Title

Adaptogenic Effects of Dihydroquercetin-Chitosan Composition during Modeling of Acute Hypoxia.

Authors

Murach, E.; Baranov, I.; Erlykina, E.; Koryagin, A.; Mochalova, A.; Smirnova, L.

Abstract

The course of preventive oral treatment with a dihydroquercetin-chitosan composition produced a strong antihypoxic effect under conditions of experimental hypobaric hypoxia (arbitrary altitude 12,000 m). The lactate/pyruvate ratio in composition-receiving rats was much lower than in hypoxic animals (by 83%), but higher than in intact specimens (by 29%). The composition of chitosan and dihydroquercetin also possessed a strong antioxidant activity.

Subjects

HYPOXEMIA; THERAPEUTIC use of antioxidants; CHITOSAN; LACTATES; PYRUVATES; LABORATORY rats; THERAPEUTICS

Publication

Bulletin of Experimental Biology & Medicine, 2014, Vol 156, Issue 3, p306

ISSN

0007-4888

Publication type

Academic Journal

DOI

10.1007/s10517-014-2336-0