Works by Arkin, Michelle R.

Results: 33

14‐3‐3 Protein‐Protein Interactions: From Mechanistic Understanding to Their Small‐Molecule Stabilization.

Published in:

ChemBioChem, 2024, v. 25, n. 14, p. 1, doi. 10.1002/cbic.202400214

By:

Somsen, Bente A.;
Cossar, Peter J.;
Arkin, Michelle R.;
Brunsveld, Luc;
Ottmann, Christian

Publication type:

Article

Deep phenotypic profiling of neuroactive drugs in larval zebrafish.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-54375-y

By:

Gendelev, Leo;
Taylor, Jack;
Myers-Turnbull, Douglas;
Chen, Steven;
McCarroll, Matthew N.;
Arkin, Michelle R.;
Kokel, David;
Keiser, Michael J.

Publication type:

Article

D13 caspase‐6‐cleaved tau, a new biomarker to complement Alzheimer's disease diagnosis.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S8, p. 1, doi. 10.1002/alz.095421

By:

Rizzi, Liara;
Rojas, Julio C.;
Ambrose, Andrew J.;
Balthazar, Marcio Luiz Figueredo;
Arkin, Michelle R.;
Grinberg, Lea T.

Publication type:

Article

Truncated tau accumulates before hyperphosphorylated tau and in relatively distinct neuronal subpopulations in entorhinal cortex and inferior temporal gyrus in Alzheimer's disease patients.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.093137

By:

Oh, Ian Michael;
Li, Song Hua;
Pereira, Felipe Luiz;
Kaur, Prabhleen;
Raju, Anya;
Jerfy, Rushil;
Suemoto, Claudia Kimie;
Leite, Renata Elaine Paraizo;
Paes, Vitor Ribeiro;
Rodriguez, Roberta Diehl;
Ambrose, Andrew J.;
Spina, Salvatore;
Seeley, William W.;
Miller, Bruce L.;
Arkin, Michelle R.;
Grinberg, Lea T.

Publication type:

Article

From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking.

Published in:

Angewandte Chemie, 2023, v. 135, n. 37, p. 1, doi. 10.1002/ange.202308004

By:

Visser, Emira J.;
Jaishankar, Priyadarshini;
Sijbesma, Eline;
Pennings, Marloes A. M.;
Vandenboorn, Edmee M. F.;
Guillory, Xavier;
Neitz, R. Jeffrey;
Morrow, John;
Dutta, Shubhankar;
Renslo, Adam R.;
Brunsveld, Luc;
Arkin, Michelle R.;
Ottmann, Christian

Publication type:

Article

A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery.

Published in:

Communications Biology, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42003-020-01402-5

By:

Chen, Steven;
Suzuki, Brian M.;
Dohrmann, Jakob;
Singh, Rahul;
Arkin, Michelle R.;
Caffrey, Conor R.

Publication type:

Article

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 7, p. 1, doi. 10.1371/journal.pntd.0001736

By:

Gunatilleke, Shamila S.;
Calvet, Claudia M.;
Johnston, Jonathan B.;
Chen, Chiung-Kuang;
Erenburg, Grigori;
Gut, Jiri;
Engel, Juan C.;
Ang, Kenny K. H.;
Mulvaney, Joseph;
Chen, Steven;
Arkin, Michelle R.;
McKerrow, James H.;
Podust, Larissa M.

Publication type:

Article

Diverse Inhibitor Chemotypes Targeting Trypanosoma cruzi CYP51.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 7, p. 1, doi. 10.1371/journal.pntd.0001736

By:

Gunatilleke, Shamila S.;
Calvet, Claudia M.;
Johnston, Jonathan B.;
Chen, Chiung-Kuang;
Erenburg, Grigori;
Gut, Jiri;
Engel, Juan C.;
Ang, Kenny K. H.;
Mulvaney, Joseph;
Chen, Steven;
Arkin, Michelle R.;
McKerrow, James H.;
Podust, Larissa M.

Publication type:

Article

Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening.

Published in:

PLoS ONE, 2019, v. 14, n. 12, p. 1, doi. 10.1371/journal.pone.0226270

By:

Sanchez, Mateo I.;
de Vries, Laura E.;
Lehmann, Christine;
Lee, Jeong T.;
Ang, Kenny K.;
Wilson, Christopher;
Chen, Steven;
Arkin, Michelle R.;
Bogyo, Matthew;
Deu, Edgar

Publication type:

Article

SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.

Published in:

Cancer Chemotherapy & Pharmacology, 2009, v. 64, n. 4, p. 723, doi. 10.1007/s00280-008-0921-5

By:

Conroy, Andrew;
Stockett, David E.;
Walker, Duncan;
Arkin, Michelle R.;
Hoch, Ute;
Fox, Judith A.;
Hawtin, Rachael Elizabeth

Publication type:

Article

A zebrafish screen reveals Reninangiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.69795

By:

Kim, Gha- Hyun J.;
Han Mo;
Liu, Harrison;
Zhihao Wu;
Chen, Steven;
Jiashun Zheng;
Xiang Zhao;
Nucum, Daryl;
Shortland, James;
Longping Peng;
Elepano, Mannuel;
Tang, Benjamin;
Olson, Steven;
Paras, Nick;
Hao Li;
Renslo, Adam R.;
Arkin, Michelle R.;
Bo Huang;
Bingwei Lu;
Sirota, Marina

Publication type:

Article

From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 37, p. 1, doi. 10.1002/anie.202308004

By:

Visser, Emira J.;
Jaishankar, Priyadarshini;
Sijbesma, Eline;
Pennings, Marloes A. M.;
Vandenboorn, Edmee M. F.;
Guillory, Xavier;
Neitz, R. Jeffrey;
Morrow, John;
Dutta, Shubhankar;
Renslo, Adam R.;
Brunsveld, Luc;
Arkin, Michelle R.;
Ottmann, Christian

Publication type:

Article

Synthetic autophagy receptor.

Published in:

Autophagy, 2024, v. 20, n. 3, p. 701, doi. 10.1080/15548627.2023.2278954

By:

Jiang, Ziwen;
Kuo, Yu-Hsuan;
Arkin, Michelle R.

Publication type:

Article

Tackling reproducibility in academic preclinical drug discovery.

Published in:

2015

By:

Frye, Stephen V.;
Arkin, Michelle R.;
Arrowsmith, Cheryl H.;
Conn, P. Jeffrey;
Glicksman, Marcie A.;
Hull-Ryde, Emily A.;
Slusher, Barbara S.

Publication type:

journal article

Caspase‐6‐cleaved tau is relevant in Alzheimer's disease and marginal in four‐repeat tauopathies: Diagnostic and therapeutic implications.

Published in:

Neuropathology & Applied Neurobiology, 2022, v. 48, n. 5, p. 1, doi. 10.1111/nan.12819

By:

Theofilas, Panos;
Piergies, Antonia M. H.;
Oh, Ian;
Lee, Yoo Bin;
Li, Song Hua;
Pereira, Felipe L.;
Petersen, Cathrine;
Ehrenberg, Alexander J.;
Eser, Rana A.;
Ambrose, Andrew J.;
Chin, Brian;
Yang, Teddy;
Khan, Shireen;
Ng, Raymond;
Spina, Salvatore;
Seeley, Willian W.;
Miller, Bruce L.;
Arkin, Michelle R.;
Grinberg, Lea T.

Publication type:

Article

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit.

Published in:

PLoS Neglected Tropical Diseases, 2011, v. 5, n. 7, p. 1, doi. 10.1371/journal.pntd.0001253

By:

De Muylder, Geraldine;
Ang, Kenny K. H.;
Chen, Steven;
Arkin, Michelle R.;
Engel, Juan C.;
McKerrow, James H.

Publication type:

Article

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit.

Published in:

PLoS Neglected Tropical Diseases, 2011, v. 5, n. 7, p. 1, doi. 10.1371/journal.pntd.0001253

By:

De Muylder, Geraldine;
Ang, Kenny K. H.;
Chen, Steven;
Arkin, Michelle R.;
Engel, Juan C.;
McKerrow, James H.

Publication type:

Article

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads.

Published in:

PLoS Neglected Tropical Diseases, 2011, v. 5, n. 5, p. 1, doi. 10.1371/journal.pntd.0001023

By:

Ang, Kenny K. H.;
Ratnam, Joseline;
Gut, Jiri;
Legac, Jennifer;
Hansell, Elizabeth;
Mackey, Zachary B.;
Skrzypczynska, Katarzyna M.;
Debnath, Anjan;
Engel, Juan C.;
Rosenthal, Philip J.;
McKerrow, James H.;
Arkin, Michelle R.;
Renslo, Adam R.

Publication type:

Article

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads.

Published in:

PLoS Neglected Tropical Diseases, 2011, v. 5, n. 5, p. 1, doi. 10.1371/journal.pntd.0001023

By:

Ang, Kenny K. H.;
Ratnam, Joseline;
Gut, Jiri;
Legac, Jennifer;
Hansell, Elizabeth;
Mackey, Zachary B.;
Skrzypczynska, Katarzyna M.;
Debnath, Anjan;
Engel, Juan C.;
Rosenthal, Philip J.;
McKerrow, James H.;
Arkin, Michelle R.;
Renslo, Adam R.

Publication type:

Article

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.

Published in:

PLoS Pathogens, 2015, v. 11, n. 7, p. 1, doi. 10.1371/journal.ppat.1005058

By:

Khare, Shilpi;
Roach, Steven L.;
Barnes, S. Whitney;
Hoepfner, Dominic;
Walker, John R.;
Chatterjee, Arnab K.;
Neitz, R. Jeffrey;
Arkin, Michelle R.;
McNamara, Case W.;
Ballard, Jaime;
Lai, Yin;
Fu, Yue;
Molteni, Valentina;
Yeh, Vince;
McKerrow, James H.;
Glynne, Richard J.;
Supek, Frantisek

Publication type:

Article

Tailoring Small Molecules for an Allosteric Site on Procaspase-6.

Published in:

ChemMedChem, 2014, v. 9, n. 1, p. 73, doi. 10.1002/cmdc.201300424

By:

Murray, Jeremy;
Giannetti, Anthony M.;
Steffek, Micah;
Gibbons, Paul;
Hearn, Brian R.;
Cohen, Frederick;
Tam, Christine;
Pozniak, Christine;
Bravo, Brandon;
Lewcock, Joe;
Jaishankar, Priyadarshini;
Ly, Cuong Q.;
Zhao, Xianrui;
Tang, Yinyan;
Chugha, Preeti;
Arkin, Michelle R.;
Flygare, John;
Renslo, Adam R.

Publication type:

Article

Inside Cover: Tailoring Small Molecules for an Allosteric Site on Procaspase-6 (ChemMedChem 1/2014).

Published in:

ChemMedChem, 2014, v. 9, n. 1, p. 2, doi. 10.1002/cmdc.201390058

By:

Murray, Jeremy;
Giannetti, Anthony M.;
Steffek, Micah;
Gibbons, Paul;
Hearn, Brian R.;
Cohen, Frederick;
Tam, Christine;
Pozniak, Christine;
Bravo, Brandon;
Lewcock, Joe;
Jaishankar, Priyadarshini;
Ly, Cuong Q.;
Zhao, Xianrui;
Tang, Yinyan;
Chugha, Preeti;
Arkin, Michelle R.;
Flygare, John;
Renslo, Adam R.

Publication type:

Article

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target.

Published in:

Nature Medicine, 2012, v. 18, n. 6, p. 956, doi. 10.1038/nm.2758

By:

Debnath, Anjan;
Parsonage, Derek;
Andrade, Rosa M;
He, Chen;
Cobo, Eduardo R;
Hirata, Ken;
Chen, Steven;
García-Rivera, Guillermina;
Orozco, Esther;
Martínez, Máximo B;
Gunatilleke, Shamila S;
Barrios, Amy M;
Arkin, Michelle R;
Poole, Leslie B;
McKerrow, James H;
Reed, Sharon L

Publication type:

Article

Tethering in RNA: An RNA-Binding Fragment Discovery Tool.

Published in:

Molecules, 2015, v. 20, n. 3, p. 4148, doi. 10.3390/molecules20034148

By:

Tran, Kiet;
Arkin, Michelle R.;
Beal, Peter A.

Publication type:

Article

Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.

Published in:

Biochemical Journal, 2015, v. 465, n. 1, p. 149, doi. 10.1042/BJ20140793

By:

Visperas, Patrick R.;
Winger, Jonathan A.;
Horton, Timothy M.;
Shah, Neel H.;
Aum, Diane J.;
Tao, Alyssa;
Barros, Tiago;
Yan, Qingrong;
Wilson, Christopher G.;
Arkin, Michelle R.;
Weiss, Arthur;
Kuriyan, John

Publication type:

Article

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.

Published in:

Nature Reviews Drug Discovery, 2004, v. 3, n. 4, p. 301, doi. 10.1038/nrd1343

By:

Arkin, Michelle R.;
Wells, James A.

Publication type:

Article

Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II

Published in:

PLoS ONE, 2010, v. 5, n. 4, p. 1, doi. 10.1371/journal.pone.0010186

By:

Hawtin, Rachael E.;
Stockett, David E.;
Byl, Jo Ann W.;
McDowell, Robert S.;
Nguyen Tan;
Arkin, Michelle R.;
Conroy, Andrew;
Wenjin Yang;
Osheroff, Neil;
Fox, Judith A.

Publication type:

Article

An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease.

Published in:

Pathogens, 2021, v. 10, n. 1, p. 71, doi. 10.3390/pathogens10010071

By:

Tyagi, Rahul;
Bulman, Christina A.;
Cho-Ngwa, Fidelis;
Fischer, Chelsea;
Marcellino, Chris;
Arkin, Michelle R.;
McKerrow, James H.;
McNamara, Case W.;
Mahoney, Matthew;
Tricoche, Nancy;
Jawahar, Shabnam;
Janetka, James W.;
Lustigman, Sara;
Sakanari, Judy;
Mitreva, Makedonka

Publication type:

Article

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.11878

By:

Gallagher, Ciara M.;
Garri, Carolina;
Cain, Erica L.;
Kenny Kean-Hooi Ang;
Wilson, Christopher G.;
Chen, Steven;
Hearn, Brian R.;
Jaishankar, Priyadarshini;
Aranda-Diaz, Andres;
Arkin, Michelle R.;
Renslo, Adam R.;
Walter, Peter

Publication type:

Article

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver.

Published in:

eLife, 2015, p. 1, doi. 10.7554/eLife.09003.001

By:

Suzawa, Miyuki;
Miranda, Diego A.;
Ramos, Karmela A.;
Ang, Kenny K.-H.;
Faivre, Emily J.;
Wilson, Christopher G.;
Caboni, Laura;
Arkin, Michelle R.;
Yeong-Sang Kim;
Fletterick, Robert J.;
Diaz, Aaron;
Schneekloth Jr., John S.;
Ingraham, Holly A.

Publication type:

Article

Caspase‐6‐cleaved tau is relevant in Alzheimer's disease but not in 4‐repeat tauopathies: Diagnostic and therapeutic implications.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.052719

By:

Piergies, Antonia M. H.;
Theofilas, Panos;
Li, Song;
Petersen, Cathrine;
Ehrenberg, Alexander J.;
Eser, Rana April;
Chin, Brian;
Yang, Teddy;
Khan, Shireen;
Ng, Raymond;
Spina, Salvatore;
Seeley, William W.;
Miller, Bruce L.;
Arkin, Michelle R.;
Grinberg, Lea T.

Publication type:

Article

Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC‐induced neurons with the V337M MAPT mutation.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.051471

By:

Theofilas, Panos;
Ambrose, Andrew J.;
Butler, David;
Wang, Chao;
Morales, Dulce O.;
Petersen, Cathrine;
Chin, Brian;
Yang, Teddy;
Khan, Shireen;
Ng, Raymond;
Kayed, Rakez;
Karch, Celeste M.;
Miller, Bruce L.;
Gestwicki, Jason E.;
Gan, Li;
Temple, Sally;
Arkin, Michelle R.;
Grinberg, Lea T.

Publication type:

Article

Novel Cruzain Inhibitors for the Treatment of Chagas' Disease.

Published in:

Chemical Biology & Drug Design, 2012, v. 80, n. 3, p. 398, doi. 10.1111/j.1747-0285.2012.01416.x

By:

Rogers, Kathleen E;
Keränen, Henrik;
Durrant, Jacob D.;
Ratnam, Joseline;
Doak, Allison;
Arkin, Michelle R.;
McCammon, J. Andrew

Publication type:

Article