Expressions and clinical significance of Sirt1, P53 and P-gp in gastric carcinoma.

FAN Lin; CHEN Rui; ZHAO Wei; LIU Jun-song; ZHANG Zheng-liang; LI Liang; WANG Ze-xing; CHE Xiang-ming

Objective To explore the expressions of Sirt1, P53 and P-gp in gastric carcinoma and investigate their correlations with clinicopathological characteristics as well as survival and prognosis. Methods The expressions of Sirt1, P53 and P-gp were detected in 68 cases of gastric carcinoma tissues and normal tissues with immunohistochemical method. The relationship between the expressions and the 68 patients' survival time was analyzed by Kaplan Meier survival curve. Results Sirt1, P53 and P-gp expressions were significantly higher in gastric carcinoma tissues than in normal tissues (P<0.01). The high expression of Sirt1 was correlated with invasion depth, lymph node metastasis and clinical TNM stage. Moreover, deeper invasion, lymph node metastasis and higher clinical TNM stage were related to higher Sirt1 expression (P<0.05). A positive correlation was found between Sirt1 expression with P53 and P-gp in gastric carcinoma (P<0.001). The survival time was shorter in patients with positive Sirt1 expression than those with negative expression (P<0.001). Conclusion The expressions of Sirt1, P53 and P-gp are higher in gastric carcinoma than in normal tissues and are related to the pathological characteristics of gastric carcinoma. Therefore, Sirt1, P53 and P-gp expressions detected in combination can serve as indicators for judging survival duration and prognosis of gastric carcinoma patients.

STOMACH cancer; STOMACH cancer patients; CARCINOMA; CARCINOMA in situ; IMMUNOHISTOCHEMISTRY techniques; MEIER, Kaplan; METASTASIS; PROGNOSIS

Journal of Xi'an Jiaotong University (Medical Sciences), 2013, Vol 34, Issue 5, p643

1671-8259

Academic Journal