Works by Akira Naganuma

Results: 65

The protein transportation pathway from Golgi to vacuoles via endosomes plays a role in enhancement of methylmercury toxicity.

Published in:

Scientific Reports, 2014, p. 1, doi. 10.1038/srep05888

By:

Gi-Wook Hwang;
Yasutaka Murai;
Tsutomu Takahashi;
Akira Naganuma

Publication type:

Article

Immature Core protein of hepatitis C virus induces an unfolded protein response through inhibition of ERAD-L in a yeast model system.

Published in:

Genes to Cells, 2017, v. 22, n. 2, p. 160, doi. 10.1111/gtc.12464

By:

Takahashi, Shota;
Sato, Naoko;
Kikuchi, Junichi;
Kakinuma, Hideaki;
Okawa, Jun;
Masuyama, Yukiko;
Iwasa, Singo;
Irokawa, Hayato;
Hwang, Gi‐Wook;
Naganuma, Akira;
Kohara, Michinori;
Kuge, Shusuke

Publication type:

Article

HeLa Cell Transformants Overproducing Mouse Metallothionein Show in vivo Resistance to cis-Platinum in Nude Mice.

Published in:

Cancer Science, 2000, v. 91, n. 1, p. 91, doi. 10.1111/j.1349-7006.2000.tb00864.x

By:

Toyoda, Haruka;
Mizushima, Tomoe;
Satoh, Masahiko;
Iizuka, Narushi;
Nomoto, Akio;
Chiba, Harumi;
Mita, Masaharu;
Naganuma, Akira;
Himeno, Seiichiro;
Imura, Nobumasa

Publication type:

Article

Methylmercury directly modifies the 105th cysteine residue in oncostatin M to promote binding to tumor necrosis factor receptor 3 and inhibit cell growth.

Published in:

Archives of Toxicology, 2023, v. 97, n. 7, p. 1887, doi. 10.1007/s00204-023-03520-5

By:

Toyama, Takashi;
Xu, Sidi;
Kanemitsu, Yoshitomi;
Hasegawa, Takashi;
Noguchi, Takuya;
Lee, Jin-Yong;
Matsuzawa, Atsushi;
Naganuma, Akira;
Hwang, Gi-Wook

Publication type:

Article

Normal organic and inorganic mercury levels in the human feto-placental system.

Published in:

Journal of Applied Toxicology, 1984, v. 4, n. 5, p. 249, doi. 10.1002/jat.2550040507

By:

Suzuki, Tsuguyoshi;
Yonemoto, Junzo;
Satoh, Hiroshi;
Naganuma, Akira;
Imura, Nobumasa;
Kigawa, Tomonori

Publication type:

Article

The Nuclear Protein HOXB13 Enhances Methylmercury Toxicity by Inducing OncostatinM and Promoting Its Binding to TNFR3 in Cultured Cells.

Published in:

Cells (2073-4409), 2020, v. 9, n. 1, p. 1, doi. 10.3390/cells9010045

By:

Takashi Toyama;
Sidi Xu;
Ryo Nakano;
Takashi Hasegawa;
Naoki Endo;
Tsutomu Takahashi;
Jin-Yong Lee;
Akira Naganuma;
Gi-Wook Hwang

Publication type:

Article

Functions of yeast helicase Ssl2p that are essential for viability are also involved in protection from the toxicity of adriamycin.

Published in:

Nucleic Acids Research, 2004, v. 32, n. 8, p. 2578, doi. 10.1093/nar/gkh582

By:

Furuchi, Takemitsu;
Takahashi, Tsutomu;
Tanaka, Shogo;
Nitta, Katsushi;
Naganuma, Akira

Publication type:

Article

Identification of substrates of F-box protein involved in methylmercury toxicity in yeast cells.

Published in:

FEBS Letters, 2015, v. 589, n. 19PartB, p. 2720, doi. 10.1016/j.febslet.2015.08.016

By:

Lee, Jin-Yong;
Ishida, Yosuke;
Kuge, Shusuke;
Naganuma, Akira;
Hwang, Gi-Wook

Publication type:

Article

The Journal of Toxicological Sciences and Fundamental Toxicological Sciences to become open access journals.

Published in:

Journal of Toxicological Sciences, 2025, v. 50, n. 5, p. R1, doi. 10.2131/jts.50.r1

By:

Toshiyuki Kaji;
Akira Naganuma

Publication type:

Article

Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures.

Published in:

Journal of Toxicological Sciences, 2019, v. 44, n. 7, p. 471, doi. 10.2131/jts.44.471

By:

Takayuki Hoshi;
Takashi Toyama;
Youichi Shinozaki;
Schuichi Koizumi;
Jin-Yong Lee;
Akira Naganuma;
Gi-Wook Hwang

Publication type:

Article

Adverse health effects of humidifier disinfectants in Korea: lung toxicity of polyhexamethylene guanidine phosphate.

Published in:

Journal of Toxicological Sciences, 2016, v. 41, n. 6, p. 711, doi. 10.2131/jts.41.711

By:

Ha-Ryong Kim;
Gi-Wook Hwang;
Akira Naganuma;
Kyu-Hyuck Chung

Publication type:

Article

History and development of The Journal of Toxicological Sciences.

Published in:

Journal of Toxicological Sciences, 2016, v. 41, p. SP11, doi. 10.2131/jts.41.SP11

By:

Akira Naganuma

Publication type:

Article

FBXO6 attenuates cadmium toxicity in HEK293 cells by inhibiting ER stress and JNK activation.

Published in:

Journal of Toxicological Sciences, 2014, v. 39, n. 6, p. 861, doi. 10.2131/jts.39.861

By:

Ke Du;
Tsutomu Takahashi;
Shusuke Kuge;
Akira Naganuma;
Gi-Wook Hwang

Publication type:

Article

Brain-specific induction of secretoglobin 3A1 expression in mice treated with methylmercury.

Published in:

Journal of Toxicological Sciences, 2013, v. 38, n. 6, p. 963, doi. 10.2131/jts.38.963

By:

Takahashi, Tsutomo;
Kim, Min-Seok;
Saito, Takahiro;
Lee, Jin-Yong;
Hwang, Gi-Wook;
Naganuma, Akira

Publication type:

Article

Low dose of methylmercury (MeHg) exposure induces caspase mediated-apoptosis in cultured neural progenitor cells.

Published in:

Journal of Toxicological Sciences, 2013, v. 38, n. 6, p. 931, doi. 10.2131/jts.38.931

By:

Watanabe, Jun;
Nakamachi, Tomoya;
Ohtaki, Hirokazu;
Naganuma, Akira;
Shioda, Seiji;
Nakajo, Shigeo

Publication type:

Article

Global chemokine expression in methylmercury-treated mice: methylmercury induces brain-specific expression of CCL3 and CCL4.

Published in:

Journal of Toxicological Sciences, 2013, v. 38, n. 6, p. 925, doi. 10.2131/jts.38.925

By:

Kim, Min-Seok;
Takahashi, Tsutomu;
Lee, Jin-Yong;
Hwang, Gi-Wook;
Naganuma, Akira

Publication type:

Article

Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells.

Published in:

Journal of Toxicological Sciences, 2013, v. 38, n. 6, p. 821, doi. 10.2131/jts.38.821

By:

Nakano, Ryo;
Takahashi, Tsutomu;
Naganuma, Akira;
Hwang, Gi-Wook

Publication type:

Article

Changes in the levels of low molecular weight metabolites in the mouse cerebellum following treatment with methylmercury.

Published in:

Journal of Toxicological Sciences, 2013, v. 38, n. 5, p. 703, doi. 10.2131/jts.38.703

By:

Gi-Wook Hwang;
Jin-Yong Lee;
Min-Seok Kim;
Masayuki Sato;
Tsutomu Takahashi;
Akira Naganuma

Publication type:

Article

Deletion of the ubiquitin-conjugating enzyme Ubc2 confers resistance to methylmercury in budding yeast by promoting Whi2 degradation.

Published in:

Journal of Toxicological Sciences, 2013, v. 38, n. 2, p. 301, doi. 10.2131/jts.38.301

By:

Gi-Wook Hwang;
Fujio Mastuyama;
Tsutomu Takahashi;
Jin-Yong Lee;
Akira Naganuma

Publication type:

Article

Identification of deubiquitinating enzymes involved in methylmercury toxicity in Saccharomyces cerevisiae.

Published in:

Journal of Toxicological Sciences, 2012, v. 37, n. 6, p. 1287, doi. 10.2131/jts.37.1287

By:

Gi-Wook Hwang;
Yukiyoshi Kimura;
Tsutomu Takahashi;
Jin-Yong Lee;
Akira Naganuma

Publication type:

Article

Ubiquitin-conjugating enzyme Cdc34 mediates methylmercury resistance in Saccharomyces cerevisiae by increasing Whi2 degradation.

Published in:

Journal of Toxicological Sciences, 2012, v. 37, n. 6, p. 1283, doi. 10.2131/jts.37.1283

By:

Gi-Wook Hwang;
Yousuke Ogiwara;
Tsutomu Takahashi;
Akira Naganuma

Publication type:

Article

Methylmercury induces a brain-specific increase in chemokine CCL4 expression in mice.

Published in:

Journal of Toxicological Sciences, 2012, v. 37, n. 6, p. 1278, doi. 10.2131/jts.37.1279

By:

Jin-Yong Lee;
Gi-Wook Hwang;
Min-Seok Kim;
Tsutomu Takahashi;
Akira Naganuma

Publication type:

Article

Methylmercury induces CCL2 expression through activation of NF-κB in human 1321N1 astrocytes.

Published in:

Journal of Toxicological Sciences, 2012, v. 37, n. 6, p. 1275, doi. 10.2131/jts.37.1275

By:

Min-Seok Kim;
Tsutomu Takahashi;
Jin-Yong Lee;
Gi-Wook Hwang;
Akira Naganuma

Publication type:

Article

Increased production of reactive oxygen species by the vacuolar-type (H<sup>+</sup>)-ATPase inhibitors bafilomycin A1 and concanamycin A in RAW 264 cells.

Published in:

Journal of Toxicological Sciences, 2012, v. 37, n. 5, p. 1045, doi. 10.2131/jts.37.1045

By:

Aya Yokomakura;
JangJa Hong;
Kazuo Ohuchi;
Seong-Eun Oh;
Jin-Yong Lee;
Nariyasu Mano;
Tsutomu Takahashi;
Gi-Wook Hwang;
Akira Naganuma

Publication type:

Article

A screening for essential cell growth-related genes involved in arsenite toxicity in Saccharomyces cerevisiae.

Published in:

Journal of Toxicological Sciences, 2011, v. 36, n. 6, p. 859, doi. 10.2131/jts.36.859

By:

Takahashi, Tsutomu;
Satake, Shohei;
Hirose, Ken-ichiro;
Gi-Wook Hwang;
Naganuma, Akira

Publication type:

Article

Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae.

Published in:

Journal of Toxicological Sciences, 2011, v. 36, n. 6, p. 855, doi. 10.2131/jts.36.855

By:

Takahashi, Tsutomu;
Nakashima, Shingo;
Masuda, Takuro;
Yoneda, Shigehiro;
Gi-Wook Hwang;
Naganuma, Akira

Publication type:

Article

siRNA-mediated silencing of the gene for heat shock transcription factor 1 causes hypersensitivity to methylmercury in HEK293 cells.

Published in:

Journal of Toxicological Sciences, 2011, v. 36, n. 6, p. 851, doi. 10.2131/jts.36.851

By:

Gi-Wook Hwang;
Ryoke, Katsunori;
Jin-Yong Lee;
Takahashi, Tsutomu;
Naganuma, Akira

Publication type:

Article

Inhibition of F-box protein FBXO6 gene expression by RNA interference enhances cadmium toxicity in HEK293 cells.

Published in:

Journal of Toxicological Sciences, 2011, v. 36, n. 6, p. 847, doi. 10.2131/jts.36.847

By:

Gi-Wook Hwang;
Ke Du;
Takahashi, Tsutomu;
Naganuma, Akira

Publication type:

Article

Gene expression profiling using DNA microarray analysis of the cerebellum of mice treated with methylmercury.

Published in:

Journal of Toxicological Sciences, 2011, v. 36, n. 3, p. 389, doi. 10.2131/jts.36.389

By:

Gi-Wook Hwang;
Jin-Yong Lee;
Katsunori Ryoke;
Fujio Matsuyama;
Jong-Mu Kim;
Tsutomu Takahashi;
Akira Naganuma

Publication type:

Article

siRNA-mediated knockdown of the melanocortin 2 receptor accessory protein 2 (MRAP2) gene confers resistance to methylmercury on HEK293 cells.

Published in:

Journal of Toxicological Sciences, 2010, v. 35, n. 6, p. 947, doi. 10.2131/jts.35.947

By:

Gi-Wook Hwang;
Seong-Eun Oh;
Takahashi, Tsutomu;
Jin-Yong Lee;
Naganuma, Akira

Publication type:

Article

Overexpression of FAP7, MIG3, TMA19, or YLR392c confers resistance to arsenite on Saccharomyces cerevisiae.

Published in:

Journal of Toxicological Sciences, 2010, v. 35, n. 6, p. 945, doi. 10.2131/jts.35.945

By:

Takahashi, Tsutomu;
Yano, Toomi;
JunXuan Zhu;
Gi-Wook Hwang;
Naganuma, Akira

Publication type:

Article

Silencing of the gene for homeobox protein HOXB13 by siRNA confers resistance to methylmercury on HEK293 cells.

Published in:

Journal of Toxicological Sciences, 2010, v. 35, n. 6, p. 941, doi. 10.2131/jts.35.941

By:

Gi-Wook Hwang;
Ryoke, Katsunori;
Takahashi, Tsutomu;
Naganuma, Akira

Publication type:

Article

Rip1 enhances methylmercury toxicity through production of reactive oxygen species (ROS) in budding yeast.

Published in:

Journal of Toxicological Sciences, 2009, v. 34, n. 6, p. 715, doi. 10.2131/jts.34.715

By:

Jin-Yong Lee;
Gi-Wook Hwang;
Naganuma, Akira

Publication type:

Article

Dysfunctional nascent polypeotide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.

Published in:

Journal of Toxicological Sciences, 2009, v. 34, n. 6, p. 703, doi. 10.2131/jts.34.703

By:

Takahashi, Tsutomu;
Hirose, Ken-ichiro;
Mizutani, Emi;
Naganuma, Akira

Publication type:

Article

Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae.

Published in:

Journal of Toxicological Sciences, 2009, v. 34, n. 4, p. 441, doi. 10.2131/jts.34.441

By:

Gi-Wook Hwang;
Sasaki, Kanae;
Takahashi, Tsutomu;
Yamamoto, Reiko;
Naganuma, Akira

Publication type:

Article

Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae.

Published in:

Journal of Toxicological Sciences, 2009, v. 34, n. 4, p. 413, doi. 10.2131/jts.34.413

By:

Gi-Wook Hwang;
Wada, Naomi;
Kuge, Shusuke;
Naganuma, Akira

Publication type:

Article

Characterization of antioxidant protection of cultured neural progenitor cells (NPC) against methylmercury (MeHg) toxicity.

Published in:

Journal of Toxicological Sciences, 2009, v. 34, n. 3, p. 315, doi. 10.2131/jts.34.315

By:

Watanabe, Jun;
Nakamachi, Tomoya;
Ogawa, Tetsuo;
Naganuma, Akira;
Nakamura, Masahisa;
Shioda, Seiji;
Nakajo, Sigeo

Publication type:

Article

Role of metallothionein as a protective factor against radiation carcinogenesis.

Published in:

Journal of Toxicological Sciences, 2008, v. 33, n. 5, p. 651, doi. 10.2131/jts.33.651

By:

Shibuya, Kiyoshi;
Nishimura, Noriko;
Suzuki, Junko S.;
Tohyama, Chiharu;
Naganuma, Akira;
Satoh, Masahiko

Publication type:

Article

Citrate enhances the protective effect of orally administered bismuth subnitrate against the nephrotoxicity of cis-diamminedichloroplatinum.

Published in:

Cancer Chemotherapy & Pharmacology, 2004, v. 53, n. 1, p. 33, doi. 10.1007/s00280-003-0706-9

By:

Kondo, Yukihiro;
Himeno, Seiichiro;
Satoh, Masahiko;
Naganuma, Akira;
Nishimura, Taiji;
Imura, Nobumasa

Publication type:

Article

Hydrogen Peroxide Causes Cell Death via Increased Transcription of HOXB13 in Human Lung Epithelial A549 Cells.

Published in:

Toxics, 2020, v. 8, n. 4, p. 78, doi. 10.3390/toxics8040078

By:

Endo, Naoki;
Toyama, Takashi;
Naganuma, Akira;
Saito, Yoshiro;
Hwang, Gi-Wook

Publication type:

Article

Effect of Metallothionein-III on Mercury-Induced Chemokine Gene Expression.

Published in:

Toxics, 2018, v. 6, n. 3, p. 48, doi. 10.3390/toxics6030048

By:

Lee, Jin-Yong;
Tokumoto, Maki;
Hwang, Gi-Wook;
Kim, Min-Seok;
Takahashi, Tsutomu;
Naganuma, Akira;
Yoshida, Minoru;
Satoh, Masahiko

Publication type:

Article

Chemokine CCL4 Induced in Mouse Brain Has a Protective Role against Methylmercury Toxicity.

Published in:

Toxics, 2018, v. 6, n. 3, p. 36, doi. 10.3390/toxics6030036

By:

Takahashi, Tsutomu;
Kim, Min-Seok;
Iwai-Shimada, Miyuki;
Fujimura, Masatake;
Toyama, Takashi;
Naganuma, Akira;
Hwang, Gi-Wook

Publication type:

Article

The Phospholipid:Diacylglycerol Acyltransferase Lro1 Is Responsible for Hepatitis C Virus Core-Induced Lipid Droplet Formation in a Yeast Model System.

Published in:

PLoS ONE, 2016, v. 11, n. 7, p. 1, doi. 10.1371/journal.pone.0159324

By:

Iwasa, Shingo;
Sato, Naoko;
Wang, Chao-Wen;
Cheng, Yun-Hsin;
Irokawa, Hayato;
Hwang, Gi-Wook;
Naganuma, Akira;
Kuge, Shusuke

Publication type:

Article

High-performance liquid chromatography with photodiode array detection for determination of nobiletin content in the brain and serum of mice administrated the natural compound.

Published in:

Analytical & Bioanalytical Chemistry, 2011, v. 400, n. 4, p. 3635, doi. 10.1007/s00216-011-5031-2

By:

Saigusa, Daisuke;
Shibuya, Masatoshi;
Jinno, Daisuke;
Yamakoshi, Hiroyuki;
Iwabuchi, Yoshiharu;
Yokosuka, Akihito;
Mimaki, Yoshihiro;
Naganuma, Akira;
Ohizumi, Yasushi;
Tomioka, Yoshihisa;
Yamakuni, Tohru

Publication type:

Article

Metal components analysis of metallothionein-III in the brain sections of metallothionein-I and metallothionein-II null mice exposed to mercury vapor with HPLC/ICP-MS.

Published in:

Analytical & Bioanalytical Chemistry, 2005, v. 381, n. 8, p. 1514, doi. 10.1007/s00216-005-3157-9

By:

Kameo, Satomi;
Nakai, Kunihiko;
Kurokawa, Naoyuki;
Kanehisa, Tomokazu;
Naganuma, Akira;
Satoh, Hiroshi

Publication type:

Article

HSC90 is required for nascent hepatitis C virus core protein stability in yeast cells

Published in:

FEBS Letters, 2012, v. 586, n. 16, p. 2318, doi. 10.1016/j.febslet.2012.05.023

By:

Kubota, Naoko;
Inayoshi, Yasutaka;
Satoh, Naoko;
Fukuda, Takashi;
Iwai, Kenta;
Tomoda, Hiroshi;
Kohara, Michinori;
Kataoka, Kazuhiro;
Shimamoto, Akira;
Furuichi, Yasuhiro;
Nomoto, Akio;
Naganuma, Akira;
Kuge, Shusuke

Publication type:

Article

Identification of F-box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae

Published in:

FEBS Letters, 2006, v. 580, n. 30, p. 6813, doi. 10.1016/j.febslet.2006.11.045

By:

Hwang, Gi-Wook;
Ishida, Yosuke;
Naganuma, Akira

Publication type:

Article

Novel Function of Metallothionein in Photoprotection: Metallothionein‐Null Mouse Exhibits Reduced Tolerance Against Ultraviolet B Injury in the Skin.

Published in:

Journal of Investigative Dermatology, 1998, v. 111, n. 4, p. 582, doi. 10.1046/j.1523-1747.1998.00342.x

By:

Hanada, Katsumi;
Sawamura, Daisuke;
Tamai, Katsuto;
Baba, Takako;
Hashimoto, Isao;
Muramatsu, Tsutomu;
Miura, Nobuhiko;
Naganuma, Akira

Publication type:

Article

Epidermal Proliferation of the Skin in Metallothionein-Null Mice.

Published in:

Journal of Investigative Dermatology, 1998, v. 110, n. 3, p. 259, doi. 10.1046/j.1523-1747.1998.00125.x

By:

Hanada, Katsumi;
Sawamura, Daisuke;
Hashimoto, Isao;
Kida, Kazuyuki;
Naganuma, Akira

Publication type:

Article

Downregulation of arginase II and renal apoptosis by inorganic mercury: overexpression of arginase II reduces its apoptosis.

Published in:

Archives of Toxicology, 2008, v. 82, n. 2, p. 67, doi. 10.1007/s00204-007-0244-z

By:

Kanda, Hironori;
Kikushima, Makoto;
Homma-Takeda, Shino;
Sumi, Daigo;
Endo, Akiko;
Toyama, Takashi;
Miura, Nobuhiko;
Naganuma, Akira;
Kumagai, Yoshito

Publication type:

Article