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XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib.
Published in:
Therapeutic Advances in Medical Oncology, 2020, p. 1, doi. 10.1177/1758835920974201
By:
- Ali, Reem;
- Alblihy, Adel;
- Toss, Michael S.;
- Algethami, Mashael;
- Al Sunni, Rabab;
- Green, Andrew R.;
- Rakha, Emad A.;
- Madhusudan, Srinivasan
Publication type:
Article
Untangling the clinicopathological significance of MRE11-RAD50-NBS1 complex in sporadic breast cancers.
Published in:
NPJ Breast Cancer, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41523-021-00350-5
By:
- Alblihy, Adel;
- Shoqafi, Ahmed;
- Toss, Michael S.;
- Algethami, Mashael;
- Harris, Anna E.;
- Jeyapalan, Jennie N.;
- Abdel-Fatah, Tarek;
- Servante, Juliette;
- Chan, Stephen Y. T.;
- Green, Andrew;
- Mongan, Nigel P.;
- Rakha, Emad A.;
- Madhusudan, Srinivasan
Publication type:
Article
FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers.
Published in:
Cancers, 2021, v. 13, n. 8, p. 1866, doi. 10.3390/cancers13081866
By:
- Mesquita, Katia A.;
- Ali, Reem;
- Doherty, Rachel;
- Toss, Michael S.;
- Miligy, Islam;
- Alblihy, Adel;
- Dorjsuren, Dorjbal;
- Simeonov, Anton;
- Jadhav, Ajit;
- Wilson III, David M.;
- Hickson, Ian;
- Tatum, Natalie J.;
- Rakha, Emad A.;
- Madhusudan, Srinivasan;
- Telleria, Carlos M.;
- Wang, Zhixiang
Publication type:
Article
Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers.
Published in:
NPJ Precision Oncology, 2022, v. 6, n. 1, p. 1, doi. 10.1038/s41698-022-00298-0
By:
- Alblihy, Adel;
- Ali, Reem;
- Algethami, Mashael;
- Shoqafi, Ahmed;
- Toss, Michael S.;
- Brownlie, Juliette;
- Tatum, Natalie J.;
- Hickson, Ian;
- Moran, Paloma Ordonez;
- Grabowska, Anna;
- Jeyapalan, Jennie N.;
- Mongan, Nigel P.;
- Rakha, Emad A.;
- Madhusudan, Srinivasan
Publication type:
Article
Clinicopathological and Functional Evaluation Reveal NBS1 as a Predictor of Platinum Resistance in Epithelial Ovarian Cancers.
Published in:
Biomedicines, 2021, v. 9, n. 1, p. 56, doi. 10.3390/biomedicines9010056
By:
- Alblihy, Adel;
- Alabdullah, Muslim L.;
- Ali, Reem;
- Algethami, Mashael;
- Toss, Michael S.;
- Mongan, Nigel P.;
- Rakha, Emad A.;
- Madhusudan, Srinivasan
Publication type:
Article
From desert flora to cancer therapy: systematic exploration of multi-pathway mechanisms using network pharmacology and molecular modeling approaches.
Published in:
Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1345415
By:
- Alblihy, Adel
Publication type:
Article
Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers.
Published in:
NPJ Breast Cancer, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41523-023-00524-3
By:
- Algethami, Mashael;
- Toss, Michael S.;
- Woodcock, Corinne L.;
- Jaipal, Chandar;
- Brownlie, Juliette;
- Shoqafi, Ahmed;
- Alblihy, Adel;
- Mesquita, Katia A.;
- Green, Andrew R.;
- Mongan, Nigel P.;
- Jeyapalan, Jennie N.;
- Rakha, Emad A.;
- Madhusudan, Srinivasan
Publication type:
Article
Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers.
Published in:
Theranostics, 2021, v. 11, n. 17, p. 8350, doi. 10.7150/thno.51456
By:
- Ali, Reem;
- Alabdullah, Muslim;
- Algethami, Mashael;
- Alblihy, Adel;
- Miligy, Islam;
- Shoqafi, Ahmed;
- Mesquita, Katia A.;
- Abdel-Fatah, Tarek;
- Chan, Stephen Y. T.;
- Pei Wen Chiang;
- Mongan, Nigel P.;
- Rakha, Emad A.;
- Tomkinson, Alan E.;
- Madhusudan, Srinivasan
Publication type:
Article
Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 13, p. 10966, doi. 10.3390/ijms241310966
By:
- Alblihy, Adel;
- Ali, Reem;
- Algethami, Mashael;
- Ritchie, Alison A.;
- Shoqafi, Ahmed;
- Alqahtani, Shatha;
- Mesquita, Katia A.;
- Toss, Michael S.;
- Ordóñez-Morán, Paloma;
- Jeyapalan, Jennie N.;
- Dekker, Lodewijk;
- Salerno, Martina;
- Hartsuiker, Edgar;
- Grabowska, Anna M.;
- Rakha, Emad A.;
- Mongan, Nigel P.;
- Madhusudan, Srinivasan
Publication type:
Article

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