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- Title
Protective Effect of Tamarindus indica Linn Against Paracetamol-Induced Hepatotoxicity in Rats.
- Authors
Pimple, B. P.; Kadam, P. V.; Badgujar, N. S.; Bafna, A. R.; Patil, M. J.
- Abstract
Protective effect of Tamarindus indica Linn (Caesalpiniaceae) was evaluated by intoxicating the rats with paracetamol (1 g/kg p.o.) for seven days. The aqueous extracts of different parts of Tamarindus indica such as fruits, leaves (350 mg/kg p.o.) and unroasted seeds (700 mg/kg p.o.) were administered for 9 days after the third dose of paracetamol. Biochemical estimations such as aspartate transaminase, alanine transaminase, alkaline phosphatase, total bilirubin and total protein were recorded on 4th and 13th day. Liver weight variation, thiopentone-induced sleeping time and histopathology were studied on 13th day. Silymarin (100 mg/kg p.o.) was used as a standard. A significant hepatoregenerative effect was observed for the aqueous extracts of tamarind leaves, fruits and unroasted seeds (p<0.05) as judged from the parameters studied.
- Publication
Indian Journal of Pharmaceutical Sciences, 2007, Vol 69, Issue 6, p827
- ISSN
0250-474X
- Publication type
Academic Journal