Works by Abate, Carmen

Results: 24

PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.589810

By:

Abate, Carmen;
Niso, Mauro;
Abatematteo, Francesca Serena;
Contino, Marialessandra;
Colabufo, Nicola Antonio;
Berardi, Francesco

Publication type:

Article

A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-39662-w

By:

Abatematteo, Francesca Serena;
Delre, Pietro;
Mercurio, Ivan;
Rezelj, Veronica V.;
Siliqi, Dritan;
Beaucourt, Stephanie;
Lattanzi, Gianluca;
Colabufo, Nicola Antonio;
Leopoldo, Marcello;
Saviano, Michele;
Vignuzzi, Marco;
Mangiatordi, Giuseppe Felice;
Abate, Carmen

Publication type:

Article

Discriminative stimulus properties of α-ethyltryptamine (α-ET) in rats: α-ET-like effects of MDMA, MDA and aryl-monomethoxy substituted derivatives of α-ET.

Published in:

Psychopharmacology, 2025, v. 242, n. 6, p. 1407, doi. 10.1007/s00213-024-06738-y

By:

Abate, Carmen;
Young, Richard;
Dukat, Malgorzata;
Glennon, Richard A.

Publication type:

Article

Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models.

Published in:

Cellular Oncology (2211-3428), 2021, v. 44, n. 6, p. 1307, doi. 10.1007/s13402-021-00638-5

By:

Niso, Mauro;
Kopecka, Joanna;
Abatematteo, Francesca Serena;
Berardi, Francesco;
Riganti, Chiara;
Abate, Carmen

Publication type:

Article

NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines.

Published in:

Cancers, 2020, v. 12, n. 2, p. 257, doi. 10.3390/cancers12020257

By:

Cantonero, Carlos;
Camello, Pedro Javier;
Abate, Carmen;
Berardi, Francesco;
Salido, Gines Maria;
Rosado, Juan Antonio;
Redondo, Pedro C.

Publication type:

Article

Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor.

Published in:

2019

By:

Liu, Chia-Chi;
Yu, Ching-Fang;
Wang, Shu-Chi;
Li, Hsueh-Yin;
Lin, Chiu-Min;
Wang, Hsia-Han;
Abate, Carmen;
Chiang, Chi-Shiun

Publication type:

journal article

New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4.

Published in:

Molecules, 2022, v. 27, n. 5, p. 1, doi. 10.3390/molecules27051682

By:

Anobile, Dario P.;
Niso, Mauro;
Puerta, Adrian;
Fraga Rodrigues, Stephanie M.;
Abatematteo, Francesca S.;
Avan, Amir;
Abate, Carmen;
Riganti, Chiara;
Giovannetti, Elisa

Publication type:

Article

Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties.

Published in:

Molecules, 2022, v. 27, n. 4, p. 1297, doi. 10.3390/molecules27041297

By:

Mastromarino, Margherita;
Niso, Mauro;
Abate, Carmen;
Proschak, Ewgenij;
Dubiel, Mariam;
Stark, Holger;
Castro, Marián;
Lacivita, Enza;
Leopoldo, Marcello

Publication type:

Article

σ 2 Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach.

Published in:

Molecules, 2021, v. 26, n. 12, p. 3743, doi. 10.3390/molecules26123743

By:

Abatematteo, Francesca Serena;
Niso, Mauro;
Lacivita, Enza;
Abate, Carmen

Publication type:

Article

Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease.

Published in:

eNeuro, 2020, v. 7, n. 6, p. 1, doi. 10.1523/ENEURO.0317-20.2020

By:

Izzo, Nicholas J.;
Colom-Cadena, Martí;
Riad, Aladdin A.;
Jinbin Xu;
Singh, Meharvan;
Abate, Carmen;
Cahill, Michael A.;
Spires-Jones, Tara L.;
Bowen, Wayne D.;
Mach, Robert H.;
Catalano, Susan M.

Publication type:

Article

Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.

Published in:

2017

By:

Pati, Maria Laura;
Hornick, John R.;
Niso, Mauro;
Berardi, Francesco;
Spitzer, Dirk;
Abate, Carmen;
Hawkins, William

Publication type:

journal article

Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer.

Published in:

Journal of Experimental & Clinical Cancer Research (17569966), 2012, v. 31, n. 1, p. 41, doi. 10.1186/1756-9966-31-41

By:

Hornick, John R;
Vangveravong, Suwanna;
Spitzer, Dirk;
Abate, Carmen;
Berardi, Francesco;
Goedegebuure, Peter;
Mach, Robert H;
Hawkins, William G

Publication type:

Article

The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 21, p. 15868, doi. 10.3390/ijms242115868

By:

Abate, Carmen;
Maurice, Tangui

Publication type:

Article

Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 7, p. 6381, doi. 10.3390/ijms24076381

By:

Thejer, Bashar M.;
Infantino, Vittoria;
Santarsiero, Anna;
Pappalardo, Ilaria;
Abatematteo, Francesca S.;
Teakel, Sarah;
Van Oosterum, Ashleigh;
Mach, Robert H.;
Denora, Nunzio;
Lee, Byung Chul;
Resta, Nicoletta;
Bagnulo, Rosanna;
Niso, Mauro;
Contino, Marialessandra;
Montsch, Bianca;
Heffeter, Petra;
Abate, Carmen;
Cahill, Michael A.

Publication type:

Article

Multi-Target Directed Ligands (MTDLs) Binding the σ 1 Receptor as Promising Therapeutics: State of the Art and Perspectives.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 12, p. 6359, doi. 10.3390/ijms22126359

By:

Abatematteo, Francesca Serena;
Niso, Mauro;
Contino, Marialessandra;
Leopoldo, Marcello;
Abate, Carmen

Publication type:

Article

Choline-Sigma-1R as an Additional Mechanism for Potentiation of Orexin by Cocaine.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 10, p. 5160, doi. 10.3390/ijms22105160

By:

Barr, Jeffrey L.;
Zhao, Pingwei;
Brailoiu, G. Cristina;
Brailoiu, Eugen;
Abate, Carmen

Publication type:

Article

MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 9, p. 3333, doi. 10.3390/ijms21093333

By:

Riganti, Chiara;
Giampietro, Roberta;
Kopecka, Joanna;
Costamagna, Costanzo;
Abatematteo, Francesca Serena;
Contino, Marialessandra;
Abate, Carmen

Publication type:

Article

Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2004, v. 370, n. 2, p. 106

By:

Colabufo, Nicola Antonio;
Berardi, Francesco;
Contino, Marialessandra;
Niso, Mauro;
Abate, Carmen;
Perrone, Roberto;
Tortorella, Vincenzo

Publication type:

Article

Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells.

Published in:

ChemBioChem, 2015, v. 16, n. 7, p. 1078, doi. 10.1002/cbic.201402712

By:

Niso, Mauro;
Riganti, Chiara;
Pati, Maria Laura;
Ghigo, Dario;
Berardi, Francesco;
Abate, Carmen

Publication type:

Article

Inside Cover: Sigma-2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity (ChemMedChem 12/2013).

Published in:

ChemMedChem, 2013, v. 8, n. 12, p. 1898, doi. 10.1002/cmdc.201390051

By:

Niso, Mauro;
Abate, Carmen;
Contino, Marialessandra;
Ferorelli, Savina;
Azzariti, Amalia;
Perrone, Roberto;
Colabufo, Nicola Antonio;
Berardi, Francesco

Publication type:

Article

Sigma-2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity.

Published in:

ChemMedChem, 2013, v. 8, n. 12, p. 2026, doi. 10.1002/cmdc.201300291

By:

Niso, Mauro;
Abate, Carmen;
Contino, Marialessandra;
Ferorelli, Savina;
Azzariti, Amalia;
Perrone, Roberto;
Colabufo, Nicola Antonio;
Berardi, Francesco

Publication type:

Article

2-Aminopyridine Derivatives as Potential σ2 Receptor Antagonists.

Published in:

ChemMedChem, 2012, v. 7, n. 10, p. 1847, doi. 10.1002/cmdc.201200246

By:

Abate, Carmen;
Ferorelli, Savina;
Niso, Mauro;
Lovicario, Cesarea;
Infantino, Vittoria;
Convertini, Paolo;
Perrone, Roberto;
Berardi, Francesco

Publication type:

Article

Inside Cover: 1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ8-Δ7 Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity (ChemMedChem 1/2011).

Published in:

ChemMedChem, 2011, v. 6, n. 1, p. 2, doi. 10.1002/cmdc.201090062

By:

Abate, Carmen;
Niso, Mauro;
Contino, Marialessandra;
Colabufo, Nicola Antonio;
Ferorelli, Savina;
Perrone, Roberto;
Berardi, Francesco

Publication type:

Article

1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ8-Δ7 Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity.

Published in:

ChemMedChem, 2011, v. 6, n. 1, p. 73, doi. 10.1002/cmdc.201000371

By:

Abate, Carmen;
Niso, Mauro;
Contino, Marialessandra;
Colabufo, Nicola Antonio;
Ferorelli, Savina;
Perrone, Roberto;
Berardi, Francesco

Publication type:

Article

Works by Abate, Carmen

PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships.

A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach.

Discriminative stimulus properties of α-ethyltryptamine (α-ET) in rats: α-ET-like effects of MDMA, MDA and aryl-monomethoxy substituted derivatives of α-ET.

Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models.

NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines.

Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor.

New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4.

Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties.

σ 2 Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach.

Proceedings from the Fourth International Symposium on σ-2 Receptors: Role in Health and Disease.

Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.

Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer.

The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0.

Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97.

Multi-Target Directed Ligands (MTDLs) Binding the σ 1 Receptor as Promising Therapeutics: State of the Art and Perspectives.

Choline-Sigma-1R as an Additional Mechanism for Potentiation of Orexin by Cocaine.

MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor.

Antiproliferative and cytotoxic effects of some σ<sub>2</sub> agonists and σ<sub>1</sub> antagonists in tumour cell lines.

Novel and Selective Fluorescent σ<sub>2</sub>-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ<sub>2</sub> Receptors in Living Cells.

Inside Cover: Sigma-2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity (ChemMedChem 12/2013).

Sigma-2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity.

2-Aminopyridine Derivatives as Potential σ<sub>2</sub> Receptor Antagonists.

Inside Cover: 1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ<sub>8</sub>-Δ<sub>7</sub> Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity (ChemMedChem 1/2011).

1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ<sub>8</sub>-Δ<sub>7</sub> Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity.