Works by Appendino, Giovanni

Results: 85

An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery?

Published in:

Angewandte Chemie, 2011, v. 123, n. 2, p. 487, doi. 10.1002/ange.201005959

By:

Avonto, Cristina;
Taglialatela-Scafati, Orazio;
Pollastro, Federica;
Minassi, Alberto;
Di Marzo, Vincenzo;
De Petrocellis, Luciano;
Appendino, Giovanni

Publication type:

Article

Selective analysis of phenolic compounds in propolis by HPLC-MS/MS.

Published in:

Phytochemical Analysis, 2008, v. 19, n. 1, p. 32, doi. 10.1002/pca.1010

By:

Medana, Claudio;
Carbone, Francesco;
Aigotti, Riccardo;
Appendino, Giovanni;
Baiocchi, Claudio

Publication type:

Article

HPLC-UV and HPLC-positive-ESI-MS analysis of the diterpenoid fraction from caper spurge ( Euphorbia lathyris) seed oil.

Published in:

Phytochemical Analysis, 2001, v. 12, n. 4, p. 255, doi. 10.1002/pca.592

By:

Bicchi, Carlo;
Appendino, Giovanni;
Cordero, Chiara;
Rubiolo, Patrizia;
Ortelli, Didier;
Veuthey, Jean-Luc

Publication type:

Article

PP059 EBC-1013 INDUCES AN ACUTE INFLAMMATORY RESPONSE IN SKIN RELEVANT CELL TYPES, PROMOTING INNATE IMMUNE CELL RECRUITMENT AND SUBSEQUENT CLOSURE OF CHRONIC, INFECTED WOUNDS.

Published in:

Journal of Wound Management, 2023, v. 24, n. 2, p. 519

By:

Cullen, Jason;
Boyle, Glen;
Pei-Yi Yap;
Pierce, Carly;
Johns, Jenny;
Pagani, Alberto;
Appendino, Giovanni;
Gordon, Victoria;
Reddell, Paul;
Parsons, Peter

Publication type:

Article

OP050 EBC-1013 INDUCES AN ACUTE INFLAMMATORY RESPONSE IN SKIN RELEVANT CELL TYPES, PROMOTING INNATE IMMUNE CELL RECRUITMENT AND SUBSEQUENT CLOSURE OF CHRONIC, INFECTED WOUNDS.

Published in:

Journal of Wound Management, 2023, v. 24, n. 2, p. 411

By:

Cullen, Jason;
Boyle, Glen;
Pei-Yi Yap;
Pierce, Carly;
Johns, Jenny;
Pagani, Alberto;
Appendino, Giovanni;
Gordon, Victoria;
Reddell, Paul;
Parsons, Peter

Publication type:

Article

Block and allosteric modulation of GABAergic currents by oenanthotoxin in rat cultured hippocampal neurons.

Published in:

2010

By:

Wyrembek, Paulina;
Lebida, Katarzyna;
Mercik, Katarzyna;
Szczuraszek, Katarzyna;
Szczot, Marcin;
Pollastro, Federica;
Appendino, Giovanni;
Mozrzymas, Jerzy W

Publication type:

journal article

The CB1/VR1 agonist arvanil induces apoptosis through an FADD/caspase-8-dependent pathway.

Published in:

British Journal of Pharmacology, 2003, v. 140, n. 6, p. 1035, doi. 10.1038/sj.bjp.0705532

By:

Sancho, Rocio;
de la Vega, Laureano;
Appendino, Giovanni;
Di Marzo, Vincenzo;
Macho, Antonio;
Muñoz, Eduardo

Publication type:

Article

Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists.

Published in:

British Journal of Pharmacology, 2003, v. 139, n. 8, p. 1417, doi. 10.1038/sj.bjp.0705387

By:

Appendino, Giovanni;
Harrison, Selena;
De Petrocellis, Luciano;
Daddario, Nives;
Bianchi, Federica;
Moriello, Aniello Schiano;
Trevisani, Marcello;
Benvenuti, Francesca;
Geppetti, Pierangelo;
Di Marzo, Vincenzo

Publication type:

Article

Cannabidiol (CBD) From Non-Cannabis Plants: Myth or Reality?

Published in:

Natural Product Communications, 2022, v. 17, n. 5, p. 1, doi. 10.1177/1934578X221098843

By:

Appendino, Giovanni;
Taglialatela-Scafati, Orazio;
Muñoz, Eduardo

Publication type:

Article

Structurally Diverse Diterpenoids from the Sanya Bay Nudibranch Hexabranchus sanguineus and Its Sponge‐Prey Chelonaplysilla sp.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 21, p. 1, doi. 10.1002/chem.202203858

By:

Shen, Shou‐Mao;
Li, Song‐Wei;
Su, Ming‐Zhi;
Yao, Li‐Gong;
Appendino, Giovanni;
Guo, Yue‐Wei

Publication type:

Article

The Combined Effect of Branching and Elongation on the Bioactivity Profile of Phytocannabinoids. Part I: Thermo-TRPs.

Published in:

Biomedicines, 2021, v. 9, n. 8, p. 1070, doi. 10.3390/biomedicines9081070

By:

Mattoteia, Daiana;
Schiano Moriello, Aniello;
Taglialatela-Scafati, Orazio;
Amodeo, Pietro;
De Petrocellis, Luciano;
Appendino, Giovanni;
Vitale, Rosa Maria;
Caprioglio, Diego

Publication type:

Article

Helichrysum italicum: THE SLEEPING GIANT OF MEDITERRANEAN HERBAL MEDICINE.

Published in:

HerbalGram, 2015, n. 105, p. 34

By:

Appendino, Giovanni;
Minassi, Alberto;
Pollastro, Federica;
Taglialatela-Scafati, Orazio;
Ballero, Mauro;
Maxia, Andrea;
Sanna, Cinzia

Publication type:

Article

Herbs and Healers from the Ancient Mediterranean through the Medieval West: Essays in Honor of John M. Riddle.

Published in:

2013

By:

Appendino, Giovanni

Publication type:

Book Review

Pyrazole-Curcumin Suppresses Cardiomyocyte Hypertrophy by Disrupting the CDK9/CyclinT1 Complex.

Published in:

Pharmaceutics, 2022, v. 14, n. 6, p. 1269, doi. 10.3390/pharmaceutics14061269

By:

Funamoto, Masafumi;
Sunagawa, Yoichi;
Gempei, Mai;
Shimizu, Kana;
Katanasaka, Yasufumi;
Shimizu, Satoshi;
Hamabe-Horiike, Toshihide;
Appendino, Giovanni;
Minassi, Alberto;
Koeberle, Andreas;
Komiyama, Maki;
Mori, Kiyoshi;
Hasegawa, Koji;
Morimoto, Tatsuya

Publication type:

Article

Herbal Products in Italy: The Thin Line between Phytotherapy, Nutrition and Parapharmaceuticals; A Normative Overview of the Fastest Growing Market in Europe.

Published in:

Pharmaceuticals (14248247), 2016, v. 9, n. 4, p. 65, doi. 10.3390/ph9040065

By:

Biagi, Marco;
Pecorari, Rita;
Appendino, Giovanni;
Miraldi, Elisabetta;
Magnano, Anna Rosa;
Governa, Paolo;
Cettolin, Giulia;
Giachetti, Daniela

Publication type:

Article

Biological properties of jatrophane polyesters, new microtubule-interacting agents.

Published in:

Cancer Chemotherapy & Pharmacology, 2003, v. 51, n. 1, p. 67, doi. 10.1007/s00280-002-0541-4

By:

Miglietta, Antonella;
Gabriel, Ludovica;
Appendino, Giovanni;
Bocca, Claudia

Publication type:

Article

Comparative Evaluation of Anticancer Activity of Natural Methoxylated Flavones Xanthomicrol and Eupatilin in A375 Skin Melanoma Cells.

Published in:

Life (2075-1729), 2024, v. 14, n. 3, p. 304, doi. 10.3390/life14030304

By:

Rosa, Antonella;
Piras, Franca;
Pollastro, Federica;
Sogos, Valeria;
Appendino, Giovanni;
Nieddu, Mariella

Publication type:

Article

An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery?

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 2, p. 467, doi. 10.1002/anie.201005959

By:

Avonto, Cristina;
Taglialatela-Scafati, Orazio;
Pollastro, Federica;
Minassi, Alberto;
Di Marzo, Vincenzo;
De Petrocellis, Luciano;
Appendino, Giovanni

Publication type:

Article

The 1,2,3-Triazole Ring as a Peptido- and Olefinomimetic Element: Discovery of Click Vanilloids and Cannabinoids.

Published in:

Angewandte Chemie International Edition, 2007, v. 46, n. 48, p. 9312, doi. 10.1002/anie.200703590

By:

Appendino, Giovanni;
Bacchiega, Sara;
Minassi, Alberto;
Cascio, Maria Grazia;
De Petrocellis, Luciano;
Di Marzo, Vincenzo

Publication type:

Article

Δ9 -Tetrahydrocannabinolic acid alleviates collagen-induced arthritis: Role of PPARγ and CB1 receptors.

Published in:

2020

By:

Palomares, Belén;
Garrido‐Rodriguez, Martín;
Gonzalo‐Consuegra, Claudia;
Gómez‐Cañas, María;
Saen‐oon, Suwipa;
Soliva, Robert;
Collado, Juan A.;
Fernández‐Ruiz, Javier;
Morello, Gaetano;
Calzado, Marco A.;
Appendino, Giovanni;
Muñoz, Eduardo;
Garrido-Rodriguez, Martín;
Gonzalo-Consuegra, Claudia;
Gómez-Cañas, María;
Saen-Oon, Suwipa;
Fernández-Ruiz, Javier

Publication type:

journal article

VCE-004.3, a cannabidiol aminoquinone derivative, prevents bleomycin-induced skin fibrosis and inflammation through PPARγ- and CB2 receptor-dependent pathways.

Published in:

2018

By:

del Rio, Carmen;
Cantarero, Irene;
Palomares, Belén;
Gómez‐Cañas, María;
Fernández‐Ruiz, Javier;
Pavicic, Carolina;
García‐Martín, Adela;
Luz Bellido, Maria;
Ortega‐Castro, Rafaela;
Pérez‐Sánchez, Carlos;
López‐Pedrera, Chary;
Appendino, Giovanni;
Calzado, Marco A.;
Muñoz, Eduardo;
Gómez-Cañas, María;
Fernández-Ruiz, Javier;
García-Martín, Adela;
Ortega-Castro, Rafaela;
Pérez-Sánchez, Carlos;
López-Pedrera, Chary

Publication type:

journal article

Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.

Published in:

2017

By:

Nadal, Xavier;
Río, Carmen;
Casano, Salvatore;
Palomares, Belén;
Ferreiro‐Vera, Carlos;
Navarrete, Carmen;
Sánchez‐Carnerero, Carolina;
Cantarero, Irene;
Bellido, Maria Luz;
Meyer, Stefan;
Morello, Gaetano;
Appendino, Giovanni;
Muñoz, Eduardo;
Del Río, Carmen;
Palomares, Belén;
Ferreiro-Vera, Carlos;
Sánchez-Carnerero, Carolina;
Muñoz, Eduardo

Publication type:

journal article

The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel.

Published in:

2017

By:

Benemei, Silvia;
De Logu, Francesco;
Li Puma, Simone;
Marone, Ilaria Maddalena;
Coppi, Elisabetta;
Ugolini, Filippo;
Liedtke, Wolfgang;
Pollastro, Federica;
Appendino, Giovanni;
Geppetti, Pierangelo;
Materazzi, Serena;
Nassini, Romina

Publication type:

journal article

Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels.

Published in:

British Journal of Pharmacology, 2014, v. 171, n. 10, p. 2608, doi. 10.1111/bph.12320

By:

De Petrocellis, Luciano;
Schiano Moriello, Aniello;
Fontana, Gabriele;
Sacchetti, Alessandro;
Passarella, Daniele;
Appendino, Giovanni;
Di Marzo, Vincenzo

Publication type:

Article

Bioactive Phloroglucinyl Heterodimers: The Tautomeric and Rotameric Equlibria of Arzanol.

Published in:

European Journal of Organic Chemistry, 2016, v. 2016, n. 28, p. 4810, doi. 10.1002/ejoc.201600597

By:

Rastrelli, Federico;
Bagno, Alessandro;
Appendino, Giovanni;
Minassi, Alberto

Publication type:

Article

The Thia-Michael Reactivity of Zerumbone and Related Cross-Conjugated Dienones: Disentangling Stoichiometry, Regiochemistry, and Addition Mode with an NMR-Spectroscopy-Based Cysteamine Assay.

Published in:

European Journal of Organic Chemistry, 2015, v. 2015, n. 17, p. 3721, doi. 10.1002/ejoc.201500237

By:

Appendino, Giovanni;
Minassi, Alberto;
Collado, Juan A.;
Pollastro, Federica;
Chianese, Giuseppina;
Taglialatela‐Scafati, Orazio;
Ayyari, Mehdi;
Garcia, Victor;
Muñoz, Eduardo

Publication type:

Article

Sesquiterpenoids from Common Ragweed ( Ambrosia artemisiifolia L.), an Invasive Biological Polluter.

Published in:

European Journal of Organic Chemistry, 2012, v. 2012, n. 27, p. 5162, doi. 10.1002/ejoc.201200650

By:

Taglialatela-Scafati, Orazio;
Pollastro, Federica;
Minassi, Alberto;
Chianese, Giuseppina;
De Petrocellis, Luciano;
Di Marzo, Vincenzo;
Appendino, Giovanni

Publication type:

Article

A Multicomponent Carba-Betti Strategy to Alkylidene Heterodimers - Total Synthesis and Structure-Activity Relationships of Arzanol.

Published in:

European Journal of Organic Chemistry, 2012, v. 2012, n. 4, p. 772, doi. 10.1002/ejoc.201101193

By:

Minassi, Alberto;
Cicione, Lavinia;
Koeberle, Andreas;
Bauer, Julia;
Laufer, Stefan;
Werz, Oliver;
Appendino, Giovanni

Publication type:

Article

Pietro Biginelli: The Man Behind the Reaction.

Published in:

European Journal of Organic Chemistry, 2011, v. 2011, n. 28, p. 5541, doi. 10.1002/ejoc.201100661

By:

Tron, Gian Cesare;
Minassi, Alberto;
Appendino, Giovanni

Publication type:

Article

Receptor Agonism and Antagonism of Dietary Bitter Compounds.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 41, p. 14775, doi. 10.1523/JNEUROSCI.2923-11.2011

By:

Brockhoff, Anne;
Behrens, Maik;
Roudnitzky, Natacha;
Appendino, Giovanni;
Avonto, Cristina;
Meyerhof, Wolfgang

Publication type:

Article

Broccoli, PTEN deletion and prostate cancer: where is the link?

Published in:

Molecular Cancer, 2010, v. 9, p. 308, doi. 10.1186/1476-4598-9-308

By:

Appendino, Giovanni;
Bardelli, Alberto

Publication type:

Article

Synthesis and biological evaluation of hydroxamate isosteres of acidic cannabinoids.

Published in:

Frontiers in Natural Products, 2024, p. 1, doi. 10.3389/fntpr.2023.1190053

By:

Amin, Hawraz Ibrahim M.;
Ruiz-Pino, Francisco;
Collado, Juan A.;
Appendino, Giovanni;
Tena-Sempere, Manuel;
Munoz, Eduardo;
Caprioglio, Diego

Publication type:

Article

First “hybrid” ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands

Published in:

FEBS Letters, 2006, v. 580, n. 2, p. 568, doi. 10.1016/j.febslet.2005.12.069

By:

Appendino, Giovanni;
Cascio, Maria Grazia;
Bacchiega, Sara;
Moriello, Aniello Schiano;
Minassi, Alberto;
Thomas, Adèle;
Ross, Ruth;
Pertwee, Roger;
De Petrocellis, Luciano;
Di Marzo, Vincenzo

Publication type:

Article

The transient receptor potential channel TRPA1: from gene to pathophysiology.

Published in:

Pflügers Archiv: European Journal of Physiology, 2012, v. 464, n. 5, p. 425, doi. 10.1007/s00424-012-1158-z

By:

Nilius, Bernd;
Appendino, Giovanni;
Owsianik, Grzegorz

Publication type:

Article

Ligustilide: a novel TRPA1 modulator.

Published in:

Pflügers Archiv: European Journal of Physiology, 2011, v. 462, n. 6, p. 841, doi. 10.1007/s00424-011-1021-7

By:

Zhong, Jian;
Pollastro, Federica;
Prenen, Jean;
Zhu, Zhiming;
Appendino, Giovanni;
Nilius, Bernd

Publication type:

Article

Umbellulone modulates TRP channels.

Published in:

Pflügers Archiv: European Journal of Physiology, 2011, v. 462, n. 6, p. 861, doi. 10.1007/s00424-011-1043-1

By:

Zhong, Jian;
Minassi, Alberto;
Prenen, Jean;
Taglialatela-Scafati, Orazio;
Appendino, Giovanni;
Nilius, Bernd

Publication type:

Article

Protective effect of capsinoid on lipid peroxidation in rat tissues induced by Fe-NTA.

Published in:

Free Radical Research, 2005, v. 39, n. 11, p. 1155, doi. 10.1080/10715760500178094

By:

Rosa, Antonella;
Deiana, Monica;
Corona, Giulia;
Atzeri, Angela;
Incani, Alessandra;
Appendino, Giovanni;
DessÌ, M. Assunta

Publication type:

Article

Antioxidant Activity of Oligomeric Acylphloroglucinols from Myrtus communis L.

Published in:

Free Radical Research, 2003, v. 37, n. 9, p. 1013

By:

Rosa, Antonella;
Deiana, Monica;
Casu, Viviana;
Corona, Giulia;
Appendino, Giovanni;
Bianchi, Federica;
Ballero, Mauro;
Dessì, M. Assunta

Publication type:

Article

Involvement of Reactive Oxygen Species in Capsaicinoid-induced Apoptosis in Transformed Cells.

Published in:

Free Radical Research, 2003, v. 37, n. 6, p. 611, doi. 10.1080/1071576031000083215

By:

Macho, Antonio;
Sancho, Rocío;
Minassi, Alberto;
Appendino, Giovanni;
Lawen, Alfons;
Muñoz, Eduardo

Publication type:

Article

Non-Volatile Terpenoids and Lipophilic Flavonoids from Achillea erba-rotta Subsp. moschata (Wulfen) I. Richardson.

Published in:

Plants (2223-7747), 2023, v. 12, n. 2, p. 402, doi. 10.3390/plants12020402

By:

Salamone, Stefano;
Aiello, Nicola;
Fusani, Pietro;
Rosa, Antonella;
Nieddu, Mariella;
Appendino, Giovanni;
Pollastro, Federica

Publication type:

Article

VCE-004.8, A Multitarget Cannabinoquinone, Attenuates Adipogenesis and Prevents Diet-Induced Obesity.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-34259-0

By:

Palomares, Belen;
Ruiz-Pino, Francisco;
Navarrete, Carmen;
Velasco, Inmaculada;
Sánchez-Garrido, Miguel A.;
Jimenez-Jimenez, Carla;
Pavicic, Carolina;
Vazquez, Maria J.;
Appendino, Giovanni;
Bellido, M. Luz;
Calzado, Marco A.;
Tena-Sempere, Manuel;
Muñoz, Eduardo

Publication type:

Article

Minor Phytocannabinoids: A Misleading Name but a Promising Opportunity for Biomedical Research.

Published in:

Biomolecules (2218-273X), 2022, v. 12, n. 8, p. 1084, doi. 10.3390/biom12081084

By:

Caprioglio, Diego;
Amin, Hawraz Ibrahim M.;
Taglialatela-Scafati, Orazio;
Muñoz, Eduardo;
Appendino, Giovanni

Publication type:

Article

Cannabinoquinones: Synthesis and Biological Profile.

Published in:

Biomolecules (2218-273X), 2021, v. 11, n. 7, p. 991, doi. 10.3390/biom11070991

By:

Caprioglio, Diego;
Mattoteia, Daiana;
Taglialatela-Scafati, Orazio;
Muñoz, Eduardo;
Appendino, Giovanni

Publication type:

Article

One‐Pot Oxidative Heterofunctionalization of Resorcinolic Cannabinoids to Non‐thiophilic Aminocannabinoquinones.

Published in:

European Journal of Organic Chemistry, 2022, v. 2022, n. 6, p. 1, doi. 10.1002/ejoc.202101410

By:

Caprioglio, Diego;
Mattoteia, Daiana;
Muñoz, Eduardo;
Taglialatela‐Scafati, Orazio;
Appendino, Giovanni

Publication type:

Article

Front Cover: Regiodivergent Synthesis of ortho‐ and para‐Cannabinoquinones (Eur. J. Org. Chem. 48/2020).

Published in:

European Journal of Organic Chemistry, 2020, v. 2020, n. 48, p. 7396, doi. 10.1002/ejoc.202001396

By:

Mattoteia, Daiana;
Taglialatela‐Scafati, Orazio;
Muñoz, Eduardo;
de la Vega, Laureano;
Caprioglio, Diego;
Appendino, Giovanni

Publication type:

Article

Regiodivergent Synthesis of ortho‐ and para‐Cannabinoquinones.

Published in:

European Journal of Organic Chemistry, 2020, v. 2020, n. 48, p. 7429, doi. 10.1002/ejoc.202001258

By:

Mattoteia, Daiana;
Taglialatela‐Scafati, Orazio;
Muñoz, Eduardo;
de la Vega, Laureano;
Caprioglio, Diego;
Appendino, Giovanni

Publication type:

Article

A Single Oxidosqualene Cyclase Produces the Seco-Triterpenoid α-Onocerin.

Published in:

Plant Physiology, 2018, v. 176, n. 2, p. 1469, doi. 10.1104/pp.17.01369

By:

Almeida, Aldo;
Lemeng Dong;
Khakimov, Bekzod;
Bassard, Jean-Etienne;
Moses, Tessa;
Lota, Frederic;
Goossens, Alain;
Appendino, Giovanni;
Bak, Søren

Publication type:

Article

Carbonyl Activation in Electrophilic Polyene Cyclizations: A Toolbox for the Design of Isoprenoid Libraries.

Published in:

Angewandte Chemie, 2017, v. 129, n. 27, p. 8043, doi. 10.1002/ange.201703455

By:

Minassi, Alberto;
Pollastro, Federica;
Chianese, Giuseppina;
Caprioglio, Diego;
Taglialatela‐Scafati, Orazio;
Appendino, Giovanni

Publication type:

Article

Omnia praeclara rara. Die Ingenol-Forschung kommt in Fahrt.

Published in:

Angewandte Chemie, 2014, v. 126, n. 4, p. 943, doi. 10.1002/ange.201308281

By:

Appendino, Giovanni

Publication type:

Article

Non-pungent capsaicinoids from sweet pepper: Synthesis and evaluation of the chemopreventive and anticancer potential.

Published in:

European Journal of Nutrition, 2003, v. 42, n. 1, p. 2, doi. 10.1007/s00394-003-0394-6

By:

Macho, Antonio;
Lucena, Concepción;
Sancho, Rocio;
Daddario, Nives;
Minassi, Alberto;
Muñoz, Eduardo;
Appendino, Giovanni

Publication type:

Article