Works matching AU Accili, Domenico

Results: 117

Dedifferentiation as a Stealthy Disruptor of β-Cell Function in Diabetes.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2025, v. 110, n. 6, p. e2096, doi. 10.1210/clinem/dgae624

By:

Son, Jinsook;
Accili, Domenico

Publication type:

Article

Reprogramming Cells to Make Insulin.

Published in:

Journal of the Endocrine Society, 2019, v. 3, n. 6, p. 1214, doi. 10.1210/js.2019-00040

By:

McKimpson, Wendy M;
Accili, Domenico

Publication type:

Article

Hypoglycemia Secondary to Sulfonylurea Ingestion in a Patient with End Stage Renal Disease: Results from a 72-Hour Fast.

Published in:

Case Reports in Endocrinology, 2015, p. 1, doi. 10.1155/2015/742781

By:

Abraham, Alice;
Rubin, Mishaela;
Accili, Domenico;
Bilezikian, John P.;
Pajvani, Utpal B.

Publication type:

Article

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability.

Published in:

Nature Medicine, 2013, v. 19, n. 8, p. 1054, doi. 10.1038/nm.3259

By:

Pajvani, Utpal B;
Qiang, Li;
Kangsamaksin, Thaned;
Kitajewski, Jan;
Ginsberg, Henry N;
Accili, Domenico

Publication type:

Article

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.

Published in:

Nature Medicine, 2011, v. 17, n. 8, p. 961, doi. 10.1038/nm.2378

By:

Pajvani, Utpal B.;
Shawber, Carrie J.;
Samuel, Varman T.;
Birkenfeld, Andreas L.;
Shulman, Gerald I.;
Kitajewski, Jan;
Accili, Domenico

Publication type:

Article

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake.

Published in:

Nature Medicine, 2009, v. 15, n. 10, p. 1195, doi. 10.1038/nm.2026

By:

Plum, Leona;
Lin, Hua V.;
Dutia, Roxanne;
Tanaka, Jun;
Aizawa, Kumiko S.;
Matsumoto, Michihiro;
Kim, Andrea J.;
Cawley, Niamh X.;
Paik, Ji-Hye;
Y. Peng Loh;
DePinho, Ronald A.;
Wardlaw, Sharon L.;
Accili, Domenico

Publication type:

Article

Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake.

Published in:

Nature Medicine, 2006, v. 12, n. 5, p. 534, doi. 10.1038/nm1392

By:

Kitamura, Tadahiro;
Yun Feng;
Ido Kitamura, Yukari;
Chua, Streamson C.;
Xu, Allison W.;
Barsh, Gregory S.;
Rossetti, Luciano;
Accili, Domenico

Publication type:

Article

The tangled path to glucose production.

Published in:

Nature Medicine, 2006, v. 12, n. 1, p. 33, doi. 10.1038/nm0106-33

By:

Matsumoto, Michihiro;
Accili, Domenico

Publication type:

Article

Turning up the heat in the fat cell.

Published in:

Nature Medicine, 2004, v. 10, n. 11, p. 1168, doi. 10.1038/nm1104-1168

By:

Accili, Domenico;
Valenti, Luca

Publication type:

Article

Generation of functional insulin-producing cells in the gut by Foxo1 ablation.

Published in:

Nature Genetics, 2012, v. 44, n. 4, p. 406, doi. 10.1038/ng.2215

By:

Talchai, Chutima;
Xuan, Shouhong;
Kitamura, Tadahiro;
DePinho, Ronald A;
Accili, Domenico

Publication type:

Article

A note of caution on the Knockout Mouse Project.

Published in:

2004

By:

Accili, Domenico

Publication type:

Letter

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

Published in:

Nature Genetics, 2002, v. 32, n. 2, p. 245, doi. 10.1038/ng890

By:

Nakae, Jun;
Biggs, William H.;
Kitamura, Tadahiro;
Cavenee, Webster K.;
Wright, Christopher V.E.;
Arden, Karen C.;
Accili, Domenico

Publication type:

Article

Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue.

Published in:

Nature Genetics, 1998, v. 20, n. 3, p. 294, doi. 10.1038/3112

By:

Lauro, Davide;
Kido, Yoshiaki;
Castle, Arthur L.;
Zarnowski, Mary-Jane;
Hayashi, Hideki;
Ebina, Yousuke;
Accili, Domenico

Publication type:

Article

Proinsulin in Girls: Relationship to Obesity, Hyperinsulinemia, and Puberty.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2002, v. 87, n. 10, p. 4673, doi. 10.1210/jc.2001-011535

By:

CHIN, DAISY;
OBERFIELD, SHARON E.;
SILFEN, MIRIAM E.;
MCMAHON, DONALD J.;
MANIBO, ALEXANDRA M.;
ACCILI, DOMENICO;
LEVINE, LENORE S.

Publication type:

Article

CLINICAL REVIEW 125: The Insulin Receptor and Its Cellular Targets.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2001, v. 86, n. 3, p. 972, doi. 10.1210/jcem.86.3.7306

By:

YOSHIAKI KIDO;
JUN NAKAE;
ACCILI, DOMENICO

Publication type:

Article

The new biology of diabetes.

Published in:

Diabetologia, 2015, v. 58, n. 11, p. 2459, doi. 10.1007/s00125-015-3722-5

By:

Pajvani, Utpal;
Accili, Domenico

Publication type:

Article

Erratum to: The new biology of diabetes.

Published in:

2015

By:

Pajvani, Utpal;
Accili, Domenico

Publication type:

Erratum

Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice.

Published in:

Annals of Medicine, 2001, v. 33, n. 1, p. 22, doi. 10.3109/07853890109002056

By:

Nakae, Jun;
Kido, Yoshiaki;
Accili, Domenico

Publication type:

Article

Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation.

Published in:

PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0047231

By:

Ido-Kitamura, Yukari;
Sasaki, Tsutomu;
Kobayashi, Masaki;
Hye-Jin Kim;
Yong-Soo Lee;
Kikuchi, Osamu;
Yokota-Hashimoto, Hiromi;
Iizuka, Katsumi;
Accili, Domenico;
Kitamura, Tadahiro

Publication type:

Article

InsR/FoxO1 Signaling Curtails Hypothalamic POMC Neuron Number.

Published in:

PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0031487

By:

Plum, Leona;
Lin, Hua V.;
Aizawa, Kumiko S.;
Yitian Liu;
Accili, Domenico

Publication type:

Article

Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.

Published in:

2005

By:

Dong, Hengjiang;
Maddux, Betty A.;
Altomonte, Jennifer;
Meseck, Marcia;
Accili, Domenico;
Terkeltaub, Robert;
Johnson, Kristen;
Youngren, Jack F.;
Goldfine, Ira D.

Publication type:

journal article

Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic.

Published in:

2004

By:

Accili, Domenico

Publication type:

research

Glucose effects on skin keratinocytes: implications for diabetes skin complications.

Published in:

2001

By:

Spravchikov, Natalia;
Sizyakov, Galina;
Gartsbein, Marina;
Accili, Domenico;
Tennenbaum, Tamar;
Wertheimer, Efrat;
Spravchikov, N;
Sizyakov, G;
Gartsbein, M;
Accili, D;
Tennenbaum, T;
Wertheimer, E

Publication type:

journal article

The IR[sub 1152] Mutant Insulin Receptor Selectively Impairs Insulin Action in Skeletal Muscle but Not in Liver.

Published in:

Diabetes, 2000, v. 49, n. 7, p. 1194, doi. 10.2337/diabetes.49.7.1194

By:

Caruso, Matilde;
Miele, Claudia;
Oliva, Andrea;
Condorelli, Gerolama;
Oriente, Francesco;
Riccardi, Gabriele;
Capaldo, Brunella;
Fiory, Francesca;
Accili, Domenico;
Formisano, Pietro;
Beguinot, Francesco

Publication type:

Article

Genetic modifiers of the insulin resistance phenotype in mice.

Published in:

2000

By:

Kido, Yoshiaki;
Philippe, Neubert;
Schaffer, Alejandro A.;
Accili, Domenico;
Kido, Y;
Philippe, N;
Schäffer, A A;
Accili, D

Publication type:

journal article

A novel human insulin receptor gene mutation uniquely inhibits insulin binding without impairing posttranslational processing.

Published in:

1994

By:

Roach, Paris;
Zick, Yehiel;
Formisano, Pietro;
Accili, Domenico;
Taylor, Simeon I.;
Gorden, Phillip;
Roach, P;
Zick, Y;
Formisano, P;
Accili, D;
Taylor, S I;
Gorden, P

Publication type:

journal article

Insulin Resistance or Insulin Deficiency.

Published in:

Diabetes, 1994, v. 43, n. 6, p. 735, doi. 10.2337/diab.43.6.735

By:

Taylor, Simeon I.;
Accili, Domenico;
Imai, Yumi

Publication type:

Article

Functional characterization of the matrix metalloproteinase-1 cigarette smoke-responsive region and association with the lung health study.

Published in:

Respiratory Research, 2012, v. 13, n. 9, p. 1, doi. 10.1186/1465-9921-13-79

By:

Wallace, Alison M.;
Mercer, Becky A.;
He, Jianqing;
Foronjy, Robert F.;
Accili, Domenico;
Sandford, Andrew J.;
Paré, Peter D.;
D'Armiento, Jeanine M.`

Publication type:

Article

Transgenic Mice to Study the Role of Dopamine Receptors in Cardiovascular Function.

Published in:

Clinical & Experimental Hypertension, 1997, v. 19, n. 1/2, p. 15, doi. 10.3109/10641969709080801

By:

Jose, Pedro A.;
Drago, John;
Accili, Domenico;
Eisner, Gilbert M.;
Felder, Robin A.

Publication type:

Article

Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36315-4

By:

Son, Jinsook;
Du, Wen;
Esposito, Mark;
Shariati, Kaavian;
Ding, Hongxu;
Kang, Yibin;
Accili, Domenico

Publication type:

Article

Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33008-2

By:

Sasako, Takayoshi;
Umehara, Toshihiro;
Soeda, Kotaro;
Kaneko, Kazuma;
Suzuki, Miho;
Kobayashi, Naoki;
Okazaki, Yukiko;
Tamura-Nakano, Miwa;
Chiba, Tomoki;
Accili, Domenico;
Kahn, C. Ronald;
Noda, Tetsuo;
Asahara, Hiroshi;
Yamauchi, Toshimasa;
Kadowaki, Takashi;
Ueki, Kohjiro

Publication type:

Article

Activation of the insulin receptor by an insulin mimetic peptide.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33274-0

By:

Park, Junhee;
Li, Jie;
Mayer, John P.;
Ball, Kerri A.;
Wu, Jiayi;
Hall, Catherine;
Accili, Domenico;
Stowell, Michael H. B.;
Bai, Xiao-chen;
Choi, Eunhee

Publication type:

Article

Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea in diabetes.

Published in:

Science Translational Medicine, 2023, v. 15, n. 681, p. 1, doi. 10.1126/scitranslmed.abq4126

By:

Watanabe, Hitoshi;
Du, Wen;
Son, Jinsook;
Sui, Lina;
Asahara, Shun-ichiro;
Kurland, Irwin J.;
Kuo, Taiyi;
Kitamoto, Takumi;
Miyachi, Yasutaka;
de Cabo, Rafael;
Accili, Domenico

Publication type:

Article

Vitamin D and COVID-19.

Published in:

European Journal of Endocrinology, 2020, v. 183, n. 5, p. 133, doi. 10.1530/EJE-20-0665

By:

Bilezikian, John P.;
Bikle, Daniel;
Hewison, Martin;
Lazaretti-Castro, Marise;
Formenti, Anna Maria;
Gupta, Aakriti;
Madhavan, Mahesh V.;
Nair, Nandini;
Babalyan, Varta;
Hutchings, Nicholas;
Napoli, Nicola;
Accili, Domenico;
Binkley, Neil;
Landry, Donald W.;
Giustina, Andrea

Publication type:

Article

Altered Central Nutrient Sensing in Male Mice Lacking Insulin Receptors in Glut4-Expressing Neurons.

Published in:

Endocrinology, 2019, v. 160, n. 9, p. 2038, doi. 10.1210/en.2019-00341

By:

Ren, Hongxia;
Vieira-de-Abreu, Adriana;
Yan, Shijun;
Reilly, Austin M;
Chan, Owen;
Accili, Domenico

Publication type:

Article

Mutations in insulin-receptor gene in insulin-resistant patients.

Published in:

1990

By:

Taylor, Simeon I.;
Kadowaki, Takahi;
Kadowaki, Hiroko;
Accili, Domenico;
Cama, Alessandro;
McKeon, Catherine;
Taylor, S I;
Kadowaki, T;
Kadowaki, H;
Accili, D;
Cama, A;
McKeon, C

Publication type:

journal article

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 4, p. 1262, doi. 10.1172/JCI61919

By:

Ding Ai;
Chiyuan Chen;
Han, Seongah;
Ganda, Anjali;
Murphy, Andrew J.;
Haeusler, Rebecca;
Thorp, Edward;
Accili, Domenico;
Horton, Jay D.;
Tall, Alan R.

Publication type:

Article

Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice.

Published in:

2009

By:

Seongah Han;
Chien-Ping Liang;
Westerterp, Marit;
Senokuchi, Takafumi;
Welch, Carrie L.;
Qizhi Wang;
Matsumoto, Michihiro;
Accili, Domenico;
Tall, Alan R.;
Han, Seongah;
Liang, Chien-Ping;
Wang, Qizhi

Publication type:

journal article

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression.

Published in:

2007

By:

Shawber, Carrie J.;
Funahashi, Yasuhiro;
Francisco, Esther;
Vorontchikhina, Marina;
Kitamura, Yukari;
Stowell, Stephanie A.;
Borisenko, Valeriya;
Feirt, Nikki;
Podgrabinska, Simona;
Shiraishi, Kazuko;
Chawengsaksophak, Kallayanee;
Rossant, Janet;
Accili, Domenico;
Skobe, Mihaela;
Kitajewski, Jan

Publication type:

journal article

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification.

Published in:

2007

By:

Kitamura, Tadahiro;
Kitamura, Yukari Ido;
Funahashi, Yasuhiro;
Shawber, Carrie J.;
Castrillon, Diego H.;
Kollipara, Ramya;
DePinho, Ronald A.;
Kitajewski, Jan;
Accili, Domenico

Publication type:

journal article

Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism.

Published in:

2006

By:

Matsumoto, Michihiro;
Han, Seongah;
Kitamura, Tadahiro;
Accili, Domenico

Publication type:

journal article

Role of the forkhead protein FoxO1 in beta cell compensation to insulin resistance.

Published in:

2006

By:

Okamoto, Haruka;
Hribal, Marta Letizia;
Lin, Hua V;
Bennett, William R;
Ward, Andrew;
Accili, Domenico

Publication type:

journal article

Role of the forkhead protein FoxO1 in β cell compensation to insulin resistance.

Published in:

Journal of Clinical Investigation, 2006, v. 116, n. 3, p. 775, doi. 10.1172/JCI24967

By:

Okamoto, Haruka;
Hribal, Marta Letizia;
Lin, Hua V.;
Bennett, William R.;
Ward, Andrew;
Accili, Domenico

Publication type:

Article

Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.

Published in:

2005

By:

Federici, Massimo;
Hribal, Marta L.;
Menghini, Rossella;
Kanno, Hiroko;
Marchetti, Valentina;
Porzio, Ottavia;
Sunnarborg, Susan W.;
Rizza, Stefano;
Serino, Matteo;
Cunsolo, Veronica;
Lauro, Davide;
Mauriello, Alessandro;
Smookler, David S.;
Sbraccia, Paolo;
Sesti, Giorgio;
Lee, David C.;
Khokha, Rama;
Accili, Domenico;
Lauro, Renato

Publication type:

journal article

Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.

Published in:

2005

By:

Banks, Alexander S.;
Jianze Li;
McKeag, Lisa;
Hribal, Marta L.;
Kashiwada, Masaki;
Accili, Domenico;
Rothman, Paul B.;
Li, Jianze

Publication type:

journal article

Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action.

Published in:

Journal of Clinical Investigation, 2005, v. 115, n. 5, p. 1314, doi. 10.1172/JCI200523096

By:

Okamoto, Haruka;
Obici, Silvana;
Accili, Domenico;
Rossetti, Luciano

Publication type:

Article

Transgenic rescue of insulin receptor--deficient mice.

Published in:

Journal of Clinical Investigation, 2004, v. 114, n. 2, p. 214, doi. 10.1172/JCI200421645

By:

Okamoto, Haruka;
Nakae, Jun;
Kitamura, Tadahiro;
Park, Byung-Chul;
Dragatsis, Loannis;
Accili, Domenico

Publication type:

Article

Transgenic rescue of insulin receptor-deficient mice.

Published in:

2004

By:

Okamoto, Haruka;
Nakae, Jun;
Kitamura, Tadahiro;
Park, Byung-Chul;
Dragatsis, Ioannis;
Accili, Domenico

Publication type:

journal article

Effect of activating and inactivating mutations of G.

Published in:

Journal of Cellular Biochemistry, 1997, v. 64, n. 2, p. 242, doi. 10.1002/(SICI)1097-4644(199702)64:2<242::AID-JCB8>3.0.CO;2-X

By:

Gordeladze, Jan Oxholm;
Høvik, Kjerstin Elisabeth;
Merendino, John Jack;
Hermouet, Sylvie;
Gutkind, Silvio;
Accili, Domenico

Publication type:

Article

Mutations in the Insulin Receptor Gene in Patients with Genetic Syndromes of Insulin Resistance and Acanthosis Nigricans.

Published in:

Journal of Investigative Dermatology, 1992, v. 98, n. 6, p. 77S, doi. 10.1111/1523-1747.ep12462281

By:

Accili, Domenico;
Barbetti, Fabrizio;
Cama, Alessandro;
Kadowaki, Hiroko;
Kadowaki, Takashi;
Imano, Eiichi;
Levy-Toledano, Rachel;
Taylor, Simeon I.

Publication type:

Article