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Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-35306-1
By:
- Widjaja, Anissa A.;
- Viswanathan, Sivakumar;
- Shekeran, Shamini G.;
- Adami, Eleonora;
- Lim, Wei-Wen;
- Chothani, Sonia;
- Tan, Jessie;
- Goh, Joyce Wei Ting;
- Chen, Hui Mei;
- Lim, Sze Yun;
- Boustany-Kari, Carine M.;
- Hawkins, Julie;
- Petretto, Enrico;
- Hübner, Norbert;
- Schafer, Sebastian;
- Coffman, Thomas M.;
- Cook, Stuart A.
Publication type:
Article
IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 7, p. 3549, doi. 10.3390/ijms23073549
By:
- Ng, Benjamin;
- Viswanathan, Sivakumar;
- Widjaja, Anissa A.;
- Lim, Wei-Wen;
- Shekeran, Shamini G.;
- Goh, Joyce Wei Ting;
- Tan, Jessie;
- Kuthubudeen, Fathima;
- Lim, Sze Yun;
- Xie, Chen;
- Schafer, Sebastian;
- Adami, Eleonora;
- Cook, Stuart A.
Publication type:
Article
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing.
Published in:
Journal of Clinical Investigation, 2014, v. 124, n. 8, p. 3419, doi. 10.1172/JCI74523
By:
- Maatz, Henrike;
- Jens, Marvin;
- Liss, Martin;
- Schafer, Sebastian;
- Heinig, Matthias;
- Kirchner, Marieluise;
- Adami, Eleonora;
- Rintisch, Carola;
- Dauksaite, Vita;
- Radke, Michael H.;
- Selbach, Matthias;
- Barton, Paul J. R.;
- Cook, Stuart A.;
- Rajewsky, Nikolaus;
- Gotthardt, Michael;
- Landthaler, Markus;
- Hubner, Norbert
Publication type:
Article
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
Published in:
Genome Biology, 2021, v. 22, n. 1, p. 1, doi. 10.1186/s13059-021-02397-w
By:
- Witte, Franziska;
- Ruiz-Orera, Jorge;
- Mattioli, Camilla Ciolli;
- Blachut, Susanne;
- Adami, Eleonora;
- Schulz, Jana Felicitas;
- Schneider-Lunitz, Valentin;
- Hummel, Oliver;
- Patone, Giannino;
- Mücke, Michael Benedikt;
- Šilhavý, Jan;
- Heinig, Matthias;
- Bottolo, Leonardo;
- Sanchis, Daniel;
- Vingron, Martin;
- Chekulaeva, Marina;
- Pravenec, Michal;
- Hubner, Norbert;
- van Heesch, Sebastiaan
Publication type:
Article
Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease.
Published in:
FASEB Journal, 2020, v. 34, n. 9, p. 11802, doi. 10.1096/fj.202001045RR
By:
- Ng, Benjamin;
- Jinrui Dong;
- Viswanathan, Sivakumar;
- Widjaja, Anissa A.;
- Paleja, Bhairav S.;
- Adami, Eleonora;
- Ko, Nicole S. J.;
- Mao Wang;
- Lim, Stella;
- Tan, Jessie;
- Chothani, Sonia P.;
- Albani, Salvatore;
- Schafer, Sebastian;
- Cook, Stuart A.
Publication type:
Article
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts.
Published in:
Rheumatology, 2021, v. 60, n. 12, p. 5820, doi. 10.1093/rheumatology/keab168
By:
- Adami, Eleonora;
- Viswanathan, Sivakumar;
- Widjaja, Anissa A;
- Ng, Benjamin;
- Chothani, Sonia;
- Zhihao, Nevin;
- Tan, Jessie;
- Lio, Pei Min;
- George, Benjamin L;
- Altunoglu, Umut;
- Ghosh, Kakaly;
- Paleja, Bhairav S;
- Schafer, Sebastian;
- Reversade, Bruno;
- Albani, Salvatore;
- Ling, Andrea Low Hsiu;
- O'Reilly, Steven;
- Cook, Stuart A
Publication type:
Article
Translational regulation shapes the molecular landscape of complex disease phenotypes.
Published in:
Nature Communications, 2015, v. 6, n. 5, p. 7200, doi. 10.1038/ncomms8200
By:
- Schafer, Sebastian;
- Adami, Eleonora;
- Heinig, Matthias;
- Rodrigues, Katharina E. Costa;
- Kreuchwig, Franziska;
- Silhavy, Jan;
- van Heesch, Sebastiaan;
- Simaite, Deimante;
- Rajewsky, Nikolaus;
- Cuppen, Edwin;
- Pravenec, Michal;
- Vingron, Martin;
- Cook, Stuart A.;
- Hubner, Norbert
Publication type:
Article
IL-11 in cardiac and renal fibrosis: Late to the party but a central player.
Published in:
2020
By:
- Corden, Benjamin;
- Adami, Eleonora;
- Sweeney, Mark;
- Schafer, Sebastian;
- Cook, Stuart A.
Publication type:
journal article
Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function.
Published in:
PLoS ONE, 2017, v. 12, n. 2, p. 1, doi. 10.1371/journal.pone.0170458
By:
- McDermott-Roe, Chris;
- Leleu, Marion;
- Rowe, Glenn C.;
- Palygin, Oleg;
- Bukowy, John D.;
- Kuo, Judy;
- Rech, Monika;
- Hermans-Beijnsberger, Steffie;
- Schaefer, Sebastian;
- Adami, Eleonora;
- Creemers, Esther E.;
- Heinig, Matthias;
- Schroen, Blanche;
- Arany, Zoltan;
- Petretto, Enrico;
- Geurts, Aron M.
Publication type:
Article
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.
Published in:
Science Translational Medicine, 2021, v. 13, n. 597, p. 1, doi. 10.1126/scitranslmed.aba8146
By:
- Widjaja, Anissa A.;
- Dong, Jinrui;
- Adami, Eleonora;
- Viswanathan, Sivakumar;
- Ng, Benjamin;
- Pakkiri, Leroy S.;
- Chothani, Sonia P.;
- Singh, Brijesh K.;
- Lim, Wei Wen;
- Zhou, Jin;
- Shekeran, Shamini G.;
- Tan, Jessie;
- Lim, Sze Yun;
- Goh, Joyce;
- Wang, Mao;
- Holgate, Robert;
- Hearn, Arron;
- Felkin, Leanne E.;
- Yen, Paul M.;
- Dear, James W.
Publication type:
Article
Rattus norvegicus BN/SHR liver and heart left ventricle ribosomal RNA depleted directional RNA sequencing.
Published in:
BMC Research Notes, 2017, v. 10, p. 1, doi. 10.1186/s13104-017-2716-4
By:
- Wyler, Emanuel;
- van Heesch, Sebastiaan;
- Adami, Eleonora;
- Hubner, Norbert;
- Landthaler, Markus
Publication type:
Article
Genomic landscape of rat strain and substrain variation.
Published in:
BMC Genomics, 2015, v. 16, n. 1, p. 1, doi. 10.1186/s12864-015-1594-1
By:
- Hermsen, Roel;
- de Ligt, Joep;
- Spee, Wim;
- Blokzijl, Francis;
- Schäfer, Sebastian;
- Adami, Eleonora;
- Boymans, Sander;
- Flink, Stephen;
- van Boxtel, Ruben;
- van der Weide, Robin H.;
- Aitman, Tim;
- Hübner, Norbert;
- Simonis, Marieke;
- Tabakoff, Boris;
- Guryev, Victor;
- Cuppen, Edwin
Publication type:
Article
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20303-z
By:
- Dong, Jinrui;
- Viswanathan, Sivakumar;
- Adami, Eleonora;
- Singh, Brijesh K.;
- Chothani, Sonia P.;
- Ng, Benjamin;
- Lim, Wei Wen;
- Zhou, Jin;
- Tripathi, Madhulika;
- Ko, Nicole S. J.;
- Shekeran, Shamini G.;
- Tan, Jessie;
- Lim, Sze Yun;
- Wang, Mao;
- Lio, Pei Min;
- Yen, Paul M.;
- Schafer, Sebastian;
- Cook, Stuart A.;
- Widjaja, Anissa A.
Publication type:
Article

Found: 13