Works by Andersson, Tommy B.

Results: 27

Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range.

Published in:

European Journal of Clinical Pharmacology, 2022, v. 78, n. 8, p. 1289, doi. 10.1007/s00228-022-03336-9

By:

Eide Kvitne, Kine;
Hole, Kristine;
Krogstad, Veronica;
Wollmann, Birgit Malene;
Wegler, Christine;
Johnson, Line K.;
Hertel, Jens K.;
Artursson, Per;
Karlsson, Cecilia;
Andersson, Shalini;
Andersson, Tommy B.;
Sandbu, Rune;
Hjelmesæth, Jøran;
Skovlund, Eva;
Christensen, Hege;
Jansson-Löfmark, Rasmus;
Åsberg, Anders;
Molden, Espen;
Robertsen, Ida

Publication type:

Article

Identification of human cytochrome P<sub>450</sub>s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data.

Published in:

European Journal of Clinical Pharmacology, 2003, v. 59, n. 5/6, p. 429, doi. 10.1007/s00228-003-0636-9

By:

Xue-Qing Li;
Björkman, Anders;
Andersson, Tommy B.;
Gustafsson, Lars L.;
Masimirembwa, Collen M.

Publication type:

Article

Cytochrome P<sub>450</sub> 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells.

Published in:

European Journal of Clinical Pharmacology, 2002, v. 58, n. 8, p. 537, doi. 10.1007/s00228-002-0512-z

By:

Bapiro, Tashinga E.;
Andersson, Tommy B.;
Otter, Charlotta;
Hasler, Julia A.;
Masimirembwa, Collen M.

Publication type:

Article

Cytochrome P450 Induction and Xeno‐Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator‐Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2018, v. 123, p. 42, doi. 10.1111/bcpt.13004

By:

Hakkola, Jukka;
Bernasconi, Camilla;
Coecke, Sandra;
Richert, Lysiane;
Andersson, Tommy B.;
Pelkonen, Olavi

Publication type:

Article

Evolution of Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2017, v. 121, n. 4, p. 234, doi. 10.1111/bcpt.12804

By:

Andersson, Tommy B.

Publication type:

Article

Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies.

Published in:

Journal of Tissue Engineering & Regenerative Medicine, 2015, v. 9, n. 9, p. 1017, doi. 10.1002/term.1652

By:

Lübberstedt, Marc;
Müller‐Vieira, Ursula;
Biemel, Klaus M.;
Darnell, Malin;
Hoffmann, Stefan A;
Knöspel, Fanny;
Wönne, Eva C;
Knobeloch, Daniel;
Nüssler, Andreas K;
Gerlach, Jörg C;
Andersson, Tommy B;
Zeilinger, Katrin

Publication type:

Article

Human hepatocytes and cytochrome P450-selective inhibitors predict variability in human drug exposure more accurately than human recombinant P450s.

Published in:

2018

By:

Lindmark, Bo;
Lundahl, Anna;
Kanebratt, Kajsa P;
Andersson, Tommy B;
Isin, Emre M

Publication type:

journal article

Ximelagatran, an oral direct thrombin inhibitor, has a low potential for cytochrome P450-mediated drug-drug interactions.

Published in:

2003

By:

Bredberg, Eva;
Andersson, Tommy B.;
Frison, Lars;
Thuresson, Annelie;
Johansson, Susanne;
Eriksson-Lepkowska, Maria;
Larsson, Marita;
Eriksson, Ulf G.

Publication type:

journal article

Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges.

Published in:

2003

By:

Masimirembwa, Collen M.;
Bredberg, Ulf;
Andersson, Tommy B.

Publication type:

journal article

Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system.

Published in:

Communications Biology, 2024, p. 1, doi. 10.1038/s42003-024-06514-w

By:

Rigal, Sophie;
Casas, Belén;
Kanebratt, Kajsa P.;
Wennberg Huldt, Charlotte;
Magnusson, Lisa U.;
Müllers, Erik;
Karlsson, Fredrik;
Clausen, Maryam;
Hansson, Sara F.;
Leonard, Louise;
Cairns, Jonathan;
Jansson Löfmark, Rasmus;
Ämmälä, Carina;
Marx, Uwe;
Gennemark, Peter;
Cedersund, Gunnar;
Andersson, Tommy B.;
Vilén, Liisa K.

Publication type:

Article

PhRMA White Paper on ADME Pharmacogenomics.

Published in:

Journal of Clinical Pharmacology, 2008, v. 48, n. 7, p. 849, doi. 10.1177/0091270008319329

By:

Williams, J. Andrew;
Andersson, Tommy;
Andersson, Tommy B.;
Blanchard, Rebecca;
Behm, Martin Otto;
Cohen, Nadine;
Edeki, Timi;
Franc, Monique;
Hiligren, Kathleen M.;
Johnson, Keith J.;
Katz, David A.;
Milton, Mark N.;
Murray, Bernard P.;
Polli, Joseph W.;
Ricci, Deb;
Shipley, Lisa A.;
Vangala, Subrahmanyam;
Wrighton, Steven A.

Publication type:

Article

Toward Preclinical Predictive Drug Testing for Metabolism and Hepatotoxicity by Using In Vitro Models Derived from Human Embryonic Stem Cells and Human Cell Lines--A Report on the Vitrocellomics EU-project.

Published in:

Alternatives to Laboratory Animals, 2011, v. 39, n. 2, p. 147, doi. 10.1177/026119291103900210

By:

Mandenius, Carl-Fredrik;
Andersson, Tommy B.;
Alves, Paula M.;
Batzl-Hartmann, Christine;
Björquist,, Petter;
Carrondo, Manuel J. T.;
Chesne, Christophe;
Coecke, Sandra;
Edsbagge, Josefina;
Fredriksson, J. Magnus;
Gerlach, Jörg C.;
Heinzle, Elmar;
Ingelman-Sundberg, Magnus;
Johansson, Inger;
Küppers-Munther, Barbara;
Müller-Vieira,, Ursula;
Noor, Fozia;
Zeilinger, Katrin

Publication type:

Article

Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines.

Published in:

Thrombosis, 2016, p. 1, doi. 10.1155/2016/8648356

By:

Ghosheh, Nidal;
Olsson, Björn;
Edsbagge, Josefina;
Küppers-Munther, Barbara;
Van Giezen, Mariska;
Asplund, Annika;
Andersson, Tommy B.;
Björquist, Petter;
Carén, Helena;
Simonsson, Stina;
Sartipy, Peter;
Synnergren, Jane

Publication type:

Article

Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients With a Wide Range of Body Weight.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 3, p. 762, doi. 10.1002/cpt.2056

By:

Wegler, Christine;
Prieto Garcia, Luna;
Klinting, Signe;
Robertsen, Ida;
Wiśniewski, Jacek R.;
Hjelmesæth, Jøran;
Åsberg, Anders;
Jansson‐Löfmark, Rasmus;
Andersson, Tommy B.;
Artursson, Per

Publication type:

Article

Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three‐Dimensional Spheroid Cultures of Primary Human Hepatocytes.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 4, p. 844, doi. 10.1002/cpt.1860

By:

Hendriks, Delilah F.G.;
Vorrink, Sabine U.;
Smutny, Tomas;
Sim, Sarah C.;
Nordling, Åsa;
Ullah, Shahid;
Kumondai, Masaki;
Jones, Barry C.;
Johansson, Inger;
Andersson, Tommy B.;
Lauschke, Volker M.;
Ingelman‐Sundberg, Magnus

Publication type:

Article

4β-Hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicin.

Published in:

British Journal of Clinical Pharmacology, 2009, v. 67, n. 1, p. 38, doi. 10.1111/j.1365-2125.2008.03309.x

By:

Diczfalusy, Ulf;
Kanebratt, Kajsa P.;
Bredberg, Eva;
Andersson, Tommy B.;
Böttiger, Ylva;
Bertilsson, Leif

Publication type:

Article

Hepatic Disposition of Ximelagatran and Its Metabolites in Pig; Prediction of the Impact of Membrane Transporters Through a Simple Disposition Model.

Published in:

Pharmaceutical Research, 2010, v. 27, n. 4, p. 597, doi. 10.1007/s11095-009-0016-y

By:

Sjögren, Erik;
Bredberg, Ulf;
Allard, Erik;
Arvidsson, Björn;
Bergquist, Jonas;
Andersson, Tommy B.;
Lennernäs, Hans

Publication type:

Article

Evaluation of 1β-Hydroxylation of Deoxycholic Acid as a Non-Invasive Urinary Biomarker of CYP3A Activity in the Assessment of Inhibition-Based Drug–Drug Interaction in Healthy Volunteers.

Published in:

Journal of Personalized Medicine, 2021, v. 11, n. 6, p. 457, doi. 10.3390/jpm11060457

By:

Li, Xue-Qing;
Thelingwani, Roslyn Stella;
Bertilsson, Leif;
Diczfalusy, Ulf;
Andersson, Tommy B.;
Masimirembwa, Collen

Publication type:

Article

Short‐ and long‐term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 9, p. 4121, doi. 10.1111/bcp.15349

By:

Kvitne, Kine Eide;
Krogstad, Veronica;
Wegler, Christine;
Johnson, Line Kristin;
Kringen, Marianne K.;
Hovd, Markus Herberg;
Hertel, Jens K.;
Heijer, Maria;
Sandbu, Rune;
Skovlund, Eva;
Artursson, Per;
Karlsson, Cecilia;
Andersson, Shalini;
Andersson, Tommy B.;
Hjelmesæth, Jøran;
Åsberg, Anders;
Jansson‐Löfmark, Rasmus;
Christensen, Hege;
Robertsen, Ida

Publication type:

Article

Integrated experimental-computational analysis of a HepaRG liver-islet microphysiological system for human-centric diabetes research.

Published in:

PLoS Computational Biology, 2022, v. 18, n. 10, p. 1, doi. 10.1371/journal.pcbi.1010587

By:

Casas, Belén;
Vilén, Liisa;
Bauer, Sophie;
Kanebratt, Kajsa P.;
Wennberg Huldt, Charlotte;
Magnusson, Lisa;
Marx, Uwe;
Andersson, Tommy B.;
Gennemark, Peter;
Cedersund, Gunnar

Publication type:

Article

The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-47737-w

By:

Prill, Sebastian;
Caddeo, Andrea;
Baselli, Guido;
Jamialahmadi, Oveis;
Dongiovanni, Paola;
Rametta, Raffaela;
Kanebratt, Kajsa P.;
Pujia, Arturo;
Pingitore, Piero;
Mancina, Rosellina Margherita;
Lindén, Daniel;
Whatling, Carl;
Janefeldt, Annika;
Kozyra, Mikael;
Ingelman-Sundberg, Magnus;
Valenti, Luca;
Andersson, Tommy B.;
Romeo, Stefano

Publication type:

Article

Highly Synchronized Expression of Lineage-Specific Genes during In Vitro Hepatic Differentiation of Human Pluripotent Stem Cell Lines.

Published in:

Stem Cells International, 2016, p. 1, doi. 10.1155/2016/8648356

By:

Ghosheh, Nidal;
Olsson, Björn;
Edsbagge, Josefina;
Küppers-Munther, Barbara;
Van Giezen, Mariska;
Asplund, Annika;
Andersson, Tommy B.;
Björquist, Petter;
Carén, Helena;
Simonsson, Stina;
Sartipy, Peter;
Synnergren, Jane

Publication type:

Article

Short‐ and long‐term effects of body weight loss following calorie restriction and gastric bypass on CYP3A‐activity – a non‐randomized three‐armed controlled trial.

Published in:

CTS: Clinical & Translational Science, 2022, v. 15, n. 1, p. 221, doi. 10.1111/cts.13142

By:

Kvitne, Kine Eide;
Robertsen, Ida;
Skovlund, Eva;
Christensen, Hege;
Krogstad, Veronica;
Wegler, Christine;
Angeles, Philip Carlo;
Wollmann, Birgit Malene;
Hole, Kristine;
Johnson, Line Kristin;
Sandbu, Rune;
Artursson, Per;
Karlsson, Cecilia;
Andersson, Shalini;
Andersson, Tommy B.;
Hjelmesæth, Jøran;
Jansson‐Löfmark, Rasmus;
Åsberg, Anders

Publication type:

Article

Biology-Inspired Microphysiological Systems to Advance Patient Benefit and Animal Welfare in Drug Development.

Published in:

Altex, 2020, v. 37, n. 3, p. 365, doi. 10.14573/altex.2001241

By:

Marx, Uwe;
Akabane, Takafumi;
Andersson, Tommy B.;
Baker, Elizabeth;
Beilmann, Mario;
Beken, Sonja;
Brendler-Schwaab, Susanne;
Cirit, Murat;
David, Rhiannon;
Dehne, Eva-Maria;
Durieux, Isabell;
Ewart, Lorna;
Fitzpatrick, Suzanne C.;
Frey, Olivier;
Fuchs, Florian;
Griffith, Linda G.;
Hamilton, Geraldine A.;
Hartung, Thomas;
Hoeng, Julia;
Hogberg, Helena

Publication type:

Article

Biology-Inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing.

Published in:

Altex, 2016, v. 33, n. 3, p. 272, doi. 10.14573/altex.1603161

By:

Marx, Uwe;
Andersson, Tommy B.;
Bahinski, Anthony;
Beilmann, Mario;
Beken, Sonja;
Cassee, Flemming R.;
Cirit, Murat;
Daneshian, Mardas;
Fitzpatrick, Susan;
Frey, Olivier;
Gaertner, Claudia;
Giese, Christoph;
Griffith, Linda;
Hartung, Thomas;
Heringa, Minne B.;
Hoeng, Julia;
de Jong, Wim H.;
Kojima, Hajime;
Kuehnl, Jochen;
Leist, Marcel

Publication type:

Article

Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 5, p. 1142, doi. 10.1002/cpt.2558

By:

Wegler, Christine;
Wiśniewski, Jacek R.;
Robertsen, Ida;
Christensen, Hege;
Kristoffer Hertel, Jens;
Hjelmesæth, Jøran;
Jansson‐Löfmark, Rasmus;
Åsberg, Anders;
Andersson, Tommy B.;
Artursson, Per

Publication type:

Article

Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies.

Published in:

Biotechnology & Bioengineering, 2012, v. 109, n. 12, p. 3172, doi. 10.1002/bit.24573

By:

Hoffmann, Stefan A.;
Müller-Vieira, Ursula;
Biemel, Klaus;
Knobeloch, Daniel;
Heydel, Sandra;
Lübberstedt, Marc;
Nüssler, Andreas K.;
Andersson, Tommy B.;
Gerlach, Jörg C.;
Zeilinger, Katrin

Publication type:

Article