Works matching AU Assaraf, Yehuda G.

Results: 59

Association of altered folylpolyglutamate synthetase pre-mRNA splicing with methotrexate unresponsiveness in early rheumatoid arthritis.

Published in:

Rheumatology, 2021, v. 60, n. 3, p. 1273, doi. 10.1093/rheumatology/keaa428

By:

Muller, Ittai B;
Lin, Marry;
Lems, Willem F;
Wee, Marieke M ter;
Wojtuszkiewicz, Anna;
Nurmohamed, Michael T;
Cloos, Jacqueline;
Assaraf, Yehuda G;
Jansen, Gerrit;
Jonge, Robert de

Publication type:

Article

The role of the zinc transporter SLC30A2/ZnT2 in transient neonatal zinc deficiency.

Published in:

Metallomics, 2017, v. 9, n. 10, p. 1352, doi. 10.1039/c7mt00162b

By:

Golan, Yarden;
Kambe, Taiho;
Assaraf, Yehuda G.

Publication type:

Article

Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia.

Published in:

Journal of Hematology & Oncology, 2015, v. 8, n. 1, p. 1, doi. 10.1186/s13045-015-0158-9

By:

Wojtuszkiewicz, Anna;
Peters, Godefridus J.;
van Woerden, Nicole L.;
Dubbelman, Boas;
Escherich, Gabriele;
Schmiegelow, Kjeld;
Sonneveld, Edwin;
Pieters, Rob;
de Ven, Peter M. van;
Jansen, Gerrit;
Assaraf, Yehuda G.;
Kaspers, Gertjan J. L.;
Cloos, Jacqueline

Publication type:

Article

Interferon-gamma-induced upregulation of immunoproteasome subunit assembly overcomes bortezomib resistance in human hematological cell lines.

Published in:

Journal of Hematology & Oncology, 2014, v. 7, n. 1, p. 1, doi. 10.1186/1756-8722-7-7

By:

Niewerth, Denise;
Kaspers, Gertjan J. L.;
Assaraf, Yehuda G.;
van Meerloo, Johan;
Kirk, Christopher J.;
Anderl, Janet;
Blank, Jonathan L.;
Van de Ven, Peter M.;
Zweegman, Sonja;
Jansen, Gerrit;
Cloos, Jacqueline

Publication type:

Article

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds.

Published in:

2020

By:

Li Petri, Giovanna;
El Hassouni, Btissame;
Sciarrillo, Rocco;
Funel, Niccola;
Mantini, Giulia;
Zeeuw van der Laan, Eveline A.;
Cascioferro, Stella;
Avan, Amir;
Zucali, Paolo Andrea;
Zaffaroni, Nadia;
Lagerweij, Tonny;
Parrino, Barbara;
Smid, Kees;
Deraco, Marcello;
Granchi, Carlotta;
Braczko, Alicja;
Smolenski, Ryszard T.;
Matherly, Larry H.;
Jansen, Gerrit;
Assaraf, Yehuda G.

Publication type:

journal article

A transcriptomic examination of encased rotifer embryos reveals the developmental trajectory leading to long-term dormancy; are they "animal seeds"?

Published in:

BMC Genomics, 2024, v. 25, n. 1, p. 1, doi. 10.1186/s12864-024-09961-1

By:

Hashimshony, Tamar;
Levin, Liron;
Fröbius, Andreas C.;
Dahan, Nitsan;
Chalifa-Caspi, Vered;
Hamo, Reini;
Gabai-Almog, Oshri;
Blais, Idit;
Assaraf, Yehuda G.;
Lubzens, Esther

Publication type:

Article

Protein-coated corrole nanoparticles for the treatment of prostate cancer cells.

Published in:

Cell Death Discovery, 2020, v. 6, n. 1, p. 1, doi. 10.1038/s41420-020-0288-x

By:

Soll, Matan;
Chen, Qiu-Cheng;
Zhitomirsky, Benny;
Lim, Punnajit P.;
Termini, John;
Gray, Harry B.;
Assaraf, Yehuda G.;
Gross, Zeev

Publication type:

Article

The Lysosomotropic Activity of Hydrophobic Weak Base Drugs is Mediated via Their Intercalation into the Lysosomal Membrane.

Published in:

Cells (2073-4409), 2020, v. 9, n. 5, p. 1082, doi. 10.3390/cells9051082

By:

Stark, Michal;
Silva, Tomás F. D.;
Levin, Guy;
Machuqueiro, Miguel;
Assaraf, Yehuda G.

Publication type:

Article

Selective Targeting and Eradication of Various Human Non-Small Cell Lung Cancer Cell Lines Using Self-Assembled Aptamer-Decorated Nanoparticles.

Published in:

Pharmaceutics, 2022, v. 14, n. 8, p. 1650, doi. 10.3390/pharmaceutics14081650

By:

Barak, Daniel;
Engelberg, Shira;
Assaraf, Yehuda G.;
Livney, Yoav D.

Publication type:

Article

Novel Selectively Targeted Multifunctional Nanostructured Lipid Carriers for Prostate Cancer Treatment.

Published in:

Pharmaceutics, 2022, v. 14, n. 1, p. 88, doi. 10.3390/pharmaceutics14010088

By:

Cohen, Lital;
Assaraf, Yehuda G.;
Livney, Yoav D.

Publication type:

Article

Developing Body-Components-Based Theranostic Nanoparticles for Targeting Ovarian Cancer.

Published in:

Pharmaceutics, 2019, v. 11, n. 5, p. 216, doi. 10.3390/pharmaceutics11050216

By:

Edelman, Ravit;
Assaraf, Yehuda G.;
Slavkin, Anton;
Dolev, Tamar;
Shahar, Tal;
Livney, Yoav D.

Publication type:

Article

Optical and Magnetic Properties of Conjugate Structures of PbSe Quantum Dots and γ-Fe<sub>2</sub>O<sub>3</sub> Nanoparticles.

Published in:

ChemPhysChem, 2009, v. 10, n. 13, p. 2235, doi. 10.1002/cphc.200900345

By:

Etgar, Lioz;
Leitus, Gregory;
Fradkin, Leonid;
Assaraf, Yehuda G.;
Tannenbaum, Rina;
Lifshitz, Efrat

Publication type:

Article

Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.

Published in:

2006

By:

Bram, Eran;
Ifergan, Ilan;
Shafran, Assaf;
Berman, Bluma;
Jansen, Gerrit;
Assaraf, Yehuda;
Assaraf, Yehuda G

Publication type:

journal article

High proportion of transient neonatal zinc deficiency causing alleles in the general population.

Published in:

Journal of Cellular & Molecular Medicine, 2019, v. 23, n. 2, p. 828, doi. 10.1111/jcmm.13982

By:

Golan, Yarden;
Lehvy, Adrian;
Horev, Guy;
Assaraf, Yehuda G.

Publication type:

Article

LysoTracker and MitoTracker Red are transport substrates of P‐glycoprotein: implications for anticancer drug design evading multidrug resistance.

Published in:

Journal of Cellular & Molecular Medicine, 2018, v. 22, n. 4, p. 2131, doi. 10.1111/jcmm.13485

By:

Zhitomirsky, Benny;
Farber, Hodaya;
Assaraf, Yehuda G.

Publication type:

Article

Methotrexate Provokes Disparate Folate Metabolism Gene Expression and Alternative Splicing in Ex Vivo Monocytes and GM-CSF- and M-CSF-Polarized Macrophages.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9641, doi. 10.3390/ijms24119641

By:

Muller, Ittai B.;
Lin, Marry;
Jonge, Robert de;
Will, Nico;
López-Navarro, Baltasar;
Laken, Conny van der;
Struys, Eduard A.;
Oudejans, Cees B. M.;
Assaraf, Yehuda G.;
Cloos, Jacqueline;
Puig-Kröger, Amaya;
Jansen, Gerrit

Publication type:

Article

Targeted Nanoparticles Harboring Jasmine-Oil-Entrapped Paclitaxel for Elimination of Lung Cancer Cells.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 3, p. 1019, doi. 10.3390/ijms22031019

By:

Engelberg, Shira;
Lin, Yuexi;
Assaraf, Yehuda G.;
Livney, Yoav D.

Publication type:

Article

DAPK enhances DDX20 protein stability via suppression of TRIM25-mediated ubiquitination-based DDX20 degradation.

Published in:

Cancer Cell International, 2024, v. 24, n. 1, p. 1, doi. 10.1186/s12935-024-03567-z

By:

Ye, Yan;
Zhang, Xiuli;
Wang, Chenyi;
Huang, Yide;
Xu, Luyun;
Liu, Hongxia;
Li, Ke;
Liu, Nannan;
Wang, Qingshui;
Zhang, Tao;
Assaraf, Yehuda G.;
Lin, Yao

Publication type:

Article

Integration of transcription regulation and functional genomic data reveals lncRNA SNHG6's role in hematopoietic differentiation and leukemia.

Published in:

Journal of Biomedical Science, 2024, v. 31, n. 1, p. 1, doi. 10.1186/s12929-024-01015-8

By:

Hazan, Joshua M.;
Amador, Raziel;
Ali-Nasser, Tahleel;
Lahav, Tamar;
Shotan, Stav Roni;
Steinberg, Miryam;
Cohen, Ziv;
Aran, Dvir;
Meiri, David;
Assaraf, Yehuda G.;
Guigó, Roderic;
Bester, Assaf C.

Publication type:

Article

Beta-casein Nanoparticles as an Oral Delivery System for Chemotherapeutic Drugs: Impact of Drug Structure and Properties on Co-assembly.

Published in:

Pharmaceutical Research, 2010, v. 27, n. 10, p. 2175, doi. 10.1007/s11095-010-0222-7

By:

Shapira, Alina;
Assaraf, Yehuda G.;
Epstein, Dikla;
Livney, Yoav D.

Publication type:

Article

Modulation of DAPK1 expression by its alternative splice variant DAPK1-215 in cancer.

Published in:

Journal of Translational Medicine, 2025, v. 23, n. 1, p. 1, doi. 10.1186/s12967-025-06127-9

By:

Wang, QingShui;
Weng, ShuYun;
Zhong, WenTing;
Lin, YouYu;
Yu, Yan;
Huang, YiMin;
Ge, LiLin;
Zhang, XiuLi;
Xue, FangQin;
Assaraf, Yehuda G.;
Lin, Yao

Publication type:

Article

Folylpolyglutamate synthetase mRNA G-quadruplexes regulate its cell protrusion localization and enhance a cancer cell invasive phenotype upon folate repletion.

Published in:

BMC Biology, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12915-023-01525-1

By:

Stark, Michal;
Levin, May;
Ulitsky, Igor;
Assaraf, Yehuda G.

Publication type:

Article

Exploring Phytochemicals for Combating Antibiotic Resistance in Microbial Pathogens.

Published in:

Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.720726

By:

Khare, Tushar;
Anand, Uttpal;
Dey, Abhijit;
Assaraf, Yehuda G.;
Chen, Zhe-Sheng;
Liu, Zhijun;
Kumar, Vinay

Publication type:

Article

The role of the LncRNA XIST/miR-15a-5p/MN1 signaling axis in gender disparities in bladder cancer prognosis.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1554829

By:

Cai, Fangzhen;
Xu, Siwei;
Li, Yinan;
He, Qingliu;
Su, Qingfu;
Chen, Heyi;
Liu, Weihui;
Chen, Jiabi;
Wang, Qingshui;
Assaraf, Yehuda G.;
Lin, Yao;
Zhuang, Wei

Publication type:

Article

Probing ATP-dependent conformational changes in the multidrug resistance protein 1 (MRP1/ABCC1) in live tumor cells with a novel recombinant single-chain Fv antibody targeted to the extracellular N-terminus.

Published in:

International Journal of Cancer, 2005, v. 116, n. 5, p. 703, doi. 10.1002/ijc.21124

By:

Binyamin, Liat;
Assaraf, Yehuda G.;
Reiter, Yoram

Publication type:

Article

Targeting an extracellular epitope of the human multidrug resistance protein 1 (MRP1) in malignant cells with a novel recombinant single chain Fv antibody.

Published in:

International Journal of Cancer, 2004, v. 110, n. 6, p. 882, doi. 10.1002/ijc.20177

By:

Binyamin, Liat;
Assaraf, Yehuda G.;
Haus-Cohen, Maya;
Stark, Michal;
Reiter, Yoram

Publication type:

Article

Disruption of P-glycoprotein anticancer drug efflux activity by a small recombinant single-chain Fv antibody fragment targeted to an extracellular epitope.

Published in:

International Journal of Cancer, 2004, v. 109, n. 5, p. 750, doi. 10.1002/ijc.20037

By:

Haus-Cohen, Maya;
Assaraf, Yehuda G.;
Binyamin, Liat;
Benhar, Itai;
Reiter, Yoram

Publication type:

Article

Loss of folylpoly-γ-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.

Published in:

International Journal of Cancer, 2003, v. 103, n. 5, p. 587, doi. 10.1002/ijc.10829

By:

Liani, Esti;
Rothem, Lilah;
Bunni, Marlene A.;
Smith, Clyde A.;
Jansen, Gerrit;
Assaraf, Yehuda G.

Publication type:

Article

Targeting multidrug resistant tumor cells with a recombinant single-chain FV fragment directed to P-glycoprotein.

Published in:

International Journal of Cancer, 2001, v. 94, n. 6, p. 864, doi. 10.1002/ijc.1552

By:

Niv, Revital;
Assaraf, Yehuda G.;
Segal, Dina;
Pirak, Esther;
Reiter, Yoram

Publication type:

Article

Harnessing Gene Expression Profiles for the Identification of Ex Vivo Drug Response Genes in Pediatric Acute Myeloid Leukemia.

Published in:

Cancers, 2020, v. 12, n. 5, p. 1247, doi. 10.3390/cancers12051247

By:

Cucchi, David G.J.;
Bachas, Costa;
van den Heuvel-Eibrink, Marry M.;
Arentsen-Peters, Susan T.C.J.M.;
Kwidama, Zinia J.;
Schuurhuis, Gerrit J.;
Assaraf, Yehuda G.;
de Haas, Valérie;
Kaspers, Gertjan J.L.;
Cloos, Jacqueline

Publication type:

Article

Clinical Implementation of Rare and Novel DPYD Variants for Personalizing Fluoropyrimidine Treatment: Challenges and Opportunities.

Published in:

International Journal of Biological Sciences, 2024, v. 21, n. 10, p. 3742, doi. 10.7150/ijbs.97686

By:

De Mattia, Elena;
Milan, Noemi;
Assaraf, Yehuda G.;
Toffoli, Giuseppe;
Cecchin, Erika

Publication type:

Article

Exploring Splicing Modulation as an Innovative Approach to Combat Pancreatic Cancer: SF3B1 Emerges as a Prognostic Indicator and Therapeutic Target.

Published in:

International Journal of Biological Sciences, 2024, v. 20, n. 9, p. 3173, doi. 10.7150/ijbs.92671

By:

Sciarrillo, Rocco;
Terrana, Francesca;
Comandatore, Annalisa;
Supadmanaba, I. Gede Putu;
Bing Wang;
El Hassouni, Btissame;
Mantini, Giulia;
Jansen, Gerrit;
Avan, Amir;
Carbone, Daniela;
Diana, Patrizia;
Peters, Godefridus J.;
Morelli, Luca;
Cloos, Jacqueline;
Assaraf, Yehuda G.;
Giovannetti, Elisa

Publication type:

Article

Nanoenabled intracellular zinc bursting for efficacious reversal of gefitinib resistance in lung cancer.

Published in:

International Journal of Biological Sciences, 2024, v. 20, n. 9, p. 3028, doi. 10.7150/ijbs.95929

By:

Junnan Li;
Assaraf, Yehuda G.;
Weimin Zuo;
Ziqi Lin;
Ka Weng Leong;
Qi Zhao;
Lipeng Zhu;
Hang Fai Kwok

Publication type:

Article

Exploring Splicing Modulation as an Innovative Approach to Combat Pancreatic Cancer: SF3B1 Emerges as a Prognostic Indicator and Therapeutic Target.

Published in:

International Journal of Biological Sciences, 2024, v. 20, n. 8, p. 3173, doi. 10.7150/ijbs.92671

By:

Sciarrillo, Rocco;
Terrana, Francesca;
Comandatore, Annalisa;
Supadmanaba, I. Gede Putu;
Wang, Bing;
El Hassouni, Btissame;
Mantini, Giulia;
Jansen, Gerrit;
Avan, Amir;
Carbone, Daniela;
Diana, Patrizia;
Peters, Godefridus J.;
Morelli, Luca;
Cloos, Jacqueline;
Assaraf, Yehuda G.;
Giovannetti, Elisa

Publication type:

Article

Nanoenabled intracellular zinc bursting for efficacious reversal of gefitinib resistance in lung cancer.

Published in:

International Journal of Biological Sciences, 2024, v. 20, n. 8, p. 3028, doi. 10.7150/ijbs.95929

By:

Junnan Li;
Assaraf, Yehuda G.;
Weimin Zuo;
Ziqi Lin;
Ka Weng Leong;
Qi Zhao;
Lipeng Zhu;
Hang Fai Kwok

Publication type:

Article

Proteasome inhibition and mechanism of resistance to a synthetic, library-based hexapeptide.

Published in:

Investigational New Drugs, 2018, v. 36, n. 5, p. 797, doi. 10.1007/s10637-018-0569-x

By:

Oerlemans, Ruud;
Berkers, Celia R.;
Assaraf, Yehuda G.;
Scheffer, George L.;
Peters, Godefridus J.;
Verbrugge, Sue Ellen;
Cloos, Jacqueline;
Slootstra, Jerry;
Meloen, Rob H.;
Shoemaker, Robert H.;
Dijkmans, Ben A. C.;
Scheper, Rik J.;
Ovaa, Huib;
Jansen, Gerrit

Publication type:

Article

Cross-Resistance to the Lipid-Soluble Antifolate Trimetrexate in Human Carcinoma Cells With the Multidrug-Resistant Phenotype.

Published in:

JNCI: Journal of the National Cancer Institute, 1989, v. 81, n. 4, p. 290, doi. 10.1093/jnci/81.4.290

By:

Assaraf, Yehuda G.;
Molina, Arturo;
Schimke, Robert T.

Publication type:

Article

Folylpolyglutamate synthetase splicing alterations in acute lymphoblastic leukemia are provoked by methotrexate and other chemotherapeutics and mediate chemoresistance.

Published in:

International Journal of Cancer, 2016, v. 138, n. 7, p. 1645, doi. 10.1002/ijc.29919

By:

Wojtuszkiewicz, Anna;
Raz, Shachar;
Stark, Michal;
Assaraf, Yehuda G.;
Jansen, Gerrit;
Peters, Godefridus J.;
Sonneveld, Edwin;
Kaspers, Gertjan J. L.;
Cloos, Jacqueline

Publication type:

Article

Genetic and Physiological Factors Affecting Human Milk Production and Composition.

Published in:

Nutrients, 2020, v. 12, n. 5, p. 1500, doi. 10.3390/nu12051500

By:

Golan, Yarden;
Assaraf, Yehuda G.

Publication type:

Article

Endothelial Progenitor Cells Promote Osteosarcoma Progression and Invasiveness via AKT/PI3K Signaling.

Published in:

Cancers, 2023, v. 15, n. 6, p. 1818, doi. 10.3390/cancers15061818

By:

Doppelt-Flikshtain, Ofri;
Younis, Amin;
Tamari, Tal;
Ginesin, Ofir;
Shentzer-Kutiel, Talia;
Nikomarov, David;
Bar-Sela, Gil;
Coyac, Benjamin R.;
Assaraf, Yehuda G.;
Zigdon-Giladi, Hadar

Publication type:

Article

Host-defense peptide mimicry for novel antitumor agents.

Published in:

FASEB Journal, 2009, v. 23, n. 12, p. 4299, doi. 10.1096/fj.09-136358

By:

Held-Kuznetsov, Viktoria;
Rotem, Shahar;
Assaraf, Yehuda G.;
Mor, Amram

Publication type:

Article

Correction: Demonstrating aspects of multiscale modeling by studying the permeation pathway of the human ZnT2 zinc transporter.

Published in:

2019

By:

Golan, Yarden;
Alhadeff, Raphael;
Glaser, Fabian;
Ganoth, Assaf;
Warshel, Arieh;
Assaraf, Yehuda G.

Publication type:

Correction Notice

ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion.

Published in:

PLoS Computational Biology, 2019, v. 15, n. 3, p. 1, doi. 10.1371/journal.pcbi.1006882

By:

Golan, Yarden;
Alhadeff, Raphael;
Warshel, Arieh;
Assaraf, Yehuda G.

Publication type:

Article

Demonstrating aspects of multiscale modeling by studying the permeation pathway of the human ZnT2 zinc transporter.

Published in:

PLoS Computational Biology, 2018, v. 14, n. 11, p. 1, doi. 10.1371/journal.pcbi.1006503

By:

Golan, Yarden;
Alhadeff, Raphael;
Glaser, Fabian;
Ganoth, Assaf;
Warshel, Arieh;
Assaraf, Yehuda G.

Publication type:

Article

Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp).

Published in:

Medicinal Research Reviews, 2021, v. 41, n. 1, p. 525, doi. 10.1002/med.21739

By:

Zhang, Hang;
Xu, Haiwei;
Ashby, Charles R.;
Assaraf, Yehuda G.;
Chen, Zhe‐Sheng;
Liu, Hong‐Min

Publication type:

Article

The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity.

Published in:

Frontiers in Pharmacology, 2024, p. 01, doi. 10.3389/fphar.2024.1450418

By:

Peters, Godefridus J.;
Kathmann, Ietje;
Giovannetti, Elisa;
Smid, Kees;
Assaraf, Yehuda G.;
Jansen, Gerrit

Publication type:

Article

Overcoming Multidrug Resistance via Photodestruction of ABCG2-Rich Extracellular Vesicles Sequestering Photosensitive Chemotherapeutics.

Published in:

PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035487

By:

Goler-Baron, Vicky;
Assaraf, Yehuda G.

Publication type:

Article

Structure and Function of ABCG2-Rich Extracellular Vesicles Mediating Multidrug Resistance.

Published in:

PLoS ONE, 2011, v. 6, n. 1, p. 1, doi. 10.1371/journal.pone.0016007

By:

Goler-Baron, Vicky;
Assaraf, Yehuda G.

Publication type:

Article

Peptides for microbe-induced cancers: latest therapeutic strategies and their advanced technologies.

Published in:

Cancer & Metastasis Reviews, 2024, v. 43, n. 4, p. 1315, doi. 10.1007/s10555-024-10197-4

By:

Lin, Ziqi;
Assaraf, Yehuda G.;
Kwok, Hang Fai

Publication type:

Article

Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications.

Published in:

Molecules, 2017, v. 22, n. 7, p. 1030, doi. 10.3390/molecules22071030

By:

Vismara, Elena;
Bongio, Chiara;
Coletti, Alessia;
Edelman, Ravit;
Serafini, Andrea;
Mauri, Michele;
Simonutti, Roberto;
Bertini, Sabrina;
Urso, Elena;
Assaraf, Yehuda G.;
Livney, Yoav D.

Publication type:

Article