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Title

HEPATOPROTECTIVE EFFECT OF Ipomoea mauritiana jacq AGAINST AMOXICILLIN INDUCED TOXICITY IN ALBINO RATS.

Authors

Sathiyapriya, S.; Mozhiyarasi, P.

Abstract

Hepatoprotective activity of aqueous extract of Ipomoea mauritiana jacq against amoxicillin induced hepatotoxicity in male albino rats was evaluated. The aqueous extract of Ipomoea mauritiana jacq (200 mg/kg body weight ) was administered along with amoxicillin (2gm/kg body weight). The plant extract was effective in protecting the liver against the injury induced by amoxicillin in rats. This was evident from significant increase in total protein level and decrease in the level of Triglyceride, Cholesterol, Bilirubin, serum marker enzymes such as SGOT, SGPT, ALP, ACP. The hepatoprotective activity was also supported by istopathological studies of liver tissue. It was concluded that the aqueous extract of Ipomoea mauritiana jacq possesses hepatoprotective activity against amoxicillin induced hepatotoxicity in male albino rats.

Subjects

AMOXICILLIN; LABORATORY rats; LIVER injuries; IPOMOEA; TOXICOLOGY; PLANT extracts

Publication

International Journal of Pharmacology & Biological Sciences, 2011, Vol 5, Issue 3, p23

ISSN

0973-6808

Publication type

Academic Journal

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