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Characterization of a new model of chemotherapy-induced heart failure with reduced ejection fraction and nephrotic syndrome in Ren-2 transgenic rats.
Published in:
Hypertension Research, 2024, v. 47, n. 11, p. 3126, doi. 10.1038/s41440-024-01865-7
By:
- Gawrys, Olga;
- Jíchová, Šárka;
- Miklovič, Matúš;
- Husková, Zuzana;
- Kikerlová, Soňa;
- Sadowski, Janusz;
- Kollárová, Petra;
- Lenčová-Popelova, Olga;
- Hošková, Lenka;
- Imig, John D.;
- Mazurova, Yvona;
- Kolář, František;
- Melenovský, Vojtěch;
- Štěrba, Martin;
- Červenka, Luděk
Publication type:
Article
Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats.
Published in:
Frontiers in Physiology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphys.2021.622882
By:
- Walkowska, Agnieszka;
- Červenka, Luděk;
- Imig, John D.;
- Falck, John R.;
- Sadowski, Janusz;
- Kompanowska-Jezierska, Elżbieta
Publication type:
Article
Kidney Response to Chemotherapy-Induced Heart Failure: mRNA Analysis in Normotensive and Ren-2 Transgenic Hypertensive Rats.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 16, p. 8475, doi. 10.3390/ijms22168475
By:
- Jíchová, Šárka;
- Gawryś, Olga;
- Kompanowska-Jezierska, Elżbieta;
- Sadowski, Janusz;
- Melenovský, Vojtěch;
- Hošková, Lenka;
- Červenka, Luděk;
- Kala, Petr;
- Veselka, Josef;
- Čertíková Chábová, Věra
Publication type:
Article
Deleterious Effects of Hyperactivity of the Renin-Angiotensin System and Hypertension on the Course of Chemotherapy-Induced Heart Failure after Doxorubicin Administration: A Study in Ren-2 Transgenic Rat.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 24, p. 9337, doi. 10.3390/ijms21249337
By:
- Kala, Petr;
- Bartušková, Hana;
- Piťha, Jan;
- Vaňourková, Zdenka;
- Kikerlová, Soňa;
- Jíchová, Šárka;
- Melenovský, Vojtěch;
- Hošková, Lenka;
- Veselka, Josef;
- Kompanowska-Jezierska, Elzbieta;
- Sadowski, Janusz;
- Gawrys, Olga;
- Maxová, Hana;
- Červenka, Luděk
Publication type:
Article
Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats.
Published in:
Frontiers in Pharmacology, 2022, v. 12, p. 1, doi. 10.3389/fphar.2021.798642
By:
- Baranowska, Iwona;
- Gawrys, Olga;
- Walkowska, Agnieszka;
- Olszynski, Krzysztof H.;
- Červenka, Luděk;
- Falck, John R.;
- Adebesin, Adeniyi M.;
- Imig, John D.;
- Kompanowska-Jezierska, Elżbieta
Publication type:
Article
Effects of Trandolapril on Structural, Contractile and Electrophysiological Remodeling in Experimental Volume Overload Heart Failure.
Published in:
Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.729568
By:
- Jarkovská, Dagmar;
- Miklovič, Matúš;
- Švíglerová, Jitka;
- Červenka, Luděk;
- Škaroupková, Petra;
- Melenovský, Vojtěch;
- Štengl, Milan
Publication type:
Article
Sex-linked differences in the course of chronic kidney disease and congestive heart failure: a study in 5/6 nephrectomized Ren-2 transgenic hypertensive rats with volume overload induced using aorto-caval fistula.
Published in:
Clinical & Experimental Pharmacology & Physiology, 2016, v. 43, n. 10, p. 883, doi. 10.1111/1440-1681.12619
By:
- Červenka, Luděk;
- Škaroupková, Petra;
- Kompanowska‐Jezierska, Elzbieta;
- Sadowski, Janusz
Publication type:
Article
Intrarenal alterations of the angiotensin-converting enzyme type 2/angiotensin 1-7 complex of the renin-angiotensin system do not alter the course of malignant hypertension in Cyp1a1-Ren-2 transgenic rats.
Published in:
Clinical & Experimental Pharmacology & Physiology, 2016, v. 43, n. 4, p. 438, doi. 10.1111/1440-1681.12553
By:
- Husková, Zuzana;
- Kopkan, Libor;
- Červenková, Lenka;
- Doleželová, Šárka;
- Vaňourková, Zdeňka;
- Škaroupková, Petra;
- Nishiyama, Akira;
- Kompanowska‐Jezierska, Elzbieta;
- Sadowski, Janusz;
- Kramer, Herbert J.;
- Červenka, Luděk
Publication type:
Article
Inhibition of soluble epoxide hydrolase counteracts the development of renal dysfunction and progression of congestive heart failure in Ren-2 transgenic hypertensive rats with aorto-caval fistula.
Published in:
Clinical & Experimental Pharmacology & Physiology, 2015, v. 42, n. 7, p. 795, doi. 10.1111/1440-1681.12419
By:
- Červenka, Luděk;
- Melenovský, Vojtěch;
- Husková, Zuzana;
- Škaroupková, Petra;
- Nishiyama, Akira;
- Sadowski, Janusz
Publication type:
Article
Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: Studies in Cyp1a1-Ren-2 transgenic rats.
Published in:
Clinical & Experimental Pharmacology & Physiology, 2014, v. 41, n. 12, p. 1003, doi. 10.1111/1440-1681.12310
By:
- Sporková, Alexandra;
- Jíchová, Šárka;
- Husková, Zuzana;
- Kopkan, Libor;
- Nishiyama, Akira;
- Hwang, Sung H;
- Hammock, Bruce D;
- Imig, John D;
- Kompanowska‐Jezierska, Elzbieta;
- Sadowski, Janusz;
- Kramer, Herbert J;
- Červenka, Luděk
Publication type:
Article
Similar renoprotection after renin-angiotensin-dependent and -independent antihypertensive therapy in 5/6-nephrectomized Ren-2 transgenic rats: are there blood pressure-independent effects?
Published in:
Clinical & Experimental Pharmacology & Physiology, 2010, v. 37, n. 12, p. 1159, doi. 10.1111/j.1440-1681.2010.05453.x
By:
- Kujal, Petr;
- Chábová, Věra Čertíková;
- Vernerová, Zdenka;
- Walkowska, Agnieszka;
- Kompanowska-Jezierska, Elzbieta;
- Sadowski, Janusz;
- Vaňourková, Zdeňka;
- Husková, Zuzana;
- Opočenský, Martin;
- Škaroupková, Petra;
- Schejbalová, Stanislava;
- Kramer, Herbert J;
- Rakušan, Dan;
- Malý, Jan;
- Netuka, Ivan;
- Vaněčková, Ivana;
- Kopkan, Libor;
- Červenka, Luděk
Publication type:
Article
Renal sympathetic denervation improves pressure-natriuresis relationship in cardiorenal syndrome: insight from studies with Ren-2 transgenic hypertensive rats with volume overload induced using aorto-caval fistula.
Published in:
Hypertension Research, 2024, v. 47, n. 4, p. 998, doi. 10.1038/s41440-024-01583-0
By:
- Honetschlägerová, Zuzana;
- Husková, Zuzana;
- Kikerlová, Soňa;
- Sadowski, Janusz;
- Kompanowska-Jezierska, Elzbieta;
- Táborský, Miloš;
- Vaňourková, Zdenka;
- Kujal, Petr;
- Červenka, Luděk
Publication type:
Article
Impaired renal autoregulation and pressure-natriuresis: any role in the development of heart failure in normotensive and angiotensin II-dependent hypertensive rats?
Published in:
Hypertension Research, 2023, v. 46, n. 10, p. 2340, doi. 10.1038/s41440-023-01401-z
By:
- Honetschlägerová, Zuzana;
- Sadowski, Janusz;
- Kompanowska-Jezierska, Elzbieta;
- Maxová, Hana;
- Táborský, Miloš;
- Kujal, Petr;
- Červenka, Luděk
Publication type:
Article
Tacrolimus-induced hypertension and nephrotoxicity in Fawn-Hooded rats are attenuated by dual inhibition of renin-angiotensin system.
Published in:
Hypertension Research, 2014, v. 37, n. 8, p. 724, doi. 10.1038/hr.2014.79
By:
- Hošková, Lenka;
- Málek, Ivan;
- Kautzner, Josef;
- Honsová, Eva;
- van Dokkum, Richard P E;
- Husková, Zuzana;
- Vojtíšková, Alžbeta;
- Varcabová, Šárka;
- Červenka, Luděk;
- Kopkan, Libor
Publication type:
Article
Renal Sympathetic Denervation Attenuates Congestive Heart Failure in Angiotensin II-Dependent Hypertension: Studies with Ren-2 Transgenic Hypertensive Rats with Aortocaval Fistula.
Published in:
Kidney & Blood Pressure Research, 2021, v. 46, n. 1, p. 95, doi. 10.1159/000513071
By:
- Honetschlagerová, Zuzana;
- Gawrys, Olga;
- Jíchová, Šárka;
- Škaroupková, Petra;
- Kikerlová, Soňa;
- Vaňourková, Zdeňka;
- Husková, Zuzana;
- Melenovský, Vojtěch;
- Kompanowska-Jezierska, Elzbieta;
- Sadowski, Janusz;
- Kolář, František;
- Novotný, Jiří;
- Hejnová, Lucie;
- Kujal, Petr;
- Červenka, Luděk
Publication type:
Article
Addition of Endothelin A-Receptor Blockade Spoils the Beneficial Effect of Combined Renin-Angiotensin and Soluble Epoxide Hydrolase Inhibition: Studies on the Course of Chronic Kidney Disease in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats.
Published in:
Kidney & Blood Pressure Research, 2019, v. 44, n. 6, p. 1493, doi. 10.1159/000504137
By:
- Čertíková Chábová, Věra;
- Kujal, Petr;
- Vaňourková, Zdeňka;
- Škaroupková, Petra;
- Sadowski, Janusz;
- Kompanowska-Jezierska, Elzbieta;
- Tesař, Vladimír;
- Hammock, Bruce;
- Imig, John;
- Maxová, Hana;
- Červenka, Luděk;
- Vaněčková, Ivana
Publication type:
Article
Enhanced Renal Vascular Responsiveness to Angiotensin II and Norepinephrine: A Unique Feature of Female Rats with Congestive Heart Failure.
Published in:
Kidney & Blood Pressure Research, 2019, v. 44, n. 5, p. 1128, doi. 10.1159/000502379
By:
- Krátký, Vojtěch;
- Kikerlová, Soňa;
- Husková, Zuzana;
- Sadowski, Janusz;
- Kolář, František;
- Červenka, Luděk
Publication type:
Article
Altered Renal Vascular Responsiveness to Vasoactive Agents in Rats with Angiotensin II-Dependent Hypertension and Congestive Heart Failure.
Published in:
Kidney & Blood Pressure Research, 2019, v. 44, n. 4, p. 792, doi. 10.1159/000501688
By:
- Vacková, Šárka;
- Kikerlová, Soňa;
- Melenovsky, Vojtěch;
- Kolář, František;
- Imig, John D.;
- Kompanowska-Jezierska, Elzbieta;
- Sadowski, Janusz;
- Červenka, Luděk
Publication type:
Article
Soluble Epoxide Hydrolase Inhibition Exhibits Antihypertensive Actions Independently of Nitric Oxide in Mice with Renovascular Hypertension.
Published in:
Kidney & Blood Pressure Research, 2012, v. 35, n. 6, p. 595, doi. 10.1159/000339883
By:
- Kopkan, Libor;
- Husková, Zuzana;
- Sporková, Alexandra;
- Varcabová, Šárka;
- Honetschlägerová, Zuzana;
- Sung Hee Hwang;
- Hsing-Ju Tsai;
- Hammock, Bruce D.;
- Imig, John D.;
- Kramer, Herbert J.;
- Bürgelová, Marcela;
- Vojtíšková, Alžběta;
- Kujal, Petr;
- Vernerová, Zdenka;
- Červenka, Luděk
Publication type:
Article
Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats.
Published in:
Kidney & Blood Pressure Research, 2012, v. 35, n. 5, p. 382, doi. 10.1159/000336823
By:
- Vaněčková, Ivana;
- Kujal, Petr;
- Husková, Zuzana;
- Vaňourková, Zdeňka;
- Vernerová, Zdenka;
- Čertíková Chábová, Věra;
- Škaroupková, Petra;
- Kramer, Herbert J.;
- Tesař, Vladimír;
- Červenka, Luděk
Publication type:
Article
Castration Has Antihypertensive and Organoprotective Effects in Male but Not in Female Heterozygous Ren-2 Rats.
Published in:
Kidney & Blood Pressure Research, 2011, v. 34, n. 1, p. 46, doi. 10.1159/000322618
By:
- Vaněčková, Ivana;
- Husková, Zuzana;
- Vaňourková, Zdeňka;
- Červenka, Luděk
Publication type:
Article
N-Acetylcysteine Attenuates Iodine Contrast Agent-Induced Nephropathy in 5/6-Nephrectomized Rats.
Published in:
Kidney & Blood Pressure Research, 2010, v. 33, n. 2, p. 149, doi. 10.1159/000315435
By:
- Šochman, Jan;
- Peregrin, Jan H.;
- Bürgelová, Marcela;
- Kopkan, Libor;
- Kramer, Herbert J.;
- Červenka, Luděk
Publication type:
Article
The Roles of Intrarenal 20-Hydroxyeicosatetraenoic and Epoxyeicosatrienoic Acids in the Regulation of Renal Function in Hypertensive Ren-2 Transgenic Rats.
Published in:
Kidney & Blood Pressure Research, 2007, v. 30, n. 5, p. 335, doi. 10.1159/000107710
By:
- Chábová, Věra Čertíková;
- Kramer, Herbert J.;
- Vaně Čková, Ivana;
- Thumová, Monika;
- Škaroupková, Petra;
- Tesař, Vladimír;
- Falck, John R.;
- Imig, John D.;
- Červenka, Luděk
Publication type:
Article
Effects of Dietary Salt Load and Salt Depletion on the Course of Hypertension and Angiotensin II Levels in Male and Female Heterozygous Ren-2 Transgenic Rats.
Published in:
Kidney & Blood Pressure Research, 2007, v. 30, n. 1, p. 45, doi. 10.1159/000099028
By:
- Husková, Zuzana;
- Kramer, Herbert;
- Vaňourková, Zdenka;
- Thumová, Monika;
- Malý, Jan;
- Opočenský, Martin;
- Škaroupková, Petra;
- Kolský, Alexander;
- Vernerová, Zdena;
- Červenka, Luděk
Publication type:
Article
Long-Term Prevention of Hypertension and End-Organ Damage in Ren-2 Transgenic Rats Is Achieved Only with Persistent but Not Transient AT<sub>1 </sub>Receptor Blockade.
Published in:
Kidney & Blood Pressure Research, 2007, v. 30, n. 1, p. 38, doi. 10.1159/000098869
By:
- Vaněčková, Ivana;
- Kopkan, Libor;
- Husková, Zuzana;
- Vaňourková, Zdenka;
- Schejbalová, Stanislava;
- Červenka, Luděk;
- Kramer, Herbert J.
Publication type:
Article
Effects of Anesthesia on Plasma and Kidney ANG II Levels in Normotensive and ANG II-Dependent Hypertensive Rats.
Published in:
Kidney & Blood Pressure Research, 2006, v. 29, n. 2, p. 74, doi. 10.1159/000092981
By:
- Husková, Zuzana;
- Kramer, Herbert J.;
- Thumová, Monika;
- Vaňourková, Zdenka;
- Bürgelová, Marcela;
- Teplan, Vladimír;
- Malý, Jan;
- Červenka, Luděk
Publication type:
Article
Lack of a Role of Neuronal Nitric Oxide Synthase in the Regulation of the Renal Function in Rats Fed a Low-Sodium Diet.
Published in:
Kidney & Blood Pressure Research, 2002, v. 25, n. 4, p. 224, doi. 10.1159/000066350
By:
- Vaněčková, Ivana;
- Kramer, Herbert J.;
- Malý, Jan;
- Bäcker, Angela;
- Bokemeyer, Dirk;
- Červenka, Luděk
Publication type:
Article
Intrarenal Infusion of Angiotensin-(1-7) Modulates Renal Functional Responses to Exogenous Angiotensin II in the Rat.
Published in:
Kidney & Blood Pressure Research, 2002, v. 25, n. 4, p. 202, doi. 10.1159/000066340
By:
- Bürgelová, Marcela;
- Kramer, Herbert J.;
- Teplan, Vladimír;
- Veličková, Gabriela;
- Vítko, Štefan;
- Heller, Jiří;
- Malý, Jan;
- Červenka, Luděk
Publication type:
Article
The treatment with sGC stimulator improves survival of hypertensive rats in response to volume-overload induced by aorto-caval fistula.
Published in:
Naunyn-Schmiedeberg's Archives of Pharmacology, 2023, v. 396, n. 12, p. 3757, doi. 10.1007/s00210-023-02561-y
By:
- Gawrys, Olga;
- Husková, Zuzana;
- Škaroupková, Petra;
- Honetschlägerová, Zuzana;
- Vaňourková, Zdeňka;
- Kikerlová, Soňa;
- Melenovský, Vojtěch;
- Bačová, Barbara Szeiffová;
- Sykora, Matúš;
- Táborský, Miloš;
- Červenka, Luděk
Publication type:
Article
Epoxyeicosatrienoic Acid-Based Therapy Attenuates the Progression of Postischemic Heart Failure in Normotensive Sprague-Dawley but Not in Hypertensive Ren-2 Transgenic Rats.
Published in:
Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00159
By:
- Hrdlička, Jaroslav;
- Neckář, Jan;
- Papoušek, František;
- Husková, Zuzana;
- Kikerlová, Soňa;
- Vaňourková, Zdenka;
- Vernerová, Zdenka;
- Akat, Firat;
- Vašinová, Jana;
- Hammock, Bruce D.;
- Hwang, Sung Hee;
- Imig, John D.;
- Falck, John R.;
- Červenka, Luděk;
- Kolář, František
Publication type:
Article
Pharmacological Blockade of Soluble Epoxide Hydrolase Attenuates the Progression of Congestive Heart Failure Combined With Chronic Kidney Disease: Insights From Studies With Fawn-Hooded Hypertensive Rats.
Published in:
Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00018
By:
- Vacková, Šárka;
- Kopkan, Libor;
- Kikerlová, Soňa;
- Husková, Zuzana;
- Sadowski, Janusz;
- Kompanowska-Jezierska, Elzbieta;
- Hammock, Bruce D.;
- Imig, John D.;
- Táborský, Miloš;
- Melenovský, Vojtěch;
- Červenka, Luděk
Publication type:
Article
Effects of Renal Denervation on the Enhanced Renal Vascular Responsiveness to Angiotensin II in High-Output Heart Failure: Angiotensin II Receptor Binding Assessment and Functional Studies in Ren-2 Transgenic Hypertensive Rats.
Published in:
Biomedicines, 2021, v. 9, n. 12, p. 1803, doi. 10.3390/biomedicines9121803
By:
- Honetschlägerová, Zuzana;
- Hejnová, Lucie;
- Novotný, Jiří;
- Marek, Aleš;
- Červenka, Luděk
Publication type:
Article
Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation.
Published in:
Biomedicines, 2021, v. 9, n. 8, p. 1053, doi. 10.3390/biomedicines9081053
By:
- Kala, Petr;
- Miklovič, Matúš;
- Jíchová, Šárka;
- Škaroupková, Petra;
- Vaňourková, Zdeňka;
- Maxová, Hana;
- Gawrys, Olga;
- Kompanowska-Jezierska, Elzbieta;
- Sadowski, Janusz;
- Imig, John D.;
- Falck, John R.;
- Veselka, Josef;
- Červenka, Luděk;
- Aiglová, Renáta;
- Vícha, Marek;
- Gloger, Vít;
- Táborský, Miloš
Publication type:
Article
Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension.
Published in:
Journal of Physiology, 2011, v. 589, n. 1, p. 207, doi. 10.1113/jphysiol.2010.199505
By:
- Honetschlägerová, Zuzana;
- Husková, Zuzana;
- Vaňourková, Zdeňka;
- Sporková, Alexandra;
- Kramer, Herbert J.;
- Hwang, Sung Hee;
- Tsai, Hsing-Ju;
- Hammock, Bruce D.;
- Imig, John D.;
- Červenka, Luděk;
- Kopkan, Libor
Publication type:
Article
Renoprotection Provided by Additional Diuretic Treatment in Partially Nephrectomized Ren-2 Transgenic Rats Subjected to the Combined RAS and ET<sub>A</sub> Blockade.
Published in:
Frontiers in Physiology, 2019, p. 1, doi. 10.3389/fphys.2019.01145
By:
- Vaněčková, Ivana;
- Hojná, Silvie;
- Vernerová, Zdenka;
- Kadlecová, Michaela;
- Rauchová, Hana;
- Kompanowska-Jezierska, Elzbieta;
- Vaňourková, Zdeňka;
- Červenka, Luděk;
- Zicha, Josef
Publication type:
Article
Sex-Linked Differences in Cardiac Atrophy After Mechanical Unloading Induced by Heterotopic Heart Transplantation.
Published in:
Physiological Research, 2024, v. 73, n. 1, p. 9, doi. 10.33549/physiolres.935217
By:
- KOLESÁR, Dushan Michael;
- KUJAL, Petr;
- MRÁZOVÁ, Iveta;
- POKORNÝ, Martin;
- ŠKAROUPKOVÁ, Petra;
- SADOWSKI, Janusz;
- ČERVENKA, Luděk;
- NETUKA, Ivan
Publication type:
Article
Effects of angiotensin-(1-7) blockade on renal function in rats with enhanced intrarenal Ang II activity.
Published in:
2005
By:
- Bürgelová, Marcela;
- Kramer, Herbert J.;
- Teplan, Vladimír;
- Thumová, Monika;
- Červenka, Luděk;
- Bürgelová, Marcela;
- Teplan, Vladimír;
- Thumová, Monika;
- Cervenka, Ludek
Publication type:
journal article
Losartan protects the rat kidney from ischemic injury.
Published in:
Kidney International Supplement, 1996, n. 55, p. S-113
By:
- HELLER, JIŘÍ;
- KRAMER, HERBERT J.;
- ČERVENKA, LUDĚK
Publication type:
Article

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