Works by Abramov, Andrey Y.

Results: 91

Hypoxic Regulation of Hand1 Controls the Fetal-Neonatal Switch in Cardiac Metabolism.

Published in:

PLoS Biology, 2013, v. 11, n. 9, p. 1, doi. 10.1371/journal.pbio.1001666

By:

Breckenridge, Ross A.;
Piotrowska, Izabela;
Ng, Keat-Eng;
Ragan, Timothy J.;
West, James A.;
Kotecha, Surendra;
Towers, Norma;
Bennett, Michael;
Kienesberger, Petra C.;
Smolenski, Ryszard T.;
Siddall, Hillary K.;
Offer, John L.;
Mocanu, Mihaela M.;
Yelon, Derek M.;
Dyck, Jason R. B.;
Griffin, Jules L.;
Abramov, Andrey Y.;
Gould, Alex P.;
Mohun, Timothy J.

Publication type:

Article

Carbon Monoxide: A Pleiotropic Redox Regulator of Life and Death.

Published in:

Antioxidants, 2024, v. 13, n. 9, p. 1121, doi. 10.3390/antiox13091121

By:

Abramov, Andrey Y.;
Myers, Isabella;
Angelova, Plamena R.

Publication type:

Article

Charcot Marie Tooth disease pathology is associated with mitochondrial dysfunction and lower glutathione production.

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-025-05612-0

By:

Komilova, Nafisa R.;
Angelova, Plamena R.;
Cali, Elisa;
Scardamaglia, Annarita;
Mirkhodjaev, Ulugbek Z.;
Houlden, Henry;
Esteras, Noemi;
Abramov, Andrey Y.

Publication type:

Article

Inorganic Polyphosphate Regulates AMPA and NMDA Receptors and Protects Against Glutamate Excitotoxicity via Activation of P2Y Receptors.

Published in:

Journal of Neuroscience, 2019, v. 39, n. 31, p. 6038, doi. 10.1523/JNEUROSCI.0314-19.2019

By:

Maiolino, Marta;
O’Neill, Nathanael;
Lariccia, Vincenzo;
Amoroso, Salvatore;
Sylantyev, Sergiy;
Angelova, Plamena R.;
Abramov, Andrey Y.

Publication type:

Article

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 41, p. 10510, doi. 10.1523/JNEUROSCI.1659-16.2016

By:

Ludtmann, Marthe H. R.;
Angelova, Plamena R.;
Ninkina, Natalia N.;
Gandhi, Sonia;
Buchman, Vladimir L.;
Abramov, Andrey Y.

Publication type:

Article

Functional Oxygen Sensitivity of Astrocytes.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 29, p. 10460, doi. 10.1523/JNEUROSCI.0045-15.2015

By:

Angelova, Plamena R.;
Kasymov, Vitaliy;
Christie, Isabel;
Sheikhbahaei, Shahriar;
Turovsky, Egor;
Marina, Nephtali;
Korsak, Alla;
Zwicker, Jennifer;
Teschemacher, Anja G.;
Ackland, Gareth L.;
Funk, Gregory D.;
Kasparov, Sergey;
Abramov, Andrey Y.;
Gourine, Alexander V.

Publication type:

Article

A Critical Role for Purinergic Signalling in the Mechanisms Underlying Generation of BOLD fMRI Responses.

Published in:

Journal of Neuroscience, 2015, v. 35, n. 13, p. 5284, doi. 10.1523/JNEUROSCI.3787-14.2015

By:

Wells, Jack A.;
Christie, Isabel N.;
Hosford, Patrick S.;
Huckstepp, Robert T. R.;
Angelova, Plamena R.;
Vihko, Pirkko;
Cork, Simon C.;
Abramov, Andrey Y.;
Teschemacher, Anja G.;
Kasparov, Sergey;
Lythgoe, Mark F.;
Gourine, Alexander V.

Publication type:

Article

The large-conductance Ca2+-activated K+ channel is essential for innate immunity.

Published in:

2004

By:

Ahluwalia, Jatinder;
Tinker, Andrew;
Clapp, Lucie H.;
Duchen, Michael R.;
Abramov, Andrey Y.;
Pope, Simon;
Nobles, Muriel;
Segal, Anthony W.

Publication type:

Letter

Mitochondrial Permeability Transition, Cell Death and Neurodegeneration.

Published in:

Cells (2073-4409), 2024, v. 13, n. 7, p. 648, doi. 10.3390/cells13070648

By:

Baev, Artyom Y.;
Vinokurov, Andrey Y.;
Potapova, Elena V.;
Dunaev, Andrey V.;
Angelova, Plamena R.;
Abramov, Andrey Y.

Publication type:

Article

Interaction of Mitochondrial Calcium and ROS in Neurodegeneration.

Published in:

Cells (2073-4409), 2022, v. 11, n. 4, p. 706, doi. 10.3390/cells11040706

By:

Baev, Artyom Y.;
Vinokurov, Andrey Y.;
Novikova, Irina N.;
Dremin, Viktor V.;
Potapova, Elena V.;
Abramov, Andrey Y.

Publication type:

Article

The Role of p53 Protein in the Realization of the Exogenous Heat Shock Protein 70 Anti-Apoptotic Effect during Axotomy.

Published in:

Cells (2073-4409), 2022, v. 11, n. 1, p. 93, doi. 10.3390/cells11010093

By:

Demyanenko, Svetlana V.;
Pitinova, Maria A.;
Dzreyan, Valentina A.;
Kalyuzhnaya, Yuliya N.;
Eid, Moez A.;
Abramov, Andrey Y.;
Evgen'ev, Michael B.;
Garbuz, David G.

Publication type:

Article

Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology.

Published in:

Cells (2073-4409), 2020, v. 9, n. 9, p. 2135, doi. 10.3390/cells9092135

By:

Esteras, Noemi;
Abramov, Andrey Y.

Publication type:

Article

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration.

Published in:

FEBS Letters, 2018, v. 592, n. 5, p. 692, doi. 10.1002/1873-3468.12964

By:

Angelova, Plamena R.;
Abramov, Andrey Y.

Publication type:

Article

Carbon monoxide shifts energetic metabolism from glycolysis to oxidative phosphorylation in endothelial cells.

Published in:

FEBS Letters, 2016, v. 590, n. 20, p. 3469, doi. 10.1002/1873-3468.12434

By:

Kaczara, Patrycja;
Motterlini, Roberto;
Kus, Kamil;
Zakrzewska, Agnieszka;
Abramov, Andrey Y.;
Chlopicki, Stefan

Publication type:

Article

Three Distinct Mechanisms Generate Oxygen Free Radicals in Neurons and Contribute to Cell Death during Anoxia and Reoxygenation.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 5, p. 1129, doi. 10.1523/JNEUROSCI.4468-06.2007

By:

Abramov, Andrey Y.;
Scorziello, Antonella;
Duchen, Michael R.

Publication type:

Article

Expression and Modulation of an NADPH Oxidase in Mammalian Astrocytes.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 40, p. 9176, doi. 10.1523/JNEUROSCI.1632-05.2005

By:

Abramov, Andrey Y.;
Jacobson, Jake;
Wientjes, Frans;
Hothersall, John;
Canevari, Laura;
Duchen, Michael R.

Publication type:

Article

β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 2, p. 565, doi. 10.1523/JNEUROSCI.4042-03.2004

By:

Abramov, Andrey Y.;
Canevari, Laura;
Duchen, Michael R.

Publication type:

Article

Changes in Intracellular Calcium and Glutathione in Astrocytes as the Primary Mechanism of Amyloid Neurotoxicity.

Published in:

Journal of Neuroscience, 2003, v. 23, n. 12, p. 5088, doi. 10.1523/JNEUROSCI.23-12-05088.2003

By:

Abramov, Andrey Y.;
Canevari, Laura;
Duchen, Michael R.

Publication type:

Article

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

Published in:

2009

By:

Cantley, James;
Selman, Colin;
Shukla, Deepa;
Abramov, Andrey Y.;
Forstreuter, Frauke;
Esteban, Miguel A.;
Claret, Marc;
Lingard, Steven J.;
Clements, Melanie;
Harten, Sarah K.;
Asare-Anane, Henry;
Batterham, Rachel L.;
Herrera, Pedro L.;
Persaud, Shanta J.;
Duchen, Michael R.;
Maxwell, Patrick H.;
Withers, Dominic J.

Publication type:

journal article

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function.

Published in:

Biological Chemistry, 2016, v. 397, n. 5, p. 383, doi. 10.1515/hsz-2015-0295

By:

Esteras, Noemí;
Dinkova-Kostova, Albena T.;
Abramov, Andrey Y.

Publication type:

Article

Pharmacological sequestration of mitochondrial calcium uptake protects against dementia and β-amyloid neurotoxicity.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-16817-9

By:

Shevtsova, Elena F.;
Angelova, Plamena R.;
Stelmashchuk, Olga A.;
Esteras, Noemi;
Vasil'eva, Nataliia A.;
Maltsev, Andrey V.;
Shevtsov, Pavel N.;
Shaposhnikov, Alexander V.;
Fisenko, Vladimir P.;
Bachurin, Sergey O.;
Abramov, Andrey Y.

Publication type:

Article

Interaction of Oxidative Stress and Misfolded Proteins in the Mechanism of Neurodegeneration.

Published in:

Life (2075-1729), 2020, v. 10, n. 7, p. 101, doi. 10.3390/life10070101

By:

Abramov, Andrey Y.;
Potapova, Elena V.;
Dremin, Viktor V.;
Dunaev, Andrey V.

Publication type:

Article

Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.

Published in:

Journal of Bioenergetics & Biomembranes, 2019, v. 51, n. 3, p. 175, doi. 10.1007/s10863-019-09798-4

By:

Dolgacheva, Ludmila P.;
Berezhnov, Alexey V.;
Fedotova, Evgeniya I.;
Zinchenko, Valery P.;
Abramov, Andrey Y.

Publication type:

Article

Elevated 4R‐tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation.

Published in:

Journal of Cellular & Molecular Medicine, 2022, v. 26, n. 4, p. 1327, doi. 10.1111/jcmm.17136

By:

Setó‐Salvia, Núria;
Esteras, Noemi;
de Silva, Rohan;
de Pablo‐Fernandez, Eduardo;
Arber, Charles;
Toomey, Christina E.;
Polke, James M.;
Morris, Huw R.;
Rohrer, Jonathan D.;
Abramov, Andrey Y.;
Patani, Rickie;
Wray, Selina;
Warner, Thomas T.

Publication type:

Article

Signal transduction in astrocytes: Localization and release of inorganic polyphosphate.

Published in:

Glia (0894-1491), 2018, v. 66, n. 10, p. 2126, doi. 10.1002/glia.23466

By:

Angelova, Plamena R.;
Iversen, Kathrine Z.;
Teschemacher, Anja G.;
Kasparov, Sergey;
Gourine, Alexander V.;
Abramov, Andrey Y.

Publication type:

Article

iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease.

Published in:

PLoS ONE, 2017, v. 12, n. 9, p. 1, doi. 10.1371/journal.pone.0184104

By:

Arber, Charles;
Angelova, Plamena R.;
Wiethoff, Sarah;
Tsuchiya, Yugo;
Mazzacuva, Francesca;
Preza, Elisavet;
Bhatia, Kailash P.;
Mills, Kevin;
Gout, Ivan;
Abramov, Andrey Y.;
Hardy, John;
Duce, James A.;
Houlden, Henry;
Wray, Selina

Publication type:

Article

Synthetic Fragments of Receptor for Advanced Glycation End Products Bind Beta-Amyloid 1-40 and Protect Primary Brain Cells From Beta-Amyloid Toxicity.

Published in:

Frontiers in Neuroscience, 2018, p. 1, doi. 10.3389/fnins.2018.00681

By:

Kamynina, Anna V.;
Esteras, Noemi;
Koroev, Dmitriy O.;
Bobkova, Natalia V.;
Balasanyants, Samson M.;
Simonyan, Ruben A.;
Avetisyan, Armine V.;
Abramov, Andrey Y.;
Volpina, Olga M.

Publication type:

Article

The Role of Mitochondria in Neurodegeneration.

Published in:

Current Medical Literature: Neurology, 2012, v. 28, n. 4, p. 93

By:

Gandhi, Sonia;
Beskina, Olga A.;
Abramov, Andrey Y.

Publication type:

Article

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.

Published in:

Nature Neuroscience, 2013, v. 16, n. 9, p. 1257, doi. 10.1038/nn.3489

By:

Burchell, Victoria S;
Nelson, David E;
Sanchez-Martinez, Alvaro;
Delgado-Camprubi, Marta;
Ivatt, Rachael M;
Pogson, Joe H;
Randle, Suzanne J;
Wray, Selina;
Lewis, Patrick A;
Houlden, Henry;
Abramov, Andrey Y;
Hardy, John;
Wood, Nicholas W;
Whitworth, Alexander J;
Laman, Heike;
Plun-Favreau, Helene

Publication type:

Article

Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease.

Published in:

Frontiers in Physiology, 2014, v. 5, p. 1, doi. 10.3389/fphys.2014.00260

By:

Dedkova, Elena N.;
Blatter, Lothar A.;
Pavlov, Evgeny;
Abramov, Andrey Y.

Publication type:

Article

Mitochondrial dysfunction and energy deprivation in the mechanism of neurodegeneration.

Published in:

Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2019, v. 44, n. 6, p. 723, doi. 10.1515/tjb-2019-0255

By:

Abramov, Andrey Y.;
Angelova, Plamena R.

Publication type:

Article

Variability of mitochondrial energy balance across brain regions.

Published in:

Journal of Neurochemistry, 2021, v. 157, n. 4, p. 1234, doi. 10.1111/jnc.15239

By:

Cheng, XinPing;
Vinokurov, Andrey Y.;
Zherebtsov, Evgeniy A.;
Stelmashchuk, Olga A.;
Angelova, Plamena R.;
Esteras, Noemi;
Abramov, Andrey Y.

Publication type:

Article

Lipid peroxidation is essential for α-synuclein-induced cell death.

Published in:

Journal of Neurochemistry, 2015, v. 133, n. 4, p. 582, doi. 10.1111/jnc.13024

By:

Angelova, Plamena R.;
Horrocks, Mathew H.;
Klenerman, David;
Gandhi, Sonia;
Abramov, Andrey Y.;
Shchepinov, Mikhail S.

Publication type:

Article

Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer's disease.

Published in:

Aging Cell, 2011, v. 10, n. 4, p. 595, doi. 10.1111/j.1474-9726.2011.00685.x

By:

Abramov, Andrey Y.;
Ionov, Maksim;
Pavlov, Evgeny;
Duchen, Michael R.

Publication type:

Article

Signalling properties of inorganic polyphosphate in the mammalian brain.

Published in:

Nature Communications, 2013, v. 4, n. 1, p. 1362, doi. 10.1038/ncomms2364

By:

Holmström, Kira M.;
Marina, Nephtali;
Baev, Artyom Y.;
Wood, Nicholas W.;
Gourine, Alexander V.;
Abramov, Andrey Y.

Publication type:

Article

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.

Published in:

2019

By:

Pauletti, Alberto;
Terrone, Gaetano;
Shekh-Ahmad, Tawfeeq;
Salamone, Alessia;
Ravizza, Teresa;
Rizzi, Massimo;
Pastore, Anna;
Pascente, Rosaria;
Liang, Li-Ping;
Villa, Bianca R;
Balosso, Silvia;
Abramov, Andrey Y;
Vliet, Erwin A van;
Giudice, Ennio Del;
Aronica, Eleonora;
Patel, Manisha;
Walker, Matthew C;
Vezzani, Annamaria;
van Vliet, Erwin A;
Del Giudice, Ennio

Publication type:

journal article

KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy.

Published in:

2018

By:

Shekh-Ahmad, Tawfeeq;
Eckel, Ramona;
Naidu, Sharadha Dayalan;
Higgins, Maureen;
Masayuki Yamamoto;
Dinkova-Kostova, Albena T.;
Kovac, Stjepana;
Abramov, Andrey Y.;
Walker, Matthew C.;
Dayalan Naidu, Sharadha;
Yamamoto, Masayuki

Publication type:

journal article

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy.

Published in:

2017

By:

Manole, Andreea;
Jaunmuktane, Zane;
Hargreaves, Iain;
Ludtmann, Marthe H. R.;
Salpietro, Vincenzo;
Bello, Oscar D.;
Pope, Simon;
Pandraud, Amelie;
Horga, Alejandro;
Scalco, Renata S.;
Abi Li;
Ashokkumar, Balasubramaniem;
Lourenc, Charles M.;
Heales, Simon;
Horvath, Rita;
Chinnery, Patrick F.;
Toro, Camilo;
Singleton, Andrew B.;
Jacques, Thomas S.;
Abramov, Andrey Y.

Publication type:

journal article

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy.

Published in:

2017

By:

Pauletti, Alberto;
Terrone, Gaetano;
Shekh-Ahmad, Tawfeeq;
Salamone, Alessia;
Ravizza, Teresa;
Rizzi, Massimo;
Pastore, Anna;
Pascente, Rosaria;
Li-Ping Liang;
Villa, Bianca R.;
Balosso, Silvia;
Abramov, Andrey Y.;
van Vliet, Erwin A.;
Del Giudice, Ennio;
Aronica, Eleonora;
Antoine, Daniel J.;
Patel, Manisha;
Walker, Matthew C.;
Vezzani, Annamaria;
Liang, Li-Ping

Publication type:

journal article

Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications.

Published in:

Brain: A Journal of Neurology, 2016, v. 139, n. 12, p. 1, doi. 10.1093/brain/aww185

By:

Kinghorn, Kerri J.;
Castillo-Quan, Jorge Iván;
Li Li;
Bhatia, Kailash P.;
Abramov, Andrey Y.;
Hardy, John;
Partridge, Linda

Publication type:

Article

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction.

Published in:

2015

By:

Kinghorn, Kerri J.;
Castillo-Quan, Jorge Iván;
Bartolome, Fernando;
Angelova, Plamena R.;
Li Li;
Pope, Simon;
Cochemé, Helena M.;
Khan, Shabana;
Asghari, Shabnam;
Bhatia, Kailash P.;
Hardy, John;
Abramov, Andrey Y.;
Partridge, Linda;
Li, Li

Publication type:

journal article

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells.

Published in:

Brain: A Journal of Neurology, 2014, v. 137, n. 5, p. 1481, doi. 10.1093/brain/awu020

By:

McNeill, Alisdair;
Magalhaes, Joana;
Shen, Chengguo;
Chau, Kai-Yin;
Hughes, Derralyn;
Mehta, Atul;
Foltynie, Tom;
Cooper, J. Mark;
Abramov, Andrey Y.;
Gegg, Matthew;
Schapira, Anthony H.V.

Publication type:

Article

Beta-amyloid activates PARP causing astrocytic metabolic failure and neuronal death.

Published in:

2011

By:

Abeti R;
Abramov AY;
Duchen MR;
Abeti, Rosella;
Abramov, Andrey Y;
Duchen, Michael R

Publication type:

journal article

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death.

Published in:

Brain: A Journal of Neurology, 2011, v. 134, n. 6, p. 1658, doi. 10.1093/brain/awr104

By:

Abeti, Rosella;
Abramov, Andrey Y.;
Duchen, Michael R.

Publication type:

Article

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations.

Published in:

Brain: A Journal of Neurology, 2010, v. 133, n. 3, p. 797, doi. 10.1093/brain/awq015

By:

Abramov, Andrey Y.;
Smulders-Srinivasan, Tora K.;
Kirby, Denise M.;
Acin-Perez, Rebeca;
Enriquez, José Antonio;
Lightowlers, Robert N.;
Duchen, Michael R.;
Turnbull, Douglass M.

Publication type:

Article

Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long‐Lived Growth Hormone Receptor Null Mice.

Published in:

Journal of Bone & Mineral Research, 2019, v. 34, n. 1, p. 106, doi. 10.1002/jbmr.3573

By:

Liu, Zhongbo;
Solesio, Maria E;
Schaffler, Mitchell B;
Frikha‐Benayed, Dorra;
Rosen, Clifford J;
Werner, Haim;
Kopchick, John J;
Pavlov, Evgeny V;
Abramov, Andrey Y;
Yakar, Shoshana

Publication type:

Article

Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction.

Published in:

FASEB Journal, 2020, v. 34, n. 6, p. 8139, doi. 10.1096/fj.201902277RR

By:

Ghosh, Rhia;
Wood‐Kaczmar, Alison;
Dobson, Lucianne;
Smith, Edward J.;
Sirinathsinghji, Eva C.;
Kriston‐Vizi, Janos;
Hargreaves, Iain P.;
Heaton, Robert;
Herrmann, Frank;
Abramov, Andrey Y.;
Lam, Amanda J.;
Heales, Simon J.;
Ketteler, Robin;
Bates, Gillian P.;
Andre, Ralph;
Tabrizi, Sarah J.

Publication type:

Article

Monoamine oxidase-A knockdown in human neuroblastoma cells reveals protection against mitochondrial toxins.

Published in:

FASEB Journal, 2014, v. 28, n. 1, p. 218, doi. 10.1096/fj.13-235481

By:

Fitzgerald, Julia C.;
Ugun-Klusek, Aslihan;
Allen, George;
De Girolamo, Luigi A.;
Hargreaves, Iain;
Ufer, Christoph;
Abramov, Andrey Y.;
Billett, E. Ellen

Publication type:

Article

Point of No Return—What Is the Threshold of Mitochondria With Permeability Transition in Cells to Trigger Cell Death.

Published in:

Journal of Cellular Physiology, 2025, v. 240, n. 1, p. 1, doi. 10.1002/jcp.31521

By:

Kritskaya, Kristina A.;
Stelmashchuk, Olga A.;
Abramov, Andrey Y.

Publication type:

Article

Age‐related changes in the energy of human mesenchymal stem cells.

Published in:

Journal of Cellular Physiology, 2022, v. 237, n. 3, p. 1753, doi. 10.1002/jcp.30638

By:

Barilani, Mario;
Lovejoy, Christopher;
Piras, Roberta;
Abramov, Andrey Y.;
Lazzari, Lorenza;
Angelova, Plamena R.

Publication type:

Article