Works by Alcalay, Roy

Results: 152
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    The effect of polygenic risk score on PD risk and phenotype in LRRK2 G2019S and GBA1 carriers.

    Published in:
    Journal of Parkinson's Disease, 2025, v. 15, n. 2, p. 291, doi. 10.1177/1877718X241310722
    By:
    • Goldstein, Orly;
    • Shani, Shachar;
    • Gana-Weisz, Mali;
    • Elkoshi, Nadav;
    • Casey, Fergal;
    • Sun, Yu H;
    • Chandratre, Khyati;
    • Cedarbaum, Jesse M;
    • Blauwendraat, Cornelis;
    • Bar-Shira, Anat;
    • Thaler, Avner;
    • Gurevich, Tanya;
    • Mirelman, Anat;
    • Giladi, Nir;
    • Orr-Urtreger, Avi;
    • Alcalay, Roy N
    Publication type:
    Article
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    Unmet Need in Early-Onset Parkinson's Disease: Deep Brain Stimulation and Pregnancy.

    Published in:
    Journal of Parkinson's Disease, 2024, v. 14, n. 6, p. 1277, doi. 10.3233/JPD-240088
    By:
    • Smilowska, Katarzyna;
    • Mehanna, Raja;
    • Fleisher, Jori E.;
    • Alcalay, Roy N.;
    • Kumar, Kishore Raj;
    • Marras, Connie;
    • Oosterbaan, Annelien M.;
    • Post, Bart;
    • Ross, Owen A.;
    • Pimentel Piemonte, Maria Elisa;
    • Fraix, Valerie;
    • Moro, Elena;
    • King Tan, Eng;
    • Savica, Rodolfo
    Publication type:
    Article
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    Safety, Pharmacokinetics, and Pharmacodynamics of Oral Venglustat in Patients with Parkinson's Disease and a GBA Mutation: Results from Part 1 of the Randomized, Double-Blinded, Placebo-Controlled MOVES-PD Trial.

    Published in:
    Journal of Parkinson's Disease, 2022, v. 12, n. 2, p. 557, doi. 10.3233/JPD-212714
    By:
    • Peterschmitt, M. Judith;
    • Saiki, Hidemoto;
    • Hatano, Taku;
    • Gasser, Thomas;
    • Isaacson, Stuart H.;
    • Gaemers, Sebastiaan J.M.;
    • Minini, Pascal;
    • Saubadu, Stéphane;
    • Sharma, Jyoti;
    • Walbillic, Samantha;
    • Alcalay, Roy N.;
    • Cutter, Gary;
    • Hattori, Nobutaka;
    • Höglinger, Günter U.;
    • Marek, Kenneth;
    • Schapira, Anthony H.V.;
    • Scherzer, Clemens R.;
    • Simuni, Tanya;
    • Giladi, Nir;
    • Sardi, Sergio Pablo
    Publication type:
    Article
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    A Virtual Cohort Study of Individuals at Genetic Risk for Parkinson's Disease: Study Protocol and Design.

    Published in:
    Journal of Parkinson's Disease, 2020, v. 10, n. 3, p. 1195, doi. 10.3233/JPD-202019
    By:
    • Schneider, Ruth B.;
    • Myers, Taylor L.;
    • Rowbotham, Helen M.;
    • Luff, Marie K.;
    • Amodeo, Katherine;
    • Sharma, Saloni;
    • Wilson, Renee;
    • Jensen-Roberts, Stella;
    • Auinger, Peggy;
    • McDermott, Michael P.;
    • Alcalay, Roy N.;
    • Biglan, Kevin;
    • Kinel, Daniel;
    • Tanner, Caroline;
    • Winter-Evans, Reni;
    • Augustine, Erika F.;
    • Cannon, Paul;
    • Holloway, Robert G.;
    • Dorsey, E. Ray
    Publication type:
    Article
    9

    An Assessment of LRRK2 Serine 935 Phosphorylation in Human Peripheral Blood Mononuclear Cells in Idiopathic Parkinson's Disease and G2019S LRRK2 Cohorts.

    Published in:
    Journal of Parkinson's Disease, 2020, v. 10, n. 2, p. 623, doi. 10.3233/JPD-191786
    By:
    • Padmanabhan, Shalini;
    • Lanz, Thomas A.;
    • Gorman, Donal;
    • Wolfe, Michele;
    • Joyce, Alison;
    • Cabrera, Carlos;
    • Lawrence-Henderson, Rosemary;
    • Levers, Najah;
    • Joshi, Neal;
    • Ma, Thong C.;
    • Liong, Christopher;
    • Narayan, Sushma;
    • Alcalay, Roy N.;
    • Hutten, Samantha J.;
    • Baptista, Marco A.S.;
    • Merchant, Kalpana
    Publication type:
    Article
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    New diagnostic and staging framework applied to established PD in the BioFIND cohort.

    Published in:
    NPJ Parkinson's Disease, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41531-025-00992-3
    By:
    • Russo, Marco J.;
    • Kang, Un Jung;
    • Alcalay, Roy N.;
    • Amara, Amy;
    • Arnedo, Vanessa;
    • Frank, Samuel;
    • Frasier, Mark;
    • Goldman, Jennifer G.;
    • Gwinn, Katrina;
    • Henchcliffe, Claire;
    • Hogarth, Penelope;
    • Naito, Anna;
    • Reimer, Alyssa N.;
    • Saint-Hilaire, Marie-Helene;
    • Swanson-Fischer, Christine;
    • Sutherland, Margaret;
    • Tuite, Paul;
    • Xie, Tao
    Publication type:
    Article
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    Longitudinal Measurements of Glucocerebrosidase activity in Parkinson's patients.

    Published in:
    Annals of Clinical & Translational Neurology, 2020, v. 7, n. 10, p. 1816, doi. 10.1002/acn3.51164
    By:
    • Alcalay, Roy N.;
    • Wolf, Pavlina;
    • Chiang, Ming Sum Ruby;
    • Helesicova, Karolina;
    • Zhang, Xiaokui Kate;
    • Merchant, Kalpana;
    • Hutten, Samantha J.;
    • Scherzer, Clemens;
    • Caspell‐Garcia, Chelsea;
    • Blauwendraat, Cornelis;
    • Foroud, Tatiana;
    • Nudelman, Kelly;
    • Gan‐Or, Ziv;
    • Simuni, Tanya;
    • Chahine, Lana M.;
    • Levy, Oren;
    • Zheng, Dandi;
    • Li, Gen;
    • Sardi, Sergio Pablo;
    • Marek, Kenneth
    Publication type:
    Article
    14

    Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease.

    Published in:
    Annals of Clinical & Translational Neurology, 2020, v. 7, n. 4, p. 449, doi. 10.1002/acn3.51022
    By:
    • Weintraub, Daniel;
    • Caspell‐Garcia, Chelsea;
    • Simuni, Tanya;
    • Cho, Hyunkeun R.;
    • Coffey, Christopher S.;
    • Aarsland, Dag;
    • Alcalay, Roy N.;
    • Barrett, Matthew J.;
    • Chahine, Lana M.;
    • Eberling, Jamie;
    • Espay, Alberto J.;
    • Hamilton, Jamie;
    • Hawkins, Keith A.;
    • Leverenz, James;
    • Litvan, Irene;
    • Richard, Irene;
    • Rosenthal, Liana S.;
    • Siderowf, Andrew;
    • York, Michele
    Publication type:
    Article
    15

    GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder.

    Published in:
    Annals of Clinical & Translational Neurology, 2015, v. 2, n. 9, p. 941, doi. 10.1002/acn3.228
    By:
    • Gan‐Or, Ziv;
    • Mirelman, Anat;
    • Postuma, Ronald B.;
    • Arnulf, Isabelle;
    • Bar‐Shira, Anat;
    • Dauvilliers, Yves;
    • Desautels, Alex;
    • Gagnon, Jean‐François;
    • Leblond, Claire S.;
    • Frauscher, Birgit;
    • Alcalay, Roy N.;
    • Saunders‐Pullman, Rachel;
    • Bressman, Susan B.;
    • Marder, Karen;
    • Monaca, Christelle;
    • Högl, Birgit;
    • Orr‐Urtreger, Avi;
    • Dion, Patrick A.;
    • Montplaisir, Jacques Y.;
    • Giladi, Nir
    Publication type:
    Article
    16

    Olfactory identification in LRRK2 G2019S mutation carriers: a relevant marker?

    Published in:
    Annals of Clinical & Translational Neurology, 2014, v. 1, n. 9, p. 670, doi. 10.1002/acn3.95
    By:
    • Saunders‐Pullman, Rachel;
    • Mirelman, Anat;
    • Wang, Cuiling;
    • Alcalay, Roy N.;
    • San Luciano, Marta;
    • Ortega, Robert;
    • Raymond, Deborah;
    • Mejia‐Santana, Helen;
    • Ozelius, Laurie;
    • Clark, Lorraine;
    • Orr‐Utreger, Avi;
    • Marder, Karen;
    • Giladi, Nir;
    • Bressman, Susan B.
    Publication type:
    Article
    17

    Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease.

    Published in:
    JAMA Neurology, 2018, v. 75, n. 11, p. 1416, doi. 10.1001/jamaneurol.2018.1885
    By:
    • Blauwendraat, Cornelis;
    • Reed, Xylena;
    • Kia, Demis A.;
    • Gan-Or, Ziv;
    • Lesage, Suzanne;
    • Pihlstrøm, Lasse;
    • Guerreiro, Rita;
    • Gibbs, J. Raphael;
    • Sabir, Marya;
    • Ahmed, Sarah;
    • Ding, Jinhui;
    • Alcalay, Roy N.;
    • Hassin-Baer, Sharon;
    • Pittman, Alan M.;
    • Brooks, Janet;
    • Edsall, Connor;
    • Hernandez, Dena G.;
    • Chung, Sun Ju;
    • Goldwurm, Stefano;
    • Toft, Mathias
    Publication type:
    Article
    18

    Progression in the LRRK2-Asssociated Parkinson Disease Population.

    Published in:
    JAMA Neurology, 2018, v. 75, n. 3, p. 312, doi. 10.1001/jamaneurol.2017.4019
    By:
    • Saunders-Pullman, Rachel;
    • Mirelman, Anat;
    • Alcalay, Roy N.;
    • Wang, Cuiling;
    • Ortega, Roberto A.;
    • Raymond, Deborah;
    • Mejia-Santana, Helen;
    • Orbe-Reilly, Martha;
    • Johannes, Brooke A.;
    • Thaler, Avner;
    • Ozelius, Laurie;
    • Orr-Urtreger, Avi;
    • Marder, Karen S.;
    • Giladi, Nir;
    • Bressman, Susan B.
    Publication type:
    Article
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    Clinical Correlations With Lewy Body Pathology in LRRK2-Related Parkinson Disease.

    Published in:
    JAMA Neurology, 2015, v. 72, n. 1, p. 100, doi. 10.1001/jamaneurol.2014.2704
    By:
    • Kalia, Lorraine V.;
    • Lang, Anthony E.;
    • Hazrati, Lili-Naz;
    • Fujioka, Shinsuke;
    • Wszolek, Zbigniew K.;
    • Dickson, Dennis W.;
    • Ross, Owen A.;
    • Van Deerlin, Vivianna M.;
    • Trojanowski, John Q.;
    • Hurtig, Howard I.;
    • Alcalay, Roy N.;
    • Marder, Karen S.;
    • Clark, Lorraine N.;
    • Gaig, Carles;
    • Tolosa, Eduardo;
    • Ruiz-Martínez, Javier;
    • Marti-Masso, Jose F.;
    • Ferrer, Isidre;
    • López de Munain, Adolfo;
    • Goldman, Samuel M.
    Publication type:
    Article
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    Cognitive and Motor Function in Long-Duration PARKIN-Associated Parkinson Disease.

    Published in:
    JAMA Neurology, 2014, v. 71, n. 1, p. 62, doi. 10.1001/jamaneurol.2013.4498
    By:
    • Alcalay, Roy N.;
    • Caccappolo, Elise;
    • Mejia-Santana, Helen;
    • Ming Xin Tang;
    • Rosado, Llency;
    • Reilly, Martha Orbe;
    • Ruiz, Diana;
    • Louis, Elan D.;
    • Comella, Cynthia L.;
    • Nance, Martha A.;
    • Bressman, Susan B.;
    • Scott, William K.;
    • Tanner, Caroline M.;
    • Mickel, Susan H.;
    • Waters, Cheryl H.;
    • Fahn, Stanley;
    • Cote, Lucien J.;
    • Frucht, Steven J.;
    • Ford, Blair;
    • Rezak, Michael
    Publication type:
    Article
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    Cognition among individuals along a spectrum of increased risk for Parkinson’s disease.

    Published in:
    PLoS ONE, 2018, v. 13, n. 8, p. 1, doi. 10.1371/journal.pone.0201964
    By:
    • Chahine, Lana M.;
    • Urbe, Liz;
    • Caspell-Garcia, Chelsea;
    • Aarsland, Dag;
    • Alcalay, Roy;
    • Barone, Paolo;
    • Burn, David;
    • Espay, Alberto J.;
    • Hamilton, Jamie L.;
    • Hawkins, Keith A.;
    • Lasch, Shirley;
    • Leverenz, James B.;
    • Litvan, Irene;
    • Richard, Irene;
    • Siderowf, Andrew;
    • Coffey, Christopher S.;
    • Simuni, Tanya;
    • Weintraub, Daniel;
    • null, null
    Publication type:
    Article
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    Clinical and Pathological Characteristics of LRRK2 G2019S Patients with PD.

    Published in:
    Journal of Molecular Neuroscience, 2012, v. 47, n. 1, p. 139, doi. 10.1007/s12031-011-9696-y
    By:
    • Poulopoulos, Markos;
    • Cortes, Etty;
    • Vonsattel, Jean-Paul;
    • Fahn, Stanley;
    • Waters, Cheryl;
    • Cote, Lucien;
    • Moskowitz, Carol;
    • Honig, Lawrence;
    • Clark, Lorraine;
    • Marder, Karen;
    • Alcalay, Roy
    Publication type:
    Article
    31

    Cerebrospinal fluid, plasma, and saliva in the BioFIND study: Relationships among biomarkers and Parkinson's disease Features.

    Published in:
    2018
    By:
    • Goldman, Jennifer G.;
    • Andrews, Howard;
    • Amara, Amy;
    • Naito, Anna;
    • Alcalay, Roy N.;
    • Shaw, Leslie M.;
    • Taylor, Peggy;
    • Xie, Tao;
    • Tuite, Paul;
    • Henchcliffe, Claire;
    • Hogarth, Penelope;
    • Frank, Samuel;
    • Saint‐Hilaire, Marie‐Helene;
    • Frasier, Mark;
    • Arnedo, Vanessa;
    • Reimer, Alyssa N.;
    • Sutherland, Margaret;
    • Swanson‐Fischer, Christine;
    • Gwinn, Katrina;
    • The Fox Investigation of New Biomarker Discovery
    Publication type:
    journal article
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    Penetrance estimate of LRRK2 p.G2019S mutation in individuals of non-Ashkenazi Jewish ancestry.

    Published in:
    2017
    By:
    • Lee, Annie J.;
    • Wang, Yuanjia;
    • Alcalay, Roy N.;
    • Mejia‐Santana, Helen;
    • Saunders‐Pullman, Rachel;
    • Bressman, Susan;
    • Corvol, Jean‐Christophe;
    • Brice, Alexis;
    • Lesage, Suzanne;
    • Mangone, Graziella;
    • Tolosa, Eduardo;
    • Pont‐Sunyer, Claustre;
    • Vilas, Dolores;
    • Schüle, Birgitt;
    • Kausar, Farah;
    • Foroud, Tatiana;
    • Berg, Daniela;
    • Brockmann, Kathrin;
    • Goldwurm, Stefano;
    • Siri, Chiara
    Publication type:
    journal article
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    The prodromal phase of leucine-rich repeat kinase 2-associated Parkinson disease: Clinical and imaging Studies.

    Published in:
    2017
    By:
    • Pont‐Sunyer, Claustre;
    • Tolosa, Eduardo;
    • Caspell‐Garcia, Chelsea;
    • Coffey, Christopher;
    • Alcalay, Roy N.;
    • Chan, Piu;
    • Duda, John E.;
    • Facheris, Maurizio;
    • Fernández‐Santiago, Rubén;
    • Marek, Kenneth;
    • Lomeña, Francisco;
    • Marras, Connie;
    • Mondragon, Elisabet;
    • Saunders‐Pullman, Rachel;
    • Waro, Bjorg;
    • Pont-Sunyer, Claustre;
    • Caspell-Garcia, Chelsea;
    • Fernández-Santiago, Rubén;
    • Lomeña, Francisco;
    • Saunders-Pullman, Rachel
    Publication type:
    journal article
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    Arm swing as a potential new prodromal marker of Parkinson's disease.

    Published in:
    2016
    By:
    • Mirelman, Anat;
    • Bernad‐Elazari, Hagar;
    • Thaler, Avner;
    • Giladi‐Yacobi, Eytan;
    • Gurevich, Tanya;
    • Gana‐Weisz, Mali;
    • Saunders‐Pullman, Rachel;
    • Raymond, Deborah;
    • Doan, Nancy;
    • Bressman, Susan B.;
    • Marder, Karen S.;
    • Alcalay, Roy N.;
    • Rao, Ashwini K.;
    • Berg, Daniela;
    • Brockmann, Kathrin;
    • Aasly, Jan;
    • Waro, Bjørg Johanne;
    • Tolosa, Eduardo;
    • Vilas, Dolores;
    • Pont‐Sunyer, Claustre
    Publication type:
    journal article
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    The NINDS Parkinson's disease biomarkers program.

    Published in:
    2016
    By:
    • Rosenthal, Liana S.;
    • Drake, Daniel;
    • Alcalay, Roy N.;
    • Babcock, Debra;
    • Bowman, F. DuBois;
    • Chen‐Plotkin, Alice;
    • Dawson, Ted M.;
    • Dewey, Richard B.;
    • German, Dwight C.;
    • Huang, Xuemei;
    • Landin, Barry;
    • McAuliffe, Matthew;
    • Petyuk, Vladislav A.;
    • Scherzer, Clemens R.;
    • Hillaire‐Clarke, Coryse St.;
    • Sieber, Beth‐Anne;
    • Sutherland, Margaret;
    • Tarn, Chi;
    • West, Andrew;
    • Vaillancourt, David
    Publication type:
    journal article
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    Nonmotor symptoms in healthy Ashkenazi Jewish carriers of the G2019S mutation in the LRRK2 gene.

    Published in:
    Movement Disorders, 2015, v. 30, n. 7, p. 981, doi. 10.1002/mds.26213
    By:
    • Mirelman, Anat;
    • Alcalay, Roy N.;
    • Saunders‐Pullman, Rachel;
    • Yasinovsky, Kira;
    • Thaler, Avner;
    • Gurevich, Tanya;
    • Mejia‐Santana, Helen;
    • Raymond, Deborah;
    • Gana‐Weisz, Mali;
    • Bar‐Shira, Anat;
    • Ozelius, Laurie;
    • Clark, Lorraine;
    • Orr‐Urtreger, Avi;
    • Bressman, Susan;
    • Marder, Karen;
    • Giladi, Nir
    Publication type:
    Article
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    Parkinson disease phenotype in Ashkenazi jews with and without LRRK2 G2019S mutations.

    Published in:
    Movement Disorders, 2013, v. 28, n. 14, p. 1966, doi. 10.1002/mds.25647
    By:
    • Alcalay, Roy N.;
    • Mirelman, Anat;
    • Saunders‐Pullman, Rachel;
    • Tang, Ming‐X;
    • Mejia Santana, Helen;
    • Raymond, Deborah;
    • Roos, Ernest;
    • Orbe‐Reilly, Martha;
    • Gurevich, Tanya;
    • Bar Shira, Anat;
    • Gana Weisz, Mali;
    • Yasinovsky, Kira;
    • Zalis, Maayan;
    • Thaler, Avner;
    • Deik, Andres;
    • Barrett, Matthew James;
    • Cabassa, Jose;
    • Groves, Mark;
    • Hunt, Ann L.;
    • Lubarr, Naomi
    Publication type:
    Article
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