Works by Araki, Wataru

Results: 35

A case with burning mouth syndrome followed by dementia with Lewy bodies: a case report.

Published in:

Frontiers in Psychiatry, 2024, p. 1, doi. 10.3389/fpsyt.2023.1329171

By:

Motoko Watanabe;
Wataru Araki;
Chihiro Takao;
Chizuko Maeda;
Risa Tominaga;
Yasuyuki Kimura;
Gayatri Nayanar;
Trang Thi Huyen Tu;
Takashi Asada;
Akira Toyofuku

Publication type:

Article

Aβ Oligomer Toxicity-Reducing Therapy for the Prevention of Alzheimer's Disease: Importance of the Nrf2 and PPARγ Pathways.

Published in:

Cells (2073-4409), 2023, v. 12, n. 10, p. 1386, doi. 10.3390/cells12101386

By:

Araki, Wataru

Publication type:

Article

Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain.

Published in:

Journal of Nanobiotechnology, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12951-023-01772-y

By:

Amano, Akiko;
Sanjo, Nobuo;
Araki, Wataru;
Anraku, Yasutaka;
Nakakido, Makoto;
Matsubara, Etsuro;
Tomiyama, Takami;
Nagata, Tetsuya;
Tsumoto, Kouhei;
Kataoka, Kazunori;
Yokota, Takanori

Publication type:

Article

An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid β-protein.

Published in:

FEBS Journal, 2009, v. 276, n. 20, p. 5832, doi. 10.1111/j.1742-4658.2009.07264.x

By:

Maeda, Tomoji;
Marutani, Toshihiro;
Kun Zou;
Araki, Wataru;
Tanabe, Chiaki;
Yagishita, Naoko;
Yamano, Yoshihisa;
Amano, Tetsuya;
Michikawa, Makoto;
Nakajima, Toshihiro;
Komano, Hiroto

Publication type:

Article

Homocysteic acid induces intraneuronal accumulation of neurotoxic Aβ42: Implications for the pathogenesis of Alzheimer's disease.

Published in:

Journal of Neuroscience Research, 2005, v. 80, n. 6, p. 869, doi. 10.1002/jnr.20514

By:

Tohru Hasegawa;
Wataru Ukai;
Dong‐Gyu Jo;
Xiangru Xu;
Mark P. Mattson;
Masaya Nakagawa;
Wataru Araki;
Toshikazu Saito;
Tatsuo Yamada

Publication type:

Article

Statins Reduce Amyloid β-Peptide Production by Modulating Amyloid Precursor Protein Maturation and Phosphorylation Through a Cholesterol-Independent Mechanism in Cultured Neurons.

Published in:

Neurochemical Research, 2013, v. 38, n. 3, p. 589, doi. 10.1007/s11064-012-0956-1

By:

Hosaka, Ai;
Araki, Wataru;
Oda, Akiko;
Tomidokoro, Yasushi;
Tamaoka, Akira

Publication type:

Article

Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10+11-splice site in the tau gene.

Published in:

2001

By:

Miyamoto, Katsuichi;
Kowalska, Anna;
Hasegawa, Masato;
Tabira, Takeshi;
Takahashi, Keikichi;
Araki, Wataru;
Akiguchi, Ichiro;
Ikemoto, Akito;
Miyamoto, K;
Kowalska, A;
Hasegawa, M;
Tabira, T;
Takahashi, K;
Araki, W;
Akiguchi, I;
Ikemoto, A

Publication type:

journal article

The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model.

Published in:

Molecular Brain, 2017, v. 10, p. 1, doi. 10.1186/s13041-016-0284-5

By:

Daisuke Tanokashira;
Naomi Mamada;
Fumiko Yamamoto;
Kaori Taniguchi;
Akira Tamaoka;
Lakshmana, Madepalli K.;
Wataru Araki

Publication type:

Article

Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1.

Published in:

Journal of Biochemistry, 2021, v. 170, n. 6, p. 729, doi. 10.1093/jb/mvab094

By:

Komaki, Keisuke;
Takano, Tetsuya;
Sato, Yutaka;
Asada, Akiko;
Ikeda, Shikito;
Yamada, Kaoru;
Wei, Ran;
Huo, Anni;
Fukuchi, Aoi;
Saito, Taro;
Ando, Kanae;
Murayama, Shigeo;
Araki, Wataru;
Kametani, Fuyuki;
Hasegawa, Masato;
Iwatsubo, Takeshi;
Tomomura, Mineko;
Fukuda, Mitsunori;
Hisanaga, Shin-ichi

Publication type:

Article

MEK inhibitors suppress β-amyloid production by altering the level of a β-C-terminal fragment of amyloid precursor protein in neuronal cells

Published in:

FEBS Letters, 2010, v. 584, n. 15, p. 3410, doi. 10.1016/j.febslet.2010.06.038

By:

Araki, Wataru;
Kametani, Fuyuki;
Oda, Akiko;
Tamaoka, Akira

Publication type:

Article

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

Published in:

Nature Medicine, 1999, v. 5, n. 5, p. 560, doi. 10.1038/8438

By:

Chui, De-Hua;
Tanahashi, Hiroshi;
Ozawa, Kazuharu;
Ikeda, Sachiya;
Checler, Frédéric;
Ueda, Otoya;
Suzuki, Hiroshi;
Araki, Wataru;
Inoue, Haruhisa;
Shirotani, Keiro;
Takahashi, Keikichi;
Gallyas, Ferenc;
Tabira, Takeshi

Publication type:

Article

How is membrane phospholipid biosynthesis controlled in neural tissues?

Published in:

Journal of Neuroscience Research, 1998, v. 51, n. 6, p. 667, doi. 10.1002/(SICI)1097-4547(19980315)51:6<667::AID-JNR1>3.0.CO;2-9

By:

Araki, Wataru;
Wurtman, Richard J.

Publication type:

Article

Potential value of soluble APPα and APPβ in CSF as biomarkers of dementia disorders: Unresolved issues and perspectives.

Published in:

Neurology & Clinical Neuroscience, 2018, v. 6, n. 4, p. 89, doi. 10.1111/ncn3.12195

By:

Araki, Wataru;
Araki, Yumiko M.;
Mizusawa, Hidehiro

Publication type:

Article

Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis.

Published in:

FASEB Journal, 2012, v. 26, n. 7, p. 3065, doi. 10.1096/fj.11-198630

By:

Mutoh, Tatsuro;
Kawamura, Naoki;
Hirabayashi, Yoshio;
Shima, Sayuri;
Miyashita, Tadayuki;
Ito, Shinji;
Asakura, Kunihiko;
Araki, Wataru;
Cazzaniga, Emanuela;
Muto, Eri;
Masserini, Massimo

Publication type:

Article

A family of membrane proteins associated with presenilin expression and γ-secretase function.

Published in:

FASEB Journal, 2008, v. 22, n. 3, p. 819, doi. 10.1096/fj.07-9072com

By:

Araki, Wataru;
Takahashi-Sasaki, Noriko;
De-Hua Chui;
Shinya Saito;
Takeda, Kazuya;
Shirotani, Keiro;
Takahashi, Keikichi;
Murayama, Kiyoko S.;
Kametani, Fuyuki;
Shiraishi, Hirohisa;
Komano, Hiroto;
Tabira, Takeshi

Publication type:

Article

Amyloid beta peptide binds a novel death-inducing protein, AB-DIP.

Published in:

FASEB Journal, 2005, v. 19, n. 10, p. 1362, doi. 10.1096/fj.05-3672fje

By:

Lakshmana, Madepalli K.;
Araki, Wataru;
Tabira, Takeshi

Publication type:

Article

Amino-truncated amyloid β-peptide (Aβ5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.

Published in:

FASEB Journal, 2004, v. 18, n. 14, p. 1755, doi. 10.1096/fj.03-1070fje

By:

Takeda, Kazuya;
Araki, Wataru;
Akiyama, Haruhiko;
Tabira, Takeshi

Publication type:

Article

Glypican-1 as an Aβ binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.

Published in:

FASEB Journal, 2004, v. 18, n. 9, p. 1013, doi. 10.1096/fj.03-1040fje

By:

Watanabe, Norifumi;
Araki, Wataru;
De-Hua Chui;
Takao Makifuchi;
Yasuo Ihara;
Takeshi Tabira

Publication type:

Article

Autoreactive-Aβ antibodies promote APP β-secretase processing.

Published in:

Journal of Neurochemistry, 2012, v. 120, n. 5, p. 732, doi. 10.1111/j.1471-4159.2011.07629.x

By:

Deng, Juan;
Hou, Huayan;
Giunta, Brian;
Mori, Takashi;
Wang, Yan-Jiang;
Fernandez, Frank;
Weggen, Sascha;
Araki, Wataru;
Obregon, Demian;
Tan, Jun

Publication type:

Article

Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif.

Published in:

Journal of Molecular Neuroscience, 2006, v. 29, n. 1, p. 35, doi. 10.1385/JMN:29:1:35

By:

Araki, Wataru;
Saito, Shinya;
Takahashi-Sasaki, Noriko;
Shiraishi, Hirohisa;
Komano, Hiroto;
Murayama, Kiyoko

Publication type:

Article

Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders.

Published in:

Biomarker Research, 2017, v. 5, p. 1, doi. 10.1186/s40364-017-0108-5

By:

Wataru Araki;
Kotaro Hattori;
Kazutomi Kanemaru;
Yuma Yokoi;
Yoshie Omachi;
Harumasa Takano;
Masuhiro Sakata;
Sumiko Yoshida;
Tadashi Tsukamoto;
Miho Murata;
Yuko Saito;
Hiroshi Kunugi;
Yu-ichi Goto;
Utako Nagaoka;
Masahiro Nagao;
Takashi Komori;
Kunimasa Arima;
Kenji Ishii;
Shigeo Murayama;
Hiroshi Matsuda

Publication type:

Article

Reconstitution of γ-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of γ-secretase complex.

Published in:

Genes to Cells, 2006, v. 11, n. 1, p. 83, doi. 10.1111/j.1365-2443.2005.00914.x

By:

Shiraishi, Hirohisa;
Marutani, Toshihiro;
Hua-Qin Wang;
Maeda, Yasuhiro;
Kurono, Yukihisa;
Takashima, Akihiko;
Araki, Wataru;
Nishimura, Masaki;
Yanagisawa, Katsuhiko;
Komano, Hiroto

Publication type:

Article

Chronic Cladribine Administration Increases Amyloid Beta Peptide Generation and Plaque Burden in Mice.

Published in:

PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0045841

By:

Hayes, Crystal D.;
Dey, Debleena;
Palavicini, Juan Pablo;
Hongjie Wang;
Araki, Wataru;
Lakshmana, Madepalli K.

Publication type:

Article

Disease-Associated Mutations of TDP-43 Promote Turnover of the Protein Through the Proteasomal Pathway.

Published in:

Molecular Neurobiology, 2014, v. 50, n. 3, p. 1049, doi. 10.1007/s12035-014-8644-6

By:

Araki, Wataru;
Minegishi, Seiji;
Motoki, Kazumi;
Kume, Hideaki;
Hohjoh, Hirohiko;
Araki, Yumiko;
Tamaoka, Akira

Publication type:

Article

Reduction of beta-amyloid accumulation by reticulon 3 in transgenic mice

Published in:

2011

By:

Araki, Wataru;
Oda, Akiko;
Motoki, Kazumi;
Hattori, Kotaro;
Itoh, Masayuki;
Yuasa, Shigeki;
Konishi, Yoshihiro;
Shin, Ryong-Woon;
Tamaoka, Akira;
Ogino, Koichi

Publication type:

Abstract

P3-320: Molecular mechanisms by which reticulon 3 regulates β-secretase BACE1

Published in:

2008

By:

Araki, Wataru;
Kume, Hideaki;
Murayama, Kiyoko S.;
Kametani, Fuyuki;
Konishi, Yoshihiro

Publication type:

Abstract

O4-06-07: Involvement of the prostaglandin E2 receptors, EP2 and EP4, in the production of amyloid-β peptides both in vitro and in vivo

Published in:

2008

By:

Hoshino, Tatsuya;
Nakaya, Tadashi;
Sugimoto, Yukihiko;
Araki, Wataru;
Narumiya, Shuh;
Suzuki, Toshiharu;
Mizushima, Tohru

Publication type:

Abstract

O2-03-08: Regulation of BACE1 function by Nogo-B/C and reticulon 3

Published in:

2006

By:

Araki, Wataru;
Murayama, Kiyoko S.;
Saito, Shinya;
Kume, Hideaki;
Akiyama, Haruhiko;
Kametani, Fuyuki

Publication type:

Abstract

O2-03-08: Regulation of BACE1 function by Nogo-B/C and reticulon 3

Published in:

2006

By:

Araki, Wataru;
Murayama, Kiyoko S.;
Saito, Shinya;
Kume, Hideaki;
Akiyama, Haruhiko;
Kametani, Fuyuki

Publication type:

Abstract

Potential repurposing of oncology drugs for the treatment of Alzheimer's disease.

Published in:

BMC Medicine, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1741-7015-11-82

By:

Araki, Wataru

Publication type:

Article

Potential repurposing of oncology drugs for the treatment of Alzheimer's disease.

Published in:

BMC Medicine, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1741-7015-11-82

By:

Araki, Wataru

Publication type:

Article

Potential repurposing of oncology drugs for the treatment of Alzheimer's disease.

Published in:

2013

By:

Araki, Wataru

Publication type:

Editorial

Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons.

Published in:

Molecular Brain, 2015, v. 8, p. 1, doi. 10.1186/s13041-015-0163-5

By:

Naomi Mamada;
Daisuke Tanokashira;
Ai Hosaka;
Fuyuki Kametani;
Akira Tamaoka;
Wataru Araki

Publication type:

Article

Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid β-protein.

Published in:

European Journal of Neuroscience, 2006, v. 24, n. 5, p. 1237, doi. 10.1111/j.1460-9568.2006.05005.x

By:

Murayama, Kiyoko S.;
Kametani, Fuyuki;
Saito, Shinya;
Kume, Hideaki;
Akiyama, Haruhiko;
Araki, Wataru

Publication type:

Article

Enhanced generation of intracellular Aβ42 amyloid peptide by mutation of presenilins PS1 and PS2.

Published in:

European Journal of Neuroscience, 2004, v. 19, n. 2, p. 258, doi. 10.1111/j.0953-816X.2003.03135.x

By:

Takeda, Kazuya;
Araki, Wataru;
Tabira, Takeshi

Publication type:

Article

Works by Araki, Wataru

A case with burning mouth syndrome followed by dementia with Lewy bodies: a case report.

Aβ Oligomer Toxicity-Reducing Therapy for the Prevention of Alzheimer's Disease: Importance of the Nrf2 and PPARγ Pathways.

Peripheral administration of nanomicelle-encapsulated anti-Aβ oligomer fragment antibody reduces various toxic Aβ species in the brain.

An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid β-protein.

Homocysteic acid induces intraneuronal accumulation of neurotoxic Aβ42: Implications for the pathogenesis of Alzheimer's disease.

Statins Reduce Amyloid β-Peptide Production by Modulating Amyloid Precursor Protein Maturation and Phosphorylation Through a Cholesterol-Independent Mechanism in Cultured Neurons.

Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10+11-splice site in the tau gene.

The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model.

Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1.

MEK inhibitors suppress β-amyloid production by altering the level of a β-C-terminal fragment of amyloid precursor protein in neuronal cells

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

How is membrane phospholipid biosynthesis controlled in neural tissues?

Potential value of soluble APP<sub>α</sub> and APP<sub>β</sub> in CSF as biomarkers of dementia disorders: Unresolved issues and perspectives.

Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis.

A family of membrane proteins associated with presenilin expression and γ-secretase function.

Amyloid beta peptide binds a novel death-inducing protein, AB-DIP.

Amino-truncated amyloid β-peptide (Aβ5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.

Glypican-1 as an Aβ binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.

Autoreactive-Aβ antibodies promote APP β-secretase processing.

Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif.

Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders.

Reconstitution of γ-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of γ-secretase complex.

Chronic Cladribine Administration Increases Amyloid Beta Peptide Generation and Plaque Burden in Mice.

Disease-Associated Mutations of TDP-43 Promote Turnover of the Protein Through the Proteasomal Pathway.

Reduction of beta-amyloid accumulation by reticulon 3 in transgenic mice

P3-320: Molecular mechanisms by which reticulon 3 regulates β-secretase BACE1

O4-06-07: Involvement of the prostaglandin E<sub>2</sub> receptors, EP<sub>2</sub> and EP<sub>4</sub>, in the production of amyloid-β peptides both in vitro and in vivo

O2-03-08: Regulation of BACE1 function by Nogo-B/C and reticulon 3

O2-03-08: Regulation of BACE1 function by Nogo-B/C and reticulon 3

Potential repurposing of oncology drugs for the treatment of Alzheimer's disease.

Potential repurposing of oncology drugs for the treatment of Alzheimer's disease.

Potential repurposing of oncology drugs for the treatment of Alzheimer's disease.

Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons.

Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid β-protein.

Enhanced generation of intracellular Aβ42 amyloid peptide by mutation of presenilins PS1 and PS2.