Works matching AU Aktories, Klaus

Results: 79

Novel bacterial ADP-ribosylating toxins: structure and function.

Published in:

Nature Reviews Microbiology, 2014, v. 12, n. 9, p. 599, doi. 10.1038/nrmicro3310

By:

Simon, Nathan C.;
Aktories, Klaus;
Barbieri, Joseph T.

Publication type:

Article

Bacterial protein toxins that modify host regulatory GTPases.

Published in:

Nature Reviews Microbiology, 2011, v. 9, n. 7, p. 487, doi. 10.1038/nrmicro2592

By:

Aktories, Klaus

Publication type:

Article

A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells.

Published in:

Nature, 1983, v. 303, n. 5913, p. 177, doi. 10.1038/303177a0

By:

Jakobs, Karl H.;
Aktories, Klaus;
Schultz, Günter

Publication type:

Article

Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function.

Published in:

Glycobiology, 2007, v. 17, n. 4, p. 15

By:

Klaus Aktories

Publication type:

Article

Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT.

Published in:

Scientific Reports, 2015, p. 7850, doi. 10.1038/srep07850

By:

Unger, Mandy;
Eichhoff, Anna Marei;
Schumacher, Lucas;
Strysio, Moritz;
Menzel, Stephan;
Schwan, Carsten;
Alzogaray, Vanina;
Zylberman, Vanesa;
Seman, Michel;
Brandner, Johanna;
Rohde, Holger;
Zhu, Kai;
Haag, Friedrich;
Mittrücker, Hans-Willi;
Goldbaum, Fernando;
Aktories, Klaus;
Koch-Nolte, Friedrich

Publication type:

Article

Rundown of somatodendritic N-methyl- D-aspartate (NMDA) receptor channels in rat hippocampal neurones: evidence for a role of the small GTPase RhoA.

Published in:

British Journal of Pharmacology, 1999, v. 127, n. 5, p. 1060, doi. 10.1038/sj.bjp.0702643

By:

Nörenberg, Wolfgang;
Hofmann, Fred;
Illes, Peter;
Aktories, Klaus;
Meyer, Dieter K

Publication type:

Article

Bacterial cytotoxins: targeting eukaryotic switches.

Published in:

Nature Reviews Microbiology, 2005, v. 3, n. 5, p. 397, doi. 10.1038/nrmicro1150

By:

Aktories, Klaus;
Barbieri, Joseph T.

Publication type:

Article

Antibodies Directed Against GalNAc- and GlcNAc-OTyrosine Posttranslational Modifications -- a New Tool for Glycoproteomic Detection.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 29, p. 1, doi. 10.1002/chem.202300392

By:

Behren, Sandra;
Schorlemer, Manuel;
Schmidt, Gudula;
Aktories, Klaus;
Westerlind, Ulrika

Publication type:

Article

Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary Clostridioides Toxins.

Published in:

Cells (2073-4409), 2022, v. 11, n. 22, p. 3661, doi. 10.3390/cells11223661

By:

Schwan, Carsten;
Lang, Alexander E.;
Schlosser, Andreas;
Fujita-Becker, Setsuko;
AlHaj, Abdulatif;
Schröder, Rasmus R.;
Faix, Jan;
Aktories, Klaus;
Mannherz, Hans Georg

Publication type:

Article

Modification of plant Rac/Rop GTPase signalling using bacterial toxin transgenes.

Published in:

Plant Journal, 2013, v. 73, n. 2, p. 314, doi. 10.1111/tpj.12040

By:

Singh, Manoj K.;
Ren, Fugang;
Giesemann, Torsten;
Bosco, Cristina Dal;
Pasternak, Taras P.;
Blein, Thomas;
Ruperti, Benedetto;
Schmidt, Gudula;
Aktories, Klaus;
Molendijk, Arthur J.;
Palme, Klaus

Publication type:

Article

Bacillus sphaericus mosquitocidal toxin (MTX) and pierisin: the enigmatic offspring from the family of ADP-ribosyltransferases.

Published in:

Molecular Microbiology, 2006, v. 62, n. 3, p. 621, doi. 10.1111/j.1365-2958.2006.05401.x

By:

Carpusca, Irina;
Jank, Thomas;
Aktories, Klaus

Publication type:

Article

GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: a mechanism for disruption of actin microfilament structure.

Published in:

Molecular Microbiology, 2000, v. 36, n. 3, p. 737, doi. 10.1046/j.1365-2958.2000.01898.x

By:

von Pawel-Rammingen, Ulrich;
Telepnev, Maxim V.;
Schmidt, Gudula;
Aktories, Klaus;
Wolf-Watz, Hans;
Rosqvist, Roland

Publication type:

Article

The amino-terminal domain of Pseudomonas aeruginosa ExoS disrupts actin filaments via small-molecular-weight GTP-binding proteins.

Published in:

Molecular Microbiology, 1999, v. 32, n. 2, p. 393, doi. 10.1046/j.1365-2958.1999.01359.x

By:

Pederson, Kristin J.;
Vallis, Amy J.;
Aktories, Klaus;
Frank, Dara W.;
Barbieri, Joseph T.

Publication type:

Article

Actin as target for modification by bacterial protein toxins.

Published in:

FEBS Journal, 2011, v. 278, n. 23, p. 4526, doi. 10.1111/j.1742-4658.2011.08113.x

By:

Aktories, Klaus;
Lang, Alexander E.;
Schwan, Carsten;
Mannherz, Hans G.

Publication type:

Article

Cytotoxic effects by microinjection of ADP-ribosylated skeletal muscle G-actin in PtK2 cells in the absence of Clostridium perfringens iota toxin.

Published in:

Medical Microbiology & Immunology, 1996, v. 184, n. 4, p. 175, doi. 10.1007/BF02456132

By:

Kiefer, Gabriele;
Lerner, Monika;
Sehr, Peter;
Just, Ingo;
Aktories, Klaus

Publication type:

Article

Clostridial ADP-ribosyltransferases - Modification of low molecular weight GTP-binding proteins and of actin by clostridial toxins.

Published in:

Medical Microbiology & Immunology, 1990, v. 179, n. 3, p. 123, doi. 10.1007/BF00202390

By:

Aktories, Klaus

Publication type:

Article

The Compound U18666A Inhibits the Intoxication of Cells by Clostridioides difficile Toxins TcdA and TcdB.

Published in:

Frontiers in Microbiology, 2021, v. 12, p. 1, doi. 10.3389/fmicb.2021.784856

By:

Papatheodorou, Panagiotis;
Kindig, Selina;
Badilla-Lobo, Adriana;
Fischer, Stephan;
Durgun, Ebru;
Thuraisingam, Tharani;
Witte, Alexander;
Song, Shuo;
Aktories, Klaus;
Chaves-Olarte, Esteban;
Rodríguez, César;
Barth, Holger

Publication type:

Article

Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins.

Published in:

PLoS Pathogens, 2018, v. 14, n. 8, p. 1, doi. 10.1371/journal.ppat.1007248

By:

Brink, Thorsten;
Leiss, Veronika;
Siegert, Peter;
Jehle, Doris;
Ebner, Julia K.;
Schwan, Carsten;
Shymanets, Aliaksei;
Wiese, Sebastian;
Nürnberg, Bernd;
Hensel, Michael;
Aktories, Klaus;
Orth, Joachim H. C.

Publication type:

Article

Targeting of the actin cytoskeleton by insecticidal toxins from Photorhabdus luminescens.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2011, v. 383, n. 3, p. 227, doi. 10.1007/s00210-010-0579-5

By:

Lang, Alexander;
Schmidt, Gudula;
Sheets, Joel;
Aktories, Klaus

Publication type:

Article

C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2007, v. 374, n. 5/6, p. 347, doi. 10.1007/s00210-006-0113-y

By:

Vogelsgesang, Martin;
Pautsch, Alexander;
Aktories, Klaus

Publication type:

Article

The uptake machinery of clostridial actin ADP-ribosylating toxins – a cell delivery system for fusion proteins and polypeptide drugs.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2002, v. 366, n. 6, p. 501, doi. 10.1007/s00210-002-0626-y

By:

Barth, Holger;
Blöcker, Dagmar;
Aktories, Klaus

Publication type:

Article

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P[sub 3] and polarity during neutrophil chemotaxis.

Published in:

Journal of Cell Biology, 2003, v. 160, n. 3, p. 375, doi. 10.1083/jcb.200208179

By:

Srinivasan, Supriya;
Fei Wang;
Glavas, Suzana;
Ott, Alexander;
Hofmann, Fred;
Aktories, Klaus;
Kalman, Daniel;
Bourne, Henry R.

Publication type:

Article

Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells.

Published in:

Journal of Physiology, 1999, v. 516, n. 1, p. 67, doi. 10.1111/j.1469-7793.1999.067aa.x

By:

Nilius, Bernd;
Voets, Thomas;
Prenen, Jean;
Barth, Holger;
Aktories, Klaus;
Kaibuchi, Kozo;
Droogmans, Guy;
Eggermont, Jan

Publication type:

Article

Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.01204

By:

Korbmacher, Michael;
Fischer, Stephan;
Landenberger, Marc;
Papatheodorou, Panagiotis;
Aktories, Klaus;
Barth, Holger

Publication type:

Article

Clostridium difficile binary toxin CDT.

Published in:

Gut Microbes, 2014, v. 5, n. 1, p. 1, doi. 10.4161/gmic.26854

By:

Gerding, Dale N.;
Johnson, Stuart;
Rupnik, Maja;
Aktories, Klaus

Publication type:

Article

The haematopoietic GTPase RhoH modulates IL3signalling through regulation of STAT activity andIL3 receptor expression.

Published in:

Molecular Cancer, 2010, v. 9, p. 225, doi. 10.1186/1476-4598-9-225

By:

Gündogdu, Mehtap S.;
He Liu;
Metzdorf, Daniela;
Hildebrand, Dagmar;
Aigner, Michael;
Aktories, Klaus;
Klaus Heeg;
Kubatzky, Katharina F.

Publication type:

Article

Semaphorins or Frizzled –it is the receptor that direct the action of clostridial glucosylating toxins.

Published in:

Signal Transduction & Targeted Therapy, 2020, v. 5, n. 1, p. N.PAG, doi. 10.1038/s41392-020-00307-3

By:

Aktories, Klaus

Publication type:

Article

Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine

Published in:

FEBS Letters, 2008, v. 582, n. 15, p. 2277, doi. 10.1016/j.febslet.2008.05.025

By:

Jank, Thomas;
Ziegler, Mathias O.P.;
Schulz, Georg E.;
Aktories, Klaus

Publication type:

Article

Crystal structure of the Clostridium limosum C3 exoenzyme

Published in:

FEBS Letters, 2008, v. 582, n. 7, p. 1032, doi. 10.1016/j.febslet.2008.02.051

By:

Vogelsgesang, Martin;
Stieglitz, Benjamin;
Herrmann, Christian;
Pautsch, Alex;
Aktories, Klaus

Publication type:

Article

Lu/BCAM Adhesion Glycoprotein Is a Receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1).

Published in:

PLoS Pathogens, 2014, v. 10, n. 1, p. 1, doi. 10.1371/journal.ppat.1003884

By:

Piteau, Marianne;
Papatheodorou, Panagiotis;
Schwan, Carsten;
Schlosser, Andreas;
Aktories, Klaus;
Schmidt, Gudula

Publication type:

Article

Pasteurella Multocida Toxin Prevents Osteoblast Differentiation by Transactivation of the MAP-Kinase Cascade via the Gαq/11 - p63RhoGEF - RhoA Axis

Published in:

PLoS Pathogens, 2013, v. 9, n. 5, p. 1, doi. 10.1371/journal.ppat.1003385

By:

Siegert, Peter;
Schmidt, Gudula;
Papatheodorou, Panagiotis;
Wieland, Thomas;
Aktories, Klaus;
Orth, Joachim H. C.

Publication type:

Article

Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria.

Published in:

PLoS Pathogens, 2009, v. 5, n. 10, p. 1, doi. 10.1371/journal.ppat.1000626

By:

Schwan, Carsten;
Stecher, Bärbel;
Tzivelekidis, Tina;
van Ham, Marco;
Rohde, Manfred;
Hardt, Wolf-Dietrich;
Wehland, Jürgen;
Aktories, Klaus

Publication type:

Article

Role of actin filaments in endothelial cell-cell adhesion and membrane stability under fluid shear stress.

Published in:

Pflügers Archiv: European Journal of Physiology, 2001, v. 442, n. 5, p. 675, doi. 10.1007/s004240100589

By:

Schnittler, Hans-Joachim;
Schneider, Stefan W.;
Raifer, Hartmann;
Luo, Fei;
Dieterich, Peter;
Just, Ingo;
Aktories, Klaus

Publication type:

Article

Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B.

Published in:

Molecular Microbiology, 2012, v. 84, n. 6, p. 1189, doi. 10.1111/j.1365-2958.2012.08078.x

By:

Genisyuerek, Selda;
Papatheodorou, Panagiotis;
Guttenberg, Gregor;
Schubert, Rolf;
Benz, Roland;
Aktories, Klaus

Publication type:

Article

Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B.

Published in:

Molecular Microbiology, 2011, v. 79, n. 6, p. 1643, doi. 10.1111/j.1365-2958.2011.07549.x

By:

Genisyuerek, Selda;
Papatheodorou, Panagiotis;
Guttenberg, Gregor;
Schubert, Rolf;
Benz, Roland;
Aktories, Klaus

Publication type:

Article

Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos.

Published in:

Nature Communications, 2015, v. 6, n. 7, p. 7807, doi. 10.1038/ncomms8807

By:

Jank, Thomas;
Eckerle, Stephanie;
Steinemann, Marcus;
Trillhaase, Christoph;
Schimpl, Marianne;
Wiese, Sebastian;
van Aalten, Daan M. F.;
Driever, Wolfgang;
Aktories, Klaus

Publication type:

Article

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation.

Published in:

Nature Communications, 2014, v. 5, n. 12, p. 5887, doi. 10.1038/ncomms6887

By:

Young, Joanna C.;
Clements, Abigail;
Lang, Alexander E.;
Garnett, James A.;
Munera, Diana;
Arbeloa, Ana;
Pearson, Jaclyn;
Hartland, Elizabeth L.;
Matthews, Stephen J.;
Mousnier, Aurelie;
Barry, David J.;
Way, Michael;
Schlosser, Andreas;
Aktories, Klaus;
Frankel, Gad

Publication type:

Article

Actin Involvement in Exocytosis from PC12 Cells: Studies on the Influence of Botulinum C2 Toxin on Stimulated Noradrenaline Release.

Published in:

Journal of Neurochemistry, 1989, v. 52, n. 2, p. 370, doi. 10.1111/j.1471-4159.1989.tb09131.x

By:

Matter, Karin;
Dreyer, Florian;
Aktories, Klaus

Publication type:

Article

Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorylation in guinea-pig smooth muscle: role of Rho proteins.

Published in:

Journal of Physiology, 1998, v. 506, n. 1, p. 83, doi. 10.1111/j.1469-7793.1998.083bx.x

By:

Lucius, Claudia;
Arner, Anders;
Steusloff, Annette;
Troschka, Monika;
Hofmann, Fred;
Aktories, Klaus;
Pfitzer, Gabriele

Publication type:

Article

Involvement of N‐glycans in binding of Photorhabdus luminescens Tc toxin.

Published in:

Cellular Microbiology, 2021, v. 23, n. 8, p. 1, doi. 10.1111/cmi.13326

By:

Ng'ang'a, Peter Njenga;
Siukstaite, Lina;
Lang, Alexander E.;
Bakker, Hans;
Römer, Winfried;
Aktories, Klaus;
Schmidt, Gudula

Publication type:

Article

Photorhabdus luminescensTc toxin is inhibited by the protease inhibitor MG132 and activated by protease cleavage resulting in increased binding to target cells.

Published in:

Cellular Microbiology, 2019, v. 21, n. 3, p. N.PAG, doi. 10.1111/cmi.12978

By:

Ost, Gerhard Stefan;
Ng'ang'a, Peter Njenga;
Lang, Alexander E.;
Aktories, Klaus

Publication type:

Article

Actin ADP-ribosylation at Threonine148 by Photorhabdus luminescens toxin TccC3 induces aggregation of intracellular F-actin.

Published in:

Cellular Microbiology, 2017, v. 19, n. 1, p. n/a, doi. 10.1111/cmi.12636

By:

Lang, Alexander E.;
Qu, Zheng;
Schwan, Carsten;
Silvan, Unai;
Unger, Andreas;
Schoenenberger, Cora‐Ann;
Aktories, Klaus;
Mannherz, Hans Georg

Publication type:

Article

Bacterial glycosyltransferase toxins.

Published in:

Cellular Microbiology, 2015, v. 17, n. 12, p. 1752, doi. 10.1111/cmi.12533

By:

Jank, Thomas;
Belyi, Yury;
Aktories, Klaus

Publication type:

Article

A systemic P asteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice.

Published in:

Cellular Microbiology, 2015, v. 17, n. 9, p. 1320, doi. 10.1111/cmi.12436

By:

Weise, Markus;
Vettel, Christiane;
Spiger, Katharina;
Gilsbach, Ralf;
Hein, Lutz;
Lorenz, Kristina;
Wieland, Thomas;
Aktories, Klaus;
Orth, Joachim H. C.

Publication type:

Article

The actin and Rho-modifying toxins PTC3 and PTC5 of P hotorhabdus luminescens: enzyme characterization and induction of MAL/ SRF-dependent transcription.

Published in:

Cellular Microbiology, 2015, v. 17, n. 4, p. 579, doi. 10.1111/cmi.12386

By:

Pfaumann, Vanda;
Lang, Alexander E.;
Schwan, Carsten;
Schmidt, Gudula;
Aktories, Klaus

Publication type:

Article

The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of P hotorhabdus luminescens ADP-ribosyltransferases.

Published in:

Cellular Microbiology, 2014, v. 16, n. 4, p. 490, doi. 10.1111/cmi.12228

By:

Lang, Alexander E.;
Ernst, Katharina;
Lee, Haram;
Papatheodorou, Panagiotis;
Schwan, Carsten;
Barth, Holger;
Aktories, Klaus

Publication type:

Article

FK506-binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells.

Published in:

Cellular Microbiology, 2012, v. 14, n. 8, p. 1193, doi. 10.1111/j.1462-5822.2012.01788.x

By:

Kaiser, Eva;
Böhm, Natalie;
Ernst, Katharina;
Langer, Simon;
Schwan, Carsten;
Aktories, Klaus;
Popoff, Michel;
Fischer, Gunter;
Barth, Holger

Publication type:

Article

Domain organization of Legionella effector SetA.

Published in:

Cellular Microbiology, 2012, v. 14, n. 6, p. 852, doi. 10.1111/j.1462-5822.2012.01761.x

By:

Jank, Thomas;
Böhmer, Kira E.;
Tzivelekidis, Tina;
Schwan, Carsten;
Belyi, Yury;
Aktories, Klaus

Publication type:

Article

Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen.

Published in:

Cellular Microbiology, 2011, v. 13, n. 3, p. 359, doi. 10.1111/j.1462-5822.2010.01539.x

By:

Dmochewitz, Lydia;
Lillich, Maren;
Kaiser, Eva;
Jennings, Laura D.;
Lang, Alexander E.;
Buchner, Johannes;
Fischer, Gunter;
Aktories, Klaus;
Collier, R. John;
Barth, Holger

Publication type:

Article

Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways.

Published in:

Cellular Microbiology, 2010, v. 12, n. 8, p. 1174, doi. 10.1111/j.1462-5822.2010.01462.x

By:

Preuß, Inga;
Hildebrand, Dagmar;
Orth, Joachim H. C.;
Aktories, Klaus;
Kubatzky, Katharina F.

Publication type:

Article