridine Derivative Using Computational Methods.
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- Crystals (2073-4352), 2023, v. 13, n. 7, p. 1020, doi. 10.3390/cryst13071020
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- Article
Polycaprolactone—Vitamin E TPGS Micellar Formulation for Oral Delivery of Paclitaxel.
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- Polymers (20734360), 2024, v. 16, n. 15, p. 2232, doi. 10.3390/polym16152232
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- Article
Fabrication and Applications of Potentiometric Membrane Sensors Based on γ-Cyclodextrin and Calixarene as Ionophores for the Determination of a Histamine H1-Receptor Antagonist: Fexofenadine.
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- Polymers (20734360), 2023, v. 15, n. 13, p. 2808, doi. 10.3390/polym15132808
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- Article
Validated LC-MS/MS Method for the Quantification of Ponatinib in Plasma: Application to Metabolic Stability.
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- PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0164967
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- Article
Ionophore-Based Polymeric Sensors for Potentiometric Assay of the Anticancer Drug Gemcitabine in Pharmaceutical Formulation: A Comparative Study.
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- Molecules, 2023, v. 28, n. 22, p. 7552, doi. 10.3390/molecules28227552
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- Article
Selective Stability Indicating Liquid Chromatographic Method Based on Quality by Design Framework and In Silico Toxicity Assessment for Infigratinib and Its Degradation Products.
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- Molecules, 2023, v. 28, n. 22, p. 7476, doi. 10.3390/molecules28227476
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- Article
An Ultrafast UPLC–MS/MS Method for Characterizing the In Vitro Metabolic Stability of Acalabrutinib.
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- Molecules, 2023, v. 28, n. 20, p. 7220, doi. 10.3390/molecules28207220
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- Article
Investigation of Fenebrutinib Metabolism and Bioactivation Using MS 3 Methodology in Ion Trap LC/MS.
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- Molecules, 2023, v. 28, n. 10, p. 4225, doi. 10.3390/molecules28104225
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- Article
Assessment of In Silico and In Vitro Selpercatinib Metabolic Stability in Human Liver Microsomes Using a Validated LC-MS/MS Method.
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- Molecules, 2023, v. 28, n. 6, p. 2618, doi. 10.3390/molecules28062618
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- Article
Development and Validation of a Rapid LC-MS/MS Method for Quantifying Alvocidib: In Silico and In Vitro Metabolic Stability Estimation in Human Liver Microsomes.
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- Molecules, 2023, v. 28, n. 5, p. 2368, doi. 10.3390/molecules28052368
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- Article
Development of an LC-MS/MS Method for Quantification of Sapitinib in Human Liver Microsomes: In Silico and In Vitro Metabolic Stability Evaluation.
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- Molecules, 2023, v. 28, n. 5, p. 2322, doi. 10.3390/molecules28052368
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- Article
Rapid LC-MS/MS Bosutinib Quantification with Applications in Metabolic Stability Estimation.
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- Molecules, 2023, v. 28, n. 4, p. 1641, doi. 10.3390/molecules28041641
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- Article
A Liquid Chromatography Tandem Mass Spectrometry Method for the Simultaneous Estimation of the Dopamine Receptor Antagonist LE300 and Its N-methyl Metabolite in Plasma: Application to a Pharmacokinetic Study.
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- Molecules, 2023, v. 28, n. 4, p. 1553, doi. 10.3390/molecules28041553
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- Article
A Rapid and Sensitive Liquid Chromatography-Tandem Mass Spectrometry Bioanalytical Method for the Quantification of Encorafenib and Binimetinib as a First-Line Treatment for Advanced (Unresectable or Metastatic) Melanoma—Application to a Pharmacokinetic Study
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- Molecules, 2023, v. 28, n. 1, p. 79, doi. 10.3390/molecules28010079
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- Article
A Novel Green Micellar HPLC-UV Method for the Estimation of Vandetanib in Pure Form, Human Urine, Human Plasma and Human Liver Microsomes Matrices with Application to Metabolic Stability Evaluation.
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- Molecules, 2022, v. 27, n. 24, p. 9038, doi. 10.3390/molecules27249038
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- Article
A Validated LC–MS/MS Assay for the Simultaneous Quantification of the FDA-Approved Anticancer Mixture (Encorafenib and Binimetinib): Metabolic Stability Estimation.
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- Molecules, 2021, v. 26, n. 9, p. 2717, doi. 10.3390/molecules26092717
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- Article
Identification of Iminium Intermediates Generation in the Metabolism of Tepotinib Using LC-MS/MS: In Silico and Practical Approaches to Bioactivation Pathway Elucidation.
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- Molecules, 2020, v. 25, n. 21, p. 5004, doi. 10.3390/molecules25215004
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- Article
Microwave-Assisted Solution-Phase Synthesis and DART-Mass Spectrometric Monitoring of a Combinatorial Library of Indolin-2,3-dione Schiff Bases with Potential Antimycobacterial Activity.
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- Molecules, 2011, v. 16, n. 6, p. 5194, doi. 10.3390/molecules16065194
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- Article
Evaluation of Alectinib Metabolic Stability in HLMs Using Fast LC-MS/MS Method: In Silico ADME Profile, P450 Metabolic Lability, and Toxic Alerts Screening.
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- Pharmaceutics, 2023, v. 15, n. 10, p. 2449, doi. 10.3390/pharmaceutics15102449
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- Article
Identification of Indazole-Based Thiadiazole-Bearing Thiazolidinone Hybrid Derivatives: Theoretical and Computational Approaches to Develop Promising Anti-Alzheimer's Candidates.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 12, p. 1667, doi. 10.3390/ph16121667
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- Article
The Synthesis, In Vitro Bio-Evaluation, and In Silico Molecular Docking Studies of Pyrazoline–Thiazole Hybrid Analogues as Promising Anti-α-Glucosidase and Anti-Urease Agents.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 12, p. 1650, doi. 10.3390/ph16121650
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- Article
Liquid chromatographic-tandem mass spectrometric assay for simultaneous quantitation of tofacitinib, cabozantinib and afatinib in human plasma and urine.
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- Tropical Journal of Pharmaceutical Research, 2016, v. 15, n. 12, p. 2683, doi. 10.4314/tjpr.v15i12.21
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- Article
Rapid validated liquid chromatographic method coupled with Tandem mass spectrometry for quantification of nintedanib in human plasma.
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- Tropical Journal of Pharmaceutical Research, 2016, v. 15, n. 11, p. 2467, doi. 10.4314/tjpr.v15i11.23
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- Article
Liquid chromatographic-mass spectrometric method for determination of drug content uniformity of two commonly used dermatology medications in a split-tablet dosage form.
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- Tropical Journal of Pharmaceutical Research, 2016, v. 15, n. 6, p. 1283, doi. 10.4314/tjpr.v15i6.22
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- Publication type:
- Article