Works by Aboussekhra, Abdelilah

Results: 59

Vincristine and lomustine induce apoptosis and p21WAF1 up-regulation in medulloblastoma and normal human epithelial and fibroblast cells.

Published in:

Journal of Neuro-Oncology, 2008, v. 87, n. 2, p. 123, doi. 10.1007/s11060-007-9502-4

By:

Zakia Shinwari;
Pulicat Manogaran;
Salman Alrokayan;
Khaled Al-Hussein;
Abdelilah Aboussekhra

Publication type:

Article

The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells.

Published in:

Journal of Neuro-Oncology, 2007, v. 83, n. 1, p. 9, doi. 10.1007/s11060-006-9301-3

By:

Huda Al-Khalaf;
Ayman Allam;
Ahmed AlKhani;
Salman Alrokayan;
Abdelilah Aboussekhra

Publication type:

Article

Endogenous osteoprotegerin (OPG) represses ERα and promotes stemness and chemoresistance in breast cancer cells.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-02151-8

By:

Alraouji, Noura N.;
Colak, Dilek;
Al-mohanna, Falah H.;
Alaiya, Ayodele A.;
Aboussekhra, Abdelilah

Publication type:

Article

Long noncoding RNA DLEU2 and ROR1 pathway induces epithelial-to-mesenchymal transition and cancer stem cells in breast cancer.

Published in:

Cell Death Discovery, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41420-024-01829-3

By:

Islam, Syed S.;
Al-Tweigeri, Taher;
Al-Harbi, Layla;
Ujjahan, Shafat;
Al-Mozaini, Maha;
Tulbah, Asma;
Aboussekhra, Abdelilah

Publication type:

Article

E2F1 activates breast stromal fibroblasts and promotes their paracrine pro-carcinogenic effects.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-87808-9

By:

Al-Kharashi, Layla A.;
Al-Mohanna, Falah H.;
Aboussekhra, Abdelilah;
Abousekhra, Abdelilah

Publication type:

Article

Survivin expression increases during aging and enhances the resistance of aged human fibroblasts to genotoxic stress.

Published in:

Age (0161-9152), 2013, v. 35, n. 3, p. 549, doi. 10.1007/s11357-011-9378-2

By:

Al-Khalaf, Huda;
Aboussekhra, Abdelilah

Publication type:

Article

TATA-binding protein promotes the selective formation of UV-induced (6-4)-photoproducts and modulates DNA repair in the TATA box.

Published in:

EMBO Journal, 1999, v. 18, n. 2, p. 433, doi. 10.1093/emboj/18.2.433

By:

Aboussekhra, Abdelilah;
Thoma, Fritz

Publication type:

Article

Eugenol Promotes Apoptosis in Leukemia Cells via Targeting the Mitochondrial Biogenesis PPRC1 Gene.

Published in:

Cells (2073-4409), 2025, v. 14, n. 4, p. 260, doi. 10.3390/cells14040260

By:

Al-Harbi, Sayer;
Alkholiwy, Elham M. A.;
Ali Ahmed, Syed Osman;
Aljurf, Mahmoud;
Al-Hejailan, Reem;
Aboussekhra, Abdelilah

Publication type:

Article

Activation of Mammary Epithelial and Stromal Fibroblasts upon Exposure to Escherichia coli Metabolites.

Published in:

Cells (2073-4409), 2024, v. 13, n. 20, p. 1723, doi. 10.3390/cells13201723

By:

Alshehri, Jamilah H.;
Al-Nasrallah, Huda K.;
Al-Ansari, Mysoon M.;
Aboussekhra, Abdelilah

Publication type:

Article

Decorin (DCN) Downregulation Activates Breast Stromal Fibroblasts and Promotes Their Pro-Carcinogenic Effects through the IL-6/STAT3/AUF1 Signaling.

Published in:

Cells (2073-4409), 2024, v. 13, n. 8, p. 680, doi. 10.3390/cells13080680

By:

Aljagthmi, Wafaa A.;
Alasmari, Manal A.;
Daghestani, Maha H.;
Al-Kharashi, Layla A.;
Al-Mohanna, Falah H.;
Aboussekhra, Abdelilah

Publication type:

Article

Osteoprotegerin (OPG) Upregulation Activates Breast Stromal Fibroblasts and Enhances Their Pro-Carcinogenic Effects through the STAT3/IL-6 Signaling.

Published in:

Cells (2073-4409), 2022, v. 11, n. 21, p. 3369, doi. 10.3390/cells11213369

By:

Al-Nasrallah, Huda K.;
Al-Ansari, Mysoon M.;
Aboussekhra, Abdelilah

Publication type:

Article

The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 1, p. 223

By:

Al-Mohanna, Mai A.;
Al-Khalaf, Huda H.;
Al-Yousef, Nujoud;
Aboussekhra, Abdelilah

Publication type:

Article

A validated RP-HPLC method for the determination of piperidone analogue of curcumin.

Published in:

Pakistan Journal of Pharmaceutical Sciences, 2020, v. 33, n. 2, p. 685, doi. 10.36721/PJPS.2020.33.2.REG.685-694.1

By:

Alomrani, Abdullah;
Alhabardi, Samiah;
Aboussekhra, Abdelilah;
Alshamsan, Aws;
Attia, Mohamed I.;
AlQuadeib, Bushra

Publication type:

Article

Interleukin-8 Dedifferentiates Primary Human Luminal Cells to Multipotent Stem Cells.

Published in:

Molecular & Cellular Biology, 2020, v. 40, n. 9, p. 1, doi. 10.1128/MCB.00508-19

By:

Al-Khalaf, Huda H.;
Ghebeh, Hazem;
Wakil, Salma M.;
Al-Mohanna, Falah;
Aboussekhra, Abdelilah

Publication type:

Article

The curcumin analogue PAC has potent anti-anaplastic thyroid cancer effects.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-30888-2

By:

Al-Mohanna, Mai;
Alraouji, Noura N.;
Alhabardi, Samiah A.;
Al-Mohanna, Falah;
Al-Otaibi, Basem;
Al-Jammaz, Ibrahim;
Aboussekhra, Abdelilah

Publication type:

Article

Identification of novel prognostic biomarkers for thyroid cancer by integrated transcriptome analysis of metastasis-associated genes.

Published in:

Frontiers in Oncology, 2025, p. 1, doi. 10.3389/fonc.2025.1536270

By:

Alnwisser, Bushra;
Alshehri, Salman;
Qattan, Amal;
Zou, Minjing;
Aboussekhra, Abdelilah;
Alzahrani, Ali S.;
Shi, Yufei

Publication type:

Article

Sequential combination of cisplatin with eugenol targets ovarian cancer stem cells through the Notch-Hes1 signalling pathway.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2019, v. 38, n. 1, p. 1, doi. 10.1186/s13046-019-1360-3

By:

Islam, Syed S.;
Aboussekhra, Abdelilah

Publication type:

Article

Prevalence of PIK3CA mutations and the SNP rs17849079 in Arab breast cancer patients.

Published in:

Cancer Biology & Therapy, 2013, v. 14, n. 10, p. 888, doi. 10.4161/cbt.25945

By:

Karakas, Bedri;
Colak, Dilek;
Kaya, Namik;
Ghebeh, Hazem;
Al-Qasem, Abeer;
Hendrayani, Fawziah;
Toulimat, Mohamed;
Al-Tweigeri, Taher;
Ben Ho Park;
Aboussekhra, Abdelilah

Publication type:

Article

PAC, a novel curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells.

Published in:

Breast Cancer Research & Treatment, 2011, v. 128, n. 1, p. 97, doi. 10.1007/s10549-010-1089-3

By:

Al-Hujaily, Ensaf;
Mohamed, Ameera;
Al-Sharif, Ibtehaj;
Youssef, Khairia;
Manogaran, Pulicat;
Al-Otaibi, Basem;
Al-Haza'a, Amal;
Al-Jammaz, Ibrahim;
Al-Hussein, Khaled;
Aboussekhra, Abdelilah

Publication type:

Article

Molecular Subtypes of Breast Cancer in Arab Women: Distribution and Prognostic Insights.

Published in:

Journal of Epidemiology & Global Health, 2025, v. 15, n. 1, p. 1, doi. 10.1007/s44197-025-00376-z

By:

Elkum, Naser;
Aboussekhra, Abdelilah;
Aboussekhra, Mouad;
Aldalham, Hanin;
Alshehri, Lama;
Alessy, Saleh;
AL-Tweigeri, Taher;
Al-Zahrani, Ali Saeed

Publication type:

Article

Senescent Breast Luminal Cells Promote Carcinogenesis through Interleukin-8-Dependent Activation of Stromal Fibroblasts.

Published in:

Molecular & Cellular Biology, 2019, v. 39, n. 2, p. 1, doi. 10.1128/MCB.00359-18

By:

Al-Khalaf, Huda H.;
Ghebeh, Hazem;
Inass, Rabia;
Aboussekhra, Abdelilah

Publication type:

Article

Interleukin-8 Activates Breast Cancer-Associated Adipocytes and Promotes Their Angiogenesis- and Tumorigenesis-Promoting Effects.

Published in:

Molecular & Cellular Biology, 2019, v. 39, n. 2, p. 1, doi. 10.1128/MCB.00332-18

By:

Al-Khalaf, Huda H.;
Al-Harbi, Bothaina;
Al-Sayed, Adher;
Arafah, Maria;
Tulbah, Asma;
Jarman, Abdulaziz;
Al-Mohanna, Falah;
Aboussekhra, Abdelilah

Publication type:

Article

Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity.

Published in:

Molecular & Cellular Biology, 2017, v. 37, n. 17, p. 1, doi. 10.1128/MCB.00101-17

By:

Al-Khalaf, Huda H.;
Amir, Mrad;
Al-Mohanna, Falah;
Tulbah, Asma;
Al-Sayed, Adher;
Aboussekhra, Abdelilah

Publication type:

Article

High DNMT1 Expression in Stromal Fibroblasts Promotes Angiogenesis and Unfavorable Outcome in Locally Advanced Breast Cancer Patients.

Published in:

Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.877219

By:

Al-Kharashi, Layla A.;
Tulbah, Asma;
Arafah, Maria;
Eldali, Abdelmonneim M.;
Al-Tweigeri, Taher;
Aboussekhra, Abdelilah

Publication type:

Article

Eugenol modulates genomic methylation and inactivates breast cancer‐associated fibroblasts through E2F1‐dependent downregulation of DNMT1/DNMT3A.

Published in:

Molecular Carcinogenesis, 2021, v. 60, n. 11, p. 784, doi. 10.1002/mc.23344

By:

Al‐Kharashi, Layla A.;
Bakheet, Tala;
AlHarbi, Wejdan A.;
Al‐Moghrabi, Nisreen;
Aboussekhra, Abdelilah

Publication type:

Article

Cucurbitacin I (JSI‐124)‐dependent inhibition of STAT3 permanently suppresses the pro‐carcinogenic effects of active breast cancer‐associated fibroblasts.

Published in:

Molecular Carcinogenesis, 2021, v. 60, n. 4, p. 242, doi. 10.1002/mc.23287

By:

Al‐Harbi, Bothaina;
Aboussekhra, Abdelilah

Publication type:

Article

Tocilizumab inhibits IL‐8 and the proangiogenic potential of triple negative breast cancer cells.

Published in:

Molecular Carcinogenesis, 2021, v. 60, n. 1, p. 51, doi. 10.1002/mc.23270

By:

Alraouji, Noura N.;
Aboussekhra, Abdelilah

Publication type:

Article

Tocilizumab potentiates cisplatin cytotoxicity and targets cancer stem cells in triple‐negative breast cancer.

Published in:

Molecular Carcinogenesis, 2020, v. 59, n. 9, p. 1041, doi. 10.1002/mc.23234

By:

Alraouji, Noura N.;
Al‐Mohanna, Falah H.;
Ghebeh, Hazem;
Arafah, Maria;
Almeer, Rafa;
Al‐Tweigeri, Taher;
Aboussekhra, Abdelilah

Publication type:

Article

Eugenol potentiates cisplatin anti‐cancer activity through inhibition of ALDH‐positive breast cancer stem cells and the NF‐κB signaling pathway.

Published in:

Molecular Carcinogenesis, 2018, v. 57, n. 3, p. 333, doi. 10.1002/mc.22758

By:

Islam, Syed S.;
Al‐Sharif, Ibtehaj;
Sultan, Ahlam;
Al‐Mazrou, Amer;
Remmal, Adnane;
Aboussekhra, Abdelilah

Publication type:

Article

p16INK4A enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction.

Published in:

Molecular Carcinogenesis, 2017, v. 56, n. 7, p. 1687, doi. 10.1002/mc.22627

By:

Al‐Khalaf, Huda H.;
Nallar, Shreeram C.;
Kalvakolanu, Dhananjaya V.;
Aboussekhra, Abdelilah

Publication type:

Article

p16INK4A induces senescence and inhibits EMT through microRNA-141/microRNA-146b-5p-dependent repression of AUF1.

Published in:

Molecular Carcinogenesis, 2017, v. 56, n. 3, p. 985, doi. 10.1002/mc.22564

By:

Al ‐ Khalaf, Huda H.;
Aboussekhra, Abdelilah

Publication type:

Article

p16INK4A inhibits the pro-metastatic potentials of osteosarcoma cells through targeting the ERK pathway and TGF-β1.

Published in:

Molecular Carcinogenesis, 2016, v. 55, n. 5, p. 525, doi. 10.1002/mc.22299

By:

Silva, Gabriela;
Aboussekhra, Abdelilah

Publication type:

Article

PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition.

Published in:

Molecular Carcinogenesis, 2016, v. 55, n. 3, p. 233, doi. 10.1002/mc.22271

By:

Al‐Qasem, Abeer;
Al‐Howail, Huda A.;
Al‐Swailem, Mashael;
Al‐Mazrou, Amer;
Al‐Otaibi, Basem;
Al‐Jammaz, Ibrahim;
Al‐Khalaf, Huda H.;
Aboussekhra, Abdelilah

Publication type:

Article

AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1.

Published in:

Oncogenesis, 2020, v. 9, n. 8, p. 1, doi. 10.1038/s41389-020-00255-1

By:

AlAhmari, Manar M.;
Al-Khalaf, Huda H.;
Al-Mohanna, Falah H.;
Ghebeh, Hazem;
Aboussekhra, Abdelilah

Publication type:

Article

KEAP1/NRF2 Mutations in Stem Cells Define an Aggressive Subset of Head and Neck Cancer Patients Who Have a Poor Prognosis, Lung Metastasis, and Therapeutic Failure.

Published in:

Cancers, 2023, v. 15, n. 20, p. 5006, doi. 10.3390/cancers15205006

By:

Islam, Syed S.;
Karakas, Bedri;
Aboussekhra, Abdelilah;
Noman, Abu Shadat M.

Publication type:

Article

Homologous recombination is involved in transcription-coupled repair of UV damage in Saccharomyces cerevisiae.

Published in:

EMBO Journal, 2005, v. 24, n. 11, p. 1999, doi. 10.1038/sj.emboj.7600665

By:

Aboussekhra, Abdelilah;
Al-Sharif, Ibtehaj S.

Publication type:

Article

Obesity is a significant risk factor for breast cancer in Arab women.

Published in:

BMC Cancer, 2014, v. 14, p. 1, doi. 10.1186/1471-2407-14-788

By:

Elkum, Naser;
Al-Tweigeri, Taher;
Ajarim, Dahish;
Al-Zahrani, Ali;
Amer, Suad M. Bin;
Aboussekhra, Abdelilah

Publication type:

Article

The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females.

Published in:

2014

By:

Al-Moghrabi, Nisreen;
Nofel, Asmaa;
Al-Yousef, Nujoud;
Madkhali, Safia;
Bin Amer, Suad M;
Alaiya, Ayodele;
Shinwari, Zakia;
Al-Tweigeri, Taher;
Karakas, Bedri;
Tulbah, Asma;
Aboussekhra, Abdelilah

Publication type:

Journal Article

Obesity is a significant risk factor for breast cancer in Arab women.

Published in:

2014

By:

Elkum, Naser;
Al-Tweigeri, Taher;
Ajarim, Dahish;
Al-Zahrani, Ali;
Amer, Suad M Bin;
Aboussekhra, Abdelilah

Publication type:

journal article

Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation.

Published in:

BMC Cancer, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-2407-13-600

By:

Al-Sharif, Ibtehaj;
Remmal, Adnane;
Aboussekhra, Abdelilah

Publication type:

Article

Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation.

Published in:

2013

By:

Al-Sharif, Ibtehaj;
Remmal, Adnane;
Aboussekhra, Abdelilah

Publication type:

journal article

Caffeine Mediates Sustained Inactivation of Breast Cancer-Associated Myofibroblasts via Up-Regulation of Tumor Suppressor Genes.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0090907

By:

Al-Ansari, Mysoon M.;
Aboussekhra, Abdelilah

Publication type:

Article

p16INK4A Positively Regulates p21WAF1 Expression by suppressing AUF1-dependent mRNA decay.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0070133

By:

Al-Khalaf, Huda H.;
Aboussekhra, Abdelilah

Publication type:

Article

p16INK4A Positively Regulates Cyclin D1 and E2F1 through Negative Control of AUF1.

Published in:

PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0021111

By:

Al-Khalaf, Huda H.;
Colak, Dilek;
Al-Saif, Maher;
Al-Bakheet, Albandary;
Hendrayani, Siti-Faujiah;
Al-Yousef, Nujoud;
Kaya, Namik;
Khabar, Khalid S.;
Aboussekhra, Abdelilah

Publication type:

Article

ATR controls the UV-related upregulation of the CDKN1A mRNA in a Cdk1/HuR-dependent manner.

Published in:

Molecular Carcinogenesis, 2014, v. 53, n. 12, p. 979, doi. 10.1002/mc.22066

By:

Al‐Khalaf, Huda H.;
Aboussekhra, Abdelilah

Publication type:

Article

ATR controls the p21WAF1/Cip1 protein up-regulation and apoptosis in response to low UV fluences.

Published in:

Molecular Carcinogenesis, 2012, v. 51, n. 12, p. 930, doi. 10.1002/mc.20864

By:

Al-Khalaf, Huda H.;
Hendrayani, Siti-Faujiah;
Aboussekhra, Abdelilah

Publication type:

Article

Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells.

Published in:

Molecular Carcinogenesis, 2010, v. 49, n. 3, p. 302, doi. 10.1002/mc.20604

By:

Elamin, Maha H.;
Shinwari, Zakia;
Hendrayani, Siti-Faujiah;
Al-Hindi, Hindi;
Al-Shail, Essam;
khafaga, Yasser;
Al-kofide, Amani;
Aboussekhra, Abdelilah

Publication type:

Article

Deficiency in the repair of UV-induced DNA damage in human skin fibroblasts compromised for the ATM gene.

Published in:

Carcinogenesis, 2002, v. 23, n. 10, p. 1617, doi. 10.1093/carcin/23.10.1617

By:

Hannan, Mohammed A.;
Hellani, Ali;
Al-Khodairy, Fahad M.;
Kunhi, Mohammed;
Siddiqui, Yunis;
Al-Yussef, Noujud;
Pangue-Cruz, Nancy;
Siewertsen, Monica;
Al-Ahdal, Mohammed N.;
Aboussekhra, Abdelilah

Publication type:

Article

p53 is dispensable for UV-induced cell cycle arrest at late G1 in mammalian cells.

Published in:

Carcinogenesis, 2001, v. 22, n. 4, p. 573, doi. 10.1093/carcin/22.4.573

By:

Al-Mohanna, Mai A.;
Al-Khodairy, Fahad M.;
Krezolek, Zbigniew;
Bertilsson, Per-Anders;
Al-Houssein, Khalid A.;
Aboussekhra, Abdelilah

Publication type:

Article

High AUF1 level in stromal fibroblasts promotes carcinogenesis and chemoresistance and predicts unfavorable prognosis among locally advanced breast cancer patients.

Published in:

2022

By:

Al-Tweigeri, Taher;
AlRaouji, Noura N.;
Tulbah, Asma;
Arafah, Maria;
Aboussekhra, Mouad;
Al-Mohanna, Falah;
Gad, Ahmed Mostafa;
Eldali, Abdelmonneim M.;
Elhassan, Tusneem A.;
Aboussekhra, Abdelilah

Publication type:

journal article