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Title: IMPACT OF REGIONAL VARIATION ON LUPEOL CONTENT IN CARISSA CARANDAS LINN. FRUITS: EVALUATION USING VALIDATED HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY.
Authors: Shailajan, Sunita; Sayed, Neelam; Tiwari, Bhavesh
Abstract: The present work is an attempt to evaluate the impact of regional variation on lupeol content in Carissa carandas Linn. fruits collected from different geographical regions of India using a validated HPTLC method. Chromatographic separation was achieved on TLC plates pre-coated with silica gel 60 F254 using toluene: methanol (8:1, v/v) as a mobile phase. Detection of lupeol was carried out by derivatizing the plates with 10 % methanolic sulphuric acid reagent followed by its densitometric scanning using CAMAG TLC scanner 4 at 366 nm. The method was validated as per ICH guidelines. Statistical analysis reveals that, the content of lupeol in different geographical region varied significantly.
Subjects: SHRUBS; HIGH performance liquid chromatography; SULFURIC acid; FRUIT; DENSITOMETRY; THERAPEUTICS
Publication: Journal of Advanced Scientific Research, 2013, Vol 4, Issue 2, p21
ISSN: 0976-9595
Publication type: Academic Journal

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IMPACT OF REGIONAL VARIATION ON LUPEOL CONTENT IN CARISSA CARANDAS LINN. FRUITS: EVALUATION USING VALIDATED HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY.