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Title: Structure and Solubility of Silybin-N-Meglumine.
Authors: LIN Jian-guang; ZHOU Zhong; WANG Chao; WANG Jian-xin
Abstract: The structure of synthesized Silybin-N-Meglumine was studied by UV, DSC, HPLC-ESI-MS. The equilibrium solubility of Silybin-N-Meglumine in water at 25 °C was measured. It was shown that Silybin-N-Meglumine exists in form of salt, which is different from simple mixture. Silybin-N-Meglumine can be easily decomposed into silybin and meglumine in acidic flow solutions, and the properties of silybin are not changed. Therefore, the DSC can be used for a reference basis to evaluate the quality of Silybin-N-Meglumine because the HPLC has a limitation to study Silybin-N-Meglumine. The equilibrium solubility of silybin and Silybin-N-Meglumine in water were respectively 37. 350 and 7182.50 mg/L at 25 °C. The solubility of silybin in water can be improved significantly via Silybin-N-Meglumine.
Subjects: AMINO sugars; SOLUBILITY; SOLUTION (Chemistry); HIGH performance liquid chromatography; SUGARS
Publication: Natural Product Research & Development, 2009, Vol 21, Issue 2, p214
ISSN: 1001-6880
Publication type: Academic Journal

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Structure and Solubility of Silybin-N-Meglumine.