Inhibitory Effect of Dry Matter of Culture Broth of Antrodia camphorata in Submerged Culture on Mice Hepatoma 22.

XU Hong-yu; KONG Xiao-ming; Zong-hua, A. O.; LU Zhen-ming; XU Zheng-hong

The inhibitory effect of dry matter of culture broth (DMCB) of Antrodia camphorata in submerged culture were evaluated with the mice transplanted Hepatoma 22 in vivo. The results showed that DMCB (500 or 1000 mg/kg b. w. ) could inhibit tumor growth,with the inhibition rates of 42% and 47%, respectively. Meanwhile, the survival time of the H22-bearing mice from DMCB treated group (1000 mg/kg b. w. ) was prolonged, when compared with that of model group. The histopathology of tumors from the various groups indicated that the tumor cells of untreated mice grew vigorously, whereas the tumor ceils from DMCB treated groups had clear nucleus pycnosis and necrosis areas. Antrodia camphorata in submerged culture possess potent antitumor acitivity in vivo.

HEPATOCELLULAR carcinoma; ANTINEOPLASTIC agents; TUMOR growth; LABORATORY mice; NECROSIS

Natural Product Research & Development, 2010, Vol 22, Issue 3, p411

1001-6880

Academic Journal