Development and characterization of niosomal drug delivery of a-lipoic acid.

Anita R. Desai; Raghuveer, I.; Chitme, H. R.; Chandra, Ramesh

The present study is an aim to overall improvement in the efficacy, reduced toxicity and enhancement of therapeutic index of niosome carrying a-lipoic acid. Niosome were prepared by reverse phase evaporation method using span and tween (20 and/or 60). The preparations were characterize with respect to size reduction, entrapment efficiency, in-vitro drug release profile and stability under specific conditions. The diameter of niosomes ranges from 1-3μm with spherical/ oval in shape. The entrapment efficiency of the vesicles was found to be 67.84 %, 74.94%, 69.84% and 72.31% for F1, F2, F3 and F4 respectively. Highly cumulative release was observed with 76.202 % for span-20, 69.72% for span-60, 81.78 % for tween-20 and 84.06 % for tween-60 respectively. Stability studies proved that optimum storage condition for niosomes was found to be 4°c.

DRUG development; DRUG delivery systems; CONTROLLED release preparations; LIPOIC acid; ANTIOXIDANTS; VITAMIN B complex; DRUG efficacy; DRUG carriers

Drug Invention Today, 2010, Vol 2, Issue 7, p325

0975-7619

Academic Journal