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Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols.
- Published in:
- Frontiers in Toxicology, 2024, p. 1, doi. 10.3389/ftox.2024.1373325
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- Article
Interpretable predictive models of genome-wide aryl hydrocarbon receptor-DNA binding reveal tissue-specific binding determinants.
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- Toxicological Sciences, 2023, v. 196, n. 2, p. 170, doi. 10.1093/toxsci/kfad094
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- Article
Updating the biologically based dose-response model for the nasal carcinogenicity of inhaled formaldehyde in the F344 rat.
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- Toxicological Sciences, 2023, v. 193, n. 1, p. 1, doi. 10.1093/toxsci/kfad028
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- Article
Incorporation of rapid association/dissociation processes in tissues into the monkey and human physiologically based pharmacokinetic models for manganese.
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- Toxicological Sciences, 2023, v. 191, n. 2, p. 212, doi. 10.1093/toxsci/kfac123
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- Article
Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods.
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- Frontiers in Pharmacology, 2022, v. 13, p. 01, doi. 10.3389/fphar.2022.980747
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- Article
A Kinetic Analysis of DNA-Deoxy Guanine Adducts in the Nasal Epithelium Produced by Inhaled Formaldehyde in Rats—Assessing Contributions to Adduct Production From Both Endogenous and Exogenous Sources of Formaldehyde.
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- Toxicological Sciences, 2020, v. 177, n. 2, p. 325, doi. 10.1093/toxsci/kfaa122
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- Article
Consideration of Styrene Transcriptomic Data Informs Mouse Lung Cyp2F2-Mediated Adverse Outcome Pathway.
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- Toxicological Sciences, 2020, v. 175, n. 1, p. 3, doi. 10.1093/toxsci/kfaa020
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- Article
Gene co-regulation and co-expression in the aryl hydrocarbon receptor-mediated transcriptional regulatory network in the mouse liver.
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- Archives of Toxicology, 2020, v. 94, n. 1, p. 113, doi. 10.1007/s00204-019-02620-5
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- Article
Developing Context Appropriate Toxicity Testing Approaches Using New Alternative Methods (NAMs).
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- Altex, 2019, v. 36, n. 4, p. 523, doi. 10.14573/altex.1906261
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- Article
A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation.
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- Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.01072
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- Article
Enhancing and Extending Biological Performance and Resilience.
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- Dose-Response, 2018, v. 16, n. 3, p. 1, doi. 10.1177/1559325818784501
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- Article
Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance.
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- Toxicological Sciences, 2017, v. 159, n. 2, p. 413, doi. 10.1093/toxsci/kfx141
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- Article
Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis.
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- Toxicological Sciences, 2017, v. 155, n. 1, p. 85, doi. 10.1093/toxsci/kfw186
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- Article
The Next Generation of Risk Assessment Multi-Year Study--Highlights of Findings, Applications to Risk Assessment, and Future Directions.
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- Environmental Health Perspectives, 2016, v. 124, n. 11, p. 1671, doi. 10.1289/EHP233
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- Article
Erratum: Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.
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- Scientific Reports, 2016, p. 33011, doi. 10.1038/srep33011
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- Article
Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.
- Published in:
- Scientific Reports, 2016, p. 28994, doi. 10.1038/srep28994
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- Article
Approaches for characterizing threshold dose-response relationships for DNA-damage pathways involved in carcinogenicity in vivo and micronuclei formation in vitro.
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- Mutagenesis, 2016, v. 31, n. 3, p. 333, doi. 10.1093/mutage/gev078
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- Article
PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water.
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- Toxicological Sciences, 2016, v. 150, n. 2, p. 269, doi. 10.1093/toxsci/kfw013
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- Article
PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human.
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- Toxicological Sciences, 2016, v. 150, n. 2, p. 441, doi. 10.1093/toxsci/kfw014
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- Article
The Human Toxome Collaboratorium: A Shared Environment for Multi-Omic Computational Collaboration within a Consortium.
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- Frontiers in Pharmacology, 2016, p. 1, doi. 10.3389/fphar.2015.00322
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- Article
Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK).
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- Environmental Health Perspectives, 2015, v. 123, n. 12, p. 1317, doi. 10.1289/ehp.1408837
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- Article
The Human Toxome Collaboratorium: a shared environment for multi-omic computational collaboration within a consortium.
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- Frontiers in Pharmacology, 2015, v. 6, p. 1, doi. 10.3389/fphar.2015.00322
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- Article
Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.
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- Toxicological Sciences, 2015, v. 148, n. 1, p. 121, doi. 10.1093/toxsci/kfv171
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- Article
Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment.
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- Toxicological Sciences, 2015, v. 147, n. 2, p. 302, doi. 10.1093/toxsci/kfv130
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- Article
Adverse Outcome Pathways can drive non-animal approaches for safety assessment.
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- Journal of Applied Toxicology, 2015, v. 35, n. 9, p. 971, doi. 10.1002/jat.3165
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- Article
The Human Toxome Project.
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- Altex, 2015, v. 32, n. 2, p. 112, doi. 10.14573/altex.1502091
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- Article
Molecular Signaling Network Motifs Provide a Mechanistic Basis for Cellular Threshold Responses.
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- Environmental Health Perspectives, 2014, v. 122, n. 12, p. 1261, doi. 10.1289/ehp.1408244
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- Article
Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage.
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- Toxicological Sciences, 2014, v. 142, n. 1, p. 56, doi. 10.1093/toxsci/kfu153
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- Article
A Framework for the Next Generation of Risk Science.
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- Environmental Health Perspectives, 2014, v. 122, n. 8, p. 796, doi. 10.1289/ehp.1307260
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- Article
Workshop Report: Developing Microphysiological Systems for Use as Regulatory Tools.
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- Altex, 2014, v. 31, n. 3, p. 1, doi. 10.14573/altex.1405151
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- Article
Developing Microphysiological Systems for Use as Regulatory Tools - Challenges and Opportunities.
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- Altex, 2014, v. 31, n. 3, p. 364, doi. 10.14573/altex.1405151
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- Article
Prenatal PCB-153 Exposure and Decreased Birth Weight: The Role of Gestational Weight Gain.
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- 2014
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- Letter to the Editor
Effects of Endogenous Formaldehyde in Nasal Tissues on Inhaled Formaldehyde Dosimetry Predictions in the Rat, Monkey, and Human Nasal Passages.
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- Toxicological Sciences, 2014, v. 138, n. 2, p. 412, doi. 10.1093/toxsci/kft333
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- Article
Dose-Response Modeling of Etoposide-Induced DNA Damage Response.
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- Toxicological Sciences, 2014, v. 137, n. 2, p. 371, doi. 10.1093/toxsci/kft259
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- Article
Lessons Learned, Challenges, and Opportunities: The U.S. Endocrine Disruptor Screening Program.
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- Altex, 2014, p. 63, doi. 10.14573/altex.1309171
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- Article
Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework.
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- Toxicological Sciences, 2013, v. 136, n. 1, p. 4, doi. 10.1093/toxsci/kft178
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- Article
Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics?
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- Environmental Health Perspectives, 2013, v. 121, n. 10, p. 1219, doi. 10.1289/ehp.1206457
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- Article
Bioactivation and Toxicity of Acetaminophen in a Rat Hepatocyte Micropatterned Coculture System.
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- Journal of Biochemical & Molecular Toxicology, 2013, v. 27, n. 10, p. 471, doi. 10.1002/jbt.21512
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- Article
Temporal Concordance Between Apical and Transcriptional Points of Departure for Chemical Risk Assessment.
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- Toxicological Sciences, 2013, v. 134, n. 1, p. 180, doi. 10.1093/toxsci/kft094
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- Article
Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action from High-Throughput In Vitro Toxicity Assays.
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- Toxicological Sciences, 2013, v. 132, n. 2, p. 327, doi. 10.1093/toxsci/kft012
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- Article
Adipose Deficiency of Nrf2 in ob/ob Mice Results in Severe Metabolic Syndrome.
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- Diabetes, 2013, v. 62, n. 3, p. 845, doi. 10.2337/db12-0584
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- Publication type:
- Article
Long-Term Stability of Primary Rat Hepatocytes in Micropatterned Cocultures.
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- Journal of Biochemical & Molecular Toxicology, 2013, v. 27, n. 3, p. 204, doi. 10.1002/jbt.21469
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- Article
Association between Arsenic Suppression of Adipogenesis and Induction of CHOP10 via the Endoplasmic Reticulum Stress.
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- Environmental Health Perspectives, 2013, v. 121, n. 2, p. 237, doi. 10.1289/ehp.1205731
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- Article
Cross-Species Transcriptomic Analysis of Mouse and Rat Lung Exposed to Chloroprene.
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- Toxicological Sciences, 2013, v. 131, n. 2, p. 629, doi. 10.1093/toxsci/kfs314
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- Article
Response to “Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity”.
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- Toxicological Sciences, 2012, v. 130, n. 2, p. 442, doi. 10.1093/toxsci/kfs284
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- Article
Modeling drug- and chemical- induced hepatotoxicity with systems biology approaches.
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- Frontiers in Physiology, 2012, v. 3, p. 1, doi. 10.3389/fphys.2012.00462
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- Article
Application of a Multi-Route Physiologically Based Pharmacokinetic Model for Manganese to Evaluate Dose-Dependent Neurological Effects in Monkeys.
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- Toxicological Sciences, 2012, v. 129, n. 2, p. 432, doi. 10.1093/toxsci/kfs212
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- Article
A Comprehensive Statistical Analysis of Predicting In Vivo Hazard Using High-Throughput In Vitro Screening.
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- Toxicological Sciences, 2012, v. 128, n. 2, p. 398, doi. 10.1093/toxsci/kfs159
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- Article
Response to “Accurate Risk-Based Chemical Screening Relies on Robust Exposure Estimates”.
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- Toxicological Sciences, 2012, v. 128, n. 1, p. 297, doi. 10.1093/toxsci/kfs144
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- Article
Cross-Regulations among NRFs and KEAP1 and Effects of their Silencing on Arsenic-Induced Antioxidant Response and Cytotoxicity in Human Keratinocytes.
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- Environmental Health Perspectives, 2012, v. 120, n. 4, p. 583, doi. 10.1289/ehp.1104580
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- Article