CHOLECALCIFEROL SUPPLEMENTATION IS ABLE TO MODULATE HYPERTENSION AND PLASMA ALDOSTERONE IN SHRSP RATS.

De Souza Santos, Rosane; Marques Vianna, Lucia

Stroke is the third leading cause of death and there are no proven neuroprotective drugs available today. Nicotinamide may have a possible effect on stroke risk factors and it's mechanism of action is probably related to nitric oxide pathway. 36 stroke prone rats were divided in groups and received nicotinamide or tap water. Some groups also received a special hypercaloric hyperlipidic diet. Were also evaluated systolic blood pressure, blood glucose and lipid profile. The supposed mechanism of action on blood pressure was associated to nitric oxide and in 6 rats were also administered L-name. Nicotinamide reduced systolic blood pressure, blood glucose, total cholesterol and LDL, is also increased HDL. L-name administration blocked the hypotensive effect of nicotinamide. Our data suggests that Nicotinamide may be a powerful drug on the control of stroke risk factors such as hypertension, blood glucose levels and dyslipidemia. There was an association between the hypotensive effect of nicotinamide and nitric oxide.

CHOLECALCIFEROL; HYPERTENSION; ALDOSTERONE; NICOTINAMIDE; CEREBROVASCULAR disease; NITRIC oxide; NEUROPROTECTIVE agents

Current Topics in Nutraceutical Research, 2009, Vol 7, Issue 3, p109

1540-7535

Academic Journal