Works by Adlard, Paul A.

Results: 103

The Compound ATH434 Prevents Alpha-Synuclein Toxicity in a Murine Model of Multiple System Atrophy.

Published in:

Journal of Parkinson's Disease, 2022, v. 12, n. 1, p. 105, doi. 10.3233/JPD-212877

By:

Finkelstein, David I.;
Shukla, Jay J.;
Cherny, Robert A.;
Billings, Jessica L.;
Saleh, Eiman;
Stefanova, Nadia;
Barnham, Kevin J.;
Adlard, Paul A.

Publication type:

Article

ATH434 Reverses Colorectal Dysfunction in the A53T Mouse Model of Parkinson's Disease.

Published in:

Journal of Parkinson's Disease, 2021, v. 11, n. 4, p. 1821, doi. 10.3233/JPD-212731

By:

Diwakarla, Shanti;
McQuade, Rachel M.;
Constable, Remy;
Artaiz, Olivia;
Lei, Enie;
Barnham, Kevin J.;
Adlard, Paul A.;
Cherny, Robert A.;
Di Natale, Madeleine R.;
Wu, Hongyi;
Chai, Xin-yi;
Lawson, Victoria A.;
Finkelstein, David I.;
Furness, John B.

Publication type:

Article

Development of a Platinum Complex as an anti-Amyloid Agent for the Therapy of Alzheimer's Disease.

Published in:

Angewandte Chemie, 2013, v. 125, n. 12, p. 3458, doi. 10.1002/ange.201209885

By:

Kenche, Vijaya B.;
Hung, Lin W.;
Perez, Keyla;
Volitakes, Irene;
Ciccotosto, Guiseppe;
Kwok, Jeffrey;
Critch, Nicole;
Sherratt, Nikki;
Cortes, Mikhalina;
Lal, Varsha;
Masters, Colin L.;
Murakami, Kazuma;
Cappai, Roberto;
Adlard, Paul A.;
Barnham, Kevin J.

Publication type:

Article

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

Published in:

Nature Medicine, 2012, v. 18, n. 2, p. 291, doi. 10.1038/nm.2613

By:

Lei, Peng;
Ayton, Scott;
Finkelstein, David I;
Spoerri, Loredana;
Ciccotosto, Giuseppe D;
Wright, David K;
Wong, Bruce X W;
Adlard, Paul A;
Cherny, Robert A;
Lam, Linh Q;
Roberts, Blaine R;
Volitakis, Irene;
Egan, Gary F;
McLean, Catriona A;
Cappai, Roberto;
Duce, James A;
Bush, Ashley I

Publication type:

Article

Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia.

Published in:

Journal of Toxicological Sciences, 2016, v. 41, n. 4, p. 449, doi. 10.2131/jts.41.449

By:

Haruna Tamano;
Kazuki Ide;
Adlard, Paul Anthony;
Bush, Ashley Ian;
Takeda, Atsushi

Publication type:

Article

Delivery of Fluorescent Nanoparticles to the Brain.

Published in:

Journal of Molecular Neuroscience, 2016, v. 60, n. 3, p. 405, doi. 10.1007/s12031-016-0833-5

By:

Shimoni, Olga;
Shi, Bingyang;
Adlard, Paul;
Bush, Ashley

Publication type:

Article

Morphologically distinct plaque types differentially affect dendritic structure and organisation in the early and late stages of Alzheimer's disease.

Published in:

Acta Neuropathologica, 2002, v. 103, n. 4, p. 377, doi. 10.1007/s00401-001-0476-6

By:

Adlard, Paul A.;
Vickers, James C.

Publication type:

Article

Correction to: The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease.

Published in:

2021

By:

Finkelstein, David I.;
Billings, Jessica L.;
Adlard, Paul A.;
Ayton, Scott;
Sedjahtera, Amelia;
Masters, Colin L.;
Wilkins, Simon;
Shackleford, David M.;
Charman, Susan A.;
Bal, Wojciech;
Zawisza, Izabela A.;
Kurowska, Ewa;
Gundlach, Andrew L.;
Ma, Sheri;
Bush, Ashley I.;
Hare, Dominic J.;
Doble, Philip A.;
Crawford, Simon;
Gautier, Elisabeth C. L.;
Parsons, Jack

Publication type:

Correction Notice

Amyloid β-Mediated Zn2+ Influx into Dentate Granule Cells Transiently Induces a Short-Term Cognitive Deficit.

Published in:

PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0115923

By:

Takeda, Atsushi;
Nakamura, Masatoshi;
Fujii, Hiroaki;
Uematsu, Chihiro;
Minamino, Tatsuya;
Adlard, Paul A.;
Bush, Ashley I.;
Tamano, Haruna

Publication type:

Article

β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin.

Published in:

PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0114174

By:

Wong, Bruce X.;
Tsatsanis, Andrew;
Lim, Linh Q.;
Adlard, Paul A.;
Bush, Ashley I.;
Duce, James A.

Publication type:

Article

Clioquinol Synergistically Augments Rescue by Zinc Supplementation in a Mouse Model of Acrodermatitis Enteropathica.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0072543

By:

Geiser, Jim;
De Lisle, Robert C.;
Finkelstein, David;
Adlard, Paul A.;
Bush, Ashley I.;
Andrews, Glen K.

Publication type:

Article

Altered Expression of ZnT10 in Alzheimer's Disease Brain

Published in:

PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0065475

By:

Bosomworth, Helen J.;
Adlard, Paul A.;
Ford, Dianne;
Valentine, Ruth A.

Publication type:

Article

Intravenous Immunglobulin Binds Beta Amyloid and Modifies Its Aggregation, Neurotoxicity and Microglial Phagocytosis In Vitro

Published in:

PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0063162

By:

Cattepoel, Susann;
Schaub, Alexander;
Ender, Miriam;
Gaida, Annette;
Kropf, Alain;
Guggisberg, Ursula;
Nolte, Marc W.;
Fabri, Louis;
Adlard, Paul A.;
Finkelstein, David I.;
Bolli, Reinhard;
Miescher, Sylvia M.

Publication type:

Article

Organotypic Brain Slice Cultures of Adult Transgenic P301S Mice--A Model for Tauopathy Studies.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0045017

By:

Mewes, Agneta;
Franke, Heike;
Singer, David;
Adlard, Paul A.

Publication type:

Article

Copper Chelator Induced Efficient Episodic Memory Recovery in a Non- Transgenic Alzheimer's Mouse Model.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043105

By:

Ceccom, Johnatan;
Coslédan, Frédéric;
Halley, Hélène;
Francès, Bernard;
Lassalle, Jean Michel;
Meunier, Bernard;
Adlard, Paul A.

Publication type:

Article

Tg2576 Cortical Neurons That Express Human Ab Are Susceptible to Extracellular Aβ-Induced, K+ Efflux Dependent Neurodegeneration.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0019026

By:

Ray, Shannon;
Howells, Claire;
Eaton, Emma D.;
Butler, Chris W.;
Shabala, Lana;
Adlard, Paul A.;
West, Adrian K.;
Bennett, William R.;
Guillemin, Gilles J.;
Chung, Roger S.

Publication type:

Article

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease.

Published in:

PLoS ONE, 2011, v. 6, n. 3, p. 1, doi. 10.1371/journal.pone.0017669

By:

Adlard, Paul A.;
Bica, Laura;
White, Anthony R.;
Nurjono, Milawaty;
Filiz, Gulay;
Crouch, Peter J.;
Donnelly, Paul S.;
Cappai, Roberto;
Finkelstein, David I.;
Bush, Ashley I.

Publication type:

Article

A review of β-amyloid neuroimaging in Alzheimer's disease.

Published in:

Frontiers in Neuroscience, 2014, v. 8, p. 1, doi. 10.3389/fnins.2014.00327

By:

Adlard, Paul A.;
Tran, Bob A.;
Finkelstein, David I.;
Desmond, Patricia M.;
Johnston, Leigh A.;
Bush, Ashley I.;
Egan, Gary F.

Publication type:

Article

Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 17, p. 4217, doi. 10.1523/JNEUROSCI.0496-05.2005

By:

Adlard, Paul A.;
Perreau, Victoria M.;
Pop, Viorela;
Cotman, Carl W.

Publication type:

Article

Metallothionein and brain inflammation.

Published in:

Journal of Biological Inorganic Chemistry (JBIC), 2011, v. 16, n. 7, p. 1103, doi. 10.1007/s00775-011-0802-y

By:

Manso, Yasmina;
Adlard, Paul;
Carrasco, Javier;
Vašák, Milan;
Hidalgo, Juan

Publication type:

Article

Evaluation of attention in APP/PS1 mice shows impulsive and compulsive behaviours.

Published in:

Genes, Brain & Behavior, 2021, v. 20, n. 1, p. 1, doi. 10.1111/gbb.12594

By:

Shepherd, Amy;
May, Carlos;
Churilov, Leonid;
Adlard, Paul A.;
Hannan, Anthony J.;
Burrows, Emma L.

Publication type:

Article

Paradoxical effects of exercise on hippocampal plasticity and cognition in mice with a heterozygous null mutation in the serotonin transporter gene.

Published in:

2019

By:

Rogers, Jake;
Chen, Feng;
Stanic, Davor;
Farzana, Farheen;
Li, Shanshan;
Zeleznikow‐Johnston, Ariel M.;
Nithianantharajah, Jess;
Churilov, Leonid;
Adlard, Paul A.;
Lanfumey, Laurence;
Hannan, Anthony J.;
Renoir, Thibault;
Zeleznikow-Johnston, Ariel M

Publication type:

journal article

Spatial memory deficits in a mouse model of late-onset Alzheimer's disease are caused by zinc supplementation and correlate with amyloid-beta levels.

Published in:

Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00174

By:

Flinn, Jane M.;
Bozzelli, P. Lorenzo;
Adlard, Paul A.;
Railey, Angela M.

Publication type:

Article

β-amyloid in biological samples: not all Aβ detection methods are created equal.

Published in:

Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00203

By:

Adlard, Paul A.;
Qiao-Xin Li;
McLean, Catriona;
Masters, Colin L.;
Bush, Ashley I.;
Fodero-Tavoletti, Michelle;
Villemagne, Victor;
Barnham, Kevin J.

Publication type:

Article

β-amyloid in biological samples: not all Aβ detection methods are created equal.

Published in:

Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00203

By:

Adlard, Paul A.;
Qiao-Xin Li;
McLean, Catriona;
Masters, Colin L.;
Bush, Ashley I.;
Fodero-Tavoletti, Michele;
Villemagne, Victor;
Barnham, Kevin J.

Publication type:

Article

Glia and zinc in ageing and Alzheimer's disease: a mechanism for cognitive decline?

Published in:

Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00137

By:

Hancock, Sara M.;
Finkelstein, David I.;
Adlard, Paul A.

Publication type:

Article

Role of metal ions in the cognitive decline of Down syndrome.

Published in:

Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00136

By:

Malakooti, Nakisa;
Pritchard, Melanie A.;
Adlard, Paul A.;
Finkelstein, David I.

Publication type:

Article

Interactions of metals and Apolipoprotein E in Alzheimer's disease.

Published in:

Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00121

By:

He Xu;
Finkelstein, David I.;
Adlard, Paul A.

Publication type:

Article

Interactions of metals and Apolipoprotein E in Alzheimer's disease.

Published in:

Frontiers in Aging Neuroscience, 2014, v. 6, p. 1, doi. 10.3389/fnagi.2014.00121

By:

He Xu;
Finkelstein, David I.;
Adlard, Paul A.

Publication type:

Article

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer’s disease.

Published in:

Brain: A Journal of Neurology, 2011, v. 134, n. 4, p. 1089, doi. 10.1093/brain/awr038

By:

Fodero-Tavoletti, Michelle T.;
Okamura, Nobuyuki;
Furumoto, Shozo;
Mulligan, Rachel S.;
Connor, Andrea R.;
McLean, Catriona A.;
Cao, Diana;
Rigopoulos, Angela;
Cartwright, Glenn A.;
O’Keefe, Graeme;
Gong, Sylvia;
Adlard, Paul A.;
Barnham, Kevin J.;
Rowe, Christopher C.;
Masters, Colin L.;
Kudo, Yukitsuka;
Cappai, Roberto;
Yanai, Kazuhiko;
Villemagne, Victor L.

Publication type:

Article

Extracellular Zn2+ Is Essential for Amyloid β1-42-Induced Cognitive Decline in the Normal Brain and Its Rescue.

Published in:

Journal of Neuroscience, 2017, v. 37, n. 30, p. 7253, doi. 10.1523/JNEUROSCI.0954-17.2017

By:

Atsushi Takeda;
Haruna Tamano;
Munekazu Tempaku;
Miku Sasaki;
Chihiro Uematsu;
Shoko Sato;
Hiroaki Kanazawa;
Datki, Zsolt L.;
Adlard, Paul A.;
Bush, Ashley I.

Publication type:

Article

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of β-Amyloid Precursor Protein.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 8, p. 3591, doi. 10.1523/JNEUROSCI.3439-14.2015

By:

Ayton, Scott;
Peng Lei;
Hare, Dominic J.;
Duce, James A.;
George, Jessica L.;
Adlard, Paul A.;
McLean, Catriona;
Rogers, Jack T.;
Cherny, Robert A.;
Finkelstein, David I.;
Bush, Ashley I.

Publication type:

Article

Stabilization of Nontoxic Aβ-Oligomers: Insights into the Mechanism of Action of Hydroxyquinolines in Alzheimer's Disease.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 7, p. 2871, doi. 10.1523/JNEUROSCI.2912-14.2015

By:

Ryan, Timothy M.;
Roberts, Blaine R.;
McColl, Gawain;
Hare, Dominic J.;
Doble, Philip A.;
Qiao-Xin Li;
Lind, Monica;
Roberts, Anne M.;
Mertens, Haydyn D. T.;
Kirby, Nigel;
Pham, Chi L. L.;
Hinds, Mark G.;
Adlard, Paul A.;
Barnham, Kevin J.;
Curtain, Cyril C.;
Masters, Colin L.

Publication type:

Article

Early existence and biochemical evolution characterise acutely synaptotoxic PrPSc.

Published in:

PLoS Pathogens, 2019, v. 15, n. 4, p. 1, doi. 10.1371/journal.ppat.1007712

By:

Foliaki, Simote Totauhelotu;
Lewis, Victoria;
Islam, Abu Mohammed Taufiqual;
Ellett, Laura Jane;
Senesi, Matteo;
Finkelstein, David Isaac;
Roberts, Blaine;
Lawson, Victoria A.;
Adlard, Paul Anthony;
Collins, Steven John

Publication type:

Article

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease.

Published in:

Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0456-2

By:

Finkelstein, David I.;
Billings, Jessica L.;
Adlard, Paul A.;
Ayto, Scott;
Sedjahtera, Amelia;
Masters, Colin L.;
Wilkins, Simon;
Shackleford, David M.;
Charman, Susan A.;
Bal, Wojciech;
Zawisza, Izabela A.;
Kurowska, Ewa;
Gundlach, Andrew L.;
Ma, Sheri;
Bush, Ashley I.;
Hare, Dominic J.;
Doble, Philip A.;
Crawford, Simon;
Gautier, Elisabeth C. L.;
Parsons, Jack

Publication type:

Article

Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion.

Published in:

Scientific Reports, 2017, p. 44426, doi. 10.1038/srep44426

By:

Castro-Hernández, Javier;
Adlard, Paul A.;
Finkelstein, David I.

Publication type:

Article

Loss of synaptic Zn2+ transporter function increases risk of febrile seizures.

Published in:

Scientific Reports, 2015, p. 17816, doi. 10.1038/srep17816

By:

Hildebrand, Michael S.;
Phillips, A. Marie;
Mullen, Saul A.;
Adlard, Paul A.;
Hardies, Katia;
Damiano, John A.;
Wimmer, Verena;
Bellows, Susannah T.;
McMahon, Jacinta M.;
Burgess, Rosemary;
Hendrickx, Rik;
Weckhuysen, Sarah;
Suls, Arvid;
De Jonghe, Peter;
Scheffer, Ingrid E.;
Petrou, Steven;
Berkovic, Samuel F.;
Reid, Christopher A.

Publication type:

Article

Editorial: The molecular pathology of cognitive decline: focus on metals.

Published in:

Frontiers in Aging Neuroscience, 2015, v. 7, p. 1, doi. 10.3389/fnagi.2015.00116

By:

Adlard, Paul A.;
Chung, Roger S.

Publication type:

Article

Alterations in zinc, copper, and iron levels in the retina and brain of Alzheimer's disease patients and the APP/PS1 mouse model.

Published in:

Metallomics, 2024, v. 16, n. 12, p. 1, doi. 10.1093/mtomcs/mfae053

By:

Mashkani, Seyed Mostafa Hosseinpour;
Bishop, David P;
Westerhausen, Mika T;
Adlard, Paul A;
Golzan, S Mojtaba

Publication type:

Article

Characterization of the spatial distribution of metals and profile of metalloprotein complexes in a mouse model of repetitive mild traumatic brain injury.

Published in:

Metallomics, 2022, v. 14, n. 12, p. 1, doi. 10.1093/mtomcs/mfac092

By:

Juan, Sydney M A;
Daglas, Maria;
Gunn, Adam P;
Lago, Larissa;
Adlard, Paul A

Publication type:

Article

Characterising the spatial and temporal brain metal profile in a mouse model of tauopathy.

Published in:

Metallomics, 2020, v. 11, n. 2, p. 301, doi. 10.1039/c9mt00267g

By:

Rao, Shalini S.;
Lago, Larissa;
Gonzalez de Vega, Raquel;
Bray, Lisa;
Hare, Dominic J.;
Clases, David;
Doble, Philip A.;
Adlard, Paul A.

Publication type:

Article

Characterising the brain metalloproteome in Down syndrome patients with concomitant Alzheimer's pathology.

Published in:

Metallomics, 2020, v. 12, n. 1, p. 114, doi. 10.1039/c9mt00196d

By:

Malakooti, Nakisa;
Roberts, Blaine;
Pritchard, Melanie A.;
Volitakis, Irene;
Kim, Ron C.;
Lott, Ira T.;
McLean, Catriona A.;
Finkelstein, David I.;
Adlard, Paul A.

Publication type:

Article

Targeting metals rescues the phenotype in an animal model of tauopathy.

Published in:

Metallomics, 2018, v. 10, n. 9, p. 1339, doi. 10.1039/c8mt00153g

By:

Sedjahtera, Amelia;
Gunawan, Lydia;
Bray, Lisa;
Hung, Lin Wai;
Parsons, Jack;
Okamura, Nobuyuki;
Villemagne, Victor L.;
Yanai, Kazuhiko;
Liu, Xiang M.;
Chan, Jacky;
Bush, Ashley I.;
Finkelstein, David I.;
Barnham, Kevin J.;
Cherny, Robert A.;
Adlard, Paul A.

Publication type:

Article

Trehalose elevates brain zinc levels following controlled cortical impact in a mouse model of traumatic brain injury.

Published in:

Metallomics, 2018, v. 10, n. 6, p. 846, doi. 10.1039/c8mt00068a

By:

Portbury, Stuart D.;
Hare, Dominic J.;
Bishop, David P.;
Finkelstein, David I.;
Doble, Philip A.;
Adlard, Paul A.

Publication type:

Article

Age modulates the injury-induced metallomic profile in the brain.

Published in:

Metallomics, 2017, v. 9, n. 4, p. 402, doi. 10.1039/c6mt00260a

By:

Portbury, Stuart D.;
Hare, Dominic J.;
Sgambelloni, Charlotte J.;
Bishop, David P.;
Finkelstein, David I.;
Doble, Philip A.;
Adlard, Paul A.

Publication type:

Article

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact.

Published in:

Metallomics, 2016, v. 8, n. 2, p. 193, doi. 10.1039/c5mt00234f

By:

Portbury, Stuart D.;
Hare, Dominic J.;
Sgambelloni, Charlotte;
Finkelstein, David I.;
Adlard, Paul A.

Publication type:

Article

Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain.

Published in:

Metallomics, 2010, n. 11, p. 745, doi. 10.1039/c0mt00039f

By:

Hare, Dominic J.;
George, Jessica L.;
Grimm, Rudolph;
Wilkins, Simon;
Adlard, Paul A.;
Cherny, Robert A.;
Bush, Ashley I.;
Finkelstein, David I.;
Doble, Philip

Publication type:

Article

Trehalose improves traumatic brain injury-induced cognitive impairment.

Published in:

PLoS ONE, 2017, v. 12, n. 8, p. 1, doi. 10.1371/journal.pone.0183683

By:

Portbury, Stuart D.;
Hare, Dominic J.;
Finkelstein, David I.;
Adlard, Paul A.

Publication type:

Article

Pharmacotherapeutic targets in Alzheimer's disease.

Published in:

Journal of Cellular & Molecular Medicine, 2009, v. 13, n. 1, p. 61, doi. 10.1111/j.1582-4934.2008.00595.x

By:

Biran, Yif'at;
Masters, Colin L.;
Barnham, Kevin J.;
Bush, Ashley I.;
Adlard, Paul A.

Publication type:

Article

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.

Published in:

Annals of Neurology, 2013, v. 73, n. 4, p. 554, doi. 10.1002/ana.23817

By:

Ayton, Scott;
Lei, Peng;
Duce, James A.;
Wong, Bruce X. W.;
Sedjahtera, Amelia;
Adlard, Paul A.;
Bush, Ashley I.;
Finkelstein, David I.

Publication type:

Article