Works by Al-Hashem, Fahaid

Results: 41

A novel therapeutic combination of vildagliptin and agomelatine alleviates the nephropathy in streptozocin-induced diabetic rats: A structural & biochemical study.

Published in:

Journal of Research in Pharmacy, 2024, v. 28, n. 4, p. 1316, doi. 10.29228/jrp.811

By:

RAMADAN, OSAMA I.;
DAMANHORY, AHMED A.;
ABD-ALLAH, EZZ-ELDIN E.;
GOMAH, TAMER A.;
MAHMOUD, MOHAMMED E.;
ABD-ALLAH, FATMA M.;
SEWILAM, HAITHAM M.;
FAYYAD, REDA M. A.;
DARWISH, MEDHAT M.;
AL-HASHEM, FAHAID;
AWAD, MOAAZ M. Y.;
DIAB, MAHMOUD;
TAYEE, E. M.;
ELSEED, MAGDY Y.;
ABDEL HADY, ALSAYED A.;
ELSIFY, ABDELHAMID K.

Publication type:

Article

Biomarker discovery and development of prognostic prediction model using metabolomic panel in breast cancer patients: a hybrid methodology integrating machine learning and explainable artificial intelligence.

Published in:

Frontiers in Molecular Biosciences, 2025, p. 1, doi. 10.3389/fmolb.2024.1426964

By:

Yagin, Fatma Hilal;
Gormez, Yasin;
Al-Hashem, Fahaid;
Ahmad, Irshad;
Ahmad, Fuzail;
Ardigò, Luca Paolo

Publication type:

Article

Platelet Metabolites as Candidate Biomarkers in Sepsis Diagnosis and Management Using the Proposed Explainable Artificial Intelligence Approach.

Published in:

Journal of Clinical Medicine, 2024, v. 13, n. 17, p. 5002, doi. 10.3390/jcm13175002

By:

Yagin, Fatma Hilal;
Aygun, Umran;
Algarni, Abdulmohsen;
Colak, Cemil;
Al-Hashem, Fahaid;
Ardigò, Luca Paolo

Publication type:

Article

Cardiac Adaptive Responses After Hypoxia in an Experimental Model.

Published in:

Angiology, 2010, v. 61, n. 2, p. 145, doi. 10.1177/0003319709352486

By:

Bin-Jaliah, Ismaeel;
Ammar, Hania I.;
Mikhailidis, Dimitri P.;
Dallak, Mohammed A.;
Al-Hashem, Fahaid H.;
Haidara, Mohamed A.;
Yassin, Hanaa Z.;
Bahnasi, Abeer A.;
Rashed, Laila A.;
Isenovic, Esma R.

Publication type:

Article

Lipopolysaccharide induces acute lung injury and alveolar haemorrhage in association with the cytokine storm, coagulopathy and AT1R/JAK/STAT augmentation in a rat model that mimics moderate and severe Covid‐19 pathology.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2022, v. 49, n. 4, p. 483, doi. 10.1111/1440-1681.13620

By:

Al‐Ani, Bahjat;
ShamsEldeen, Asmaa M.;
Kamar, Samaa S.;
Haidara, Mohamed A.;
Al‐Hashem, Fahaid;
Alshahrani, Mohammad Y.;
Al‐Hakami, Ahmed M.;
Kader, Dina H. Abdel;
Maarouf, Amro

Publication type:

Article

Metformin ameliorates ROS-p53-collagen axis of fibrosis and dyslipidemia in type 2 diabetes mellitus-induced left ventricular injury.

Published in:

Archives of Physiology & Biochemistry, 2023, v. 129, n. 3, p. 734, doi. 10.1080/13813455.2020.1869265

By:

Al-Ani, Bahjat;
Alzamil, Norah M.;
Hewett, Peter W.;
Al-Hashem, Fahaid;
Bin-Jaliah, Ismaeel;
Shatoor, Abdullah S.;
Kamar, Samaa S.;
Latif, Noha S. Abdel;
Haidara, Mohamed A.;
Dawood, Amal F.

Publication type:

Article

Vitamin E protects against the modulation of TNF-α-AMPK axis and inhibits pancreas injury in a rat model of L-arginine-induced acute necrotising pancreatitis.

Published in:

Archives of Physiology & Biochemistry, 2023, v. 129, n. 1, p. 148, doi. 10.1080/13813455.2020.1806330

By:

Al-Hashem, Fahaid;
Abd Ellatif, Mohamed;
ShamsEldeen, Asmaa M.;
Kamar, Samaa S.;
Al-Ani, Bahjat;
Haidara, Mohamed A.

Publication type:

Article

Captopril suppresses hepatic mammalian target of rapamycin cell signaling and biomarkers of inflammation and oxidative stress in thioacetamide-induced hepatotoxicity in rats.

Published in:

Archives of Physiology & Biochemistry, 2021, v. 127, n. 5, p. 414, doi. 10.1080/13813455.2019.1647249

By:

Al-Hashem, Fahaid;
Al Humayed, Suliman;
Haidara, Mohamed A.;
Abdel Latif, Noha S.;
Al-Ani, Bahjat

Publication type:

Article

Insulin protects against type 1 diabetes mellitus-induced aortopathy associated with the inhibition of biomarkers of vascular injury in rats.

Published in:

Archives of Physiology & Biochemistry, 2021, v. 127, n. 3, p. 266, doi. 10.1080/13813455.2019.1632900

By:

Bin-Jaliah, Ismaeel;
Hewett, Peter W.;
Al-Hashem, Fahaid;
Haidara, Mohamed A.;
Abdel Kader, Dina H.;
Morsy, M. D.;
Al-Ani, Bahjat

Publication type:

Article

Ghrelin prevents cardiac cell apoptosis during cardiac remodelling post experimentally induced myocardial infarction in rats via activation of Raf-MEK1/2-ERK1/2 signalling.

Published in:

Archives of Physiology & Biochemistry, 2019, v. 125, n. 2, p. 93, doi. 10.1080/13813455.2018.1437751

By:

Eid, Refaat A.;
Alkhateeb, Mahmoud A.;
Al-Shraim, Mubarak;
Eleawa, Samy M.;
Shatoor, Abdullah S.;
El-Kott, Attalla Farag;
Zaki, Mohamed Samir Ahmed;
Shatoor, Khalid A.;
Bin-Jaliah, Ismaeel;
Al-Hashem, Fahaid H.

Publication type:

Article

Enhanced hepatic insulin signaling in the livers of high altitude native rats under basal conditions and in the livers of low altitude native rats under insulin stimulation: a mechanistic study.

Published in:

Archives of Physiology & Biochemistry, 2017, v. 123, n. 3, p. 145, doi. 10.1080/13813455.2016.1275701

By:

Al Dera, Hussain;
Eleawa, Samy M.;
Al-Hashem, Fahaid H.;
Mahzari, Moeber M.;
Hoja, Ibrahim;
Al Khateeb, Mahmoud

Publication type:

Article

Insulin and vanadium protect against osteoarthritis development secondary to diabetes mellitus in rats.

Published in:

Archives of Physiology & Biochemistry, 2016, v. 122, n. 3, p. 148, doi. 10.3109/13813455.2016.1159698

By:

El Karib, Abbas O.;
Al-Ani, Bahjat;
Al-Hashem, Fahaid;
Dallak, Mohammad;
Bin-Jaliah, Ismaeel;
El-Gamal, Basiouny;
Bashir, Salah O.;
Eid, Refaat A.;
Haidara, Mohamed A.

Publication type:

Article

Acylated ghrelin protects aorta damage post-MI via activation of eNOS and inhibition of angiotensin-converting enzyme induced activation of NAD(P)H-dependent oxidase.

Published in:

Ultrastructural Pathology, 2018, v. 42, n. 5, p. 416, doi. 10.1080/01913123.2018.1526242

By:

Eid, Refaat A.;
El-Kott, Attalla Farag;
Zaki, Mohamed Samir Ahmed;
Eldeen, Muhammad Alaa;
Al-Hashem, Fahaid H;
Alkhateeb, Mahmoud A.;
Alassiri, Mohammed;
Aldera, Hussain

Publication type:

Article

Exercise protects against insulin-dependent diabetes-induced osteoarthritis in rats: A scanning electron microscopy study.

Published in:

Ultrastructural Pathology, 2017, v. 41, n. 3, p. 252, doi. 10.1080/01913123.2017.1313346

By:

Al-Hashem, Fahaid;
El Karib, Abbas O.;
Bin-Jaliah, Ismaeel;
Dallak, Mohammad;
Sakr, Hussein F.;
Eid, Refaat A.;
Zaki, Mohamed Samir A.;
Al-Shamsi, Mariam;
Haidara, Mohamed A.;
Al-Ani, Bahjat

Publication type:

Article

Identifying iNOS and glycogen as biomarkers for degenerated cerebellar purkinje cells in autism spectrum disorder: Protective effects of erythropoietin and zinc sulfate.

Published in:

PLoS ONE, 2025, v. 20, n. 2, p. 1, doi. 10.1371/journal.pone.0317695

By:

Al-Garni, Abdulaziz M.;
Hosny, Sara A.;
Almasabi, Faris;
Shati, Ayed A.;
Alzamil, Norah M.;
ShamsEldeen, Asmaa M.;
El-Shafei, Asmaa A.;
Al-Hashem, Fahaid;
Zafrah, Hind;
Maarouf, Amro;
Al-Ani, Bahjat;
Bin-Jaliah, Ismaeel;
Kamar, Samaa S.

Publication type:

Article

Vanillylacetone attenuates cadmium chloride-induced hippocampal damage and memory loss through upregulation of nuclear factor erythroid 2-related factor 2 gene and protein expression.

Published in:

Neural Regeneration Research, 2024, v. 19, n. 12, p. 2750, doi. 10.4103/1673-5374.391300

By:

AL-Hashem, Fahaid H.;
Bashir, Salah O.;
Dawood, Amal F.;
Aboonq, Moutasem S.;
Bin-Jaliah, Ismaeel;
Al-Garni, Abdulaiziz M.;
Morsy, Mohamed D.

Publication type:

Article

Explainable Boosting Machines Identify Key Metabolomic Biomarkers in Rheumatoid Arthritis.

Published in:

Medicina (1010660X), 2025, v. 61, n. 5, p. 833, doi. 10.3390/medicina61050833

By:

Yagin, Fatma Hilal;
Colak, Cemil;
Algarni, Abdulmohsen;
Algarni, Ali;
Al-Hashem, Fahaid;
Ardigò, Luca Paolo

Publication type:

Article

Proposed Comprehensive Methodology Integrated with Explainable Artificial Intelligence for Prediction of Possible Biomarkers in Metabolomics Panel of Plasma Samples for Breast Cancer Detection.

Published in:

Medicina (1010660X), 2025, v. 61, n. 4, p. 581, doi. 10.3390/medicina61040581

By:

Colak, Cemil;
Yagin, Fatma Hilal;
Algarni, Abdulmohsen;
Algarni, Ali;
Al-Hashem, Fahaid;
Ardigò, Luca Paolo

Publication type:

Article

Untargeted Lipidomic Biomarkers for Liver Cancer Diagnosis: A Tree-Based Machine Learning Model Enhanced by Explainable Artificial Intelligence.

Published in:

Medicina (1010660X), 2025, v. 61, n. 3, p. 405, doi. 10.3390/medicina61030405

By:

Colak, Cemil;
Yagin, Fatma Hilal;
Algarni, Abdulmohsen;
Algarni, Ali;
Al-Hashem, Fahaid;
Ardigò, Luca Paolo

Publication type:

Article

Resveratrol Pretreatment Ameliorates p53-Bax Axis and Augments the Survival Biomarker B-Cell Lymphoma 2 Modulated by Paracetamol Overdose in a Rat Model of Acute Liver Injury.

Published in:

Pharmacology, 2020, v. 105, n. 1/2, p. 39, doi. 10.1159/000502632

By:

Al Humayed, Suliman;
Al-Hashem, Fahaid;
Haidara, Mohamed A.;
El Karib, Abbas O.;
Kamar, Samaa S.;
Amin, Shaimaa N.;
Al-Ani, Bahjat

Publication type:

Article

Predictive biomarkers of mortality in patients with severe COVID-19 hospitalized in intensive care unit.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1416715

By:

Ramos dos Santos Medeiros, Sandrelli Meridiana de Fátima;
Nepomuceno Sousa Lino, Bruna Maria;
Pietta Perez, Vinícius;
Soares Sousa, Eduardo Sérgio;
Helena Campana, Eloiza;
Miyajima, Fábio;
Veloso Carvalho-Silva, Wlisses Henrique;
Dejani, Naiara Naiana;
de Sousa Fernandes, Matheus Santos;
Yagin, Fatma Hilal;
Al-Hashem, Fahaid;
Elkholi, Safaa M.;
Alyami, Hanan;
Oliveira Souto, Fabrício

Publication type:

Article

Pilot-Study to Explore Metabolic Signature of Type 2 Diabetes: A Pipeline of Tree-Based Machine Learning and Bioinformatics Techniques for Biomarkers Discovery.

Published in:

Nutrients, 2024, v. 16, n. 10, p. 1537, doi. 10.3390/nu16101537

By:

Yagin, Fatma Hilal;
Al-Hashem, Fahaid;
Ahmad, Irshad;
Ahmad, Fuzail;
Alkhateeb, Abedalrhman

Publication type:

Article

Preventive roles of swimming exercise and pioglitazone treatment on hepatic dysfunction in a rat model of metabolic syndrome.

Published in:

Canadian Journal of Physiology & Pharmacology, 2014, v. 92, n. 2, p. 162, doi. 10.1139/cjpp-2013-0043

By:

Sakr, Hussein F.;
Al-Hashem, Fahaid H.;
El-Naby, Waffaa M. Hassab;
Alkhateeb, Mahmoud A.;
Zaki, Mohamed Samir A.;
Refaey, Hesham M. El;
Morsy, Mohamed D.

Publication type:

Article

Cardioprotective effect of ghrelin against myocardial infarction-induced left ventricular injury via inhibition of SOCS3 and activation of JAK2/STAT3 signaling.

Published in:

Basic Research in Cardiology, 2018, v. 113, n. 2, p. 0, doi. 10.1007/s00395-018-0671-4

By:

Eid, Refaat A.;
Alkhateeb, Mahmoud A.;
Eleawa, Samy;
Al-Hashem, Fahaid H.;
Al-Shraim, Mubarak;
El-kott, Attalla Farag;
Zaki, Mohamed Samir Ahmed;
Dallak, Mohammad A.;
Aldera, Hussain

Publication type:

Article

Enhancing type 2 diabetes mellitus prediction by integrating metabolomics and tree-based boosting approaches.

Published in:

Frontiers in Endocrinology, 2024, p. 1, doi. 10.3389/fendo.2024.1444282

By:

Arslan, Ahmet Kadir;
Yagin, Fatma Hilal;
Algarni, Abdulmohsen;
Karaaslan, Erol;
Al-Hashem, Fahaid;
Ardigò, Luca Paolo

Publication type:

Article

Increased systemic low grade inflammation in high altitude native rats mediated by adrenergic receptors (669.7).

Published in:

FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.669.7

By:

AL‐Hashem, Fahaid;
Assiri, Abdullah;
Shatoor, Abdullah;
Elrafaey, Hisham;
Alessa, Riyad;
Alkhateeb, Mahmoud

Publication type:

Article

Potential roles for vitamins E and C in combination in modulation against exhaustive swimming‐and high altitude‐associated lung injury in rats.

Published in:

FASEB Journal, 2013, v. 27, p. 632.2, doi. 10.1096/fasebj.27.1_supplement.632.2

By:

AL‐Hashem, Fahaid;
Alkhateeb, Mahmoud

Publication type:

Article

Metformin inhibits mTOR–HIF‐1α axis and profibrogenic and inflammatory biomarkers in thioacetamide‐induced hepatic tissue alterations.

Published in:

Journal of Cellular Physiology, 2019, v. 234, n. 6, p. 9328, doi. 10.1002/jcp.27616

By:

Al‐Hashem, Fahaid;
Al‐Humayed, Suliman;
Amin, Shaimaa N.;
Kamar, Samaa S.;
Mansy, Soheir S.;
Hassan, Sarah;
Abdel‐Salam, Lubna O.;
Ellatif, Mohamed Abd;
Alfaifi, Mohammed;
Haidara, Mohamed A.;
Al‐Ani, Bahjat

Publication type:

Article

Metabolomics Biomarker Discovery to Optimize Hepatocellular Carcinoma Diagnosis: Methodology Integrating AutoML and Explainable Artificial Intelligence.

Published in:

Diagnostics (2075-4418), 2024, v. 14, n. 18, p. 2049, doi. 10.3390/diagnostics14182049

By:

Yagin, Fatma Hilal;
El Shawi, Radwa;
Algarni, Abdulmohsen;
Colak, Cemil;
Al-Hashem, Fahaid;
Ardigò, Luca Paolo

Publication type:

Article

Combining the Strengths of the Explainable Boosting Machine and Metabolomics Approaches for Biomarker Discovery in Acute Myocardial Infarction.

Published in:

Diagnostics (2075-4418), 2024, v. 14, n. 13, p. 1353, doi. 10.3390/diagnostics14131353

By:

Arslan, Ahmet Kadir;
Yagin, Fatma Hilal;
Algarni, Abdulmohsen;
AL-Hashem, Fahaid;
Ardigò, Luca Paolo

Publication type:

Article

Targeting the Dysregulation of Pancreatic AMPK-iNOS-p53 Axis by Metformin in a Rat Model of L-arginine-Induced Acute Pancreatitis.

Published in:

International Journal of Morphology, 2024, v. 42, n. 6, p. 1679, doi. 10.4067/s0717-95022024000601679

By:

Alzamil, Norah M.;
Al-Hashem, Fahaid

Publication type:

Article

Metformin Inhibits ROS/TNF-α Axis-Mediated Chronic Kidney Disease Induced by TAA Independent of Leukocyte Infiltration in Association with the Inhibition of Kidney Injury Biomarkers.

Published in:

International Journal of Morphology, 2023, v. 41, n. 4, p. 1191, doi. 10.4067/s0717-95022023000401191

By:

Al-Hashem, Fahaid

Publication type:

Article

Suppression of L-Arginine-Induced Acute Necrotizing Pancreatitis in Rats by Metformin Associated with the Inhibition of Myeloperoxidase and Activation of Interleukin-10.

Published in:

International Journal of Morphology, 2021, v. 39, n. 1, p. 102, doi. 10.4067/s0717-95022021000100102

By:

Al-Hashem, Fahaid

Publication type:

Article

Acetaminophen Induces Alterations to the Renal Tubular Ultrastructure in a Rat Model of Acute Nephrotoxicity Protected by Resveratrol and Quercetin.

Published in:

International Journal of Morphology, 2020, v. 38, n. 3, p. 585, doi. 10.4067/s0717-95022020000300585

By:

Haidara, Mohamed A.;
Al-Ani, Bahjat;
Eid, Refaat A.;
Mohammed, Muataz E. D.;
Al-Hashem, Fahaid;
Dallak, Mohammad

Publication type:

Article

Suppression of Thioacetamide-Induced Hepatic Injury in Rats treatment with Resveratrol: Role of mammalian Target of Rapamycin (mTOR) Cell Signaling.

Published in:

International Journal of Morphology, 2020, v. 38, n. 3, p. 558, doi. 10.4067/s0717-95022020000300558

By:

Dallak, Mohammad;
Al-Hashem, Fahaid;
Haidara, Mohamed A.;
Abd Ellatif, Mohamed;
Kamar, Samaa S.;
ShamsEldeeen, Asmaa M.;
Dawood, Amal F.;
Ebrahim, Hasnaa A.;
Al-Ani, Bahjat

Publication type:

Article

Inhibition of Paracetamol-Induced Acute Kidney Damage in Rats Using a Combination of Resveratrol and Quercetin.

Published in:

International Journal of Morphology, 2019, v. 37, n. 4, p. 1422, doi. 10.4067/s0717-95022019000401422

By:

Haidara, Mohamed A.;
Al-Hashem, Fahaid;
El Karib, Abbas O.;
Zaki, Mohamed S.;
Kamar, Samaa S.;
El-Bidawy, Mahmoud H.;
Al-Ani, Bahjat

Publication type:

Article

Ghrelin Improves the Fine Structure of Atrial Natriuretic Factor (ANF) Granules and Intercalated Disc Junctions in Experimentally-Induced Myocardial Infarction in Rats.

Published in:

International Journal of Morphology, 2018, v. 36, n. 3, p. 1031, doi. 10.4067/S0717-95022018000301031

By:

Eid, Refaat A.;
Ahmed Zaki, Mohamed Samir;
Alghamdi, Mansour A.;
Al-Shraim, Mubarak;
El-kott, Attalla Farag;
Al-Hashem, Fahaid H.;
Aldera, Hussain;
Alkhateeb, Mahmoud A.

Publication type:

Article

Metformin Protects Against Thioacetamide Induced Liver injury in Rats.

Published in:

International Journal of Morphology, 2018, v. 36, n. 3, p. 984, doi. 10.4067/S0717-95022018000300984

By:

Al-Hashem, Fahaid;
AlHumayed, Suliman;
Ellatif, Mohamed Abd;
Amin, Shaimaa Nasr;
Kamar, Samaa Samir;
Al-Ani1, Bahjat;
Haidara, Mohamed A.

Publication type:

Article

Metformin Pretreatment Ameliorates Diabetic Nephropathy Induced by a Combination of High Fat Diet and Streptozotocin in Rats.

Published in:

International Journal of Morphology, 2018, v. 36, n. 3, p. 969, doi. 10.4067/S0717-95022018000300969

By:

Dallak, Mohammad;
Bin-Jaliah, Ismaeel;
Al-Hashem, Fahaid;
Kamar, Samaa S.;
Abdel Kader, Dina H.;
Amin, Shaimaa N.;
Haidara, Mohamed A.;
Al-Ani, Bahjat

Publication type:

Article

The Relationship of Birth Weight, Body Shape and Body Composition at Birth to Altitude in Saudi Arabia.

Published in:

International Journal of Morphology, 2016, v. 34, n. 3, p. 1109, doi. 10.4067/S0717-95022016000300048

By:

Khalid, Mohammed Elhabib Mohammed;
Ahmed, Humeda Sweket;
Osman, Osama Mirghani;
Al Hashem, Fahaid Hassan

Publication type:

Article

The association between physical activity and overweight and obesity in a population of children at high and low altitudes in Southwestern Saudi Arabia.

Published in:

Journal of Family & Community Medicine, 2016, v. 23, n. 2, p. 82, doi. 10.4103/2230-8229.181011

By:

Ahmed, Humeda S.;
Khalid, Mohammed E. M.;
Osman, Osama M.;
Al-Hashem, Fahaid H.;
Ballal, Mansour A.

Publication type:

Article