Works by Amata, Emanuele

Results: 29

Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands.

Published in:

ChemMedChem, 2025, v. 20, n. 9, p. 1, doi. 10.1002/cmdc.202401015

By:

Cosentino, Giuseppe;
Dichiara, Maria;
Costanzo, Giuliana;
Coco, Alessandro;
Pasquinucci, Lorella;
Marrazzo, Agostino;
Rescifina, Antonio;
Amata, Emanuele

Publication type:

Article

S2RSLDB: a comprehensive manually curated, internet-accessible database of the sigma-2 receptor selective ligands.

Published in:

Journal of Cheminformatics, 2017, v. 9, n. 1, p. 1, doi. 10.1186/s13321-017-0191-5

By:

Nastasi, Giovanni;
Miceli, Carla;
Pittalà, Valeria;
Modica, Maria;
Prezzavento, Orazio;
Romeo, Giuseppe;
Rescifina, Antonio;
Marrazzo, Agostino;
Amata, Emanuele

Publication type:

Article

Design, Synthesis, and Evaluation of Novel (−)‐cis‐N‐Normetazocine Derivatives: In Vitro and Molecular Modeling Insights.

Published in:

Chemical Biology & Drug Design, 2024, v. 104, n. 6, p. 1, doi. 10.1111/cbdd.70037

By:

Costanzo, Giuliana;
Coco, Alessandro;
Cosentino, Giuseppe;
Patamia, Vincenzo;
Parenti, Carmela;
Amata, Emanuele;
Marrazzo, Agostino;
Rescifina, Antonio;
Pasquinucci, Lorella

Publication type:

Article

Enhancing HDAC Inhibitor Screening: Addressing Zinc Parameterization and Ligand Protonation in Docking Studies.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 2, p. 850, doi. 10.3390/ijms26020850

By:

Buccheri, Rocco;
Coco, Alessandro;
Pasquinucci, Lorella;
Amata, Emanuele;
Marrazzo, Agostino;
Rescifina, Antonio

Publication type:

Article

Design, synthesis, in vitro evaluation, and molecular modeling studies of N‐substituted benzomorphans, analogs of LP2, as novel MOR ligands.

Published in:

Chemical Biology & Drug Design, 2023, v. 101, n. 6, p. 1382, doi. 10.1111/cbdd.14220

By:

Costanzo, Giuliana;
Patamia, Vincenzo;
Turnaturi, Rita;
Parenti, Carmela;
Zagni, Chiara;
Lombino, Jessica;
Amata, Emanuele;
Marrazzo, Agostino;
Pasquinucci, Lorella;
Rescifina, Antonio

Publication type:

Article

Discovery of 3‐(2‐aminoethyl)‐thiazolidine‐2,4‐diones as a novel chemotype of sigma‐1 receptor ligands.

Published in:

Chemical Biology & Drug Design, 2022, v. 100, n. 1, p. 25, doi. 10.1111/cbdd.14047

By:

Elkholy, Nada;
Abdelwaly, Ahmad;
Mohamed, Karim;
Amata, Emanuele;
Lombino, Jessica;
Cosentino, Giuseppe;
Intagliata, Sebastiano;
Helal, Mohamed A.

Publication type:

Article

Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5ʹ‐monophosphate glycosidase.

Published in:

Chemical Biology & Drug Design, 2018, v. 91, n. 2, p. 519, doi. 10.1111/cbdd.13113

By:

Pistarà, Venerando;
Amata, Emanuele;
Dichiara, Maria;
Damigella, Arcangelo;
Marrazzo, Agostino;
Prezzavento, Orazio;
Punzo, Francesco;
Rescifina, Antonio;
Floresta, Giuseppe

Publication type:

Article

Designing drugs optimized for both blood–brain barrier permeation and intra-cerebral partition.

Published in:

Expert Opinion on Drug Discovery, 2024, v. 19, n. 3, p. 317, doi. 10.1080/17460441.2023.2294118

By:

Dichiara, Maria;
Cosentino, Giuseppe;
Giordano, Giorgia;
Pasquinucci, Lorella;
Marrazzo, Agostino;
Costanzo, Giuliana;
Amata, Emanuele

Publication type:

Article

Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors.

Published in:

Molecules, 2024, v. 29, n. 11, p. 2697, doi. 10.3390/molecules29112697

By:

Zampieri, Daniele;
Romano, Maurizio;
Fortuna, Sara;
Amata, Emanuele;
Dichiara, Maria;
Cosentino, Giuseppe;
Marrazzo, Agostino;
Mamolo, Maria Grazia

Publication type:

Article

New Insights into the Opioid Analgesic Profile of cis -(−)- N -Normetazocine-derived Ligands.

Published in:

Molecules, 2023, v. 28, n. 12, p. 4827, doi. 10.3390/molecules28124827

By:

Costanzo, Giuliana;
Turnaturi, Rita;
Parenti, Carmela;
Spoto, Salvatore;
Piana, Silvia;
Dichiara, Maria;
Zagni, Chiara;
Galambos, Anna Rita;
Essmat, Nariman;
Marrazzo, Agostino;
Amata, Emanuele;
Al-Khrasani, Mahmoud;
Pasquinucci, Lorella

Publication type:

Article

Cytotoxicity Profiles and Neuroprotective Properties of the Novel Ifenprodil Analogues as Sigma Ligands.

Published in:

Molecules, 2023, v. 28, n. 8, p. 3431, doi. 10.3390/molecules28083431

By:

Zampieri, Daniele;
Calabretti, Antonella;
Romano, Maurizio;
Fortuna, Sara;
Collina, Simona;
Amata, Emanuele;
Dichiara, Maria;
Marrazzo, Agostino;
Mamolo, Maria Grazia

Publication type:

Article

Novel N -normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain.

Published in:

Molecules, 2022, v. 27, n. 16, p. 5135, doi. 10.3390/molecules27165135

By:

Turnaturi, Rita;
Chiechio, Santina;
Pasquinucci, Lorella;
Spoto, Salvatore;
Costanzo, Giuliana;
Dichiara, Maria;
Piana, Silvia;
Grasso, Margherita;
Amata, Emanuele;
Marrazzo, Agostino;
Parenti, Carmela

Publication type:

Article

Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity.

Published in:

Molecules, 2021, v. 26, n. 13, p. 3860, doi. 10.3390/molecules26133860

By:

Romeo, Giuseppe;
Ciaffaglione, Valeria;
Amata, Emanuele;
Dichiara, Maria;
Calabrese, Loredana;
Vanella, Luca;
Sorrenti, Valeria;
Grosso, Salvo;
D'Amico, Agata Grazia;
D'Agata, Velia;
Intagliata, Sebastiano;
Salerno, Loredana

Publication type:

Article

A Pseudouridine Isoxazolidinyl Nucleoside Analogue Structural Analysis: A Morphological Approach.

Published in:

Molecules, 2018, v. 23, n. 12, p. 3381, doi. 10.3390/molecules23123381

By:

Floresta, Giuseppe;
Pistarà, Venerando;
Christensen, Kirsten E.;
Amata, Emanuele;
Marrazzo, Agostino;
Gentile, Davide;
Rescifina, Antonio;
Punzo, Francesco

Publication type:

Article

Two‐Step Synthesis of Enantiomerically Pure Morphans from (R)‐Carvone.

Published in:

ChemMedChem, 2024, v. 19, n. 24, p. 1, doi. 10.1002/cmdc.202400596

By:

Costanzo, Giuliana;
Cosentino, Giuseppe;
Pasquinucci, Lorella;
Amata, Emanuele;
Schepmann, Dirk;
Wünsch, Bernhard

Publication type:

Article

HDAC/σ1R Dual-Ligand as a Targeted Melanoma Therapeutic.

Published in:

Pharmaceuticals (14248247), 2025, v. 18, n. 2, p. 179, doi. 10.3390/ph18020179

By:

Leotta, Claudia Giovanna;
Barbaraci, Carla;
Fiorito, Jole;
Coco, Alessandro;
di Giacomo, Viviana;
Amata, Emanuele;
Marrazzo, Agostino;
Pitari, Giovanni Mario

Publication type:

Article

Synthesis and Structure-Activity Relationships of (−)-cis-N-Normetazocine-Based LP1 Derivatives.

Published in:

Pharmaceuticals (14248247), 2018, v. 11, n. 2, p. 40, doi. 10.3390/ph11020040

By:

Pasquinucci, Lorella;
Amata, Emanuele;
Arena, Emanuela;
Turnaturi, Rita;
Parenti, Carmela;
Georgoussi, Zafiroula;
Pallaki, Paschalina;
Camarda, Valeria;
Calò, Girolamo;
Montenegro, Lucia

Publication type:

Article

Identification and Characterization of Hundreds of Potent and Selective Inhibitors of Trypanosoma brucei Growth from a Kinase-Targeted Library Screening Campaign.

Published in:

PLoS Neglected Tropical Diseases, 2014, v. 8, n. 10, p. 1, doi. 10.1371/journal.pntd.0003253

By:

Diaz, Rosario;
Luengo-Arratta, Sandra A.;
Seixas, João D.;
Amata, Emanuele;
Devine, William;
Cordon-Obras, Carlos;
Rojas-Barros, Domingo I.;
Jimenez, Elena;
Ortega, Fatima;
Crouch, Sabrinia;
Colmenarejo, Gonzalo;
Fiandor, Jose Maria;
Martin, Jose Julio;
Berlanga, Manuela;
Gonzalez, Silvia;
Manzano, Pilar;
Navarro, Miguel;
Pollastri, Michael P.

Publication type:

Article

Identification and Characterization of Hundreds of Potent and Selective Inhibitors of Trypanosoma brucei Growth from a Kinase-Targeted Library Screening Campaign.

Published in:

PLoS Neglected Tropical Diseases, 2014, v. 8, n. 10, p. 1, doi. 10.1371/journal.pntd.0003253

By:

Diaz, Rosario;
Luengo-Arratta, Sandra A.;
Seixas, João D.;
Amata, Emanuele;
Devine, William;
Cordon-Obras, Carlos;
Rojas-Barros, Domingo I.;
Jimenez, Elena;
Ortega, Fatima;
Crouch, Sabrinia;
Colmenarejo, Gonzalo;
Fiandor, Jose Maria;
Martin, Jose Julio;
Berlanga, Manuela;
Gonzalez, Silvia;
Manzano, Pilar;
Navarro, Miguel;
Pollastri, Michael P.

Publication type:

Article

Morphing of Ibogaine: A Successful Attempt into the Search for Sigma-2 Receptor Ligands.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 3, p. 488, doi. 10.3390/ijms20030488

By:

Floresta, Giuseppe;
Dichiara, Maria;
Gentile, Davide;
Prezzavento, Orazio;
Marrazzo, Agostino;
Rescifina, Antonio;
Amata, Emanuele

Publication type:

Article

Novel Structural Insight into Inhibitors of Heme Oxygenase-1 (HO-1) by New Imidazole-Based Compounds: Biochemical and In Vitro Anticancer Activity Evaluation.

Published in:

Molecules, 2018, v. 23, n. 5, p. 1209, doi. 10.3390/molecules23051209

By:

Greish, Khaled F.;
Salerno, Loredana;
Al Zahrani, Reem;
Amata, Emanuele;
Modica, Maria N.;
Romeo, Giuseppe;
Marrazzo, Agostino;
Prezzavento, Orazio;
Sorrenti, Valeria;
Rescifina, Antonio;
Floresta, Giuseppe;
Intagliata, Sebastiano;
Pittalà, Valeria

Publication type:

Article

Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists.

Published in:

Molecules, 2018, v. 23, n. 3, p. 677, doi. 10.3390/molecules23030677

By:

Turnaturi, Rita;
Parenti, Carmela;
Prezzavento, Orazio;
Marrazzo, Agostino;
Pallaki, Paschalina;
Georgoussi, Zafiroula;
Amata, Emanuele;
Pasquinucci, Lorella

Publication type:

Article

In vitro and in silico analysis of imatinib analogues as anti- Trypanosoma cruzi drug candidates.

Published in:

Parasitology, 2023, v. 150, n. 4, p. 359, doi. 10.1017/S0031182023000057

By:

Nesic de Freitas, Luca S. F.;
da Silva, Cristiane França;
Intagliata, Sebastiano;
Amata, Emanuele;
Salerno, Loredana;
Soeiro, Maria de Nazaré Correia

Publication type:

Article

Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries.

Published in:

Clinical Science, 2017, v. 131, n. 14, p. 1701, doi. 10.1042/CS20170157

By:

Amata, Emanuele;
Pittalà, Valeria;
Marrazzo, Agostino;
Parenti, Carmela;
Prezzavento, Orazio;
Arena, Emanuela;
Nabavi, Seyed Mohammad;
Salerno, Loredana

Publication type:

Article

Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products.

Published in:

Marine Drugs, 2019, v. 17, n. 2, p. 113, doi. 10.3390/md17020113

By:

Floresta, Giuseppe;
Amata, Emanuele;
Gentile, Davide;
Romeo, Giuseppe;
Marrazzo, Agostino;
Pittalà, Valeria;
Salerno, Loredana;
Rescifina, Antonio

Publication type:

Article

A Structure- and Ligand-Based Virtual Screening of a Database of "Small" Marine Natural Products for the Identification of "Blue" Sigma-2 Receptor Ligands.

Published in:

Marine Drugs, 2018, v. 16, n. 10, p. 384, doi. 10.3390/md16100384

By:

Barbaraci, Carla;
Gentile, Davide;
Turnaturi, Rita;
Marrazzo, Agostino;
Rescifina, Antonio;
Floresta, Giuseppe;
Amata, Emanuele

Publication type:

Article

Identification of Potentially Potent Heme Oxygenase 1 Inhibitors through 3D‐QSAR Coupled to Scaffold‐Hopping Analysis.

Published in:

ChemMedChem, 2018, v. 13, n. 13, p. 1336, doi. 10.1002/cmdc.201800176

By:

Floresta, Giuseppe;
Amata, Emanuele;
Dichiara, Maria;
Marrazzo, Agostino;
Salerno, Loredana;
Romeo, Giuseppe;
Prezzavento, Orazio;
Pittalà, Valeria;
Rescifina, Antonio

Publication type:

Article

Heme Oxygenase Database (HemeOxDB) and QSAR Analysis of Isoform 1 Inhibitors.

Published in:

ChemMedChem, 2017, v. 12, n. 22, p. 1873, doi. 10.1002/cmdc.201700321

By:

Amata, Emanuele;
Marrazzo, Agostino;
Dichiara, Maria;
Modica, Maria N.;
Salerno, Loredana;
Prezzavento, Orazio;
Nastasi, Giovanni;
Rescifina, Antonio;
Romeo, Giuseppe;
Pittalà, Valeria

Publication type:

Article

Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases.

Published in:

ChemMedChem, 2017, v. 12, n. 16, p. 1235, doi. 10.1002/cmdc.201700259

By:

Dichiara, Maria;
Marrazzo, Agostino;
Prezzavento, Orazio;
Collina, Simona;
Rescifina, Antonio;
Amata, Emanuele

Publication type:

Article