Found: 58

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  • Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response.

    Published in:
    Nature Communications, 2023, v. 14, p. 1, doi. 10.1038/s41467-023-38271-5
    By:
    • Pagadala, Meghana;
    • Sears, Timothy J.;
    • Wu, Victoria H.;
    • Pérez-Guijarro, Eva;
    • Kim, Hyo;
    • Castro, Andrea;
    • Talwar, James V.;
    • Gonzalez-Colin, Cristian;
    • Cao, Steven;
    • Schmiedel, Benjamin J.;
    • Goudarzi, Shervin;
    • Kirani, Divya;
    • Au, Jessica;
    • Zhang, Tongwu;
    • Landi, Teresa;
    • Salem, Rany M.;
    • Morris, Gerald P.;
    • Harismendy, Olivier;
    • Patel, Sandip Pravin;
    • Alexandrov, Ludmil B.
    Publication type:
    Article

  • DNA damage and somatic mutations in mammalian cells after irradiation with a nail polish dryer.

    Published in:
    Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-35876-8
    By:
    • Zhivagui, Maria;
    • Hoda, Areebah;
    • Valenzuela, Noelia;
    • Yeh, Yi-Yu;
    • Dai, Jason;
    • He, Yudou;
    • Nandi, Shuvro P.;
    • Otlu, Burcak;
    • Van Houten, Bennett;
    • Alexandrov, Ludmil B.
    Publication type:
    Article

  • Nonnegative/Binary matrix factorization with a D-Wave quantum annealer.

    Published in:
    PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0206653
    By:
    • O’Malley, Daniel;
    • Vesselinov, Velimir V.;
    • Alexandrov, Boian S.;
    • Alexandrov, Ludmil B.
    Publication type:
    Article

  • Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.

    Published in:
    Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03099-x
    By:
    • George, Julie;
    • Alexandrov, Ludmil B.;
    • Seidel, Danila;
    • Leenders, Frauke;
    • Maas, Lukas;
    • Müller, Christian;
    • Dahmen, Ilona;
    • Delhomme, Tiffany M.;
    • Ardin, Maude;
    • Leblay, Noemie;
    • Byrnes, Graham;
    • Sun, Ruping;
    • De Reynies, Aurélien;
    • McLeer-Florin, Anne;
    • Bosco, Graziella;
    • Malchers, Florian;
    • Menon, Roopika;
    • Altmüller, Janine;
    • Becker, Christian;
    • Nürnberg, Peter
    Publication type:
    Article

  • The driver landscape of sporadic chordoma.

    Published in:
    Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01026-0
    By:
    • Tarpey, Patrick S.;
    • Behjati, Sam;
    • Young, Matthew D.;
    • Martincorena, Inigo;
    • Alexandrov, Ludmil B.;
    • Farndon, Sarah J.;
    • Guzzo, Charlotte;
    • Hardy, Claire;
    • Latimer, Calli;
    • Butler, Adam P.;
    • Teague, Jon W.;
    • Shlien, Adam;
    • Futreal, P. Andrew;
    • Shah, Sohrab;
    • Bashashati, Ali;
    • Jamshidi, Farzad;
    • Nielsen, Torsten O.;
    • Huntsman, David;
    • Baumhoer, Daniel;
    • Brandner, Sebastian
    Publication type:
    Article

  • Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

    Published in:
    Nature Communications, 2017, v. 8, n. 6, p. 15936, doi. 10.1038/ncomms15936
    By:
    • Behjati, Sam;
    • Tarpey, Patrick S.;
    • Haase, Kerstin;
    • Ye, Hongtao;
    • Young, Matthew D.;
    • Alexandrov, Ludmil B.;
    • Farndon, Sarah J.;
    • Collord, Grace;
    • Wedge, David C.;
    • Martincorena, Inigo;
    • Cooke, Susanna L.;
    • Davies, Helen;
    • Mifsud, William;
    • Lidgren, Mathias;
    • Martin, Sancha;
    • Latimer, Calli;
    • Maddison, Mark;
    • Butler, Adam P.;
    • Teague, Jon W.;
    • Pillay, Nischalan
    Publication type:
    Article

  • Mutational signatures of ionizing radiation in second malignancies.

    Published in:
    Nature Communications, 2016, v. 7, n. 9, p. 12605, doi. 10.1038/ncomms12605
    By:
    • Behjati, Sam;
    • Gundem, Gunes;
    • Wedge, David C.;
    • Roberts, Nicola D.;
    • Tarpey, Patrick S.;
    • Cooke, Susanna L.;
    • Van Loo, Peter;
    • Alexandrov, Ludmil B.;
    • Ramakrishna, Manasa;
    • Davies, Helen;
    • Nik-Zainal, Serena;
    • Hardy, Claire;
    • Latimer, Calli;
    • Raine, Keiran M.;
    • Stebbings, Lucy;
    • Menzies, Andy;
    • Jones, David;
    • Shepherd, Rebecca;
    • Butler, Adam P.;
    • Teague, Jon W.
    Publication type:
    Article

  • Germline MC1R status influences somatic mutation burden in melanoma.

    Published in:
    Nature Communications, 2016, v. 7, n. 7, p. 12064, doi. 10.1038/ncomms12064
    By:
    • Robles-Espinoza, Carla Daniela;
    • Roberts, Nicola D.;
    • Chen, Shuyang;
    • Leacy, Finbarr P.;
    • Alexandrov, Ludmil B.;
    • Pornputtapong, Natapol;
    • Halaban, Ruth;
    • Krauthammer, Michael;
    • Cui, Rutao;
    • Timothy Bishop, D.;
    • Adams, David J.
    Publication type:
    Article

  • The topography of mutational processes in breast cancer genomes.

    Published in:
    Nature Communications, 2016, v. 7, n. 5, p. 11383, doi. 10.1038/ncomms11383
    By:
    • Morganella, Sandro;
    • Alexandrov, Ludmil B.;
    • Glodzik, Dominik;
    • Zou, Xueqing;
    • Davies, Helen;
    • Staaf, Johan;
    • Sieuwerts, Anieta M.;
    • Brinkman, Arie B.;
    • Martin, Sancha;
    • Ramakrishna, Manasa;
    • Butler, Adam;
    • Kim, Hyung-Yong;
    • Borg, Åke;
    • Sotiriou, Christos;
    • Futreal, P. Andrew;
    • Campbell, Peter J.;
    • Span, Paul N.;
    • Van Laere, Steven;
    • Lakhani, Sunil R.;
    • Eyfjord, Jorunn E.
    Publication type:
    Article

  • A mutational signature in gastric cancer suggests therapeutic strategies.

    Published in:
    Nature Communications, 2015, v. 6, n. 10, p. 8683, doi. 10.1038/ncomms9683
    By:
    • Alexandrov, Ludmil B.;
    • Nik-Zainal, Serena;
    • Siu, Hoi Cheong;
    • Leung, Suet Yi;
    • Stratton, Michael R
    Publication type:
    Article

  • Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.

    Published in:
    Nature Communications, 2015, v. 6, n. 4, p. 6605, doi. 10.1038/ncomms7605
    By:
    • Hong, Matthew K.H.;
    • Macintyre, Geoff;
    • Wedge, David C.;
    • Van Loo, Peter;
    • Patel, Keval;
    • Lunke, Sebastian;
    • Alexandrov, Ludmil B.;
    • Sloggett, Clare;
    • Cmero, Marek;
    • Marass, Francesco;
    • Tsui, Dana;
    • Mangiola, Stefano;
    • Lonie, Andrew;
    • Naeem, Haroon;
    • Sapre, Nikhil;
    • Phal, Pramit M.;
    • Kurganovs, Natalie;
    • Chin, Xiaowen;
    • Kerger, Michael;
    • Warren, Anne Y.
    Publication type:
    Article

  • Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.

    Published in:
    Nature Communications, 2014, v. 5, n. 1, p. 2997, doi. 10.1038/ncomms3997
    By:
    • Bolli, Niccolo;
    • Avet-Loiseau, Hervé;
    • Wedge, David C.;
    • Van Loo, Peter;
    • Alexandrov, Ludmil B.;
    • Martincorena, Inigo;
    • Dawson, Kevin J.;
    • Iorio, Francesco;
    • Nik-Zainal, Serena;
    • Bignell, Graham R.;
    • Hinton, Jonathan W.;
    • Li, Yilong;
    • Tubio, Jose M.C.;
    • McLaren, Stuart;
    • O' Meara, Sarah;
    • Butler, Adam P.;
    • Teague, Jon W.;
    • Mudie, Laura;
    • Anderson, Elizabeth;
    • Rashid, Naim
    Publication type:
    Article

  • APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa.

    Published in:
    Science Translational Medicine, 2018, v. 10, n. 455, p. 1, doi. 10.1126/scitranslmed.aas9668
    By:
    • Cho, Raymond J.;
    • Alexandrov, Ludmil B.;
    • den Breems, Nicoline Y.;
    • Atanasova, Velina S.;
    • Farshchian, Mehdi;
    • Purdom, Elizabeth;
    • Nguyen, Tran N.;
    • Coarfa, Cristian;
    • Rajapakshe, Kimal;
    • Prisco, Marco;
    • Sahu, Joya;
    • Tassone, Patrick;
    • Greenawalt, Evan J.;
    • Collisson, Eric A.;
    • Wu, Wei;
    • Yao, Hui;
    • Su, Xiaoping;
    • Guttmann-Gruber, Christina;
    • Hofbauer, Josefina Piñón;
    • Hashmi, Raabia
    Publication type:
    Article

  • Somatic mutational profiles and germline polygenic risk scores in human cancer.

    Published in:
    Genome Medicine, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13073-022-01016-y
    By:
    • Liu, Yuxi;
    • Gusev, Alexander;
    • Heng, Yujing J.;
    • Alexandrov, Ludmil B.;
    • Kraft, Peter
    Publication type:
    Article

  • Somatic mutational profiles and germline polygenic risk scores in human cancer.

    Published in:
    Genome Medicine, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13073-022-01016-y
    By:
    • Liu, Yuxi;
    • Gusev, Alexander;
    • Heng, Yujing J.;
    • Alexandrov, Ludmil B.;
    • Kraft, Peter
    Publication type:
    Article

  • The role of structural parameters in DNA cyclization.

    Published in:
    BMC Bioinformatics, 2016, v. 17, p. 1, doi. 10.1186/s12859-016-0897-9
    By:
    • Alexandrov, Ludmil B.;
    • Bishop, Alan R.;
    • Rasmussen, Kim Ø.;
    • Alexandrov, Boian S.
    Publication type:
    Article

  • The genome as a record of environmental exposure.

    Published in:
    Mutagenesis, 2015, v. 30, n. 6, p. 763, doi. 10.1093/mutage/gev073
    By:
    • Nik-Zainal, Serena;
    • Kucab, Jill E.;
    • Morganella, Sandro;
    • Glodzik, Dominik;
    • Alexandrov, Ludmil B.;
    • Arlt, Volker M.;
    • Weninger, Annette;
    • Hollstein, Monica;
    • Stratton, Michael R.;
    • Phillips, David H.
    Publication type:
    Article

  • Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

    Published in:
    Nature Genetics, 2015, v. 47, n. 6, p. 689, doi. 10.1038/ng0615-689b
    By:
    • Cooper, Colin S;
    • Eeles, Rosalind;
    • Wedge, David C;
    • Van Loo, Peter;
    • Gundem, Gunes;
    • Alexandrov, Ludmil B;
    • Kremeyer, Barbara;
    • Butler, Adam;
    • Lynch, Andrew G;
    • Camacho, Niedzica;
    • Massie, Charlie E;
    • Kay, Jonathan;
    • Luxton, Hayley J;
    • Edwards, Sandra;
    • Kote-Jarai, Zsofia;
    • Dennis, Nening;
    • Merson, Sue;
    • Leongamornlert, Daniel;
    • Zamora, Jorge;
    • Corbishley, Cathy
    Publication type:
    Article

  • Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.

    Published in:
    Nature Genetics, 2015, v. 47, n. 5, p. 505, doi. 10.1038/ng.3252
    By:
    • Schulze, Kornelius;
    • Imbeaud, Sandrine;
    • Letouzé, Eric;
    • Rebouissou, Sandra;
    • Couchy, Gabrielle;
    • Meiller, Clément;
    • Shinde, Jayendra;
    • Soysouvanh, Frederic;
    • Calatayud, Anna-Line;
    • Pelletier, Laura;
    • Calvo, Fabien;
    • Nault, Jean-Charles;
    • Bioulac-Sage, Paulette;
    • Stratton, Michael R;
    • Llovet, Josep M;
    • Zucman-Rossi, Jessica;
    • Alexandrov, Ludmil B;
    • Calderaro, Julien;
    • Pinyol, Roser;
    • Balabaud, Charles
    Publication type:
    Article

  • Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

    Published in:
    Nature Genetics, 2015, v. 47, n. 4, p. 367, doi. 10.1038/ng.3221
    By:
    • Cooper, Colin S;
    • Clark, Jeremy;
    • Hurst, Rachel;
    • Mithen, Richard;
    • Bristow, Robert G;
    • Boutros, Paul C;
    • Fraser, Michael;
    • Greenman, Christopher;
    • Berney, Dan;
    • Voet, Thierry;
    • Easton, Douglas;
    • Warren, Anne Y;
    • Eeles, Rosalind;
    • Foster, Christopher S;
    • Brewer, Daniel S;
    • Neal, David E;
    • Wedge, David C;
    • Gundem, Gunes;
    • Alexandrov, Ludmil B;
    • Kremeyer, Barbara
    Publication type:
    Article

  • Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer.

    Published in:
    Nature Genetics, 2014, v. 46, n. 5, p. 487, doi. 10.1038/ng.2955
    By:
    • Nik-Zainal, Serena;
    • Wedge, David C;
    • Alexandrov, Ludmil B;
    • Petljak, Mia;
    • Butler, Adam P;
    • Bolli, Niccolo;
    • Davies, Helen R;
    • Knappskog, Stian;
    • Martin, Sancha;
    • Papaemmanuil, Elli;
    • Ramakrishna, Manasa;
    • Shlien, Adam;
    • Simonic, Ingrid;
    • Xue, Yali;
    • Tyler-Smith, Chris;
    • Campbell, Peter J;
    • Stratton, Michael R
    Publication type:
    Article

  • RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.

    Published in:
    Nature Genetics, 2014, v. 46, n. 2, p. 116, doi. 10.1038/ng.2874
    By:
    • Papaemmanuil, Elli;
    • Rapado, Inmaculada;
    • Li, Yilong;
    • Potter, Nicola E;
    • Wedge, David C;
    • Tubio, Jose;
    • Alexandrov, Ludmil B;
    • Van Loo, Peter;
    • Cooke, Susanna L;
    • Marshall, John;
    • Martincorena, Inigo;
    • Hinton, Jonathan;
    • Gundem, Gunes;
    • van Delft, Frederik W;
    • Nik-Zainal, Serena;
    • Jones, David R;
    • Ramakrishna, Manasa;
    • Titley, Ian;
    • Stebbings, Lucy;
    • Leroy, Catherine
    Publication type:
    Article

  • Inactivating CUX1 mutations promote tumorigenesis.

    Published in:
    Nature Genetics, 2014, v. 46, n. 1, p. 33, doi. 10.1038/ng.2846
    By:
    • Wong, Chi C;
    • Martincorena, Inigo;
    • Rust, Alistair G;
    • Rashid, Mamunur;
    • Alifrangis, Constantine;
    • Alexandrov, Ludmil B;
    • Tiffen, Jessamy C;
    • Kober, Christina;
    • Green, Anthony R;
    • Massie, Charles E;
    • Nangalia, Jyoti;
    • Lempidaki, Stella;
    • Döhner, Hartmut;
    • Döhner, Konstanze;
    • Bray, Sarah J;
    • McDermott, Ultan;
    • Papaemmanuil, Elli;
    • Campbell, Peter J;
    • Adams, David J
    Publication type:
    Article

  • Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation.

    Published in:
    Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09828-0
    By:
    • Brinkman, Arie B.;
    • Nik-Zainal, Serena;
    • Simmer, Femke;
    • Rodríguez-González, F. Germán;
    • Smid, Marcel;
    • Alexandrov, Ludmil B.;
    • Butler, Adam;
    • Martin, Sancha;
    • Davies, Helen;
    • Glodzik, Dominik;
    • Zou, Xueqing;
    • Ramakrishna, Manasa;
    • Staaf, Johan;
    • Ringnér, Markus;
    • Sieuwerts, Anieta;
    • Ferrari, Anthony;
    • Morganella, Sandro;
    • Fleischer, Thomas;
    • Kristensen, Vessela;
    • Gut, Marta
    Publication type:
    Article

  • The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.

    Published in:
    Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06027-1
    By:
    • Inman, Gareth J.;
    • Wang, Jun;
    • Nagano, Ai;
    • Alexandrov, Ludmil B.;
    • Purdie, Karin J.;
    • Taylor, Richard G.;
    • Sherwood, Victoria;
    • Thomson, Jason;
    • Hogan, Sarah;
    • Spender, Lindsay C.;
    • South, Andrew P.;
    • Stratton, Michael;
    • Chelala, Claude;
    • Harwood, Catherine A.;
    • Proby, Charlotte M.;
    • Leigh, Irene M.
    Publication type:
    Article

  • Binding of Nucleoid-Associated Protein Fis to DNA Is Regulated by DNA Breathing Dynamics.

    Published in:
    PLoS Computational Biology, 2013, v. 9, n. 1, p. 1, doi. 10.1371/journal.pcbi.1002881
    By:
    • Nowak-Lovato, Kristy;
    • Alexandrov, Ludmil B.;
    • Banisadr, Afsheen;
    • Bauer, Amy L.;
    • Bishop, Alan R.;
    • Usheva, Anny;
    • Mu, Fangping;
    • Hong-Geller, Elizabeth;
    • Rasmussen, Kim Ø.;
    • Hlavacek, William S.;
    • Alexandrov, Boian S.
    Publication type:
    Article

  • Assigning mutational signatures to individual samples and individual somatic mutations with SigProfilerAssignment.

    Published in:
    Bioinformatics, 2023, v. 39, n. 12, p. 1, doi. 10.1093/bioinformatics/btad756
    By:
    • Díaz-Gay, Marcos;
    • Vangara, Raviteja;
    • Barnes, Mark;
    • Wang, Xi;
    • Islam, S M Ashiqul;
    • Vermes, Ian;
    • Duke, Stephen;
    • Narasimman, Nithish Bharadhwaj;
    • Yang, Ting;
    • Jiang, Zichen;
    • Moody, Sarah;
    • Senkin, Sergey;
    • Brennan, Paul;
    • Stratton, Michael R;
    • Alexandrov, Ludmil B
    Publication type:
    Article

  • Examining clustered somatic mutations with SigProfilerClusters.

    Published in:
    Bioinformatics, 2022, v. 38, n. 13, p. 3470, doi. 10.1093/bioinformatics/btac335
    By:
    • Bergstrom, Erik N;
    • Kundu, Mousumy;
    • Tbeileh, Noura;
    • Alexandrov, Ludmil B
    Publication type:
    Article

  • Stem cell replication, somatic mutations and role of randomness in the development of cancer.

    Published in:
    European Journal of Epidemiology, 2019, v. 34, n. 5, p. 439, doi. 10.1007/s10654-018-0477-6
    By:
    • Perduca, Vittorio;
    • Alexandrov, Ludmil B.;
    • Kelly-Irving, Michelle;
    • Delpierre, Cyrille;
    • Omichessan, Hanane;
    • Little, Mark P.;
    • Vineis, Paolo;
    • Severi, Gianluca
    Publication type:
    Article

  • Strength of immune selection in tumors varies with sex and age.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-17981-0
    By:
    • Castro, Andrea;
    • Pyke, Rachel Marty;
    • Zhang, Xinlian;
    • Thompson, Wesley Kurt;
    • Day, Chi-Ping;
    • Alexandrov, Ludmil B.;
    • Zanetti, Maurizio;
    • Carter, Hannah
    Publication type:
    Article

  • DNA Dynamics Is Likely to Be a Factor in the Genomic Nucleotide Repeats Expansions Related to Diseases.

    Published in:
    PLoS ONE, 2011, v. 6, n. 5, p. 1, doi. 10.1371/journal.pone.0019800
    By:
    • Alexandrov, Boian S.;
    • Valtchinov, Vlad I.;
    • Alexandrov, Ludmil B.;
    • Gelev, Vladimir;
    • Dagon, Yossi;
    • Bock, Jonathan;
    • Kohane, Isaac S.;
    • Rasmussen, Kim Ø.;
    • Bishop, Alan R.;
    • Usheva, Anny
    Publication type:
    Article

  • Mammalian Stem Cells Reprogramming in Response to Terahertz Radiation.

    Published in:
    PLoS ONE, 2010, v. 5, n. 12, p. 1, doi. 10.1371/journal.pone.0015806
    By:
    • Bock, Jonathan;
    • Fukuyo, Yayoi;
    • Kang, Sona;
    • Phipps, M. Lisa;
    • Alexandrov, Ludmil B.;
    • Rasmussen, Kim Ø.;
    • Bishop, Alan R.;
    • Rosen, Evan D.;
    • Martinez, Jennifer S.;
    • Hou-Tong Chen;
    • Rodriguez, George;
    • Alexandrov, Boian S.;
    • Usheva, Anny
    Publication type:
    Article

  • Computer Modeling Describes Gravity-Related Adaptation in Cell Cultures.

    Published in:
    PLoS ONE, 2009, v. 4, n. 12, p. 1, doi. 10.1371/journal.pone.0008332
    By:
    • Alexandrov, Ludmil B.;
    • Alexandrova, Stoyana;
    • Usheva, Anny
    Publication type:
    Article

  • An overview of mutational and copy number signatures in human cancer.

    Published in:
    Journal of Pathology, 2022, v. 257, n. 4, p. 454, doi. 10.1002/path.5912
    By:
    • Steele, Christopher D;
    • Pillay, Nischalan;
    • Alexandrov, Ludmil B
    Publication type:
    Article

  • Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas.

    Published in:
    Journal of Pathology, 2017, v. 242, n. 1, p. 10, doi. 10.1002/path.4880
    By:
    • Pilati, Camilla;
    • Shinde, Jayendra;
    • Alexandrov, Ludmil B;
    • Assié, Guillaume;
    • André, Thierry;
    • Hélias‐Rodzewicz, Zofia;
    • Ducoudray, Romain;
    • Le Corre, Delphine;
    • Zucman‐Rossi, Jessica;
    • Emile, Jean‐François;
    • Bertherat, Jérôme;
    • Letouzé, Eric;
    • Laurent‐Puig, Pierre
    Publication type:
    Article

  • The evolutionary history of lethal metastatic prostate cancer.

    Published in:
    Nature, 2015, v. 520, n. 7547, p. 353, doi. 10.1038/nature14347
    By:
    • Gundem, Gunes;
    • Van Loo, Peter;
    • Kremeyer, Barbara;
    • Alexandrov, Ludmil B.;
    • Tubio, Jose M. C.;
    • Papaemmanuil, Elli;
    • Brewer, Daniel S.;
    • Kallio, Heini M. L.;
    • Högnäs, Gunilla;
    • Annala, Matti;
    • Kivinummi, Kati;
    • Goody, Victoria;
    • Latimer, Calli;
    • O'Meara, Sarah;
    • Dawson, Kevin J.;
    • Isaacs, William;
    • Emmert-Buck, Michael R.;
    • Nykter, Matti;
    • Foster, Christopher;
    • Kote-Jarai, Zsofia
    Publication type:
    Article

  • Genome sequencing of normal cells reveals developmental lineages and mutational processes.

    Published in:
    Nature, 2014, v. 513, n. 7518, p. 422, doi. 10.1038/nature13448
    By:
    • Behjati, Sam;
    • Huch, Meritxell;
    • van Boxtel, Ruben;
    • Karthaus, Wouter;
    • Wedge, David C.;
    • Martincorena, Iñigo;
    • Petljak, Mia;
    • Alexandrov, Ludmil B.;
    • Gundem, Gunes;
    • Tarpey, Patrick S.;
    • Roerink, Sophie;
    • Maddison, Mark;
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  • Corrigendum: Signatures of mutational processes in human cancer.

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    • Borg, Ake;
    • Børresen-Dale, Anne-Lise;
    • Boyault, Sandrine;
    • Burkhardt, Birgit;
    • Butler, Adam P.;
    • Caldas, Carlos;
    • Davies, Helen R.;
    • Desmedt, Christine;
    • Eils, Roland;
    • Eyfjörd, Jórunn Erla;
    • Foekens, John A.;
    • Greaves, Mel
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  • Signatures of mutational processes in human cancer.

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    By:
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    • Nik-Zainal, Serena;
    • Wedge, David C.;
    • Aparicio, Samuel A. J. R.;
    • Behjati, Sam;
    • Biankin, Andrew V.;
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    • Børresen-Dale, Anne-Lise;
    • Boyault, Sandrine;
    • Burkhardt, Birgit;
    • Butler, Adam P.;
    • Caldas, Carlos;
    • Davies, Helen R.;
    • Desmedt, Christine;
    • Eils, Roland;
    • Eyfjörd, Jórunn Erla;
    • Foekens, John A.;
    • Greaves, Mel
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    Carcinogenesis, 2016, v. 37, n. 6, p. 531, doi. 10.1093/carcin/bgw055
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    • Alexandrov, Ludmil B.
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  • Whole-exome sequencing reveals the impact of UVA light mutagenesis in xeroderma pigmentosum variant human cells.

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    • Munford, Veridiana;
    • Ienne, Susan;
    • Alexandrov, Ludmil B;
    • Menck, Carlos Frederico Martins
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  • Fast randomization of large genomic datasets while preserving alteration counts.

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    • Alexandrov, Ludmil B.;
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  • Insights into BRCA Cancer Predisposition from Integrated Germline and Somatic Analyses in 7632 Cancers.

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    • Usheva, Anny
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  • The genomic and epigenomic evolutionary history of papillary renal cell carcinomas.

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    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16546-5
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    • Alexandrov, Ludmil B.
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    • Corradini, Paolo;
    • Anderson, Kenneth C.;
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    • Papaemmanuil, Elli;
    • Alexandrov, Ludmil B.;
    • Puente, Xose S.;
    • Campo, Elias
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  • Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice.

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    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-019-14261-4
    By:
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    • Jen, Kuang-Yu;
    • del Rosario, Reyno;
    • Fredlund, Erik;
    • Hirst, Gillian;
    • Alexandrov, Ludmil B.;
    • Adams, David;
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  • Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4.

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    Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-13471-0
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    • Luis Callejas-Valera, Juan;
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    • Sharabi, Andrew B.;
    • Cohen, Ezra E. W.;
    • Chen, Qianming;
    • Lyons, J. Guy;
    • Alexandrov, Ludmil B.;
    • Gutkind, J. Silvio
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  • Subclonal diversification of primary breast cancer revealed by multiregion sequencing.

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    Nature Medicine, 2015, v. 21, n. 7, p. 751, doi. 10.1038/nm.3886
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    • Desmedt, Christine;
    • Gundem, Gunes;
    • Van Loo, Peter;
    • Aas, Turid;
    • Alexandrov, Ludmil B;
    • Larsimont, Denis;
    • Davies, Helen;
    • Li, Yilong;
    • Ju, Young Seok;
    • Ramakrishna, Manasa;
    • Haugland, Hans Kristian;
    • Lilleng, Peer Kaare;
    • Nik-Zainal, Serena;
    • McLaren, Stuart;
    • Butler, Adam;
    • Martin, Sancha;
    • Glodzik, Dominic
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