Works by Akiyoshi Nakayama

Results: 51

Dasatinib suppresses particulate-induced pyroptosis and acute lung inflammation.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1250383

By:

Yixi Pan;
Kenta Ikoma;
Risa Matsui;
Akiyoshi Nakayama;
Naoki Takemura;
Tatsuya Saitoh

Publication type:

Article

Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.

Published in:

Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-019-0339-0

By:

Nakatochi, Masahiro;
Kanai, Masahiro;
Nakayama, Akiyoshi;
Hishida, Asahi;
Kawamura, Yusuke;
Ichihara, Sahoko;
Akiyama, Masato;
Ikezaki, Hiroaki;
Furusyo, Norihiro;
Shimizu, Seiko;
Yamamoto, Ken;
Hirata, Makoto;
Okada, Rieko;
Kawai, Sayo;
Kawaguchi, Makoto;
Nishida, Yuichiro;
Shimanoe, Chisato;
Ibusuki, Rie;
Takezaki, Toshiro;
Nakajima, Mayuko

Publication type:

Article

The relationships between titers of anti-Ro or anti-La as measured by ELISA and salivary production rate with age correction.

Published in:

Modern Rheumatology, 2008, v. 18, n. 6, p. 578, doi. 10.3109/s10165-008-0098-0

By:

Takada, Kunio;
Suzuki, Kimihiro;
Matsumoto, Mitsuyo;
Okada, Makoto;
Nakanishi, Takashi;
Horikoshi, Hideyuki;
Higuchi, Tomoaki;
Nakayama, Akiyoshi;
Ohsuzu, Fumitaka

Publication type:

Article

Recent Advances in Dysuricemia: Toward Optimal Serum Urate Level.

Published in:

Biomedicines, 2024, v. 12, n. 5, p. 1094, doi. 10.3390/biomedicines12051094

By:

Kurajoh, Masafumi;
Nakayama, Akiyoshi

Publication type:

Article

Dysuricemia.

Published in:

Biomedicines, 2023, v. 11, n. 12, p. 3169, doi. 10.3390/biomedicines11123169

By:

Nakayama, Akiyoshi;
Kurajoh, Masafumi;
Toyoda, Yu;
Takada, Tappei;
Ichida, Kimiyoshi;
Matsuo, Hirotaka

Publication type:

Article

A Proposal for Practical Diagnosis of Renal Hypouricemia: Evidenced from Genetic Studies of Nonfunctional Variants of URAT1/SLC22A12 among 30,685 Japanese Individuals.

Published in:

Biomedicines, 2021, v. 9, n. 8, p. 1012, doi. 10.3390/biomedicines9081012

By:

Kawamura, Yusuke;
Nakayama, Akiyoshi;
Shimizu, Seiko;
Toyoda, Yu;
Nishida, Yuichiro;
Hishida, Asahi;
Katsuura-Kamano, Sakurako;
Shibuya, Kenichi;
Tamura, Takashi;
Kawaguchi, Makoto;
Suzuki, Satoko;
Iwasawa, Satoko;
Nakashima, Hiroshi;
Ibusuki, Rie;
Uemura, Hirokazu;
Hara, Megumi;
Takeuchi, Kenji;
Takada, Tappei;
Tsunoda, Masashi;
Arisawa, Kokichi

Publication type:

Article

Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population.

Published in:

Science Translational Medicine, 2009, v. 1, n. 5, p. 1, doi. 10.1126/scitranslmed.3000237

By:

Matsuo, Hirotaka;
Takada, Tappei;
Ichida, Kimiyoshi;
Nakamura, Takahiro;
Nakayama, Akiyoshi;
Ikebuchi, Yuki;
Ito, Kousei;
Kusanagi, Yasuyoshi;
Chiba, Toshinori;
Tadokoro, Shin;
Takada, Yuzo;
Oikawa, Yuji;
Inoue, Hiroki;
Suzuki, Koji;
Okada, Riek;
Nishiyama, Junichiro;
Domoto, Hideharu;
Watanabe, Satoru;
Fujita, Masanori;
Morimoto, Yuji

Publication type:

Article

Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep05227

By:

Nakayama, Akiyoshi;
Matsuo, Hirotaka;
Nakaoka, Hirofumi;
Nakamura, Takahiro;
Nakashima, Hiroshi;
Takada, Yuzo;
Oikawa, Yuji;
Takada, Tappei;
Sakiyama, Masayuki;
Shimizu, Seiko;
Kawamura, Yusuke;
Chiba, Toshinori;
Abe, Junko;
Wakai, Kenji;
Kawai, Sayo;
Okada, Rieko;
Tamura, Takashi;
Shichijo, Yuka;
Akashi, Airi;
Suzuki, Hiroshi

Publication type:

Article

ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep03755

By:

Hirotaka Matsuo;
Akiyoshi Nakayama;
Masayuki Sakiyama;
Toshinori Chiba;
Seiko Shimizu;
Yusuke Kawamura;
Hiroshi Nakashima;
Takahiro Nakamura;
Yuzo Takada;
Yuji Oikawa;
Tappei Takada;
Hirofumi Nakaoka;
Junko Abe;
Hiroki Inoue;
Kenji Wakai;
Sayo Kawai;
Yin Guang;
Hiroko Nakagawa;
Toshimitsu Ito;
Kazuki Niwa

Publication type:

Article

Common dysfunctional variants in ABCG2 are a major cause of early-onset gout.

Published in:

Scientific Reports, 2013, p. 1, doi. 10.1038/srep02014

By:

Hirotaka Matsuo;
Kimiyoshi Ichida;
Tappei Takada;
Akiyoshi Nakayama;
Hiroshi Nakashima;
Takahiro Nakamura;
Yusuke Kawamura;
Yuzo Takada;
Ken Yamamoto;
Hiroki Inoue;
Yuji Oikawa;
Mariko Naito;
Asahi Hishida;
Kenji Wakai;
Chisa Okada;
Seiko Shimizu;
Masayuki Sakiyama;
Toshinori Chiba;
Hiraku Ogata;
Kazuki Niwa

Publication type:

Article

OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.842717

By:

Toyoda, Yu;
Kawamura, Yusuke;
Nakayama, Akiyoshi;
Morimoto, Keito;
Shimizu, Seiko;
Tanahashi, Yuki;
Tamura, Takashi;
Kondo, Takaaki;
Kato, Yasufumi;
Ichida, Kimiyoshi;
Suzuki, Hiroshi;
Shinomiya, Nariyoshi;
Kobayashi, Yasushi;
Takada, Tappei;
Matsuo, Hirotaka

Publication type:

Article

Association Between Serum Uric Acid Levels/Hyperuricemia and Hypertension Among 85,286 Japanese Workers.

Published in:

2016

By:

Yokokawa, Hirohide;
Fukuda, Hiroshi;
Suzuki, Akihito;
Fujibayashi, Kazutoshi;
Naito, Toshio;
Uehara, Yuki;
Nakayama, Akiyoshi;
Matsuo, Hirotaka;
Sanada, Hironobu;
Jose, Pedro A.;
Miwa, Yuichi;
Hisaoka, Teruhiko;
Isonuma, Hiroshi

Publication type:

journal article

Expression of a human NPT1/SLC17A1 missense variant which increases urate export.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2016, v. 35, n. 10-12, p. 536, doi. 10.1080/15257770.2016.1149192

By:

Sakiyama, Masayuki;
Matsuo, Hirotaka;
Nagamori, Shushi;
Ling, Wei;
Kawamura, Yusuke;
Nakayama, Akiyoshi;
Higashino, Toshihide;
Chiba, Toshinori;
Ichida, Kimiyoshi;
Kanai, Yoshikatsu;
Shinomiya, Nariyoshi

Publication type:

Article

ABCG2 Dysfunction Increases the Risk of Renal Overload Hyperuricemia.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2014, v. 33, n. 4-6, p. 266, doi. 10.1080/15257770.2013.866679

By:

Matsuo, Hirotaka;
Takada, Tappei;
Nakayama, Akiyoshi;
Shimizu, Toru;
Sakiyama, Masayuki;
Shimizu, Seiko;
Chiba, Toshinori;
Nakashima, Hiroshi;
Nakamura, Takahiro;
Takada, Yuzo;
Sakurai, Yutaka;
Hosoya, Tatsuo;
Shinomiya, Nariyoshi;
Ichida, Kimiyoshi

Publication type:

Article

Identification of a Hypouricemia Patient with SLC2A9 R380W, A Pathogenic Mutation for Renal Hypouricemia Type 2.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2014, v. 33, n. 4-6, p. 261, doi. 10.1080/15257770.2013.857781

By:

Chiba, Toshinori;
Matsuo, Hirotaka;
Nagamori, Shushi;
Nakayama, Akiyoshi;
Kawamura, Yusuke;
Shimizu, Seiko;
Sakiyama, Masayuki;
Hosoyamada, Makoto;
Kawai, Sayo;
Okada, Rieko;
Hamajima, Nobuyuki;
Kanai, Yoshikatsu;
Shinomiya, Nariyoshi

Publication type:

Article

ABCG2 Dysfunction Increases Serum Uric Acid by Decreased Intestinal Urate Excretion.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2014, v. 33, n. 4-6, p. 275, doi. 10.1080/15257770.2013.854902

By:

Takada, Tappei;
Ichida, Kimiyoshi;
Matsuo, Hirotaka;
Nakayama, Akiyoshi;
Murakami, Keizo;
Yamanashi, Yoshihide;
Kasuga, Hiroshi;
Shinomiya, Nariyoshi;
Suzuki, Hiroshi

Publication type:

Article

ABCG2/BCRP Dysfunction as a Major Cause of Gout.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2011, v. 30, n. 12, p. 1117, doi. 10.1080/15257770.2011.633954

By:

Matsuo, Hirotaka;
Takada, Tappei;
Ichida, Kimiyoshi;
Nakamura, Takahiro;
Nakayama, Akiyoshi;
Suzuki, Hiroshi;
Hosoya, Tatsuo;
Shinomiya, Nariyoshi

Publication type:

Article

ABCG2 is a High-Capacity Urate Transporter and its Genetic Impairment Increases Serum Uric Acid Levels in Humans.

Published in:

Nucleosides, Nucleotides & Nucleic Acids, 2011, v. 30, n. 12, p. 1091, doi. 10.1080/15257770.2011.633953

By:

Nakayama, Akiyoshi;
Matsuo, Hirotaka;
Takada, Tappei;
Ichida, Kimiyoshi;
Nakamura, Takahiro;
Ikebuchi, Yuki;
Ito, Kousei;
Hosoya, Tatsuo;
Kanai, Yoshikatsu;
Suzuki, Hiroshi;
Shinomiya, Nariyoshi

Publication type:

Article

ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout.

Published in:

Annals of Clinical & Translational Neurology, 2015, v. 2, n. 3, p. 302, doi. 10.1002/acn3.167

By:

Matsuo, Hirotaka;
Tomiyama, Hiroyuki;
Satake, Wataru;
Chiba, Toshinori;
Onoue, Hiroyuki;
Kawamura, Yusuke;
Nakayama, Akiyoshi;
Shimizu, Seiko;
Sakiyama, Masayuki;
Funayama, Manabu;
Nishioka, Kenya;
Shimizu, Toru;
Kaida, Kenichi;
Kamakura, Keiko;
Toda, Tatsushi;
Hattori, Nobutaka;
Shinomiya, Nariyoshi

Publication type:

Article

Carrier frequency of the GJB2 mutations that cause hereditary hearing loss in the Japanese population.

Published in:

Journal of Human Genetics, 2015, v. 60, n. 10, p. 613, doi. 10.1038/jhg.2015.82

By:

Taniguchi, Mirei;
Matsuo, Hirotaka;
Shimizu, Seiko;
Nakayama, Akiyoshi;
Suzuki, Koji;
Hamajima, Nobuyuki;
Shinomiya, Nariyoshi;
Nishio, Shinya;
Kosugi, Shinji;
Usami, Shin-ichi;
Ito, Juichi;
Kitajiri, Shin-ichiro

Publication type:

Article

Oridonin suppresses particulate-induced NLRP3-independent IL-1α release to prevent crystallopathy in the lung.

Published in:

International Immunology, 2022, v. 34, n. 10, p. 493, doi. 10.1093/intimm/dxac018

By:

Ikoma, Kenta;
Takahama, Michihiro;
Kimishima, Atsushi;
Pan, Yixi;
Taura, Manabu;
Nakayama, Akiyoshi;
Arai, Masayoshi;
Takemura, Naoki;
Saitoh, Tatsuya

Publication type:

Article

Nanaomycin E inhibits NLRP3 inflammasome activation by preventing mitochondrial dysfunction.

Published in:

International Immunology, 2022, v. 34, n. 10, p. 505, doi. 10.1093/intimm/dxac028

By:

Matsui, Yudai;
Takemura, Naoki;
Shirasaki, Yoshitaka;
Takahama, Michihiro;
Noguchi, Yoshihiko;
Ikoma, Kenta;
Pan, Yixi;
Nishida, Shuhei;
Taura, Manabu;
Nakayama, Akiyoshi;
Funatsu, Takashi;
Misawa, Takuma;
Harada, Yoshie;
Sunazuka, Toshiaki;
Saitoh, Tatsuya

Publication type:

Article

Common variants of a urate-associated gene LRP2 are not associated with gout susceptibility.

Published in:

Rheumatology International, 2014, v. 34, n. 4, p. 473, doi. 10.1007/s00296-013-2924-8

By:

Nakayama, Akiyoshi;
Matsuo, Hirotaka;
Shimizu, Toru;
Takada, Yuzo;
Nakamura, Takahiro;
Shimizu, Seiko;
Chiba, Toshinori;
Sakiyama, Masayuki;
Naito, Mariko;
Morita, Emi;
Ichida, Kimiyoshi;
Shinomiya, Nariyoshi

Publication type:

Article

Regulation of Urate Homeostasis by Membrane Transporters.

Published in:

Gout, Urate, & Crystal Deposition Disease, 2024, v. 2, n. 2, p. 206, doi. 10.3390/gucdd2020016

By:

Takada, Tappei;
Miyata, Hiroshi;
Toyoda, Yu;
Nakayama, Akiyoshi;
Ichida, Kimiyoshi;
Matsuo, Hirotaka

Publication type:

Article

Coffee Consumption Reduces Gout Risk Independently of Serum Uric Acid Levels: Mendelian Randomization Analyses Across Ancestry Populations.

Published in:

ACR Open Rheumatology, 2022, v. 4, n. 6, p. 534, doi. 10.1002/acr2.11425

By:

Shirai, Yuya;
Nakayama, Akiyoshi;
Kawamura, Yusuke;
Toyoda, Yu;
Nakatochi, Masahiro;
Shimizu, Seiko;
Shinomiya, Nariyoshi;
Okada, Yukinori;
Matsuo, Hirotaka

Publication type:

Article

Hyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2.

Published in:

Scientific Reports, 2016, p. 31003, doi. 10.1038/srep31003

By:

Matsuo, Hirotaka;
Tsunoda, Tomoyuki;
Ooyama, Keiko;
Sakiyama, Masayuki;
Sogo, Tsuyoshi;
Takada, Tappei;
Nakashima, Akio;
Nakayama, Akiyoshi;
Kawaguchi, Makoto;
Higashino, Toshihide;
Wakai, Kenji;
Ooyama, Hiroshi;
Hokari, Ryota;
Suzuki, Hiroshi;
Ichida, Kimiyoshi;
Inui, Ayano;
Fujimori, Shin;
Shinomiya, Nariyoshi

Publication type:

Article

Identification of rs671, a common variant of ALDH2, as a gout susceptibility locus.

Published in:

Scientific Reports, 2016, p. 25360, doi. 10.1038/srep25360

By:

Sakiyama, Masayuki;
Matsuo, Hirotaka;
Nakaoka, Hirofumi;
Yamamoto, Ken;
Nakayama, Akiyoshi;
Nakamura, Takahiro;
Kawai, Sayo;
Okada, Rieko;
Ooyama, Hiroshi;
Shimizu, Toru;
Shinomiya, Nariyoshi

Publication type:

Article

The effects of URAT1/SLC22A12 nonfunctional variants,R90H and W258X, on serum uric acid levels and gout/hyperuricemia progression.

Published in:

Scientific Reports, 2016, p. 20148, doi. 10.1038/srep20148

By:

Sakiyama, Masayuki;
Matsuo, Hirotaka;
Shimizu, Seiko;
Nakashima, Hiroshi;
Nakamura, Takahiro;
Nakayama, Akiyoshi;
Higashino, Toshihide;
Naito, Mariko;
Suma, Shino;
Hishida, Asahi;
Satoh, Takahiro;
Sakurai, Yutaka;
Takada, Tappei;
Ichida, Kimiyoshi;
Ooyama, Hiroshi;
Shimizu, Toru;
Shinomiya, Nariyoshi

Publication type:

Article

Common variant of <italic>BCAS3</italic> is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese.

Published in:

BMC Medical Genetics, 2018, v. 19, n. 1, p. N.PAG, doi. 10.1186/s12881-018-0583-z

By:

Sakiyama, Masayuki;
Matsuo, Hirotaka;
Nakaoka, Hirofumi;
Kawamura, Yusuke;
Kawaguchi, Makoto;
Higashino, Toshihide;
Nakayama, Akiyoshi;
Akashi, Airi;
Ueyama, Jun;
Kondo, Takaaki;
Wakai, Kenji;
Sakurai, Yutaka;
Yamamoto, Ken;
Ooyama, Hiroshi;
Shinomiya, Nariyoshi

Publication type:

Article

SNP-based heritability estimates of gout and its subtypes determined by genome-wide association studies of clinically defined gout.

Published in:

Rheumatology, 2023, v. 62, n. 5, p. e144, doi. 10.1093/rheumatology/keac597

By:

Toyoda, Yu;
Nakatochi, Masahiro;
Nakayama, Akiyoshi;
Kawamura, Yusuke;
Nakaoka, Hirofumi;
Wakai, Kenji;
Matsuo, Keitaro;
Matsuo, Hirotaka;
Consortium, for the Japan Gout Genomics

Publication type:

Article

Genetic epidemiological analysis of hypouricaemia from 4993 Japanese on non-functional variants of URAT1/SLC22A12 gene.

Published in:

Rheumatology, 2022, v. 61, n. 3, p. 1276, doi. 10.1093/rheumatology/keab545

By:

Nakayama, Akiyoshi;
Kawamura, Yusuke;
Toyoda, Yu;
Shimizu, Seiko;
Kawaguchi, Makoto;
Aoki, Yuka;
Takeuchi, Kenji;
Okada, Rieko;
Kubo, Yoko;
Imakiire, Toshihiko;
Iwasawa, Satoko;
Nakashima, Hiroshi;
Tsunoda, Masashi;
Ito, Keiichi;
Kumagai, Hiroo;
Takada, Tappei;
Ichida, Kimiyoshi;
Shinomiya, Nariyoshi;
Matsuo, Hirotaka

Publication type:

Article

Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12.

Published in:

Rheumatology, 2021, v. 60, n. 11, p. 5224, doi. 10.1093/rheumatology/keab327

By:

Toyoda, Yu;
Kawamura, Yusuke;
Nakayama, Akiyoshi;
Nakaoka, Hirofumi;
Higashino, Toshihide;
Shimizu, Seiko;
Ooyama, Hiroshi;
Morimoto, Keito;
Uchida, Naohiro;
Shigesawa, Ryuichiro;
Takeuchi, Kenji;
Inoue, Ituro;
Ichida, Kimiyoshi;
Suzuki, Hiroshi;
Shinomiya, Nariyoshi;
Takada, Tappei;
Matsuo, Hirotaka

Publication type:

Article

An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate.

Published in:

Rheumatology, 2021, v. 60, n. 9, p. 4430, doi. 10.1093/rheumatology/keab404

By:

Nakatochi, Masahiro;
Toyoda, Yu;
Kanai, Masahiro;
Nakayama, Akiyoshi;
Kawamura, Yusuke;
Hishida, Asahi;
Mikami, Haruo;
Matsuo, Keitaro;
Takezaki, Toshiro;
Momozawa, Yukihide;
Project, The Biobank Japan;
Kamatani, Yoichiro;
Ichihara, Sahoko;
Shinomiya, Nariyoshi;
Yokota, Mitsuhiro;
Wakai, Kenji;
Okada, Yukinori;
Matsuo, Hirotaka;
Urate), the Japan Uric Acid Genomics Consortium (Japan

Publication type:

Article

First clinical practice guideline for renal hypouricaemia: a rare disorder that aided the development of urate-lowering drugs for gout.

Published in:

Rheumatology, 2021, v. 60, n. 9, p. 3961, doi. 10.1093/rheumatology/keab322

By:

Nakayama, Akiyoshi;
Matsuo, Hirotaka;
Abhishek, Abhishek;
Ichida, Kimiyoshi;
Shinomiya, Nariyoshi;
Hypouricaemia, for the members of Guideline Development Committee of Clinical Practice Guideline for Renal

Publication type:

Article

Identification of a dysfunctional splicing mutation in the SLC22A12/URAT1 gene causing renal hypouricaemia type 1: a report on two families.

Published in:

Rheumatology, 2020, v. 59, n. 12, p. 3988, doi. 10.1093/rheumatology/keaa461

By:

Kawamura, Yusuke;
Toyoda, Yu;
Ohnishi, Takuma;
Hisatomi, Ryutaro;
Higashino, Toshihide;
Nakayama, Akiyoshi;
Shimizu, Seiko;
Yanagi, Masato;
Kamimaki, Isamu;
Fujimaru, Rika;
Suzuki, Hiroshi;
Shinomiya, Nariyoshi;
Takada, Tappei;
Matsuo, Hirotaka

Publication type:

Article

Meta-analysis confirms an association between gout and a common variant of LRRC16A locus.

Published in:

Modern Rheumatology, 2017, v. 27, n. 3, p. 553, doi. 10.1080/14397595.2016.1218413

By:

Hiraku Ogata;
Hirotaka Matsuo;
Masayuki Sakiyama;
Toshihide Higashino;
Makoto Kawaguchi;
Akiyoshi Nakayama;
Mariko Naito;
Hiroshi Ooyama;
Kimiyoshi Ichida;
Nariyoshi Shinomiya

Publication type:

Article

NPT1/SLC17A1 Is a Renal Urate Exporter in Humans and Its Common Gain-of-Function Variant Decreases the Risk of Renal Underexcretion Gout.

Published in:

Arthritis & Rheumatology, 2015, v. 67, n. 1, p. 281, doi. 10.1002/art.38884

By:

Chiba, Toshinori;
Matsuo, Hirotaka;
Kawamura, Yusuke;
Nagamori, Shushi;
Nishiyama, Takashi;
Wei, Ling;
Nakayama, Akiyoshi;
Nakamura, Takahiro;
Sakiyama, Masayuki;
Takada, Tappei;
Taketani, Yutaka;
Suma, Shino;
Naito, Mariko;
Oda, Takashi;
Kumagai, Hiroo;
Moriyama, Yoshinori;
Ichida, Kimiyoshi;
Shimizu, Toru;
Kanai, Yoshikatsu;
Shinomiya, Nariyoshi

Publication type:

Article

Strong genetic effect on gout revealed by genetic risk score from meta-analysis of two genome-wide association studies.

Published in:

2025

By:

Nakayama, Akiyoshi;
Kawamura, Yusuke;
Nakatochi, Masahiro;
Toyoda, Yu;
Nakajima, Mayuko;
Maehara, Kazuki;
Kirihara, Mana;
Shimizu, Seiko;
Matsuo, Keitaro;
Matsuo, Hirotaka;
the Japan Gout Genomics Consortium (Japan Gout);
Shimizu, Toru;
Ooyama, Hiroshi;
Ooyama, Keiko;
Nagase, Mitsuo;
Hidaka, Yuji;
Yamamoto, Ken;
Takada, Tappei;
Ichida, Kimiyoshi;
Wakai, Kenji

Publication type:

Letter

Identification of novel gout loci from trans-ethnic meta-analysis of serum urate level.

Published in:

2025

By:

Kawamura, Yusuke;
Nakayama, Akiyoshi;
Nakatochi, Masahiro;
Aoki, Yuka;
Toyoda, Yu;
Nakamura, Takahiro;
Shimizu, Seiko;
Matsuo, Keitaro;
Shinomiya, Nariyoshi;
Matsuo, Hirotaka;
for Japan Gout Genomics Consortium (Japan Gout);
Yamamoto, Ken;
Shimizu, Toru;
Ooyama, Hiroshi;
Ooyama, Keiko;
Nagase, Mitsuo;
Hidaka, Yuji;
Takada, Tappei;
Ichida, Kimiyoshi;
Wakai, Kenji

Publication type:

Letter

Biochemical characterization of renal hypouricemia-associated mutations in urate transporter genes using human cells.

Published in:

Human Cell, 2024, v. 37, n. 4, p. 1231, doi. 10.1007/s13577-024-01079-6

By:

Toyoda, Yu;
Takada, Tappei;
Nakayama, Akiyoshi;
Shinomiya, Nariyoshi;
Matsuo, Hirotaka

Publication type:

Article

A meta-analysis of genome-wide association studies using Japanese and Taiwanese has revealed novel loci associated with gout susceptibility.

Published in:

2022

By:

Chang, Shun-Jen;
Toyoda, Yu;
Kawamura, Yusuke;
Nakamura, Takahiro;
Nakatochi, Masahiro;
Nakayama, Akiyoshi;
Liao, Wei-Ting;
Shimizu, Seiko;
Takada, Tappei;
Takeuchi, Kenji;
Wakai, Kenji;
Shi, Yongyong;
Shinomiya, Nariyoshi;
Chen, Chung-Jen;
Li, Changgui;
Okada, Yukinori;
Ichida, Kimiyoshi;
Matsuo, Hirotaka;
for Japan Gout Genomics Consortium (Japan Gout);
Shirai, Yuya

Publication type:

Literature Review

Increase of serum uric acid levels associated with APOE ε2 haplotype: a clinico-genetic investigation and in vivo approach.

Published in:

Human Cell, 2021, v. 34, n. 6, p. 1727, doi. 10.1007/s13577-021-00609-w

By:

Ogura, Masatsune;
Toyoda, Yu;
Sakiyama, Masayuki;
Kawamura, Yusuke;
Nakayama, Akiyoshi;
Yamanashi, Yoshihide;
Takada, Tappei;
Shimizu, Seiko;
Higashino, Toshihide;
Nakajima, Mayuko;
Naito, Mariko;
Hishida, Asahi;
Kawai, Sayo;
Okada, Rieko;
Sasaki, Makoto;
Ayaori, Makoto;
Suzuki, Hiroshi;
Takata, Koki;
Ikewaki, Katsunori;
Harada-Shiba, Mariko

Publication type:

Article

Porphyrin accumulation in humans with common dysfunctional variants of ABCG2, a porphyrin transporter: potential association with acquired photosensitivity.

Published in:

Human Cell, 2021, v. 34, n. 4, p. 1082, doi. 10.1007/s13577-021-00534-y

By:

Sakiyama, Masayuki;
Matsuo, Hirotaka;
Toyoda, Yu;
Yonekura, Yuiko;
Ishikawa, Takahiro;
Nakayama, Akiyoshi;
Higashino, Toshihide;
Kawamura, Yusuke;
Fujimoto, Norihiro;
Shinomiya, Nariyoshi;
Satoh, Takahiro

Publication type:

Article

Both variants of A1CF and BAZ1B genes are associated with gout susceptibility: a replication study and meta-analysis in a Japanese population.

Published in:

Human Cell, 2021, v. 34, n. 2, p. 293, doi. 10.1007/s13577-021-00485-4

By:

Kawaguchi, Makoto;
Nakayama, Akiyoshi;
Aoyagi, Yuka;
Nakamura, Takahiro;
Shimizu, Seiko;
Kawamura, Yusuke;
Takao, Mikiya;
Tamura, Takashi;
Hishida, Asahi;
Nagayoshi, Mako;
Nagase, Mitsuo;
Ooyama, Keiko;
Ooyama, Hiroshi;
Shinomiya, Nariyoshi;
Matsuo, Hirotaka

Publication type:

Article

Dysfunctional ABCG2 gene polymorphisms are associated with serum uric acid levels and all-cause mortality in hemodialysis patients.

Published in:

Human Cell, 2020, v. 33, n. 3, p. 559, doi. 10.1007/s13577-020-00342-w

By:

Nakashima, Akio;
Ichida, Kimiyoshi;
Ohkido, Ichiro;
Yokoyama, Keitaro;
Matsuo, Hirotaka;
Ohashi, Yuki;
Takada, Tappei;
Nakayama, Akiyoshi;
Suzuki, Hiroshi;
Shinomiya, Nariyoshi;
Urashima, Mitsuyoshi;
Yokoo, Takashi

Publication type:

Article

A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population.

Published in:

2020

By:

Akashi, Airi;
Nakayama, Akiyoshi;
Kamatani, Yoichiro;
Higashino, Toshihide;
Shimizu, Seiko;
Kawamura, Yusuke;
Imoto, Misaki;
Naito, Mariko;
Hishida, Asahi;
Kawaguchi, Makoto;
Takao, Mikiya;
Matsuo, Michinori;
Takada, Tappei;
Ichida, Kimiyoshi;
Ooyama, Hiroshi;
Shinomiya, Nariyoshi;
Matsuo, Hirotaka

Publication type:

Literature Review

Clinical practice guideline for renal hypouricemia (1st edition).

Published in:

Human Cell, 2019, v. 32, n. 2, p. 83, doi. 10.1007/s13577-019-00239-3

By:

Nakayama, Akiyoshi;
Matsuo, Hirotaka;
Ohtahara, Akira;
Ogino, Kazuhide;
Hakoda, Masayuki;
Hamada, Toshihiro;
Hosoyamada, Makoto;
Yamaguchi, Satoshi;
Hisatome, Ichiro;
Ichida, Kimiyoshi;
Shinomiya, Nariyoshi

Publication type:

Article

A common variant of MAF/c- MAF, transcriptional factor gene in the kidney, is associated with gout susceptibility.

Published in:

Human Cell, 2018, v. 31, n. 1, p. 10, doi. 10.1007/s13577-017-0186-6

By:

Higashino, Toshihide;
Matsuo, Hirotaka;
Okada, Yukinori;
Nakashima, Hiroshi;
Shimizu, Seiko;
Sakiyama, Masayuki;
Tadokoro, Shin;
Nakayama, Akiyoshi;
Kawaguchi, Makoto;
Komatsu, Mako;
Hishida, Asahi;
Nakatochi, Masahiro;
Ooyama, Hiroshi;
Imaki, Junko;
Shinomiya, Nariyoshi

Publication type:

Article

Common variant of ALPK1 is not associated with gout: a replication study.

Published in:

Human Cell, 2015, v. 28, n. 1, p. 1, doi. 10.1007/s13577-014-0103-1

By:

Chiba, Toshinori;
Matsuo, Hirotaka;
Sakiyama, Masayuki;
Nakayama, Akiyoshi;
Shimizu, Seiko;
Wakai, Kenji;
Suma, Shino;
Nakashima, Hiroshi;
Sakurai, Yutaka;
Shimizu, Toru;
Ichida, Kimiyoshi;
Shinomiya, Nariyoshi

Publication type:

Article

A common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility.

Published in:

Human Cell, 2014, v. 27, n. 2, p. 1, doi. 10.1007/s13577-013-0081-8

By:

Masayuki Sakiyama;
Hirotaka Matsuo;
Seiko Shimizu;
Toshinori Chiba;
Akiyoshi Nakayama;
Yuzo Takada;
Takahiro Nakamura;
Tappei Takada;
Emi Morita;
Mariko Naito;
Kenji Wakai;
Hiroki Inoue;
Seishiro Tatsukawa;
Junki Sato;
Kazumi Shimono;
Toshiaki Makino;
Takahiro Satoh;
Hiroshi Suzuki;
Yoshikatsu Kanai;
Nobuyuki Hamajima

Publication type:

Article