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Title: Sulforaphane Inhibits Osteoclastogenesis by Inhibiting Nuclear Factor-κB.
Authors: Soo-Jin Kim; So-Young Kang; Hyun-Hee Shin; Hye-Seon Choi
Abstract: We show that sulforaphane inhibits osteoclastogenesis in the presence of macrophage colony-stimulating factor (M-CSF) and receptor for activation of nuclear factor-κB ligand (RANKL) in osteoclast (OC) precursors. Sulforaphane, an aliphatic isothiocyanate, is a known cancer chemo-preventative agent with antioxidative properties. Nuclear factor-κB (NF-κB) is a critical transcription factor in RANKL-induced osteoclastogenesis, and electrophoretic mobility shift assays (EMSAs) and assay of NF-κB-mediated secreted alkaline phosphatase (SEAP) revealed that sulforaphane selectively inhibited NF-κB activation induced by RANKL. Inhibition may involve interaction of sulforaphane with thiol groups, since it was prevented by reducing agents.
Publication: Molecules & Cells (Springer Nature), 2005, Vol 20, Issue 3, p364
ISSN: 1016-8478
Publication type: Academic Journal
DOI: 10.1016/s1016-8478(23)13240-7

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Sulforaphane Inhibits Osteoclastogenesis by Inhibiting Nuclear Factor-κB.