Works by Alessi, Dario

Results: 111

Redox-driven photoselective self-assembly.

Published in:

Nature Communications, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41467-025-58890-4

By:

Alessi, Dario;
Morgan, Luca;
Pelorosso, Elisa;
Graiff, Claudia;
Pinter, Piermaria;
Aliprandi, Alessandro

Publication type:

Article

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor.

Published in:

PLoS Biology, 2009, v. 7, n. 6, p. 1, doi. 10.1371/journal.pbio.1000126

By:

Zeqiraj, Elton;
Filippi, Beatrice Maria;
Goldie, Simon;
Navratilova, Iva;
Boudeau, Jérôme;
Deak, Maria;
Alessi, Dario R.;
van Aalten, Daan M. F.

Publication type:

Article

Terpyridine Diphosphine Ruthenium Complexes as Efficient Photocatalysts for the Transfer Hydrogenation of Carbonyl Compounds.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 65, p. 1, doi. 10.1002/chem.202201722

By:

Ballico, Maurizio;
Alessi, Dario;
Jandl, Christian;
Lovison, Denise;
Baratta, Walter

Publication type:

Article

Enantioselective Cytotoxicity of Chiral Diphosphine Ruthenium(II) Complexes Against Cancer Cells.

Published in:

Chemistry - A European Journal, 2022, v. 28, n. 33, p. 1, doi. 10.1002/chem.202200200

By:

Lovison, Denise;
Alessi, Dario;
Allegri, Lorenzo;
Baldan, Federica;
Ballico, Maurizio;
Damante, Giuseppe;
Galasso, Marilisa;
Guardavaccaro, Daniele;
Ruggieri, Silvia;
Melchior, Andrea;
Veclani, Daniele;
Nardon, Chiara;
Baratta, Walter

Publication type:

Article

Inhibition of glycogen synthase kinase-3 by insulin...

Published in:

Nature, 1995, v. 378, n. 6559, p. 785, doi. 10.1038/378785a0

By:

Cross, Darren A. E.;
Alessi, Dario R.

Publication type:

Article

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.87098

By:

Dhekne, Herschel S.;
Tonelli, Francesca;
Yeshaw, Wondwossen M.;
Chiang, Claire Y.;
Limouse, Charles;
Jaimon, Ebsy;
Purlyte, Elena;
Alessi, Dario R.;
Pfeffer, Suzanne R.

Publication type:

Article

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion.

Published in:

Science Signaling, 2010, v. 3, n. 115, p. 1, doi. 10.1126/scisignal.2000616

By:

Zagórska, Anna;
Deak, Maria;
Campbell, David G.;
Banerjee, Sourav;
Hirano, Mariko;
Aizawa, Shinichi;
Prescott, Alan R.;
Alessi, Dario R.

Publication type:

Article

New Insights into mTOR Signaling: mTORC2 and Beyond.

Published in:

Science Signaling, 2009, v. 2, n. 67, p. 1, doi. 10.1126/scisignal.267pe27

By:

Alessi, Dario R.;
Pearce, Laura R.;
García-Martínez, Juan M.

Publication type:

Article

USP45 deubiquitylase controls ERCC1- XPF endonuclease-mediated DNA damage responses.

Published in:

EMBO Journal, 2015, v. 34, n. 3, p. 326, doi. 10.15252/embj.201489184

By:

Perez‐Oliva, Ana B;
Lachaud, Christophe;
Szyniarowski, Piotr;
Muñoz, Ivan;
Macartney, Thomas;
Hickson, Ian;
Rouse, John;
Alessi, Dario R

Publication type:

Article

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.

Published in:

EMBO Journal, 2011, v. 30, n. 9, p. 1730, doi. 10.1038/emboj.2011.78

By:

Filippi, Beatrice M;
de los Heros, Paola;
Mehellou, Youcef;
Navratilova, Iva;
Gourlay, Robert;
Deak, Maria;
Plater, Lorna;
Toth, Rachel;
Zeqiraj, Elton;
Alessi, Dario R

Publication type:

Article

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction.

Published in:

EMBO Journal, 2005, v. 24, n. 10, p. 1810, doi. 10.1038/sj.emboj.7600667

By:

Sakamoto, Kei;
McCarthy, Afshan;
Smith, Darrin;
Green, Kevin A.;
Hardie, D. Grahame;
Ashworth, Alan;
Alessi, Dario R.

Publication type:

Article

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis.

Published in:

EMBO Journal, 2005, v. 24, n. 8, p. 1571, doi. 10.1038/sj.emboj.7600633

By:

McManus, Edward J.;
Sakamoto, Kei;
Armit, Laura J.;
Ronaldson, Leah;
Shpiro, Natalia;
Marquez, Rodolfo;
Alessi, Dario R.

Publication type:

Article

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

Published in:

EMBO Journal, 2004, v. 23, n. 20, p. 3918, doi. 10.1038/sj.emboj.7600379

By:

Komander, David;
Fairservice, Alison;
Deak, Maria;
Kular, Gursant S;
Prescott, Alan R;
Peter Downes, C;
Safrany, Stephen T;
Alessi, Dario R;
M F van Aalten, Daan

Publication type:

Article

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation.

Published in:

EMBO Journal, 2004, v. 23, n. 10, p. 2071, doi. 10.1038/sj.emboj.7600218

By:

McManus, Edward J.;
Collins, Barry J.;
Ashby, Peter R.;
Prescott, Alan R.;
Murray-Tait, Victoria;
Armit, Laura J.;
Arthur, J. Simon C.;
Alessi, Dario R.

Publication type:

Article

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

Published in:

EMBO Journal, 2004, v. 23, n. 4, p. 833, doi. 10.1038/sj.emboj.7600110

By:

Lizcano, Jose M.;
Göransson, Olga;
Toth, Rachel;
Deak, Maria;
Morrice, Nick A.;
Boudeau, Jérôme;
Hawley, Simon A.;
Udd, Lina;
Mäkelä, Tomi P.;
Hardie, D. Grahame;
Alessi, Dario R.

Publication type:

Article

MO25a/ß interact with STRADa/ß enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

Published in:

EMBO Journal, 2003, v. 22, n. 19, p. 5102, doi. 10.1093/emboj/cdg490

By:

Boudeau, Jérôme;
Baas, Annette F.;
Deak, Maria;
Amorrice, Nick;
Kieloch, Agnieszka;
Schutkowski, Mike;
Prescott, Alan R.;
Clevers, Hans C.;
Alessi, Dario R.

Publication type:

Article

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation.

Published in:

EMBO Journal, 2003, v. 22, n. 16, p. 4202, doi. 10.1093/emboj/cdg407

By:

Collins, Barry J.;
Deak, Maria;
Carthur, J. Simon;
Armit, Laura J.;
Alessi, Dario R.

Publication type:

Article

Crystal structure of MO25a in complex with the C terminus of the pseudo kinase STE20-related adaptor.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 2, p. 193, doi. 10.1038/nsmb716

By:

Milburn, Christine C.;
Boudeau, Jerome;
Deak, Maria;
Alessi, Dario R.;
Daan M.F. van Aalten, Dario R.

Publication type:

Article

High-Content Peptide Microarrays for Deciphering Kinase Specificity and Biology.

Published in:

Angewandte Chemie, 2004, v. 116, n. 20, p. 2725, doi. 10.1002/ange.200453900

By:

Mike Schutkowski;
Ulf Reimer;
Sören Panse;
Liying Dong;
Jose M. Lizcano;
Dario R. Alessi;
Jens Schneider-Mergener

Publication type:

Article

LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson's disease and dementia with Lewy bodies.

Published in:

Acta Neuropathologica, 2021, v. 142, n. 1, p. 117, doi. 10.1007/s00401-021-02313-3

By:

Grochowska, Martyna M.;
Carreras Mascaro, Ana;
Boumeester, Valerie;
Natale, Domenico;
Breedveld, Guido J.;
Geut, Hanneke;
van Cappellen, Wiggert A.;
Boon, Agnita J. W.;
Kievit, Anneke J. A.;
Sammler, Esther;
Parchi, Piero;
Cortelli, Pietro;
Alessi, Dario R.;
van de Berg, Wilma D. J.;
Bonifati, Vincenzo;
Mandemakers, Wim

Publication type:

Article

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.67900

By:

Khan, Shahzad S.;
Yuriko Sobu;
Dhekne, Herschel S.;
Tonelli, Francesca;
Berndsen, Kerryn;
Alessi, Dario R.;
Pfeffer, Suzanne R.

Publication type:

Article

PRR5L degradation promotes mTORC2-mediated PKC-? phosphorylation and cell migration downstream of G?12.

Published in:

Nature Cell Biology, 2012, v. 14, n. 7, p. 686, doi. 10.1038/ncb2507

By:

Gan, Xiaoqing;
Wang, Jiyong;
Wang, Chen;
Sommer, Eeva;
Kozasa, Tohru;
Srinivasula, Srinivasa;
Alessi, Dario;
Offermanns, Stefan;
Simon, Melvin I.;
Wu, Dianqing

Publication type:

Article

FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.

Published in:

Nature Cell Biology, 2004, v. 6, n. 5, p. 393, doi. 10.1038/ncb1119

By:

Godi, Anna;
Campli, Antonella Di;
Konstantakopoulos, Athanasios;
Tullio, Giuseppe Di;
Alessi, Dario R.;
Kular, Gursant S.;
Daniele, Tiziana;
Marra, Pierfrancesco;
Lucocq, John M.;
Matteis, M. Antonietta De

Publication type:

Article

TSC1?TSC2: a complex tale of PKB-mediated S6K regulation.

Published in:

Nature Cell Biology, 2002, v. 4, n. 9, p. E214, doi. 10.1038/ncb0902-e214

By:

McManus, Edward J.;
Alessi, Dario R.

Publication type:

Article

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00954-1

By:

Maniaci, Chiara;
Hughes, Scott J.;
Testa, Andrea;
Wenzhang Chen;
Lamont, Douglas J.;
Rocha, Sonia;
Alessi, Dario R.;
Romeo, Roberto;
Ciulli, Alessio

Publication type:

Article

Role of the WNK-activated SPAK kinase in regulating blood pressure.

Published in:

EMBO Molecular Medicine, 2010, v. 2, n. 2, p. 63, doi. 10.1002/emmm.200900058

By:

Rafiqi, Fatema H.;
Zuber, Annie Mercier;
Glover, Mark;
Richardson, Ciaran;
Fleming, Stewart;
Jovanović, Sofija;
Jovanović, Aleksandar;
O'Shaughnessy, Kevin M.;
Alessi, Dario R.

Publication type:

Article

A meeting of minds: Overcoming roadblocks in the development of therapies for neurodegenerative disorders.

Published in:

EMBO Molecular Medicine, 2009, v. 1, n. 3, p. 139, doi. 10.1002/emmm.200900021

By:

Muqit, Miratul M. K.;
Alessi, Dario R.

Publication type:

Article

Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase.

Published in:

2019

By:

Purlyte, Elena;
Dhekne, Herschel S;
Sarhan, Adil R;
Gomez, Rachel;
Lis, Pawel;
Wightman, Melanie;
Martinez, Terina N;
Tonelli, Francesca;
Pfeffer, Suzanne R;
Alessi, Dario R

Publication type:

Correction Notice

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.

Published in:

EMBO Journal, 2018, v. 37, n. 12, p. 1, doi. 10.15252/embj.201798694

By:

Härtlova, Anetta;
Herbst, Susanne;
Peltier, Julien;
Rodgers, Angela;
Bilkei‐Gorzo, Orsolya;
Fearns, Antony;
Dill, Brian D.;
Lee, Heyne;
Flynn, Rowan;
Cowley, Sally A.;
Davies, Paul;
Lewis, Patrick A.;
Ganley, Ian G.;
Martinez, Jennifer;
Alessi, Dario R.;
Reith, Alastair D.;
Trost, Matthias;
Gutierrez, Maximiliano G.

Publication type:

Article

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Published in:

EMBO Journal, 2018, v. 37, n. 1, p. 1, doi. 10.15252/embj.201798099

By:

Purlyte, Elena;
Dhekne, Herschel S.;
Sarhan, Adil R.;
Gomez, Rachel;
Lis, Pawel;
Wightman, Melanie;
Martinez, Terina N.;
Tonelli, Francesca;
Pfeffer, Suzanne R.;
Alessi, Dario R.

Publication type:

Article

The hVps34- SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.

Published in:

EMBO Journal, 2016, v. 35, n. 20, p. 2263, doi. 10.15252/embj.201670010

By:

Bago, Ruzica;
Sommer, Eeva;
Castel, Pau;
Crafter, Claire;
Bailey, Fiona P;
Shpiro, Natalia;
Baselga, José;
Cross, Darren;
Eyers, Patrick A;
Alessi, Dario R

Publication type:

Article

The hVps34- SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.

Published in:

EMBO Journal, 2016, v. 35, n. 17, p. 1902, doi. 10.15252/embj.201693929

By:

Bago, Ruzica;
Sommer, Eeva;
Castel, Pau;
Crafter, Claire;
Bailey, Fiona P;
Shpiro, Natalia;
Baselga, José;
Cross, Darren;
Eyers, Patrick A;
Alessi, Dario R

Publication type:

Article

3'phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium.

Published in:

FASEB Journal, 2006, v. 20, n. 14, p. 2556, doi. 10.1096/fj.06-6252fje

By:

Budas, Grant R.;
Sukhodub, Andrey;
Alessi, Dario R.;
Jovanović, Aleksandar

Publication type:

Article

Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice.

Published in:

FASEB Journal, 2006, v. 20, n. 13, p. 2214, doi. 10.1096/fj.05-5676com

By:

Rexhepaj, Rexhep;
Grahammer, Florian;
Völkl, Harald;
Remy, Christine;
Wagner, Carsten A.;
Sandulache, Diana;
Artunc, Ferruh;
Henke, Guido;
Nammi, Srinivas;
Capasso, Giovambattista;
Alessi, Dario R.;
Lang, Florian

Publication type:

Article

LKB1 and AMPK and the cancer-metabolism link - ten years after.

Published in:

BMC Biology, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1741-7007-11-36

By:

Grahame Hardie, D.;
Alessi, Dario R.

Publication type:

Article

The New p.F1700L LRRK2 Variant Causes Parkinson's Disease by Extensively Increasing Kinase Activity.

Published in:

Movement Disorders, 2023, v. 38, n. 6, p. 1105, doi. 10.1002/mds.29385

By:

Borsche, Max;
Pratuseviciute, Neringa;
Schaake, Susen;
Hinrichs, Frauke;
Morel, Gabriel;
Uter, Jan;
Lohmann, Katja;
Klein, Christine;
Alessi, Dario R.;
Hagenah, Johann;
Sammler, Esther

Publication type:

Article

Structural biology: Security measures of a master regulator.

Published in:

Nature, 2013, v. 497, n. 7448, p. 193, doi. 10.1038/nature12101

By:

Alessi, Dario R.;
Kulathu, Yogesh

Publication type:

Article

Structural basis for the specificity of PPM1H phosphatase for Rab GTPases.

Published in:

EMBO Reports, 2021, v. 22, n. 11, p. 1, doi. 10.15252/embr.202152675

By:

Waschbüsch, Dieter;
Berndsen, Kerryn;
Lis, Pawel;
Knebel, Axel;
Lam, Yuko PY;
Alessi, Dario R;
Khan, Amir R

Publication type:

Article

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

Published in:

EMBO Reports, 2015, v. 16, n. 8, p. 939, doi. 10.15252/embr.201540352

By:

Kazlauskaite, Agne;
Martínez‐Torres, R Julio;
Wilkie, Scott;
Kumar, Atul;
Peltier, Julien;
Gonzalez, Alba;
Johnson, Clare;
Zhang, Jinwei;
Hope, Anthony G;
Peggie, Mark;
Trost, Matthias;
Aalten, Daan MF;
Alessi, Dario R;
Prescott, Alan R;
Knebel, Axel;
Walden, Helen;
Muqit, Miratul MK

Publication type:

Article

Structural insights into the recognition of substrates and activators by the OSR1 kinase.

Published in:

EMBO Reports, 2007, v. 8, n. 9, p. 839, doi. 10.1038/sj.embor.7401048

By:

Villa, Fabrizio;
Goebel, Jürgen;
Rafiqi, Fatema H;
Deak, Maria;
Thastrup, Jacob;
Alessi, Dario R;
van Aalten, Daan M F

Publication type:

Article

The nuts and bolts of AGC protein kinases.

Published in:

Nature Reviews Molecular Cell Biology, 2010, v. 11, n. 1, p. 9, doi. 10.1038/nrm2822

By:

Pearce, Laura R.;
Komander, David;
Alessi, Dario R.

Publication type:

Article

Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer.

Published in:

IUBMB Life, 2023, v. 75, n. 4, p. 282, doi. 10.1002/iub.2715

By:

Newton, Alexandra C.;
Alessi, Dario R.

Publication type:

Article

Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 6, p. 2492, doi. 10.1523/JNEUROSCI.4248-14.2015

By:

Ning Zhang;
Gordon, Sarah L.;
Fritsch, Maximilian J.;
Esoof, Noor;
Campbell, David G.;
Gourlay, Robert;
Velupillai, Srikannathasan;
Macartney, Thomas;
Peggie, Mark;
van Aalten, Daan M. F.;
Cousin, Michael A.;
Alessi, Dario R.

Publication type:

Article

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes.

Published in:

2009

By:

Libby G;
Donnelly LA;
Donnan PT;
Alessi DR;
Morris AD;
Evans JM;
Libby, Gillian;
Donnelly, Louise A;
Donnan, Peter T;
Alessi, Dario R;
Morris, Andrew D;
Evans, Josie M M

Publication type:

journal article

New Users of Metformin Are at Low Risk of Incident Cancer.

Published in:

Diabetes Care, 2009, v. 32, n. 9, p. 1620, doi. 10.2337/dc08-2175

By:

Libby, Gillian;
Donnelly, Louise A.;
Donnan, Peter T.;
Alessi, Dario R.;
Morris, Andrew D.;
Evans, Josie M. M.

Publication type:

Article

Small-Molecule Inhibitors of PDK1.

Published in:

ChemMedChem, 2008, v. 3, n. 12, p. 1810, doi. 10.1002/cmdc.200800195

By:

Peifer, Christian;
Alessi, Dario R.

Publication type:

Article

Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease.

Published in:

Biochemical Society Transactions, 2012, v. 40, n. 5, p. 1039, doi. 10.1042/BST20120178

By:

Lewis, Patrick A.;
Alessi, Dario R.

Publication type:

Article

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.

Published in:

Nature Medicine, 2014, v. 20, n. 11, p. 1340, doi. 10.1038/nm.3646

By:

Schönhuber, Nina;
Seidler, Barbara;
Schuck, Kathleen;
Veltkamp, Christian;
Schachtler, Christina;
Zukowska, Magdalena;
Eser, Stefan;
Paul, Mariel C;
Klein, Sabine;
Schneider, Günter;
Alessi, Dario R;
Varela, Ignacio;
Kind, Alexander;
Schnieke, Angelika E;
Rad, Roland;
Schmid, Roland M;
Saur, Dieter;
Feyerabend, Thorsten B;
Rodewald, Hans-Reimer;
Eser, Philipp

Publication type:

Article

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

Published in:

Biochemical Journal, 2022, v. 479, n. 18, p. 1941, doi. 10.1042/BCJ20220308

By:

Malik, Asad U.;
Karapetsas, Athanasios;
Nirujogi, Raja S.;
Chatterjee, Deep;
Phung, Toan K.;
Wightman, Melanie;
Gourlay, Robert;
Morrice, Nick;
Mathea, Sebastian;
Knapp, Stefan;
Alessi, Dario R.

Publication type:

Article

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

Published in:

Biochemical Journal, 2022, v. 479, n. 17, p. 1941, doi. 10.1042/BCJ20220308

By:

Malik, Asad U.;
Karapetsas, Athanasios;
Nirujogi, Raja S.;
Chatterjee, Deep;
Phung, Toan K.;
Wightman, Melanie;
Gourlay, Robert;
Morrice, Nick;
Mathea, Sebastian;
Knapp, Stefan;
Alessi, Dario R.

Publication type:

Article