Works matching AU Alexandrov, Ludmil B

Results: 60
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    Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers : The Sherlock-Lung Study.

    Published in:
    American Journal of Epidemiology, 2021, v. 190, n. 6, p. 962, doi. 10.1093/aje/kwaa234
    By:
    • Landi, Maria Teresa;
    • Synnott, Naoise C;
    • Rosenbaum, Jennifer;
    • Zhang, Tongwu;
    • Zhu, Bin;
    • Shi, Jianxin;
    • Zhao, Wei;
    • Kebede, Michael;
    • Sang, Jian;
    • Choi, Jiyeon;
    • Mendoza, Laura;
    • Pacheco, Marwil;
    • Hicks, Belynda;
    • Caporaso, Neil E;
    • Abubakar, Mustapha;
    • Gordenin, Dmitry A;
    • Wedge, David C;
    • Alexandrov, Ludmil B;
    • Rothman, Nathaniel;
    • Lan, Qing
    Publication type:
    Article
    8

    Tracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers : The Sherlock-Lung Study.

    Published in:
    American Journal of Epidemiology, 2021, v. 190, n. 5, p. 962, doi. 10.1093/aje/kwaa234
    By:
    • Landi, Maria Teresa;
    • Synnott, Naoise C;
    • Rosenbaum, Jennifer;
    • Zhang, Tongwu;
    • Zhu, Bin;
    • Shi, Jianxin;
    • Zhao, Wei;
    • Kebede, Michael;
    • Sang, Jian;
    • Choi, Jiyeon;
    • Mendoza, Laura;
    • Pacheco, Marwil;
    • Hicks, Belynda;
    • Caporaso, Neil E;
    • Abubakar, Mustapha;
    • Gordenin, Dmitry A;
    • Wedge, David C;
    • Alexandrov, Ludmil B;
    • Rothman, Nathaniel;
    • Lan, Qing
    Publication type:
    Article
    9

    Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

    Published in:
    Nature Genetics, 2015, v. 47, n. 6, p. 689, doi. 10.1038/ng0615-689b
    By:
    • Cooper, Colin S;
    • Eeles, Rosalind;
    • Wedge, David C;
    • Van Loo, Peter;
    • Gundem, Gunes;
    • Alexandrov, Ludmil B;
    • Kremeyer, Barbara;
    • Butler, Adam;
    • Lynch, Andrew G;
    • Camacho, Niedzica;
    • Massie, Charlie E;
    • Kay, Jonathan;
    • Luxton, Hayley J;
    • Edwards, Sandra;
    • Kote-Jarai, Zsofia;
    • Dennis, Nening;
    • Merson, Sue;
    • Leongamornlert, Daniel;
    • Zamora, Jorge;
    • Corbishley, Cathy
    Publication type:
    Article
    10

    Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.

    Published in:
    Nature Genetics, 2015, v. 47, n. 5, p. 505, doi. 10.1038/ng.3252
    By:
    • Schulze, Kornelius;
    • Imbeaud, Sandrine;
    • Letouzé, Eric;
    • Rebouissou, Sandra;
    • Couchy, Gabrielle;
    • Meiller, Clément;
    • Shinde, Jayendra;
    • Soysouvanh, Frederic;
    • Calatayud, Anna-Line;
    • Pelletier, Laura;
    • Calvo, Fabien;
    • Nault, Jean-Charles;
    • Bioulac-Sage, Paulette;
    • Stratton, Michael R;
    • Llovet, Josep M;
    • Zucman-Rossi, Jessica;
    • Alexandrov, Ludmil B;
    • Calderaro, Julien;
    • Pinyol, Roser;
    • Balabaud, Charles
    Publication type:
    Article
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    Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

    Published in:
    Nature Genetics, 2015, v. 47, n. 4, p. 367, doi. 10.1038/ng.3221
    By:
    • Cooper, Colin S;
    • Clark, Jeremy;
    • Hurst, Rachel;
    • Mithen, Richard;
    • Bristow, Robert G;
    • Boutros, Paul C;
    • Fraser, Michael;
    • Greenman, Christopher;
    • Berney, Dan;
    • Voet, Thierry;
    • Easton, Douglas;
    • Warren, Anne Y;
    • Eeles, Rosalind;
    • Foster, Christopher S;
    • Brewer, Daniel S;
    • Neal, David E;
    • Wedge, David C;
    • Gundem, Gunes;
    • Alexandrov, Ludmil B;
    • Kremeyer, Barbara
    Publication type:
    Article
    12

    Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer.

    Published in:
    Nature Genetics, 2014, v. 46, n. 5, p. 487, doi. 10.1038/ng.2955
    By:
    • Nik-Zainal, Serena;
    • Wedge, David C;
    • Alexandrov, Ludmil B;
    • Petljak, Mia;
    • Butler, Adam P;
    • Bolli, Niccolo;
    • Davies, Helen R;
    • Knappskog, Stian;
    • Martin, Sancha;
    • Papaemmanuil, Elli;
    • Ramakrishna, Manasa;
    • Shlien, Adam;
    • Simonic, Ingrid;
    • Xue, Yali;
    • Tyler-Smith, Chris;
    • Campbell, Peter J;
    • Stratton, Michael R
    Publication type:
    Article
    13

    RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.

    Published in:
    Nature Genetics, 2014, v. 46, n. 2, p. 116, doi. 10.1038/ng.2874
    By:
    • Papaemmanuil, Elli;
    • Rapado, Inmaculada;
    • Li, Yilong;
    • Potter, Nicola E;
    • Wedge, David C;
    • Tubio, Jose;
    • Alexandrov, Ludmil B;
    • Van Loo, Peter;
    • Cooke, Susanna L;
    • Marshall, John;
    • Martincorena, Inigo;
    • Hinton, Jonathan;
    • Gundem, Gunes;
    • van Delft, Frederik W;
    • Nik-Zainal, Serena;
    • Jones, David R;
    • Ramakrishna, Manasa;
    • Titley, Ian;
    • Stebbings, Lucy;
    • Leroy, Catherine
    Publication type:
    Article
    14

    Inactivating CUX1 mutations promote tumorigenesis.

    Published in:
    Nature Genetics, 2014, v. 46, n. 1, p. 33, doi. 10.1038/ng.2846
    By:
    • Wong, Chi C;
    • Martincorena, Inigo;
    • Rust, Alistair G;
    • Rashid, Mamunur;
    • Alifrangis, Constantine;
    • Alexandrov, Ludmil B;
    • Tiffen, Jessamy C;
    • Kober, Christina;
    • Green, Anthony R;
    • Massie, Charles E;
    • Nangalia, Jyoti;
    • Lempidaki, Stella;
    • Döhner, Hartmut;
    • Döhner, Konstanze;
    • Bray, Sarah J;
    • McDermott, Ultan;
    • Papaemmanuil, Elli;
    • Campbell, Peter J;
    • Adams, David J
    Publication type:
    Article
    15

    Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response.

    Published in:
    Nature Communications, 2023, v. 14, p. 1, doi. 10.1038/s41467-023-38271-5
    By:
    • Pagadala, Meghana;
    • Sears, Timothy J.;
    • Wu, Victoria H.;
    • Pérez-Guijarro, Eva;
    • Kim, Hyo;
    • Castro, Andrea;
    • Talwar, James V.;
    • Gonzalez-Colin, Cristian;
    • Cao, Steven;
    • Schmiedel, Benjamin J.;
    • Goudarzi, Shervin;
    • Kirani, Divya;
    • Au, Jessica;
    • Zhang, Tongwu;
    • Landi, Teresa;
    • Salem, Rany M.;
    • Morris, Gerald P.;
    • Harismendy, Olivier;
    • Patel, Sandip Pravin;
    • Alexandrov, Ludmil B.
    Publication type:
    Article
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    APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa.

    Published in:
    Science Translational Medicine, 2018, v. 10, n. 455, p. 1, doi. 10.1126/scitranslmed.aas9668
    By:
    • Cho, Raymond J.;
    • Alexandrov, Ludmil B.;
    • den Breems, Nicoline Y.;
    • Atanasova, Velina S.;
    • Farshchian, Mehdi;
    • Purdom, Elizabeth;
    • Nguyen, Tran N.;
    • Coarfa, Cristian;
    • Rajapakshe, Kimal;
    • Prisco, Marco;
    • Sahu, Joya;
    • Tassone, Patrick;
    • Greenawalt, Evan J.;
    • Collisson, Eric A.;
    • Wu, Wei;
    • Yao, Hui;
    • Su, Xiaoping;
    • Guttmann-Gruber, Christina;
    • Hofbauer, Josefina Piñón;
    • Hashmi, Raabia
    Publication type:
    Article
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    Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

    Published in:
    Nature Communications, 2017, v. 8, n. 6, p. 15936, doi. 10.1038/ncomms15936
    By:
    • Behjati, Sam;
    • Tarpey, Patrick S.;
    • Haase, Kerstin;
    • Ye, Hongtao;
    • Young, Matthew D.;
    • Alexandrov, Ludmil B.;
    • Farndon, Sarah J.;
    • Collord, Grace;
    • Wedge, David C.;
    • Martincorena, Inigo;
    • Cooke, Susanna L.;
    • Davies, Helen;
    • Mifsud, William;
    • Lidgren, Mathias;
    • Martin, Sancha;
    • Latimer, Calli;
    • Maddison, Mark;
    • Butler, Adam P.;
    • Teague, Jon W.;
    • Pillay, Nischalan
    Publication type:
    Article
    25

    Mutational signatures of ionizing radiation in second malignancies.

    Published in:
    Nature Communications, 2016, v. 7, n. 9, p. 12605, doi. 10.1038/ncomms12605
    By:
    • Behjati, Sam;
    • Gundem, Gunes;
    • Wedge, David C.;
    • Roberts, Nicola D.;
    • Tarpey, Patrick S.;
    • Cooke, Susanna L.;
    • Van Loo, Peter;
    • Alexandrov, Ludmil B.;
    • Ramakrishna, Manasa;
    • Davies, Helen;
    • Nik-Zainal, Serena;
    • Hardy, Claire;
    • Latimer, Calli;
    • Raine, Keiran M.;
    • Stebbings, Lucy;
    • Menzies, Andy;
    • Jones, David;
    • Shepherd, Rebecca;
    • Butler, Adam P.;
    • Teague, Jon W.
    Publication type:
    Article
    26

    Germline MC1R status influences somatic mutation burden in melanoma.

    Published in:
    Nature Communications, 2016, v. 7, n. 7, p. 12064, doi. 10.1038/ncomms12064
    By:
    • Robles-Espinoza, Carla Daniela;
    • Roberts, Nicola D.;
    • Chen, Shuyang;
    • Leacy, Finbarr P.;
    • Alexandrov, Ludmil B.;
    • Pornputtapong, Natapol;
    • Halaban, Ruth;
    • Krauthammer, Michael;
    • Cui, Rutao;
    • Timothy Bishop, D.;
    • Adams, David J.
    Publication type:
    Article
    27

    The topography of mutational processes in breast cancer genomes.

    Published in:
    Nature Communications, 2016, v. 7, n. 5, p. 11383, doi. 10.1038/ncomms11383
    By:
    • Morganella, Sandro;
    • Alexandrov, Ludmil B.;
    • Glodzik, Dominik;
    • Zou, Xueqing;
    • Davies, Helen;
    • Staaf, Johan;
    • Sieuwerts, Anieta M.;
    • Brinkman, Arie B.;
    • Martin, Sancha;
    • Ramakrishna, Manasa;
    • Butler, Adam;
    • Kim, Hyung-Yong;
    • Borg, Åke;
    • Sotiriou, Christos;
    • Futreal, P. Andrew;
    • Campbell, Peter J.;
    • Span, Paul N.;
    • Van Laere, Steven;
    • Lakhani, Sunil R.;
    • Eyfjord, Jorunn E.
    Publication type:
    Article
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    Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.

    Published in:
    Nature Communications, 2015, v. 6, n. 4, p. 6605, doi. 10.1038/ncomms7605
    By:
    • Hong, Matthew K.H.;
    • Macintyre, Geoff;
    • Wedge, David C.;
    • Van Loo, Peter;
    • Patel, Keval;
    • Lunke, Sebastian;
    • Alexandrov, Ludmil B.;
    • Sloggett, Clare;
    • Cmero, Marek;
    • Marass, Francesco;
    • Tsui, Dana;
    • Mangiola, Stefano;
    • Lonie, Andrew;
    • Naeem, Haroon;
    • Sapre, Nikhil;
    • Phal, Pramit M.;
    • Kurganovs, Natalie;
    • Chin, Xiaowen;
    • Kerger, Michael;
    • Warren, Anne Y.
    Publication type:
    Article
    30

    Heterogeneity of genomic evolution and mutational profiles in multiple myeloma.

    Published in:
    Nature Communications, 2014, v. 5, n. 1, p. 2997, doi. 10.1038/ncomms3997
    By:
    • Bolli, Niccolo;
    • Avet-Loiseau, Hervé;
    • Wedge, David C.;
    • Van Loo, Peter;
    • Alexandrov, Ludmil B.;
    • Martincorena, Inigo;
    • Dawson, Kevin J.;
    • Iorio, Francesco;
    • Nik-Zainal, Serena;
    • Bignell, Graham R.;
    • Hinton, Jonathan W.;
    • Li, Yilong;
    • Tubio, Jose M.C.;
    • McLaren, Stuart;
    • O' Meara, Sarah;
    • Butler, Adam P.;
    • Teague, Jon W.;
    • Mudie, Laura;
    • Anderson, Elizabeth;
    • Rashid, Naim
    Publication type:
    Article
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    Arsenic is a potent co-mutagen of ultraviolet light.

    Published in:
    Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05659-4
    By:
    • Speer, Rachel M.;
    • Nandi, Shuvro P.;
    • Cooper, Karen L.;
    • Zhou, Xixi;
    • Yu, Hui;
    • Guo, Yan;
    • Hudson, Laurie G.;
    • Alexandrov, Ludmil B.;
    • Liu, Ke Jian
    Publication type:
    Article
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    The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.

    Published in:
    Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06027-1
    By:
    • Inman, Gareth J.;
    • Wang, Jun;
    • Nagano, Ai;
    • Alexandrov, Ludmil B.;
    • Purdie, Karin J.;
    • Taylor, Richard G.;
    • Sherwood, Victoria;
    • Thomson, Jason;
    • Hogan, Sarah;
    • Spender, Lindsay C.;
    • South, Andrew P.;
    • Stratton, Michael;
    • Chelala, Claude;
    • Harwood, Catherine A.;
    • Proby, Charlotte M.;
    • Leigh, Irene M.
    Publication type:
    Article
    38

    Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.

    Published in:
    Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03099-x
    By:
    • George, Julie;
    • Alexandrov, Ludmil B.;
    • Seidel, Danila;
    • Leenders, Frauke;
    • Maas, Lukas;
    • Müller, Christian;
    • Dahmen, Ilona;
    • Delhomme, Tiffany M.;
    • Ardin, Maude;
    • Leblay, Noemie;
    • Byrnes, Graham;
    • Sun, Ruping;
    • De Reynies, Aurélien;
    • McLeer-Florin, Anne;
    • Bosco, Graziella;
    • Malchers, Florian;
    • Menon, Roopika;
    • Altmüller, Janine;
    • Becker, Christian;
    • Nürnberg, Peter
    Publication type:
    Article
    39

    The driver landscape of sporadic chordoma.

    Published in:
    Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01026-0
    By:
    • Tarpey, Patrick S.;
    • Behjati, Sam;
    • Young, Matthew D.;
    • Martincorena, Inigo;
    • Alexandrov, Ludmil B.;
    • Farndon, Sarah J.;
    • Guzzo, Charlotte;
    • Hardy, Claire;
    • Latimer, Calli;
    • Butler, Adam P.;
    • Teague, Jon W.;
    • Shlien, Adam;
    • Futreal, P. Andrew;
    • Shah, Sohrab;
    • Bashashati, Ali;
    • Jamshidi, Farzad;
    • Nielsen, Torsten O.;
    • Huntsman, David;
    • Baumhoer, Daniel;
    • Brandner, Sebastian
    Publication type:
    Article
    40

    Subclonal diversification of primary breast cancer revealed by multiregion sequencing.

    Published in:
    Nature Medicine, 2015, v. 21, n. 7, p. 751, doi. 10.1038/nm.3886
    By:
    • Yates, Lucy R;
    • Gerstung, Moritz;
    • Knappskog, Stian;
    • Desmedt, Christine;
    • Gundem, Gunes;
    • Van Loo, Peter;
    • Aas, Turid;
    • Alexandrov, Ludmil B;
    • Larsimont, Denis;
    • Davies, Helen;
    • Li, Yilong;
    • Ju, Young Seok;
    • Ramakrishna, Manasa;
    • Haugland, Hans Kristian;
    • Lilleng, Peer Kaare;
    • Nik-Zainal, Serena;
    • McLaren, Stuart;
    • Butler, Adam;
    • Martin, Sancha;
    • Glodzik, Dominic
    Publication type:
    Article
    41

    Strength of immune selection in tumors varies with sex and age.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-17981-0
    By:
    • Castro, Andrea;
    • Pyke, Rachel Marty;
    • Zhang, Xinlian;
    • Thompson, Wesley Kurt;
    • Day, Chi-Ping;
    • Alexandrov, Ludmil B.;
    • Zanetti, Maurizio;
    • Carter, Hannah
    Publication type:
    Article
    42

    The genomic and epigenomic evolutionary history of papillary renal cell carcinomas.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16546-5
    By:
    • Zhu, Bin;
    • Poeta, Maria Luana;
    • Costantini, Manuela;
    • Zhang, Tongwu;
    • Shi, Jianxin;
    • Sentinelli, Steno;
    • Zhao, Wei;
    • Pompeo, Vincenzo;
    • Cardelli, Maurizio;
    • Alexandrov, Boian S.;
    • Otlu, Burcak;
    • Hua, Xing;
    • Jones, Kristine;
    • Brodie, Seth;
    • Dabrowska, Malgorzata Ewa;
    • Toro, Jorge R.;
    • Yeager, Meredith;
    • Wang, Mingyi;
    • Hicks, Belynda;
    • Alexandrov, Ludmil B.
    Publication type:
    Article
    43

    Timing the initiation of multiple myeloma.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15740-9
    By:
    • Rustad, Even H.;
    • Yellapantula, Venkata;
    • Leongamornlert, Daniel;
    • Bolli, Niccolò;
    • Ledergor, Guy;
    • Nadeu, Ferran;
    • Angelopoulos, Nicos;
    • Dawson, Kevin J.;
    • Mitchell, Thomas J.;
    • Osborne, Robert J.;
    • Ziccheddu, Bachisio;
    • Carniti, Cristiana;
    • Montefusco, Vittorio;
    • Corradini, Paolo;
    • Anderson, Kenneth C.;
    • Moreau, Philippe;
    • Papaemmanuil, Elli;
    • Alexandrov, Ludmil B.;
    • Puente, Xose S.;
    • Campo, Elias
    Publication type:
    Article
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    Mammalian Stem Cells Reprogramming in Response to Terahertz Radiation.

    Published in:
    PLoS ONE, 2010, v. 5, n. 12, p. 1, doi. 10.1371/journal.pone.0015806
    By:
    • Bock, Jonathan;
    • Fukuyo, Yayoi;
    • Kang, Sona;
    • Phipps, M. Lisa;
    • Alexandrov, Ludmil B.;
    • Rasmussen, Kim Ø.;
    • Bishop, Alan R.;
    • Rosen, Evan D.;
    • Martinez, Jennifer S.;
    • Hou-Tong Chen;
    • Rodriguez, George;
    • Alexandrov, Boian S.;
    • Usheva, Anny
    Publication type:
    Article
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    Corrigendum: Signatures of mutational processes in human cancer.

    Published in:
    Nature, 2013, v. 502, n. 7470, p. 258, doi. 10.1038/nature12666
    By:
    • Alexandrov, Ludmil B.;
    • Nik-Zainal, Serena;
    • Wedge, David C.;
    • Aparicio, Samuel A. J. R.;
    • Behjati, Sam;
    • Biankin, Andrew V.;
    • Bignell, Graham R.;
    • Bolli, Niccolò;
    • Borg, Ake;
    • Børresen-Dale, Anne-Lise;
    • Boyault, Sandrine;
    • Burkhardt, Birgit;
    • Butler, Adam P.;
    • Caldas, Carlos;
    • Davies, Helen R.;
    • Desmedt, Christine;
    • Eils, Roland;
    • Eyfjörd, Jórunn Erla;
    • Foekens, John A.;
    • Greaves, Mel
    Publication type:
    Article
    48

    Signatures of mutational processes in human cancer.

    Published in:
    Nature, 2013, v. 500, n. 7463, p. 415, doi. 10.1038/nature12477
    By:
    • Alexandrov, Ludmil B.;
    • Nik-Zainal, Serena;
    • Wedge, David C.;
    • Aparicio, Samuel A. J. R.;
    • Behjati, Sam;
    • Biankin, Andrew V.;
    • Bignell, Graham R.;
    • Bolli, Niccolò;
    • Borg, Ake;
    • Børresen-Dale, Anne-Lise;
    • Boyault, Sandrine;
    • Burkhardt, Birgit;
    • Butler, Adam P.;
    • Caldas, Carlos;
    • Davies, Helen R.;
    • Desmedt, Christine;
    • Eils, Roland;
    • Eyfjörd, Jórunn Erla;
    • Foekens, John A.;
    • Greaves, Mel
    Publication type:
    Article
    49

    The genome as a record of environmental exposure.

    Published in:
    Mutagenesis, 2015, v. 30, n. 6, p. 763, doi. 10.1093/mutage/gev073
    By:
    • Nik-Zainal, Serena;
    • Kucab, Jill E.;
    • Morganella, Sandro;
    • Glodzik, Dominik;
    • Alexandrov, Ludmil B.;
    • Arlt, Volker M.;
    • Weninger, Annette;
    • Hollstein, Monica;
    • Stratton, Michael R.;
    • Phillips, David H.
    Publication type:
    Article
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