Works matching AU Asselbergh, Bob

Results: 35

Ageing Signatures and Disturbed Muscle Regeneration in Muscle Proteome of Inclusion Body Myositis.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2025, v. 16, n. 3, p. 1, doi. 10.1002/jcsm.13845

By:

de Vries, Geert M.;
Asselbergh, Bob;
Monticelli, Alice;
De Jonghe, Peter;
Maudsley, Stuart;
Van Den Bergh, Peter Y. K.;
Bigot, Anne;
De Bleecker, Jan L.;
Ermanoska, Biljana;
De Ridder, Willem;
Baets, Jonathan

Publication type:

Article

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.

Published in:

Molecular Neurodegeneration, 2015, v. 10, n. 1, p. 1, doi. 10.1186/s13024-015-0024-9

By:

Bettens, Karolien;
Vermeulen, Steven;
Van Cauwenberghe, Caroline;
Heeman, Bavo;
Asselbergh, Bob;
Robberecht, Caroline;
Engelborghs, Sebastiaan;
Vandenbulcke, Mathieu;
Vandenberghe, Rik;
De Deyn, Peter Paul;
Cruts, Marc;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

Caspase-14-Deficient Mice Are More Prone to the Development of Parakeratosis.

Published in:

Journal of Investigative Dermatology, 2013, v. 133, n. 3, p. 742, doi. 10.1038/jid.2012.350

By:

Hoste, Esther;
Denecker, Geertrui;
Gilbert, Barbara;
Van Nieuwerburgh, Filip;
van der Fits, Leslie;
Asselbergh, Bob;
De Rycke, Riet;
Hachem, Jean-Pierre;
Deforce, Dieter;
Prens, Errol P;
Vandenabeele, Peter;
Declercq, Wim

Publication type:

Article

Mutant HSPB1 causes loss of translational repression by binding to PCBP1, an RNA binding protein with a possible role in neurodegenerative disease.

Published in:

Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-016-0407-3

By:

Geuens, Thomas;
De Winter, Vicky;
Rajan, Nicholas;
Achsel, Tilmann;
Mateiu, Ligia;
Almeida-Souza, Leonardo;
Asselbergh, Bob;
Bouhy, Delphine;
Auer-Grumbach, Michaela;
Bagni, Claudia;
Timmerman, Vincent

Publication type:

Article

Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-35908-3

By:

Ermanoska, Biljana;
Asselbergh, Bob;
Morant, Laura;
Petrovic-Erfurth, Maria-Luise;
Hosseinibarkooie, Seyyedmohsen;
Leitão-Gonçalves, Ricardo;
Almeida-Souza, Leonardo;
Bervoets, Sven;
Sun, Litao;
Lee, LaTasha;
Atkinson, Derek;
Khanghahi, Akram;
Tournev, Ivaylo;
Callaerts, Patrick;
Verstreken, Patrik;
Yang, Xiang-Lei;
Wirth, Brunhilde;
Rodal, Avital A.;
Timmerman, Vincent;
Goode, Bruce L.

Publication type:

Article

Autophagy induction by piplartine ameliorates axonal degeneration caused by mutant HSPB1 and HSPB8 in Charcot-Marie-Tooth type 2 neuropathies.

Published in:

Autophagy, 2025, v. 21, n. 5, p. 1116, doi. 10.1080/15548627.2024.2439649

By:

Sisto, Angela;
van Wermeskerken, Tamira;
Pancher, Michael;
Gatto, Pamela;
Asselbergh, Bob;
Assunção Carreira, Ágata Sofia;
De Winter, Vicky;
Adami, Valentina;
Provenzani, Alessandro;
Timmerman, Vincent

Publication type:

Article

HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies.

Published in:

Autophagy, 2023, v. 19, n. 8, p. 2217, doi. 10.1080/15548627.2023.2179780

By:

Tedesco, Barbara;
Vendredy, Leen;
Adriaenssens, Elias;
Cozzi, Marta;
Asselbergh, Bob;
Crippa, Valeria;
Cristofani, Riccardo;
Rusmini, Paola;
Ferrari, Veronica;
Casarotto, Elena;
Chierichetti, Marta;
Mina, Francesco;
Pramaggiore, Paola;
Galbiati, Mariarita;
Piccolella, Margherita;
Baets, Jonathan;
Baeke, Femke;
De Rycke, Riet;
Mouly, Vincent;
Laurenzi, Tommaso

Publication type:

Article

Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.

Published in:

Autophagy, 2019, v. 15, n. 6, p. 1051, doi. 10.1080/15548627.2019.1569930

By:

Haidar, Mansour;
Asselbergh, Bob;
Adriaenssens, Elias;
De Winter, Vicky;
Timmermans, Jean-Pierre;
Auer-Grumbach, Michaela;
Juneja, Manisha;
Timmerman, Vincent

Publication type:

Article

Small Heat-Shock Protein HSPB1 Mutants Stabilize Microtubules in Charcot-Marie-Tooth Neuropathy.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 43, p. 15320, doi. 10.1523/JNEUROSCI.3266-11.2011

By:

Almeida-Souza, Leonardo;
Asselbergh, Bob;
d'Ydewalle, Constantin;
Moonens, Kristof;
Goethals, Sofie;
Winter, Vicky de;
Azmi, Abdelkrim;
Irobi, Joy;
Timmermans, Jean-Pierre;
Gevaert, Kris;
Remaut, Han;
Den Bosch, Ludo Van;
Timmerman, Vincent;
Janssens, Sophie

Publication type:

Article

A weakened interface in the P182L variant of HSP27 associated with severe Charcot‐Marie‐Tooth neuropathy causes aberrant binding to interacting proteins.

Published in:

EMBO Journal, 2021, v. 40, n. 8, p. 1, doi. 10.15252/embj.2019103811

By:

Reid Alderson, T;
Adriaenssens, Elias;
Asselbergh, Bob;
Pritišanac, Iva;
Van Lent, Jonas;
Gastall, Heidi Y;
Wälti, Marielle A;
Louis, John M;
Timmerman, Vincent;
Baldwin, Andrew J;
LP Benesch, Justin

Publication type:

Article

Acute injury in the peripheral nervous system triggers an alternative macrophage response.

Published in:

Journal of Neuroinflammation, 2012, v. 9, n. 1, p. 176, doi. 10.1186/1742-2094-9-176

By:

Ydens, Elke;
Cauwels, Anje;
Asselbergh, Bob;
Goethals, Sofie;
Peeraer, Lieve;
Lornet, Guillaume;
Almeida-Souza, Leonardo;
Van Ginderachter, Jo A.;
Timmerman, Vincent;
Janssens, Sophie

Publication type:

Article

Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis.

Published in:

EMBO Molecular Medicine, 2011, v. 3, n. 4, p. 222, doi. 10.1002/emmm.201000125

By:

Festjens, Nele;
Bogaert, Pieter;
Batni, Anjana;
Houthuys, Erica;
Plets, Evelyn;
Vanderschaeghe, Dieter;
Laukens, Bram;
Asselbergh, Bob;
Parthoens, Eef;
De Rycke, Riet;
Willart, Monique A.;
Jacques, Peggy;
Elewaut, Dirk;
Brouckaert, Peter;
Lambrecht, Bart N.;
Huygen, Kris;
Callewaert, Nico

Publication type:

Article

RNA Interference Targeting Small Heat Shock Protein B8 Failed to Improve Distal Hereditary Motor Neuropathy in the Mouse Model.

Published in:

Journal of Gene Medicine, 2025, v. 27, n. 2, p. 1, doi. 10.1002/jgm.70013

By:

Vendredy, Leen;
De Winter, Vicky;
Van Lent, Jonas;
Orije, Jasmien;
Authier, Tatiana Da Silva;
Katona, Istvan;
Asselbergh, Bob;
Adriaenssens, Elias;
Weis, Joachim;
Verhoye, Marleen;
Timmerman, Vincent

Publication type:

Article

Abscisic Acid Deficiency Causes Changes in Cuticle Permeability and Pectin Composition That Influence Tomato Resistance to Botrytis cinerea.

Published in:

Plant Physiology, 2010, v. 154, n. 2, p. 847, doi. 10.1104/pp.110.158972

By:

Curvers, Katrien;
Seifi, Hamed;
Mouille, Grégory;
De Rycke, Riet;
Asselbergh, Bob;
Van Hecke, Annelies;
Vanderschaeghe, Dieter;
Höfte, Herman;
Callewaert, Nico;
Van Breusegem, Frank;
Höfte, Monica

Publication type:

Article

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8.

Published in:

Acta Neuropathologica, 2018, v. 135, n. 1, p. 131, doi. 10.1007/s00401-017-1756-0

By:

Bouhy, Delphine;
Juneja, Manisha;
Katona, Istvan;
Holmgren, Anne;
Asselbergh, Bob;
De Winter, Vicky;
Hochepied, Tino;
Goossens, Steven;
Haigh, Jody J.;
Libert, Claude;
Groote, Chantal Ceuterick-de;
Irobi, Joy;
Weis, Joachim;
Timmerman, Vincent

Publication type:

Article

Mitochondria-associated membranes as hubs for neurodegeneration.

Published in:

Acta Neuropathologica, 2016, v. 131, n. 4, p. 505, doi. 10.1007/s00401-015-1528-7

By:

Krols, Michiel;
Isterdael, Gert;
Asselbergh, Bob;
Kremer, Anna;
Lippens, Saskia;
Timmerman, Vincent;
Janssens, Sophie

Publication type:

Article

Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-mediated phosphorylation of neurofilaments.

Published in:

Acta Neuropathologica, 2013, v. 126, n. 1, p. 93, doi. 10.1007/s00401-013-1133-6

By:

Holmgren, Anne;
Bouhy, Delphine;
Winter, Vicky;
Asselbergh, Bob;
Timmermans, Jean-Pierre;
Irobi, Joy;
Timmerman, Vincent

Publication type:

Article

Rare missense mutations in ABCA7 might increase Alzheimer's disease risk by plasma membrane exclusion.

Published in:

Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-022-01346-3

By:

Bossaerts, Liene;
Hendrickx Van de Craen, Elisabeth;
Cacace, Rita;
Asselbergh, Bob;
Van Broeckhoven, Christine

Publication type:

Article

Abscisic acid deficiency leads to rapid activation of tomato defence responses upon infection with Erwinia chrysanthemi.

Published in:

Molecular Plant Pathology, 2008, v. 9, n. 1, p. 11, doi. 10.1111/j.1364-3703.2007.00437.x

By:

ASSELBERGH, BOB;
ACHUO, ANDREW ENOW;
HÖFTE, MONICA;
VAN GIJSEGEM, FRÉDÉRIQUE

Publication type:

Article

Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00831-2

By:

Perneel, Jolien;
Lastra Osua, Miranda;
Alidadiani, Sara;
Peeters, Nele;
De Witte, Linus;
Heeman, Bavo;
Manzella, Simona;
De Rycke, Riet;
Brooks, Mieu;
Perkerson, Ralph B.;
Calus, Elke;
De Coster, Wouter;
Neumann, Manuela;
Mackenzie, Ian R. A.;
Van Dam, Debby;
Asselbergh, Bob;
Ellender, Tommas;
Zhou, Xiaolai;
Rademakers, Rosa

Publication type:

Article

Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.

Published in:

Molecular Neurodegeneration, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13024-024-00725-9

By:

Vandermeulen, Lina;
Geric, Ivana;
Fumagalli, Laura;
Kreir, Mohamed;
Lu, Ashley;
Nonneman, Annelies;
Premereur, Jessie;
Wolfs, Leen;
Policarpo, Rafaela;
Fattorelli, Nicola;
De Bondt, An;
Van Den Wyngaert, Ilse;
Asselbergh, Bob;
Fiers, Mark;
De Strooper, Bart;
d'Ydewalle, Constantin;
Mancuso, Renzo

Publication type:

Article

Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1A.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 7, p. 2885, doi. 10.1093/brain/awac475

By:

Lent, Jonas Van;
Vendredy, Leen;
Adriaenssens, Elias;
Authier, Tatiana Da Silva;
Asselbergh, Bob;
Kaji, Marcus;
Weckhuysen, Sarah;
Bosch, Ludo Van Den;
Baets, Jonathan;
Timmerman, Vincent

Publication type:

Article

Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunction.

Published in:

2021

By:

Lent, Jonas Van;
Verstraelen, Peter;
Asselbergh, Bob;
Adriaenssens, Elias;
Mateiu, Ligia;
Verbist, Christophe;
Winter, Vicky De;
Eggermont, Kristel;
Bosch, Ludo Van Den;
Vos, Winnok H De;
Timmerman, Vincent;
Van Lent, Jonas;
De Winter, Vicky;
Van Den Bosch, Ludo;
De Vos, Winnok H

Publication type:

journal article

Nonsense mutations in alpha-II spectrin in three families with juvenile onset hereditary motor neuropathy.

Published in:

2019

By:

Beijer, Danique;
Deconinck, Tine;
Bleecker, Jan L De;
Dotti, Maria Teresa;
Malandrini, Alessandro;
Urtizberea, J Andoni;
Zulaica, Miren;
Munain, Adolfo López de;
Asselbergh, Bob;
Jonghe, Peter De;
Baets, Jonathan;
De Bleecker, Jan L;
López de Munain, Adolfo;
De Jonghe, Peter

Publication type:

journal article

Loss-of-function mutations in the ATP13A2/PARK9 gene cause complicated hereditary spastic paraplegia (SPG78).

Published in:

2017

By:

Estrada-Cuzcano, Alejandro;
Martin, Shaun;
Chamova, Teodora;
Synofzik, Matthis;
Timmann, Dagmar;
Holemans, Tine;
Andreeva, Albena;
Reichbauer, Jennifer;
De Rycke, Riet;
Dae-In Chang;
van Veen, Sarah;
Samuel, Jean;
Schöls, Ludger;
Pöppel, Thorsten;
Mollerup Sørensen, Danny;
Asselbergh, Bob;
Klein, Christine;
Zuchner, Stephan;
Jordanova, Albena;
Vangheluwe, Peter

Publication type:

journal article

Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia.

Published in:

2015

By:

Hardies, Katia;
de Kovel, Carolien G. F.;
Weckhuysen, Sarah;
Asselbergh, Bob;
Geuens, Thomas;
Deconinck, Tine;
Azmi, Abdelkrim;
May, Patrick;
Brilstra, Eva;
Becker, Felicitas;
Barisic, Nina;
Craiu, Dana;
Braun, Kees P. J.;
Lal, Dennis;
Thiele, Holger;
Schubert, Julian;
Weber, Yvonne;
van 't Slot, Ruben;
Nürnberg, Peter;
Balling, Rudi

Publication type:

journal article

BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-65664-z

By:

Adriaenssens, Elias;
Tedesco, Barbara;
Mediani, Laura;
Asselbergh, Bob;
Crippa, Valeria;
Antoniani, Francesco;
Carra, Serena;
Poletti, Angelo;
Timmerman, Vincent

Publication type:

Article

HSPB1 Facilitates the Formation of Non-Centrosomal Microtubules.

Published in:

PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0066541

By:

Almeida-Souza, Leonardo;
Asselbergh, Bob;
De Winter, Vicky;
Goethals, Sofie;
Timmerman, Vincent;
Janssens, Sophie

Publication type:

Article

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation.

Published in:

Cell Research, 2011, v. 21, n. 2, p. 290, doi. 10.1038/cr.2010.150

By:

Remijsen, Quinten;
Berghe, Tom Vanden;
Wirawan, Ellen;
Asselbergh, Bob;
Parthoens, Eef;
De Rycke, Riet;
Noppen, Sam;
Delforge, Michel;
Willems, Jean;
Vandenabeele, Peter

Publication type:

Article

Diffusion kurtosis imaging to detect amyloidosis in an APP/PS1 mouse model for Alzheimer's disease.

Published in:

Magnetic Resonance in Medicine, 2013, v. 69, n. 4, p. 1115, doi. 10.1002/mrm.24680

By:

Vanhoutte, Greetje;
Pereson, Sandra;
Delgado y Palacios, Rafael;
Guns, Pieter‐Jan;
Asselbergh, Bob;
Veraart, Jelle;
Sijbers, Jan;
Verhoye, Marleen;
Broeckhoven, Christine;
Linden, Annemie

Publication type:

Article

Contribution of rare homozygous and compound heterozygous VPS13C missense mutations to dementia with Lewy bodies and Parkinson's disease.

Published in:

Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01121-w

By:

Smolders, Stefanie;
Philtjens, Stéphanie;
Crosiers, David;
Sieben, Anne;
Hens, Elisabeth;
Heeman, Bavo;
Van Mossevelde, Sara;
Pals, Philippe;
Asselbergh, Bob;
Dos Santos Dias, Roberto;
Vermeiren, Yannick;
Vandenberghe, Rik;
Engelborghs, Sebastiaan;
De Deyn, Peter Paul;
Martin, Jean-Jacques;
Cras, Patrick;
Annaert, Wim;
Van Broeckhoven, Christine;
BELNEU consortium;
van der Linden, Chris

Publication type:

Article

Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I.

Published in:

Human Mutation, 2011, v. 32, n. 6, p. E2211, doi. 10.1002/humu.21481

By:

Rotthier, Annelies;
Penno, Anke;
Rautenstrauss, Bernd;
Auer-Grumbach, Michaela;
Stettner, Georg M.;
Asselbergh, Bob;
Van Hoof, Kim;
Sticht, Heinrich;
Lévy, Nicolas;
Timmerman, Vincent;
Hornemann, Thorsten;
Janssens, Katrien

Publication type:

Article

Sensory neuropathy-causing mutations in ATL3 affect ER–mitochondria contact sites and impair axonal mitochondrial distribution.

Published in:

Human Molecular Genetics, 2019, v. 28, n. 4, p. 615, doi. 10.1093/hmg/ddy352

By:

Krols, Michiel;
Asselbergh, Bob;
Rycke, Riet De;
Winter, Vicky De;
Seyer, Alexandre;
Müller, Franz-Josef;
Kurth, Ingo;
Bultynck, Geert;
Timmerman, Vincent;
Janssens, Sophie

Publication type:

Article

Mutant HSPB8 causes motor neuron-specific neurite degeneration.

Published in:

Human Molecular Genetics, 2010, v. 19, n. 16, p. 3254, doi. 10.1093/hmg/ddq234

By:

Irobi, Joy;
Almeida-Souza, Leonardo;
Asselbergh, Bob;
De Winter, Vicky;
Goethals, Sofie;
Dierick, Ines;
Krishnan, Jyothsna;
Timmermans, Jean-Pierre;
Robberecht, Wim;
De Jonghe, Peter;
Van Den Bosch, Ludo;
Janssens, Sophie;
Timmerman, Vincent

Publication type:

Article

Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12909-9

By:

Bervoets, Sven;
Wei, Na;
Erfurth, Maria-Luise;
Yusein-Myashkova, Shazie;
Ermanoska, Biljana;
Mateiu, Ligia;
Asselbergh, Bob;
Blocquel, David;
Kakad, Priyanka;
Penserga, Tyrone;
Thomas, Florian P;
Guergueltcheva, Velina;
Tournev, Ivailo;
Godenschwege, Tanja;
Jordanova, Albena;
Yang, Xiang-Lei

Publication type:

Article