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A common genetic variant within SCN10A modulates cardiac SCN5A expression.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 4, p. 1844, doi. 10.1172/JCI73140
By:
- van den Boogaard, Malou;
- Smemo, Scott;
- Burnicka-Turek, Ozanna;
- Arnolds, David E.;
- van de Werken, Harmen J. G.;
- Klous, Petra;
- McKean, David;
- Muehlschlegel, Jochen D.;
- Moosmann, Julia;
- Okan Toka;
- Xinan H. Yang;
- Koopmann, Tamara T.;
- Adriaens, Michiel E.;
- Bezzina, Connie R.;
- de Laat, Wouter;
- Seidman, Christine;
- Seidman, J. G.;
- Christoffels, Vincent M.;
- Nobrega, Marcelo A.;
- Barnett, Phil
Publication type:
Article
Allele-specific expression analysis for complex genetic phenotypes applied to a unique dilated cardiomyopathy cohort.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-27591-7
By:
- van Beek, Daan;
- Verdonschot, Job;
- Derks, Kasper;
- Brunner, Han;
- de Kok, Theo M.;
- Arts, Ilja C. W.;
- Heymans, Stephane;
- Kutmon, Martina;
- Adriaens, Michiel
Publication type:
Article
EFMviz: A COBRA Toolbox Extension to Visualize Elementary Flux Modes in Genome-Scale Metabolic Models.
Published in:
Metabolites (2218-1989), 2020, v. 10, n. 2, p. 66, doi. 10.3390/metabo10020066
By:
- Sarathy, Chaitra;
- Kutmon, Martina;
- Lenz, Michael;
- Adriaens, Michiel E.;
- Evelo, Chris T.;
- Arts, Ilja C.W.
Publication type:
Article
User-friendly solutions for microarray quality control and pre-processing on ArrayAnalysis.org.
Published in:
Nucleic Acids Research, 2013, v. 41, p. W71, doi. 10.1093/nar/gkt293
By:
- Eijssen, Lars M. T.;
- Jaillard, Magali;
- Adriaens, Michiel E.;
- Gaj, Stan;
- de Groot, Philip J.;
- Müller, Michael;
- Evelo, Chris T.
Publication type:
Article
Quantifying postprandial glucose responses using a hybrid modeling approach: Combining mechanistic and data-driven models in The Maastricht Study.
Published in:
PLoS ONE, 2023, v. 18, n. 7, p. 1, doi. 10.1371/journal.pone.0285820
By:
- Erdős, Balázs;
- van Sloun, Bart;
- Goossens, Gijs H.;
- O'Donovan, Shauna D.;
- de Galan, Bastiaan E.;
- van Greevenbroek, Marleen M. J.;
- Stehouwer, Coen D. A.;
- Schram, Miranda T.;
- Blaak, Ellen E.;
- Adriaens, Michiel E.;
- van Riel, Natal A. W.;
- Arts, Ilja C. W.
Publication type:
Article
Hepatic insulin resistance and muscle insulin resistance are characterized by distinct postprandial plasma metabolite profiles: a cross-sectional study.
Published in:
Cardiovascular Diabetology, 2024, v. 23, n. 1, p. 1, doi. 10.1186/s12933-024-02188-0
By:
- Gijbels, Anouk;
- Erdős, Balázs;
- Trouwborst, Inez;
- Jardon, Kelly M.;
- Adriaens, Michiel E.;
- Goossens, Gijs H.;
- Blaak, Ellen E.;
- Feskens, Edith J. M.;
- Afman, Lydia A.
Publication type:
Article
Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart.
Published in:
PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0097380
By:
- Koopmann, Tamara T.;
- Adriaens, Michiel E.;
- Moerland, Perry D.;
- Marsman, Roos F.;
- Westerveld, Margriet L.;
- Lal, Sean;
- Zhang, Taifang;
- Simmons, Christine Q.;
- Baczko, Istvan;
- dos Remedios, Cristobal;
- Bishopric, Nanette H.;
- Varro, Andras;
- George Jr, Alfred L.;
- Lodder, Elisabeth M.;
- Bezzina, Connie R.
Publication type:
Article
Molecular Pathways Involved in Prostate Carcinogenesis: Insights from Public Microarray Datasets.
Published in:
PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0049831
By:
- Baetke, Sarah C.;
- Adriaens, Michiel E.;
- Seigneuric, Renaud;
- Evelo, Chris T.;
- Eijssen, Lars M. T.
Publication type:
Article
Phenotypic clustering of dilated cardiomyopathy patients highlights important pathophysiological differences.
Published in:
European Heart Journal, 2021, v. 42, n. 2, p. 162, doi. 10.1093/eurheartj/ehaa841
By:
- Verdonschot, Job A J;
- Merlo, Marco;
- Dominguez, Fernando;
- Wang, Ping;
- Henkens, Michiel T H M;
- Adriaens, Michiel E;
- Hazebroek, Mark R;
- Masè, Marco;
- Escobar, Luis E;
- Cobas-Paz, Rafael;
- Derks, Kasper W J;
- van den Wijngaard, Arthur;
- Krapels, Ingrid P C;
- Brunner, Han G;
- Sinagra, Gianfranco;
- Garcia-Pavia, Pablo;
- Heymans, Stephane R B
Publication type:
Article
Leveraging continuous glucose monitoring for personalized modeling of insulin-regulated glucose metabolism.
Published in:
Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-58703-6
By:
- Erdős, Balázs;
- O'Donovan, Shauna D.;
- Adriaens, Michiel E.;
- Gijbels, Anouk;
- Trouwborst, Inez;
- Jardon, Kelly M.;
- Goossens, Gijs H.;
- Afman, Lydia A.;
- Blaak, Ellen E.;
- van Riel, Natal A. W.;
- Arts, Ilja C. W.
Publication type:
Article
Comparison of metabolic states using genome-scale metabolic models.
Published in:
PLoS Computational Biology, 2021, v. 17, n. 11, p. 1, doi. 10.1371/journal.pcbi.1009522
By:
- Sarathy, Chaitra;
- Breuer, Marian;
- Kutmon, Martina;
- Adriaens, Michiel E.;
- Evelo, Chris T.;
- Arts, Ilja C. W.
Publication type:
Article
Stratifying cellular metabolism during weight loss: an interplay of metabolism, metabolic flexibility and inflammation.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-58358-z
By:
- Tareen, Samar H. K.;
- Kutmon, Martina;
- de Kok, Theo M.;
- Mariman, Edwin C. M.;
- van Baak, Marleen A.;
- Evelo, Chris T.;
- Adriaens, Michiel E.;
- Arts, Ilja C. W.
Publication type:
Article
Hepatic Steatosis Contributes to the Development of Muscle Atrophy via Inter-Organ Crosstalk.
Published in:
Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.733625
By:
- Pasmans, Kenneth;
- Adriaens, Michiel E.;
- Olinga, Peter;
- Langen, Ramon;
- Rensen, Sander S.;
- Schaap, Frank G.;
- Olde Damink, Steven W. M.;
- Caiment, Florian;
- van Loon, Luc J. C.;
- Blaak, Ellen E.;
- Meex, Ruth C. R.
Publication type:
Article
Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia.
Published in:
Epigenetics & Chromatin, 2016, v. 9, p. 1, doi. 10.1186/s13072-016-0090-4
By:
- Adriaens, Michiel E.;
- Prickaerts, Peggy;
- Chan-Seng-Yue, Michelle;
- van den Beucken, Twan;
- Dahlmans, Vivian E. H.;
- Eijssen, Lars M.;
- Beck, Timothy;
- Wouters, Bradly G.;
- Voncken, Jan Willem;
- Evelo, Chris T. A.
Publication type:
Article
Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3.
Published in:
Epigenetics & Chromatin, 2016, v. 9, p. 1, doi. 10.1186/s13072-016-0086-0
By:
- Prickaerts, Peggy;
- Adriaens, Michiel E.;
- van den Beucken, Twan;
- Koch, Elizabeth;
- Dubois, Ludwig;
- Dahlmans, Vivian E. H.;
- Gits, Caroline;
- Evelo, Chris T. A.;
- Chan-Seng-Yue, Michelle;
- Wouters, Bradly G.;
- Voncken, Jan Willem
Publication type:
Article
MK3 controls Polycomb target gene expression via negative feedback on ERK.
Published in:
Epigenetics & Chromatin, 2012, v. 5, n. 1, p. 12, doi. 10.1186/1756-8935-5-12
By:
- Prickaerts, Peggy;
- Niessen, Hanneke E.C.;
- Mouchel-Vielh, Emmanuèle;
- Dahlmans, Vivian E.H.;
- van den Akker, Guus G.H.;
- Geijselaers, Claudia;
- Adriaens, Michiel E.;
- Spaapen, Frank;
- Yoshihiro Takihara;
- Rapp, Ulf R.;
- Peronnet, Frédérique;
- Willem Voncken, Jan
Publication type:
Article
Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.
Published in:
Nature Communications, 2014, v. 5, n. 10, p. 5203, doi. 10.1038/ncomms6203
By:
- van den Beucken, Twan;
- Koch, Elizabeth;
- Chu, Kenneth;
- Rupaimoole, Rajesha;
- Prickaerts, Peggy;
- Adriaens, Michiel;
- Voncken, Jan Willem;
- Harris, Adrian L.;
- Buffa, Francesca M.;
- Haider, Syed;
- Starmans, Maud H. W.;
- Yao, Cindy Q.;
- Ivan, Mircea;
- Ivan, Cristina;
- Pecot, Chad V.;
- Boutros, Paul C.;
- Sood, Anil K.;
- Koritzinsky, Marianne;
- Wouters, Bradly G.
Publication type:
Article
An interferon-related signature characterizes the whole blood transcriptome profile of insulin-resistant individuals—the CODAM study.
Published in:
Genes & Nutrition, 2021, v. 16, n. 1, p. 1, doi. 10.1186/s12263-021-00702-7
By:
- Kalafati, Marianthi;
- Kutmon, Martina;
- Evelo, Chris T.;
- van der Kallen, Carla J. H.;
- Schalkwijk, Casper G.;
- Stehouwer, Coen D. A.;
- Consortium, B. I. O. S.;
- Blaak, Ellen E.;
- van Greevenbroek, Marleen M. J.;
- Adriaens, Michiel
Publication type:
Article
Logical modelling reveals the PDC-PDK interaction as the regulatory switch driving metabolic flexibility at the cellular level.
Published in:
Genes & Nutrition, 2019, v. 14, n. 1, p. N.PAG, doi. 10.1186/s12263-019-0647-5
By:
- Tareen, Samar HK;
- Kutmon, Martina;
- Arts, Ilja CW;
- de Kok, Theo M;
- Evelo, Chris T;
- Adriaens, Michiel E
Publication type:
Article
Exploring the cellular network of metabolic flexibility in the adipose tissue.
Published in:
Genes & Nutrition, 2018, v. 13, n. 1, p. N.PAG, doi. 10.1186/s12263-018-0609-3
By:
- Tareen, Samar H. K.;
- Kutmon, Martina;
- Adriaens, Michiel E.;
- Mariman, Edwin C. M.;
- de Kok, Theo M.;
- Arts, Ilja C. W.;
- Evelo, Chris T.
Publication type:
Article
Personalized computational model quantifies heterogeneity in postprandial responses to oral glucose challenge.
Published in:
PLoS Computational Biology, 2021, v. 17, n. 3, p. 1, doi. 10.1371/journal.pcbi.1008852
By:
- Erdős, Balázs;
- van Sloun, Bart;
- Adriaens, Michiel E.;
- O'Donovan, Shauna D.;
- Langin, Dominique;
- Astrup, Arne;
- Blaak, Ellen E.;
- Arts, Ilja C. W.;
- van Riel, Natal A. W.
Publication type:
Article
Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction.
Published in:
2018
By:
- Adriaens, Michiel E.;
- Lodder, Elisabeth M.;
- Moreno-Moral, Aida;
- Šilhavý, Jan;
- Heinig, Matthias;
- Glinge, Charlotte;
- Belterman, Charly;
- Wolswinkel, Rianne;
- Petretto, Enrico;
- Pravenec, Michal;
- Remme, Carol Ann;
- Bezzina, Connie R.
Publication type:
journal article
Analysis of high-dimensional metabolomics data with complex temporal dynamics using RM-ASCA+.
Published in:
PLoS Computational Biology, 2023, v. 19, n. 6, p. 1, doi. 10.1371/journal.pcbi.1011221
By:
- Erdős, Balázs;
- Westerhuis, Johan A.;
- Adriaens, Michiel E.;
- O'Donovan, Shauna D.;
- Xie, Ren;
- Singh-Povel, Cécile M.;
- Smilde, Age K.;
- Arts, Ilja C. W.
Publication type:
Article
Replication Errors Made During Oogenesis Lead to Detectable De Novo mtDNA Mutations in Zebrafish Oocytes with a Low mtDNA Copy Number.
Published in:
Genetics, 2016, v. 204, n. 4, p. 1423, doi. 10.1534/genetics.116.194035
By:
- Otten, Auke B. C.;
- Stassen, Alphons P. M.;
- Adriaens, Michiel;
- Gerards, Mike;
- Dohmen, Richard G. J.;
- Timmer, Adriana J.;
- Vanherle, Sabina J. V.;
- Kamps, Rick;
- Boesten, Iris B. W.;
- Vanoevelen, Jo M.;
- Muller, Marc;
- Smeets, Hubert J. M.
Publication type:
Article
Organ-Specific Gene Expression Changes in the Fetal Liver and Placenta in Response to Maternal Folate Depletion.
Published in:
Nutrients, 2016, v. 8, n. 10, p. 661, doi. 10.3390/nu8100661
By:
- McKay, Jill A.;
- Long Xie;
- Adriaens, Michiel;
- Evelo, Chris T.;
- Ford, Dianne;
- Mathers, John C.
Publication type:
Article
Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.
Published in:
Genome Biology, 2017, v. 18, p. 1, doi. 10.1186/s13059-017-1286-z
By:
- Heinig, Matthias;
- Adriaens, Michiel E.;
- Schafer, Sebastian;
- van Deutekom, Hanneke W. M.;
- Lodder, Elisabeth M.;
- Ware, James S.;
- Schneider, Valentin;
- Felkin, Leanne E.;
- Creemers, Esther E.;
- Meder, Benjamin;
- Katus, Hugo A.;
- Rühle, Frank;
- Stoll, Monika;
- Cambien, François;
- Villard, Eric;
- Charron, Philippe;
- Varro, Andras;
- Bishopric, Nanette H.;
- George Jr, Alfred L.;
- dos Remedios, Cristobal
Publication type:
Article
Mapping out the gut microbiota-dependent trimethylamine N-oxide super pathway for systems biology applications.
Published in:
Frontiers in Systems Biology, 2023, v. 3, p. 1, doi. 10.3389/fsysb.2023.1074749
By:
- Valenbreder, Isabel M. E.;
- Balăn, Sonia;
- Breuer, Marian;
- Adriaens, Michiel E.
Publication type:
Article
Elucidating the Corneal Endothelial Cell Proliferation Capacity through an Interspecies Transcriptome Comparison.
Published in:
Advanced Biology, 2023, v. 7, n. 10, p. 1, doi. 10.1002/adbi.202300065
By:
- Català, Pere;
- Vivensang, Flora;
- van Beek, Daan;
- Adriaens, Michiel E.;
- Dickman, Mor M.;
- LaPointe, Vanessa L.S.;
- Kutmon, Martina
Publication type:
Article
Profiling Cellular Processes in Adipose Tissue during Weight Loss Using Time Series Gene Expression.
Published in:
Genes, 2018, v. 9, n. 11, p. 525, doi. 10.3390/genes9110525
By:
- Tareen, Samar H. K.;
- Adriaens, Michiel E.;
- Arts, Ilja C. W.;
- de Kok, Theo M.;
- Vink, Roel G.;
- Roumans, Nadia J. T.;
- van Baak, Marleen A.;
- Mariman, Edwin C. M.;
- Evelo, Chris T.;
- Kutmon, Martina
Publication type:
Article
Impact of In Utero Folate Exposure on DNA Methylation and Its Potential Relevance for Later‐Life Health—Evidence from Mouse Models Translated to Human Cohorts.
Published in:
Molecular Nutrition & Food Research, 2022, v. 66, n. 3, p. 1, doi. 10.1002/mnfr.202100789
By:
- Kok, Dieuwertje E.;
- Richmond, Rebecca C.;
- Adriaens, Michiel;
- Evelo, Chris T.;
- Ford, Dianne;
- Mathers, John C.;
- Robinson, Natassia;
- McKay, Jill A.
Publication type:
Article
The Effect of Partly Replacing Vegetable Fat with Bovine Milk Fat in Infant Formula on Postprandial Lipid and Energy Metabolism: A Proof‐of‐principle Study in Healthy Young Male Adults.
Published in:
Molecular Nutrition & Food Research, 2021, v. 65, n. 9, p. 1, doi. 10.1002/mnfr.202000848
By:
- Hageman, Jeske H.J.;
- Erdõs, Balázs;
- Keijer, Jaap;
- Adriaens, Michiel;
- Wit, Britt;
- Stañková, Barbora;
- Tvrzická, Eva;
- Arts, Ilja C.W.;
- Nieuwenhuizen, Arie G.
Publication type:
Article
Maternal folate depletion during early development and high fat feeding from weaning elicit similar changes in gene expression, but not in DNA methylation, in adult offspring.
Published in:
Molecular Nutrition & Food Research, 2017, v. 61, n. 4, p. n/a, doi. 10.1002/mnfr.201600713
By:
- McKay, Jill A.;
- Xie, Long;
- Adriaens, Michiel;
- Evelo, Chris T.;
- Ford, Dianne;
- Mathers, John C.
Publication type:
Article
Gene promoter DNA methylation patterns have a limited role in orchestrating transcriptional changes in the fetal liver in response to maternal folate depletion during pregnancy.
Published in:
Molecular Nutrition & Food Research, 2016, v. 60, n. 9, p. 2031, doi. 10.1002/mnfr.201600079
By:
- McKay, Jill A.;
- Adriaens, Michiel;
- Evelo, Chris T.;
- Ford, Dianne;
- Mathers, John C.
Publication type:
Article
Bilberries reduce low-grade inflammation in individuals with features of metabolic syndrome.
Published in:
Molecular Nutrition & Food Research, 2012, v. 56, n. 10, p. 1501, doi. 10.1002/mnfr.201200195
By:
- Kolehmainen, Marjukka;
- Mykkänen, Otto;
- Kirjavainen, Pirkka V.;
- Leppänen, Tiina;
- Moilanen, Eeva;
- Adriaens, Michiel;
- Laaksonen, David E.;
- Hallikainen, Maarit;
- Puupponen-Pimiä, Riitta;
- Pulkkinen, Leena;
- Mykkänen, Hannu;
- Gylling, Helena;
- Poutanen, Kaisa;
- Törrönen, Riitta
Publication type:
Article
A user-friendly workflow for analysis of Illumina gene expression bead array data available at the arrayanalysis.org portal.
Published in:
BMC Genomics, 2015, v. 16, n. 1, p. 1, doi. 10.1186/s12864-015-1689-8
By:
- Eijssen, Lars M. T.;
- Goelela, Varshna S.;
- Kelder, Thomas;
- Adriaens, Michiel E.;
- Evelo, Chris T.;
- Radonji, Marijana
Publication type:
Article
Muscle and liver insulin resistance have distinct plasma protein profiles; a proteomics analysis using the Diogenes cohort.
Published in:
Nederlands Tijdschrift voor Diabetologie (NTvD), 2023, v. 21, n. 4, p. 32
By:
- Kemper, Esther J.;
- Blaak, Ellen E.;
- Adriaens, Michiel;
- Meex, Ruth C. R.
Publication type:
Article
From SNPs to pathways: Biological interpretation of type 2 diabetes (T2DM) genome wide association study (GWAS) results.
Published in:
PLoS ONE, 2018, v. 13, n. 4, p. 1, doi. 10.1371/journal.pone.0193515
By:
- Cirillo, Elisa;
- Kutmon, Martina;
- Gonzalez Hernandez, Manuel;
- Hooimeijer, Tom;
- Adriaens, Michiel E.;
- Eijssen, Lars M. T.;
- Parnell, Laurence D.;
- Coort, Susan L.;
- Evelo, Chris T.
Publication type:
Article
Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans.
Published in:
2019
By:
- van der Kolk, Birgitta W.;
- Kalafati, Marianthi;
- Adriaens, Michiel;
- Greevenbroek, Marleen M. J. van;
- Vogelzangs, Nicole;
- Saris, Wim H. M.;
- Astrup, Arne;
- Valsesia, Armand;
- Langin, Dominique;
- van der Kallen, Carla J. H.;
- Eussen, Simone J. P. M.;
- Schalkwijk, Casper G.;
- Stehouwer, Coen D. A.;
- Goossens, Gijs H.;
- Arts, Ilja C. W.;
- Jocken, Johan W. E.;
- Evelo, Chris T.;
- Blaak, Ellen E.;
- van Greevenbroek, Marleen M J
Publication type:
journal article

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