Works by Altmann, Karl‐Heinz

Results: 103

Total Synthesis of the Bacterial RNA Polymerase Inhibitor Ripostatin B.

Published in:

Angewandte Chemie, 2012, v. 124, n. 14, p. 3461, doi. 10.1002/ange.201200871

By:

Glaus, Florian;
Altmann, Karl-Heinz

Publication type:

Article

Identifizierung eines immunsuppressiven Wirkstoffmoleküls durch strukturbasiertes virtuelles Screening nach Inhibitoren von Protein-Protein-Wechselwirkungen.

Published in:

Angewandte Chemie, 2012, v. 124, n. 1, p. 264, doi. 10.1002/ange.201105901

By:

Geppert, Tim;
Bauer, Stefanie;
Hiss, Jan A.;
Conrad, Elea;
Reutlinger, Michael;
Schneider, Petra;
Weisel, Martin;
Pfeiffer, Bernhard;
Altmann, Karl-Heinz;
Waibler, Zoe;
Schneider, Gisbert

Publication type:

Article

Wertvolles aus der Tiefe des Meeres: die Entdeckung und Totalsynthese der Ammosamide.

Published in:

Angewandte Chemie, 2010, v. 122, n. 39, p. 7090, doi. 10.1002/ange.201002788

By:

Zurwerra, Didier;
Wullschleger, Christoph W.;
Altmann, Karl-Heinz

Publication type:

Article

Synthesis of the Multidrug Reversal Agent Ko143 and Its Parent Natural Product Fumitremorgin C.

Published in:

Helvetica Chimica Acta, 2023, v. 106, n. 2, p. 1, doi. 10.1002/hlca.202200171

By:

Zechner, Melanie;
Altmann, Karl‐Heinz

Publication type:

Article

Synthesis, Profiling, and Bioactive Conformation of trans‐Cyclopropyl Epothilones.

Published in:

Helvetica Chimica Acta, 2019, v. 102, n. 5, p. N.PAG, doi. 10.1002/hlca.201900078

By:

Kuzniewski, Christian N.;
Glauser, Simon;
Gaugaz, Fabienne Z.;
Schiess, Raphael;
Rodríguez‐Salarichs, Javier;
Vetterli, Stefan;
Horlacher, Oliver P.;
Gertsch, Jürg;
Redondo‐Horcajo, Mariano;
Canales, Angeles;
Jiménez‐Barbero, Jesús;
Díaz, José Fernando;
Altmann, Karl‐Heinz

Publication type:

Article

Front Cover: Cyclization by Intramolecular Suzuki‐Miyaura Cross‐Coupling–A Review (Chem. Eur. J. 1/2025).

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 1, p. 1, doi. 10.1002/chem.202580101

By:

Caso, Carolina;
Altmann, Karl‐Heinz

Publication type:

Article

Cyclization by Intramolecular Suzuki‐Miyaura Cross‐Coupling–A Review.

Published in:

Chemistry - A European Journal, 2025, v. 31, n. 1, p. 1, doi. 10.1002/chem.202402664

By:

Caso, Carolina;
Altmann, Karl‐Heinz

Publication type:

Article

Cover Feature: Experimental and Theoretical Studies on the Reactions of Aliphatic Imines with Isocyanates (Chem. Eur. J. 14/2024).

Published in:

2024

By:

Cotter, Etienne;
Pultar, Felix;
Riniker, Sereina;
Altmann, Karl‐Heinz

Publication type:

Correction Notice

Experimental and Theoretical Studies on the Reactions of Aliphatic Imines with Isocyanates.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 14, p. 1, doi. 10.1002/chem.202304272

By:

Cotter, Etienne;
Pultar, Felix;
Riniker, Sereina;
Altmann, Karl‐Heinz

Publication type:

Article

Cover Feature: Synthesis and Structure‐Activity Relationship Studies of C(13)‐Desmethylene‐(−)‐Zampanolide Analogs (Chem. Eur. J. 36/2023).

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 36, p. 1, doi. 10.1002/chem.202301652

By:

Brütsch, Tobias M.;
Cotter, Etienne;
Lucena‐Agell, Daniel;
Redondo‐Horcajo, Mariano;
Davies, Carolina;
Pfeiffer, Bernhard;
Pagani, Sandro;
Berardozzi, Simone;
Fernando Díaz, J.;
Miller, John H.;
Altmann, Karl‐Heinz

Publication type:

Article

Synthesis and Structure‐Activity Relationship Studies of C(13)‐Desmethylene‐(−)‐Zampanolide Analogs.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 36, p. 1, doi. 10.1002/chem.202300703

By:

Brütsch, Tobias M.;
Cotter, Etienne;
Lucena‐Agell, Daniel;
Redondo‐Horcajo, Mariano;
Davies, Carolina;
Pfeiffer, Bernhard;
Pagani, Sandro;
Berardozzi, Simone;
Fernando Díaz, J.;
Miller, John H.;
Altmann, Karl‐Heinz

Publication type:

Article

Cover Feature: Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders (Chem. Eur. J. 2/2022).

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 2, p. 1, doi. 10.1002/chem.202104474

By:

Marzullo, Paola;
Boiarska, Zlata;
Pérez‐Peña, Helena;
Abel, Anne‐Catherine;
Álvarez‐Bernad, Beatriz;
Lucena‐Agell, Daniel;
Vasile, Francesca;
Sironi, Maurizio;
Altmann, Karl‐Heinz;
Prota, Andrea E.;
Díaz, J. Fernando;
Pieraccini, Stefano;
Passarella, Daniele

Publication type:

Article

Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 2, p. 1, doi. 10.1002/chem.202103520

By:

Marzullo, Paola;
Boiarska, Zlata;
Pérez‐Peña, Helena;
Abel, Anne‐Catherine;
Álvarez‐Bernad, Beatriz;
Lucena‐Agell, Daniel;
Vasile, Francesca;
Sironi, Maurizio;
Altmann, Karl‐Heinz;
Prota, Andrea E.;
Díaz, J. Fernando;
Pieraccini, Stefano;
Passarella, Daniele

Publication type:

Article

Synthesis of Morpholine‐Based Analogues of (−)‐Zampanolide and Their Biological Activity.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 19, p. 5936, doi. 10.1002/chem.202003996

By:

Bold, Christian Paul;
Gut, Melanie;
Schürmann, Jasmine;
Lucena‐Agell, Daniel;
Gertsch, Jürg;
Díaz, José Fernando;
Altmann, Karl‐Heinz

Publication type:

Article

Die chemische Synthese von Peptiden und Proteinen.

Published in:

Chemie in unserer Zeit, 1993, v. 27, n. 6, p. 274, doi. 10.1002/ciuz.19930270603

By:

Altmann, Karl-Heinz;
Mutter, Manfred

Publication type:

Article

Die Totalsynthese von Isoxeniolid A**.

Published in:

Angewandte Chemie, 2024, v. 136, n. 9, p. 1, doi. 10.1002/ange.202315423

By:

Betschart, Leo;
Altmann, Karl‐Heinz

Publication type:

Article

Synthese und Biologische Untersuchungen von C(13)/C(13′)‐Bis(desmethyl)disorazol Z**.

Published in:

Angewandte Chemie, 2023, v. 135, n. 5, p. 1, doi. 10.1002/ange.202212190

By:

Bold, Christian Paul;
Lucena‐Agell, Daniel;
Oliva, María Ángela;
Díaz, José Fernando;
Altmann, Karl‐Heinz

Publication type:

Article

Die Totalsynthese des Antibiotikums Disciformycin B durch Ringschlussmetathese.

Published in:

Angewandte Chemie, 2020, v. 132, n. 40, p. 17546, doi. 10.1002/ange.202004589

By:

Waser, Philipp;
Altmann, Karl‐Heinz

Publication type:

Article

Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter.

Published in:

Cell Discovery, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41421-021-00247-4

By:

Yan, Renhong;
Li, Yaning;
Müller, Jennifer;
Zhang, Yuanyuan;
Singer, Simon;
Xia, Lu;
Zhong, Xinyue;
Gertsch, Jürg;
Altmann, Karl-Heinz;
Zhou, Qiang

Publication type:

Article

Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans.

Published in:

PLoS Neglected Tropical Diseases, 2013, v. 7, n. 3, p. 1, doi. 10.1371/journal.pntd.0002143

By:

Scherr, Nicole;
Gersbach, Philipp;
Dangy, Jean-Pierre;
Bomio, Claudio;
Li, Jun;
Altmann, Karl-Heinz;
Pluschke, Gerd

Publication type:

Article

Structure-Activity Relationship Studies on the Macrolide Exotoxin Mycolactone of Mycobacterium ulcerans.

Published in:

PLoS Neglected Tropical Diseases, 2013, v. 7, n. 3, p. 1, doi. 10.1371/journal.pntd.0002143

By:

Scherr, Nicole;
Gersbach, Philipp;
Dangy, Jean-Pierre;
Bomio, Claudio;
Li, Jun;
Altmann, Karl-Heinz;
Pluschke, Gerd

Publication type:

Article

Zur Synthese von ( S)-α-Methylserin enthaltenden Peptiden.

Published in:

Angewandte Chemie, 1988, v. 100, n. 6, p. 855, doi. 10.1002/ange.19881000611

By:

Altmann, Eva;
Altmann, Karl-Heinz;
Mutter, Manfred

Publication type:

Article

New Natural Noncannabinoid Ligands for Cannabinoid Type-2 (CB<sub>2</sub>) Receptors.

Published in:

Journal of Receptors & Signal Transduction, 2006, v. 26, n. 5/6, p. 709, doi. 10.1080/10799890600942674

By:

GERTSCH, JÜRG;
RADUNER, STEFAN;
ALTMANN, KARL-HEINZ

Publication type:

Article

Rational Design of Membrane-Pore-Forming Peptides.

Published in:

Small, 2017, v. 13, n. 40, p. n/a, doi. 10.1002/smll.201701316

By:

Pillong, Max;
Hiss, Jan A.;
Schneider, Petra;
Lin, Yen‐Chu;
Posselt, Gernot;
Pfeiffer, Bernhard;
Blatter, Markus;
Müller, Alex T.;
Bachler, Simon;
Neuhaus, Claudia S.;
Dittrich, Petra S.;
Altmann, Karl‐Heinz;
Wessler, Silja;
Schneider, Gisbert

Publication type:

Article

Peptides: Rational Design of Membrane-Pore-Forming Peptides (Small 40/2017).

Published in:

Small, 2017, v. 13, n. 40, p. n/a, doi. 10.1002/smll.201770213

By:

Pillong, Max;
Hiss, Jan A.;
Schneider, Petra;
Lin, Yen‐Chu;
Posselt, Gernot;
Pfeiffer, Bernhard;
Blatter, Markus;
Müller, Alex T.;
Bachler, Simon;
Neuhaus, Claudia S.;
Dittrich, Petra S.;
Altmann, Karl‐Heinz;
Wessler, Silja;
Schneider, Gisbert

Publication type:

Article

Total Synthesis of the Bacterial RNA Polymerase Inhibitor Ripostatin B.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 14, p. 3405, doi. 10.1002/anie.201200871

By:

Glaus, Florian;
Altmann, Karl-Heinz

Publication type:

Article

Immunosuppressive Small Molecule Discovered by Structure-Based Virtual Screening for Inhibitors of Protein-Protein Interactions.

Published in:

Angewandte Chemie International Edition, 2012, v. 51, n. 1, p. 258, doi. 10.1002/anie.201105901

By:

Geppert, Tim;
Bauer, Stefanie;
Hiss, Jan A.;
Conrad, Elea;
Reutlinger, Michael;
Schneider, Petra;
Weisel, Martin;
Pfeiffer, Bernhard;
Altmann, Karl-Heinz;
Waibler, Zoe;
Schneider, Gisbert

Publication type:

Article

Treasures from the Sea: Discovery and Total Synthesis of Ammosamides.

Published in:

Angewandte Chemie International Edition, 2010, v. 49, n. 39, p. 6936, doi. 10.1002/anie.201002788

By:

Zurwerra, Didier;
Wullschleger, Christoph W.;
Altmann, Karl-Heinz

Publication type:

Article

Total Synthesis of the Marine Diterpenoid Blumiolide C.

Published in:

Angewandte Chemie International Edition, 2008, v. 47, n. 52, p. 10081, doi. 10.1002/anie.200804004

By:

Hamel, Cotinica;
Prusov, Evgeny V.;
Gertsch, Jürg;
Schweizer, W. Bernd;
Altmann, Karl-Heinz

Publication type:

Article

Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno‐foetal amino acid transport.

Published in:

Journal of Cellular & Molecular Medicine, 2020, v. 24, n. 21, p. 12681, doi. 10.1111/jcmm.15840

By:

Zaugg, Jonas;
Huang, Xiao;
Ziegler, Fabian;
Rubin, Matthias;
Graff, Julien;
Müller, Jennifer;
Moser‐Hässig, Ruedi;
Powell, Theresa;
Gertsch, Jürg;
Altmann, Karl‐Heinz;
Albrecht, Christiane

Publication type:

Article

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 6, p. 1392, doi. 10.3390/ijms20061392

By:

Balaguer, Francisco de Asís;
Estévez-Gallego, Juan;
Giménez-Abián, Juan Francisco;
Oliva, María Ángela;
Díaz, J. Fernando;
Mühlethaler, Tobias;
Prota, Andrea E.;
Steinmetz, Michel O.;
Calvo, Enrique;
Risinger, April L.;
Mooberry, Susan L.;
Sorensen, Erik J.;
Vanderwal, Christopher D.;
Altmann, Karl-Heinz

Publication type:

Article

Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 5, p. 1113, doi. 10.3390/ijms20051113

By:

Gaugaz, Fabienne Zdenka;
Chicca, Andrea;
Redondo-Horcajo, Mariano;
Barasoain, Isabel;
Díaz, J. Fernando;
Altmann, Karl-Heinz

Publication type:

Article

Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration.

Published in:

International Journal of Molecular Sciences, 2017, v. 18, n. 5, p. 971, doi. 10.3390/ijms18050971

By:

Field, Jessica J.;
Northcote, Peter T.;
Paterson, Ian;
Altmann, Karl-Heinz;
Díaz, J. Fernando;
Miller, John H.

Publication type:

Article

STUDIES OF A CHEMICALLY MODIFIED OLIGODEOXYNUCLEOTIDE CONTAINING A 5-ATOM AMIDE BACKBONE WHICH EXHIBITS IMPROVED BINDING TO RNA.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2001, v. 20, n. 4-7, p. 991, doi. 10.1081/NCN-100002475

By:

Wilds, ChristopherJ.;
Minasov, George;
Natt, François;
von Matt, Peter;
Altmann, Karl-Heinz;
Egli, Martin

Publication type:

Article

Total Synthesis of Isoxeniolide A**.

Published in:

Angewandte Chemie International Edition, 2024, v. 63, n. 9, p. 1, doi. 10.1002/anie.202315423

By:

Betschart, Leo;
Altmann, Karl‐Heinz

Publication type:

Article

Total Synthesis of Isoxeniolide A**.

Published in:

Angewandte Chemie International Edition, 2024, v. 63, n. 9, p. 1, doi. 10.1002/anie.202315423

By:

Betschart, Leo;
Altmann, Karl‐Heinz

Publication type:

Article

Synthesis and Biological Evaluation of C(13)/C(13′)‐Bis(desmethyl)disorazole Z**.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 5, p. 1, doi. 10.1002/anie.202212190

By:

Bold, Christian Paul;
Lucena‐Agell, Daniel;
Oliva, María Ángela;
Díaz, José Fernando;
Altmann, Karl‐Heinz

Publication type:

Article

An RCM‐Based Total Synthesis of the Antibiotic Disciformycin B.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 40, p. 17393, doi. 10.1002/anie.202004589

By:

Waser, Philipp;
Altmann, Karl‐Heinz

Publication type:

Article

Patupilone (epothilone B, EPO906) inhibits growth and metastasis of experimental prostate tumors in vivo.

Published in:

Prostate, 2005, v. 65, n. 3, p. 231, doi. 10.1002/pros.20289

By:

O'Reilly, Terence;
McSheehy, Paul Michael John;
Wenger, Fritz;
Hattenberger, Marc;
Muller, Melanie;
Vaxelaire, Juliane;
Altmann, Karl-Heinz;
Wartmann, Markus

Publication type:

Article

The ups and downs of nucleic acid duplex stability: structure–stability studies on chemically-modified DNA:RNA duplexes.

Published in:

Nucleic Acids Research, 1997, v. 25, n. 22, p. 4429, doi. 10.1093/nar/25.22.4429

By:

Freier, Susan M.;
Altmann, Karl-Heinz

Publication type:

Article

Structure, Function and Pharmacology of SLC7 Family Members and Homologues.

Published in:

Chimia, 2022, v. 76, n. 12, p. 1011, doi. 10.2533/chimia.2022.1011

By:

Jeckelmann, Jean-Marc;
Zaugg, Jonas;
Morozova, Veronika;
Müller, Jennifer;
Kantipudi, Satish;
Schroeder, Mariana;
Graff, Julien;
Albrecht, Christiane;
Altmann, Karl-Heinz;
Gertsch, Jürg;
Fotiadis, Dimitrios

Publication type:

Article

Generating Bioactive Natural Product-inspired Molecules with Machine Intelligence.

Published in:

Chimia, 2022, v. 76, n. 5, p. 396, doi. 10.2533/chimia.2022.396

By:

Schneider, Petra;
Altmann, Karl-Heinz;
Schneider, Gisbert

Publication type:

Article

Editorial.

Published in:

Chimia, 2022, v. 76, n. 5, p. 385

By:

Altmann, Karl-Heinz

Publication type:

Article

Towards a new tuberculosis drug: pyridomycin - nature's isoniazid.

Published in:

EMBO Molecular Medicine, 2012, v. 4, n. 10, p. 1032, doi. 10.1002/emmm.201201689

By:

Hartkoorn, Ruben C.;
Sala, Claudia;
Neres, João;
Pojer, Florence;
Magnet, Sophie;
Mukherjee, Raju;
Uplekar, Swapna;
Boy-Röttger, Stefanie;
Altmann, Karl-Heinz;
Cole, Stewart T.

Publication type:

Article

Contextual Compound Screening for Improved Therapeutic Discovery.

Published in:

ChemBioChem, 2013, v. 14, n. 18, p. 2512, doi. 10.1002/cbic.201300409

By:

Evensen, Lasse;
Odlo, Kristin;
Micklem, David R.;
Littlewood‐Evans, Amanda;
Wood, Jeanette;
Kuzniewski, Christian;
Altmann, Karl‐Heinz;
Hansen, Trond Vidar;
Lorens, James B.

Publication type:

Article

Cover Picture: Making Epothilones Fluoresce: Design, Synthesis, and Biological Characterization of a Fluorescent N12-Aza-Epothilone (Azathilone) (ChemBioChem 15/2009).

Published in:

ChemBioChem, 2009, v. 10, n. 15, p. 2405, doi. 10.1002/cbic.200990065

By:

Gertsch, Jürg;
Feyen, Fabian;
Bützberger, Alexander;
Gerber, Barbara;
Pfeiffer, Bernhard;
Altmann, Karl-Heinz

Publication type:

Article

Making Epothilones Fluoresce: Design, Synthesis, and Biological Characterization of a Fluorescent N12-Aza-Epothilone (Azathilone).

Published in:

ChemBioChem, 2009, v. 10, n. 15, p. 2513, doi. 10.1002/cbic.200900376

By:

Gertsch, Jürg;
Feyen, Fabian;
Bützberger, Alexander;
Gerber, Barbara;
Pfeiffer, Bernhard;
Altmann, Karl-Heinz

Publication type:

Article

Differential Effects of Natural Product Microtubule Stabilizers on Microtubule Assembly: Single Agent and Combination Studies with Taxol, Epothilone B, and Discodermolide.

Published in:

ChemBioChem, 2009, v. 10, n. 1, p. 166, doi. 10.1002/cbic.200800556

By:

Gertsch, Jürg;
Meier, Sarah;
Müller, Martin;
Altmann, Karl-Heinz

Publication type:

Article

Synthesis and Biological Evaluation of Aza-Epothilones.

Published in:

ChemBioChem, 2000, v. 1, n. 1, p. 67, doi. 10.1002/1439-7633(20000703)1:1<67::AID-CBIC67>3.0.CO;2-I

By:

Schinzer, Dieter;
Altmann, Karl-Heinz;
Stuhlmann, Friedrich;
Bauer, Armin;
Wartmann, Markus

Publication type:

Article

Studies towards the Total Synthesis of Amycolamicin: A Chiral Auxiliary‐Based Diels‐Alder Approach towards the Decalin Core.

Published in:

European Journal of Organic Chemistry, 2022, v. 2022, n. 30, p. 1, doi. 10.1002/ejoc.202200761

By:

Frossard, Thomas M.;
Trapp, Nils;
Altmann, Karl‐Heinz

Publication type:

Article