Title

Transcriptional pharmacology of neurodegenerative disorders: novel venue towards neuroprotection against excitotoxicity?

Authors

Memo, M.; Segman, R.; Gritsenko, I.; Nemanov, L.; Lerer, B.; Kramer, I.; Zer-Zion, M.; Kletz, I.; Ebstein, R.P.

Abstract

Transcription factors NF-κB/Rel represent the point of convergence of several signalling pathways relevant to neurodegeneration. The finding that salicylates elicit neuroprotection via blockade of NF-κB provides new opportunities for pharmacological intervention.

Subjects

NF-kappa B; NEUROLOGICAL disorders; CELLULAR signal transduction

Publication

Molecular Psychiatry, 1997, Vol 2, Issue 3, p192

ISSN

1359-4184

Publication type

Academic Journal