Works by Alayash, Abdu I.

Results: 43

Functional comparison of hemoglobin purified by different methods and their biophysical implications.

Published in:

Biotechnology & Bioengineering, 2010, v. 106, n. 1, p. 76, doi. 10.1002/bit.22659

By:

Elmer, Jacob;
Buehler, Paul W.;
Jia, Yiping;
Wood, Francine;
Harris, David R.;
Alayash, Abdu I.;
Palmer, Andre F.

Publication type:

Article

Memorial – Dr. Joseph C. Fratantoni.

Published in:

2016

By:

Alayash, Abdu I.

Publication type:

Obituary

Impact of cold storage on the oxygenation and oxidation reactions of red blood cells.

Published in:

Frontiers in Physiology, 2024, p. 1, doi. 10.3389/fphys.2024.1427094

By:

Kassa, Tigist;
Jana, Sirsendu;
Jin Hyen Baek;
Alayash, Abdu I.

Publication type:

Article

Targeting βCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects.

Published in:

Metallomics, 2017, v. 9, n. 9, p. 1260, doi. 10.1039/c7mt00104e

By:

Kassa, Tigist;
Brad Strader, Michael;
Nakagawa, Akito;
Zapol, Warren M.;
Alayash, Abdu I.

Publication type:

Article

Hemoglobin-based blood substitutes: oxygen carriers, pressor agents, or oxidants?

Published in:

Nature Biotechnology, 1999, v. 17, n. 6, p. 545, doi. 10.1038/9849

By:

Alayash, Abdu I.

Publication type:

Article

Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2016, v. 55, n. 2, p. 288, doi. 10.1165/rcmb.2015-0197OC

By:

Chintagari, Narendranath Reddy;
Jana, Sirsendu;
Alayash, Abdu I.

Publication type:

Article

Mixed S-Nitrosylated Polymerized Bovine Hemoglobin Species Moderate Hemodynamic Effects in Acutely Hypoxic Rats.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2010, v. 42, n. 2, p. 200, doi. 10.1165/rcmb.2008-0364OC

By:

Irwin, David;
Buehler, Paul W.;
Alayash, Abdu I.;
Yiping Jia;
Bonventura, Joe;
Foreman, Ben;
White, Molly;
Jacobs, Robert;
Piteo, Brian;
TissotvanPatot, Martha C.;
Hamilton, Karyn L.;
Gotshall, Robert W.

Publication type:

Article

Voxelotor treatment of a patient with sickle cell disease and very severe anemia.

Published in:

American Journal of Hematology, 2019, v. 94, n. 4, p. E88, doi. 10.1002/ajh.25389

By:

Shet, Arun S.;
Mendelsohn, Laurel;
Harper, Julia;
Ostrowski, David;
Henry, Eric R.;
Gwaabe, Eveline;
Nichols, Jim;
Alayash, Abdu I.;
Eaton, William A.;
Thein, Swee Lay

Publication type:

Article

Biopreservation and reversal of oxidative injury during blood storage by a novel curcumin-based gel formulation.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-82943-1

By:

Hicks, Wayne;
Jana, Sirsendu;
Kassa, Tigist;
Prince, Richard;
Cabrales, Pedro;
Friedman, Joel;
Alayash, Abdu I.

Publication type:

Article

Comparison of the oxidative reactivity of recombinant fetal and adult human hemoglobin: implications for the design of hemoglobin-based oxygen carriers.

Published in:

Bioscience Reports, 2018, v. 38, n. 4, p. 1, doi. 10.1042/BSR20180370

By:

Simons, Michelle;
Gretton, Svetlana;
Silkstone, Gary G. A.;
Rajagopal, Badri S.;
Allen-Baume, Victoria;
Syrett, Natalie;
Shaik, Thoufieq;
Leiva-Eriksson, Nelida;
Ronda, Luca;
Mozzarelli, Andrea;
Strader, Michael B.;
Alayash, Abdu I.;
Reeder, Brandon J.;
Cooper, Chris E.

Publication type:

Article

O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: Structural and functional consequences of β93Cys modification.

Published in:

Proteins, 2005, v. 59, n. 4, p. 840, doi. 10.1002/prot.20453

By:

Boykins, Robert A.;
Buehler, Paul W.;
Jia, Yiping;
Venable, Richard;
Alayash, Abdu I.

Publication type:

Article

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.

Published in:

2009

By:

Boretti, Felicitas S.;
Buehler, Paul W.;
d'Agnillo, Felice;
Kluge, Katharina;
Glaus, Tony;
Butt, Omer I.;
Yiping Jia;
Goede, Jeroen;
Pereira, Claudia P.;
Maggiorini, Marco;
Schoedon, Gabriele;
Alayash, Abdu I.;
Schaer, Dominik J.;
Jia, Yiping

Publication type:

journal article

Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0166657

By:

Shah, Sandeep N.;
Gelderman, Monique P.;
Lewis, Emily M. A.;
Farrel, John;
Wood, Francine;
Strader, Michael Brad;
Alayash, Abdu I.;
Vostal, Jaroslav G.

Publication type:

Article

HIF-1α-Dependent Metabolic Reprogramming, Oxidative Stress, and Bioenergetic Dysfunction in SARS-CoV-2-Infected Hamsters.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 1, p. 558, doi. 10.3390/ijms24010558

By:

Jana, Sirsendu;
Heaven, Michael R.;
Stauft, Charles B.;
Wang, Tony T.;
Williams, Matthew C.;
D'Agnillo, Felice;
Alayash, Abdu I.

Publication type:

Article

Cell-Free Hemoglobin Does Not Attenuate the Effects of SARS-CoV-2 Spike Protein S1 Subunit in Pulmonary Endothelial Cells.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 16, p. 9041, doi. 10.3390/ijms22169041

By:

Jana, Sirsendu;
Heaven, Michael R.;
Alayash, Abdu I.

Publication type:

Article

The Providence Mutation (βK82D) in Human Hemoglobin Substantially Reduces βCysteine 93 Oxidation and Oxidative Stress in Endothelial Cells.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 24, p. 9453, doi. 10.3390/ijms21249453

By:

Jana, Sirsendu;
Strader, Michael Brad;
Alayash, Abdu I.

Publication type:

Article

Familial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (α2β2Pro100Leu).

Published in:

Protein Science: A Publication of the Protein Society, 2012, v. 21, n. 10, p. 1444, doi. 10.1002/pro.2130

By:

Mollan, Todd L.;
Abraham, Bindu;
Strader, Michael Brad;
Jia, Yiping;
Lozier, Jay N.;
Olson, John S.;
Alayash, Abdu I.

Publication type:

Article

Biological action of nitric oxide donor compounds on platelets from patients with sickle cell....

Published in:

British Journal of Haematology, 2001, v. 112, n. 4, p. 1048, doi. 10.1046/j.1365-2141.2001.02623.x

By:

Mondoro, Traci Heath;
Ryan, Beth Brockner;
Hrinczenko, Borys W.;
Schechter, Alan N.;
Vostal, Jaroslav G.;
Alayash, Abdu I.

Publication type:

Article

Effect of nitric oxide and nitric oxide donors on red blood cell oxygen transport.

Published in:

British Journal of Haematology, 2000, v. 110, n. 2, p. 412, doi. 10.1046/j.1365-2141.2000.02203.x

By:

Hrinczenko, Borys W.;
Alayash, Abdu I.;
Wink, David A.;
Gladwin, Mark T.;
Rodgers, Griffin P.;
Schechter, Alan N.

Publication type:

Article

Dissection of the radical reactions linked to fetal hemoglobin reveals enhanced pseudoperoxidase activity.

Published in:

Frontiers in Physiology, 2015, v. 6, p. 1, doi. 10.3389/fphys.2015.00039

By:

Ratanasopa, Khuanpiroon;
Strader, Michael Brad;
Alayash, Abdu I.;
Bulow, Leif

Publication type:

Article

Characterization of heme binding to recombinant α1-microglobulin.

Published in:

Frontiers in Physiology, 2014, v. 5, p. 1, doi. 10.3389/fphys.2014.00465

By:

Karnaukhova, Elena;
Rutardottir, Sigurbjörg;
Rajabi, Mohsen;
Rosenlöf, Lena Wester;
Alayash, Abdu I.;
Åkerström, Bo

Publication type:

Article

Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems.

Published in:

Transfusion, 2004, v. 44, n. 10, p. 1516, doi. 10.1111/j.1537-2995.2004.04081.x

By:

Buehler, Paul W.;
Alayash, Abdu I.

Publication type:

Article

Hemoglobin-based blood substitutes and the hazards of blood radicals.

Published in:

Free Radical Research, 2000, v. 33, n. 4, p. 341, doi. 10.1080/10715760000300881

By:

Alayash, Abdu I.

Publication type:

Article

Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help?

Published in:

Biomolecules (2218-273X), 2017, v. 7, n. 1, p. 2, doi. 10.3390/biom7010002

By:

Alayash, Abdu I.

Publication type:

Article

Hemoglobin‐based oxygen carriers: Biochemical, biophysical differences, and safety.

Published in:

Transfusion, 2025, v. 65, n. 2, p. 386, doi. 10.1111/trf.18116

By:

Jahr, Jonathan S.;
MacKinnon, Khrystia;
Baum, Victor C.;
Alayash, Abdu I.

Publication type:

Article

Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016.

Published in:

2018

By:

Vostal, Jaroslav G.;
Buehler, Paul W.;
Gelderman, Monique P.;
Alayash, Abdu I.;
Doctor, Alan;
Zimring, James C.;
Glynn, Simone A.;
Hess, John R.;
Klein, Harvey;
Acker, Jason P.;
Spinella, Philip C.;
D'Alessandro, Angelo;
Palsson, Bernhard;
Raife, Thomas J.;
Busch, Michael P.;
McMahon, Timothy J.;
Intaglietta, Marcos;
Swartz, Harold M.;
Dubick, Michael A.;
Cardin, Sylvain

Publication type:

research

Hemoglobin Oxidation Reactions in Stored Blood.

Published in:

Antioxidants, 2022, v. 11, n. 4, p. N.PAG, doi. 10.3390/antiox11040747

By:

Alayash, Abdu I.

Publication type:

Article

Caffeic acid: an antioxidant with novel antisickling properties.

Published in:

FEBS Open Bio, 2021, v. 11, n. 12, p. 3293, doi. 10.1002/2211-5463.13295

By:

Kassa, Tigist;
Whalin, James G.;
Richards, Mark P.;
Alayash, Abdu I.

Publication type:

Article

Differential heme release from various hemoglobin redox states and the upregulation of cellular heme oxygenase-1.

Published in:

FEBS Open Bio, 2016, v. 6, n. 9, p. 876, doi. 10.1002/2211-5463.12103

By:

Kassa, Tigist;
Jana, Sirsendu;
Meng, Fantao;
Alayash, Abdu I.

Publication type:

Article

Effects of carbon monoxide (CO) delivery by a CO donor or hemoglobin on vascular hypoxia inducible factor 1α and mitochondrial respiration

Published in:

FEBS Open Bio, 2012, v. 2, p. 113, doi. 10.1016/j.fob.2012.05.003

By:

Reiter, Chad E.N.;
Alayash, Abdu I.

Publication type:

Article

Effects of carbon monoxide (CO) delivery by a CO donor or hemoglobin on vascular hypoxia inducible factor 1α and mitochondrial respiration.

Published in:

FEBS Open Bio, 2012, v. 2, n. 1, p. 113, doi. 10.1016/j.fob.2012.05.003

By:

Reiter, Chad E. N.;
Alayash, Abdu I.

Publication type:

Article

Antisickling Drugs Targeting βCys93 Reduce Iron Oxidation and Oxidative Changes in Sickle Cell Hemoglobin.

Published in:

Frontiers in Physiology, 2019, p. 1, doi. 10.3389/fphys.2019.00931

By:

Kassa, Tigist;
Wood, Francine;
Strader, Michael Brad;
Alayash, Abdu I.

Publication type:

Article

Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function.

Published in:

British Journal of Haematology, 2016, v. 175, n. 4, p. 714, doi. 10.1111/bjh.14280

By:

Shi, Patricia A.;
Choi, Erika;
Chintagari, Narendranath R.;
Nguyen, Julia;
Guo, Xinhua;
Yazdanbakhsh, Karina;
Mohandas, Narla;
Alayash, Abdu I.;
Manci, Elizabeth A.;
Belcher, John D.;
Vercellotti, Gregory M.

Publication type:

Article

Engineering oxidative stability in human hemoglobin based on the Hb providence (βK82D) mutation and genetic cross-linking.

Published in:

Biochemical Journal, 2017, v. 474, n. 24, p. 4171, doi. 10.1042/BCJ20170491

By:

Strader, Michael Brad;
Bangle, Rachel;
Parker Siburt, Claire J.;
Varnado, Cornelius L.;
Soman, Jayashree;
Benitez Cardenas, Andres S.;
Samuel, Premila P.;
Singleton, Eileen W.;
Crumbliss, Alvin L.;
Olson, John S.;
Alayash, Abdu I.

Publication type:

Article

OXYGEN THERAPEUTICS: CAN WE TAME HAEMOGLOBIN?

Published in:

Nature Reviews Drug Discovery, 2004, v. 3, n. 2, p. 152, doi. 10.1038/nrd1307

By:

Alayash, Abdu I.

Publication type:

Article

Post-translational modification as a response to cellular stress induced by hemoglobin oxidation in sickle cell disease.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-71096-6

By:

Strader, Michael Brad;
Jana, Sirsendu;
Meng, Fantao;
Heaven, Michael R.;
Shet, Arun S.;
Thein, Swee Lay;
Alayash, Abdu I.

Publication type:

Article

Changes in hemoglobin oxidation and band 3 during blood storage impact oxygen sensing and mitochondrial bioenergetic pathways in the human pulmonary arterial endothelial cell model.

Published in:

Frontiers in Physiology, 2023, p. 1, doi. 10.3389/fphys.2023.1278763

By:

Jana, Sirsendu;
Kassa, Tigist;
Wood, Francine;
Hicks, Wayne;
Alayash, Abdu I.

Publication type:

Article

Allosteric effects on oxidative and nitrosative reactions of cell-free hemoglobins.

Published in:

IUBMB Life, 2007, v. 59, n. 8/9, p. 498, doi. 10.1080/15216540601188546

By:

Bonaventura, Celia;
Henkens, Robert;
Alayash, Abdu I.;
Crumbliss, Alvin L.

Publication type:

Article

Haptoglobin Preferentially Binds β but Not α Subunits Cross-Linked Hemoglobin Tetramers with Minimal Effects on Ligand and Redox Reactions.

Published in:

PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0059841

By:

Jia, Yiping;
Wood, Francine;
Buehler, Paul W.;
Alayash, Abdu I.

Publication type:

Article

Reactions of Nitric Oxide and Hydrogen Peroxide with Hemoglobin-Based Blood Substitutes.

Published in:

Annals of the New York Academy of Sciences, 1994, v. 738, n. 1, p. 378, doi. 10.1111/j.1749-6632.1994.tb21825.x

By:

ALAYASH, ABDU I.;
CASHON, ROBERT E.

Publication type:

Article

The Impact of COVID-19 Infection on Oxygen Homeostasis: A Molecular Perspective.

Published in:

Frontiers in Physiology, 2021, v. 12, p. 1, doi. 10.3389/fphys.2021.711976

By:

Alayash, Abdu I.

Publication type:

Article

Effects of α subunit substitutions on the oxidation of βCys93 and the stability of sickle cell hemoglobin.

Published in:

Redox Report, 2020, v. 25, n. 1, p. 95, doi. 10.1080/13510002.2020.1834250

By:

Hicks, Wayne;
Meng, Fantao;
Kassa, Tigist;
Alayash, Abdu I.

Publication type:

Article

Oxidized Mutant Human Hemoglobins S and E Induce Oxidative Stress and Bioenergetic Dysfunction in Human Pulmonary Endothelial Cells.

Published in:

Frontiers in Physiology, 2017, p. 1, doi. 10.3389/fphys.2017.01082

By:

Jana, Sirsendu;
Meng, Fantao;
Hirsch, Rhoda E.;
Friedman, Joel M.;
Alayash, Abdu I.

Publication type:

Article